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Original Article

Heat shock protein 72 (HSP72), hyperthermia-inducible immunogenic determinant on leukemic K562 and Ewing's Sarcoma cells

Pages 39-48 | Accepted 22 Aug 1996, Published online: 09 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

A. Graham Pockley, Peter Vaupel & Gabriele Multhoff. (2020) NK cell-based therapeutics for lung cancer. Expert Opinion on Biological Therapy 20:1, pages 23-33.
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Jay Campisi, Craig Sharkey, John D. Johnson, Alexzander Asea, Thomas Maslanik, Isaac Bernstein-Hanley & Monika Fleshner. (2012) Stress-induced facilitation of host response to bacterial challenge in F344 rats is dependent on extracellular heat shock protein 72 and independent of alpha beta T cells. Stress 15:6, pages 637-646.
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Benjamin Frey, Eva-Maria Weiss, Yvonne Rubner, Roland Wunderlich, Oliver J. Ott, Rolf Sauer, Rainer Fietkau & Udo S. Gaipl. (2012) Old and new facts about hyperthermia-induced modulations of the immune system. International Journal of Hyperthermia 28:6, pages 528-542.
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Gabriele Multhoff. (2009) Activation of natural killer cells by heat shock protein 70. International Journal of Hyperthermia 25:3, pages 169-175.
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Baris E. Dayanc, Sarah H. Beachy, Julie R. Ostberg & Elizabeth A. Repasky. (2008) Dissecting the role of hyperthermia in natural killer cell mediated anti-tumor responses. International Journal of Hyperthermia 24:1, pages 41-56.
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G. Multhoff. (2002) Activation of natural killer cells by heat shock protein 70. International Journal of Hyperthermia 18:6, pages 576-585.
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Articles from other publishers (22)

Maxim Shevtsov, Susanne Kaesler, Christian Posch, Gabriele Multhoff & Tilo Biedermann. (2021) Magnetic nanoparticles in theranostics of malignant melanoma. EJNMMI Research 11:1.
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Bruno Fauvet, Andrija Finka, Marie-Pierre Castanié-Cornet, Anne-Marie Cirinesi, Pierre Genevaux, Manfredo Quadroni & Pierre Goloubinoff. (2021) Bacterial Hsp90 Facilitates the Degradation of Aggregation-Prone Hsp70–Hsp40 Substrates. Frontiers in Molecular Biosciences 8.
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Mieszko Lachota, Marianna Vincenti, Magdalena Winiarska, Kjetil Boye, Radosław Zagożdżon & Karl-Johan Malmberg. (2020) Prospects for NK Cell Therapy of Sarcoma. Cancers 12:12, pages 3719.
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Gabriele Multhoff, Sophie Seier, Stefan Stangl, Wolfgang Sievert, Maxim Shevtsov, Caroline Werner, A. Graham Pockley, Christiane Blankenstein, Martin Hildebrandt, Robert Offner, Norbert Ahrens, Konrad Kokowski, Matthias Hautmann, Claus Rödel, Rainer Fietkau, Dorota Lubgan, Rudolf Huber, Hubert Hautmann, Thomas Duell, Michael Molls, Hanno Specht, Bernhard Haller, Michal Devecka, Andreas Sauter & Stephanie E. Combs. (2020) Targeted Natural Killer Cell–Based Adoptive Immunotherapy for the Treatment of Patients with NSCLC after Radiochemotherapy: A Randomized Phase II Clinical Trial. Clinical Cancer Research 26:20, pages 5368-5379.
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Stephanie Combs, Thomas Schmid, Peter Vaupel & Gabriele Multhoff. (2016) Stress Response Leading to Resistance in Glioblastoma—The Need for Innovative Radiotherapy (iRT) Concepts. Cancers 8:1, pages 15.
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Clarissa Amaya, Vittal Kurisetty, Jessica Stiles, Alice M Nyakeriga, Arunkumar Arumugam, Rajkumar Lakshmanaswamy, Cristian E Botez, Dianne C Mitchell & Brad A Bryan. (2014) A genomics approach to identify susceptibilities of breast cancer cells to “fever-range” hyperthermia. BMC Cancer 14:1.
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Mathias Gehrmann, Stefan Stangl, Gemma A. Foulds, Rupert Oellinger, Stephanie Breuninger, Roland Rad, Alan G. Pockley & Gabriele Multhoff. (2014) Tumor Imaging and Targeting Potential of an Hsp70-Derived 14-Mer Peptide. PLoS ONE 9:8, pages e105344.
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Valerie Francescutti & Joseph J. Skitzki. (2012) Sarcomas and the Immune System: Implications for Therapeutic Strategies. Surgical Oncology Clinics of North America 21:2, pages 341-355.
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M. Mohamed, G. Borchard & O. Jordan. (2012) In situ forming implants for local chemotherapy and hyperthermia of bone tumors. Journal of Drug Delivery Science and Technology 22:5, pages 393-408.
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Patrice Donfack, Gabriele Multhoff & Arnulf Materny. (2011) Label‐Free Nondestructive Discrimination of Colon Carcinoma Sublines and Biomolecular Insights into their Differential Hsp70 Expression: DNA/RNA Nucleobase Specific Changes. ChemBioChem 12:12, pages 1922-1936.
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Lucie Sedlackova, Martin Spacek, Ernst Holler, Zuzana Imryskova & Ilona Hromadnikova. (2010) Heat-shock protein expression in leukemia. Tumor Biology 32:1, pages 33-44.
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Patrizia Bottoni, Bruno Giardina & Roberto Scatena. (2009) Proteomic profiling of heat shock proteins: An emerging molecular approach with direct pathophysiological and clinical implications. PROTEOMICS - Clinical Applications 3:6, pages 636-653.
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Emily J. Noonan, Gregory Fournier & Lawrence E. Hightower. (2008) Surface expression of Hsp70B’ in response to proteasome inhibition in human colon cells. Cell Stress and Chaperones 13:1, pages 105-110.
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Ming Zhao, Rui Chen, Aiping Li & Jianwei Zhou. (2007) Effects of hemin and thermal stress exposure on JWA expression. Frontiers of Medicine in China 1:1, pages 104-108.
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Karla Melendez, Erik S. Wallen, Bruce S. Edwards, Charlotte D. Mobarak, David G. Bear & Pope L. Moseley. (2006) Heat shock protein 70 and glycoprotein 96 are differentially expressed on the surface of malignant and nonmalignant breast cells. Cell Stress & Chaperones 11:4, pages 334.
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P. Deepak, S. Kumar & A. Acharya. (2016) Heat Shock Proteins (HSP): Future Trends in Cancer Immunotherapy. European Journal of Inflammation 4:1, pages 1-10.
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C. Gross, D. Hansch, R. Gastpar & G. Multhoff. (2003) Interaction of Heat Shock Protein 70 Peptide with NK Cells Involves the NK Receptor CD94. Biological Chemistry 384:2.
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Eugene D Ponomarev, Tatyana N Tarasenko & Alexander M Sapozhnikov. (2000) Splenic cytotoxic cells recognize surface HSP70 on culture-adapted EL-4 mouse lymphoma cells. Immunology Letters 74:2, pages 133-139.
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Brian A. Rabinovich, John Shannon, Ruey-Chyi Su & Richard G. Miller. (2000) Stress Renders T Cell Blasts Sensitive to Killing by Activated Syngeneic NK Cells. The Journal of Immunology 165:5, pages 2390-2397.
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Karin E. Schilbach, Andreas Geiselhart, Johannes T. Wessels, Dietrich Niethammer & Rupert Handgretinger. (2000) Human γδ T Lymphocytes Exert Natural and IL–2–Induced Cytotoxicity to Neuroblastoma Cells. Journal of Immunotherapy 23:5, pages 536-548.
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Gabriele Multhoff, Lee Mizzen, Christopher C. Winchester, Caroline M. Milner, Susanne Wenk, Guenther Eissner, Harm H. Kampinga, Barbara Laumbacher & Judith Johnson. (1999) Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cells. Experimental Hematology 27:11, pages 1627-1636.
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Claus Botzler, Joachim Ellwart, Wolfgang Günther, Günther Eißner & Gabriele Multhoff. (1999) Synergistic effects of heat and ET-18-OCH3 on membrane expression of hsp70 and lysis of leukemic K562 cells. Experimental Hematology 27:3, pages 470-478.
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