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Research-Article

Inhibitors of Cytochrome P-450s and Their Mechanism of Action

Bernard Testa School of Pharmacy University of Lausanne, CH-1005, Lausanne, Switzerland
&
Peter Jenner Department of Neurology, Institute of Psychiatry, London, SE5 8AF, Great Britain
Pages 1-117 | Published online: 22 Sep 2008

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Tomoaki Anabuki, Miu Tsukahara, Hideyuki Matsuura & Kosaku Takahashi. (2016) Tandem photoaffinity labeling of a target protein using a linker with biotin, alkyne and benzophenone groups and a bioactive small molecule with an azide group. Bioscience, Biotechnology, and Biochemistry 80:3, pages 432-439.
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David E. Amacher. (2006) A Toxicologist's Guide to the Preclinical Assessment of Hepatic Microsomal Enzyme Induction. Toxicology Mechanisms and Methods 16:7, pages 385-394.
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Shiuan-Woei Lin Wu, Wen-Chi Jean, Fu-Chuo Peng & Robert Edwards. (2003) Cytochrome P-4503A1 Catalyzes the Formation of MA 1 from Territrem a in Liver Microsomes of 7-Week-Old Female Wistar Rats. Journal of Toxicology and Environmental Health, Part A 66:5, pages 453-467.
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Fu-Chuo Peng & Shiuan-Woei Lin Wu. (2002) METABOLISM OF TERRITREM A IN LIVER MICROSOMES FROM MALE WISTAR RATS: 3. CYTOCHROME P-450 ISOFORMS CATALYZING TRA METABOLISM. Journal of Toxicology and Environmental Health, Part A 65:24, pages 2163-2175.
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Marlène L.N. Dubuisson, Bertrand de Wergifosse, Pierre Kremers, Jacqueline Marchand-Brynaert, André Trouet & Jean-François Rees. (2001) Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes. Free Radical Research 34:3, pages 285-296.
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R. J. Weaver. (2001) Assessment of drug-drug interactions: concepts and approaches. Xenobiotica 31:8-9, pages 499-538.
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Jeffrey C Boehm & Jerry L Adams. (2000) New inhibitors of p38 kinase. Expert Opinion on Therapeutic Patents 10:1, pages 25-37.
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H. Yin, J. Racha, S.-Y. Li, N. Olejnik, H. Satoh & D. Moore. (2000) Automated high throughput human CYP isoform activity assay using SPE-LC/MS method: application in CYP inhibition evaluation. Xenobiotica 30:2, pages 141-154.
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D. F. V. LEWIS, B. G. LAKE, M. DICKINS, P. J. EDDERSHAW, M. H. TARBIT & P. S. GOLDFARB. (1999) Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4. Xenobiotica 29:4, pages 361-393.
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O. PELKONEN, J. MÄEENPÄEÄ, P. TAAVITSAINEN, A. RAUTIO & H. RAUNIO. (1998) Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica 28:12, pages 1203-1253.
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K. Zomorodi & J. B. Houston. (1997) Selectivity of omeprazole inhibition towards rat liver cytochromes P450. Xenobiotica 27:1, pages 49-58.
Read now
D. F. V. LEWIS*B. G. LAKE. (1997) Molecular modelling of mammalian CYP2B isoforms and their interaction with substrates, inhibitors and redox partners. Xenobiotica 27:5, pages 443-478.
Read now
E. A. Rekka, M. Soldan, I. Belai, K. J. Netter & E. Maser. (1996) Biotransformation and detoxification of insecticidal metyrapone analogues by carbonyl reduction in the human liver. Xenobiotica 26:12, pages 1221-1229.
Read now
R. J. Griffin, D. B. Rutt, C. M. Henesey & P. J. Harvison. (1996) In vitro metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in the Fischer 344 rat and New Zealand white rabbit. Xenobiotica 26:4, pages 369-380.
Read now
Arnold R. Goeptar, Heleen Scheerens & Nico P. E. Vermeulen. (1995) Oxygen and Xenobiotic Reductase Activities of Cytochrome P450. Critical Reviews in Toxicology 25:1, pages 25-65.
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S. K. Kuwahara, T. J. Shinn, B. D. Schreider, M. L. Phan & A. N. Kotake. (1995) Aminopyrine infusion breath test for the determination of changes in P450 metabolism in vivo. Xenobiotica 25:9, pages 973-980.
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Claude B‐Bernard & BernardJ. R. Philogène. (1993) Insecticide synergists: Role, importance, and perspectives. Journal of Toxicology and Environmental Health 38:2, pages 199-223.
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Urs A. Boelsterli. (1993) Specific Targets of Covalent Drug-Protein Interactions in Hepatocytes and Their Toxicological Significance in Drug-Induced Liver Injury. Drug Metabolism Reviews 25:4, pages 395-451.
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Y. Nishibe & M. Hirata. (1993) Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes. Xenobiotica 23:6, pages 681-692.
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M.-C. Canivenc-Lavier, C. Brunold, M.-H. Siess & M. Suschetet. (1993) Evidence for tangeretin O-demethylation by rat and human liver microsomes. Xenobiotica 23:3, pages 259-266.
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K. A. Bachmann, M. S. Madhira & G. O. Rankin. (1992) The effects of cobalt chloride, SKF-525A, and N-(3,5-dichlorophenyl)succinimide on in vivo hepatic mixed function oxidase activity as determined by single-sample plasma clearances. Xenobiotica 22:1, pages 27-31.
Read now
J. N. Petitte, R. J. Etches & C. E. Anderson‐Langmuir. (1991) Effect of metyrapone on the timing of oviposition and ovarian steroidogenesis in the laying hen. British Poultry Science 32:4, pages 809-819.
Read now
R. M. Vromans, R. van de Straat, M. Groeneveld & N. P. E. Vermeulen. (1990) One-electron reduction of mitomycin c by rat liver: Role of cytochrome P-450 and NADPH-cytochrome P-450 reductase. Xenobiotica 20:9, pages 967-978.
Read now
S. Cottrell, G. C. Hartman, D. F. V. Lewis & D. V. Parke. (1990) Studies on the cytochrome P-450 of avocado (Persa americana) mesocarp microsomal fraction. Xenobiotica 20:7, pages 711-726.
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A. R. Boobis, D. Sesardic, B. P. Murray, R. J. Edwards, A. M. Singleton, K. J. Rich, S. Murray, R. De La Torre, J. Segura, O. Pelkonen, M. Pasanen, S. Kobayashi, T. Zhi-guang & D. S. Davies. (1990) Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors. Xenobiotica 20:11, pages 1139-1161.
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Bernard Testa. (1990) Mechanisms of inhibition of xenobiotic-metabolizing enzymes. Xenobiotica 20:11, pages 1129-1137.
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Marcel Mesnil, Bernard Testa & Peter Jenner. (1988) In vitro Inhibition by Stiripentol of Rat Brain Cytochrome P-450-Mediated Naphthalene Hydroxylation. Xenobiotica 18:9, pages 1097-1106.
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Michael Murray. (1987) Mechanisms of the Inhibition of Cytochrome P 450-Mediated Drug Oxidation by Therapeutic Agents. Drug Metabolism Reviews 18:1, pages 55-81.
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B. Clement & M. Zimmermann. (1987) Characteristics of the microsomal N-hydroxylation of benzamidine to benzamidoxime. Xenobiotica 17:6, pages 659-667.
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Lev M. Weiner. (1986) Magnetic Resonance Study of the Structure and Functions of Cytochrome P45. Critical Reviews in Biochemistry 20:2, pages 139-200.
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Ingeborg Schuster. (1985) The interaction of representative members from two classes of antimycotics—the azoles and the allylamines—with cytochromes P-450 in steroidogenic tissues and liver. Xenobiotica 15:6, pages 529-546.
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E. J. Ariëns. (1984) Domestication of Chemistry by Design of Safer Chemicals: Structure-Activity Relationships. Drug Metabolism Reviews 15:3, pages 425-504.
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C. Bäärnhielm, I. Skånberg & K. O. Borg. (1984) Cytochrome P-450-dependent oxidation of felodipine—a 1,4-dihydropyridine—to the corresponding pyridine. Xenobiotica 14:9, pages 719-726.
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J. C. Rhodes, S. T. Hall & J. B. Houston. (1984) Inhibition of antipyrine metabolite formation in rats in vivo. Xenobiotica 14:9, pages 677-686.
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M. A. Hayes, E. Roberts, M. V. Jago, S. H. Safe, E. Farber & R. C. Cameron. (1984) Influences of various xenobiotic inducers on cytocidal toxicity of lasiocarpine and senecionine in primary cultures of rat hepatocytes. Journal of Toxicology and Environmental Health 14:5-6, pages 683-694.
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Alvito P. Alvares. (1981) Cytochrome P-450s: Research Highlights of the Last Two Decades. Drug Metabolism Reviews 12:2, pages 431-436.
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Goran Bozinovic, Tim L Sit, Richard Di Giulio, Lauren F Wills & Marjorie F Oleksiak. (2013) Genomic and physiological responses to strong selective pressure during late organogenesis: few gene expression changes found despite striking morphological differences. BMC Genomics 14:1, pages 779.
Crossref
Andrew G. Leach. 2015. Tactics in Contemporary Drug Design. Tactics in Contemporary Drug Design 107 158 .
Emily J. Hanan, Anne van Abbema, Kathy Barrett, Wade S. Blair, Jeff Blaney, Christine Chang, Charles Eigenbrot, Sean Flynn, Paul Gibbons, Christopher A. Hurley, Jane R. Kenny, Janusz Kulagowski, Leslie Lee, Steven R. Magnuson, Claire Morris, Jeremy Murray, Richard M. Pastor, Tom Rawson, Michael Siu, Mark Ultsch, Aihe Zhou, Deepak Sampath & Joseph P. Lyssikatos. (2012) Discovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors. Journal of Medicinal Chemistry 55:22, pages 10090-10107.
Crossref
Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach & Dennis A. Smith. 2012. Reactive Drug Metabolites. Reactive Drug Metabolites 93 129 .
Finis L. Cavender. 2003. Patty's Toxicology. Patty's Toxicology 1 84 .
Finis L. Cavender & John O'Donohue. 2003. Patty's Toxicology. Patty's Toxicology 1 108 .
Zaheer Ul-Haq, Waqasuddin Khan, Syeda Rehana Zia & Sadaf Iqbal. (2012) Structure-based 3D-QSAR models and dynamics analysis of novel N-benzyl pyridinone as p38α MAP kinase inhibitors for anticytokine activity. Journal of Molecular Graphics and Modelling 36, pages 48-61.
Crossref
Kazuhiro Yamada, Yuko Yoshizawa & Keimei Oh. (2012) Synthesis of 2RS,4RS-1-[2-Phenyl-4-[2-(2-trifluromethoxy-phenoxy)-ethyl]-1,3-dioxolan-2-yl-methyl]-1H-1,2,4-triazole Derivatives as Potent Inhibitors of Brassinosteroid Biosynthesis. Molecules 17:4, pages 4460-4473.
Crossref
Joo Yun Lee, Nam Sook Kang & Young Kee Kang. (2012) Binding free energies of inhibitors to iron porphyrin complex as a model for Cytochrome P450. Biopolymers 97:4, pages 219-228.
Crossref
Keimei Oh, Kazuhiro Yamada, Tadao Asami & Yuko Yoshizawa. (2012) Synthesis of novel brassinosteroid biosynthesis inhibitors based on the ketoconazole scaffold. Bioorganic & Medicinal Chemistry Letters 22:4, pages 1625-1628.
Crossref
Upendra P. Dahal, Carolyn Joswig-Jones & Jeffrey P. Jones. (2011) Comparative Study of the Affinity and Metabolism of Type I and Type II Binding Quinoline Carboxamide Analogues by Cytochrome P450 3A4. Journal of Medicinal Chemistry 55:1, pages 280-290.
Crossref
Keimei Oh, Kouta Nakai, Kazuhiro Yamada & Yuko Yoshizawa. (2012) Synthesis of novel triazole derivatives as potent inhibitor of allene oxide synthase (CYP74A), a key enzyme in jasmonic acid biosynthesis. Journal of Pesticide Science 37:1, pages 80-84.
Crossref
Wolfgang Dekant & Spiridon Vamvakas. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Wolfgang Dekant & Spiridon Vamvakas. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Hang Ruan, Zhen Zhang, Xin-fang Liang, Yan Fu, Mei-qin Su, Qi-lin Liu, Xiu-min Wang & Xuan Zhu. (2011) Metabolism of dl-praeruptorin a in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry. Archives of Pharmacal Research 34:8, pages 1311-1321.
Crossref
Carrie R. Fleming & Richard T. Di Giulio. (2011) The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio). Ecotoxicology 20:6, pages 1300-1314.
Crossref
Christoph T. Zimmer & Ralf Nauen. (2011) Cytochrome P450 mediated pyrethroid resistance in European populations of Meligethes aeneus (Coleoptera: Nitidulidae). Pesticide Biochemistry and Physiology 100:3, pages 264-272.
Crossref
Fabiana Caporuscio, Giulio Rastelli, Carol Imbriano & Alberto Del Rio. (2011) Structure-Based Design of Potent Aromatase Inhibitors by High-Throughput Docking. Journal of Medicinal Chemistry 54:12, pages 4006-4017.
Crossref
H Thomas, M Strolin Benedetti, P Dostert & F Oesch. (1994) The Effect of Indobufen on the Activities of Selected Rat Liver Phase I and Phase II Drug Metabolizing Enzymes, Peroxisomal β-oxidation and Hepatic Glutathione Status. Journal of Pharmacy and Pharmacology 46:10, pages 833-837.
Crossref
Diane E Matthew, M Tarbit, H Humphrey & J B Houston. (1986) In-Vivo Determinations of the Potency of Ketoconazole in Inhibiting Drug Metabolism in the Rat. Journal of Pharmacy and Pharmacology 38:Supplement_12, pages 31P-31P.
Crossref
David Crouzier, Jean-Claude Debouzy, Florian Nachon, Dominique Debouzy, Guy Lallement & Frédéric Canini. (2011) Anticushing Drug Metyrapone Exhibits Specific Interactions with Serine Containing Systems. A Possible Molecular Target?. Pharmacology & Pharmacy 02:04, pages 322-331.
Crossref
Graham F. Smith. 2011. Progress in Medicinal Chemistry Volume 50. Progress in Medicinal Chemistry Volume 50 1 47 .
. (2011) 10.1007/BF00189717. CrossRef Listing of Deleted DOIs.
Crossref
D. Ramoutar, R. S. Cowles, E. RequintinaJr.Jr. & S. R. Alm. (2010) Synergism Between Demethylation Inhibitor Fungicides or Gibberellin Inhibitor Plant Growth Regulators and Bifenthrin in a Pyrethroid-Resistant Population of Listronotus maculicollis (Coleoptera: Curculionidae). Journal of Economic Entomology 103:5, pages 1810-1814.
Crossref
Eva Stjernschantz & Chris Oostenbrink. (2010) Improved Ligand-Protein Binding Affinity Predictions Using Multiple Binding Modes. Biophysical Journal 98:11, pages 2682-2691.
Crossref
Chi-Chi Peng, Josh T. Pearson, Dan A. Rock, Carolyn A. Joswig-Jones & Jeffrey P. Jones. (2010) The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4. Archives of Biochemistry and Biophysics 497:1-2, pages 68-81.
Crossref
R.I. Sanchez & F.C. Kauffman. 2010. Comprehensive Toxicology. Comprehensive Toxicology 109 128 .
Stefanie D. Krämer & Bernard Testa. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:10, pages 1477-1660.
Crossref
Dirk Tischler, Dirk Eulberg, Silvia Lakner, Stefan R. Kaschabek, Willem J. H. van Berkel & Michael Schlömann. (2009) Identification of a Novel Self-Sufficient Styrene Monooxygenase from Rhodococcus opacus 1CP. Journal of Bacteriology 191:15, pages 4996-5009.
Crossref
Graham D Moores, Despina Philippou, Valerio Borzatta, Paolo Trincia, Philip Jewess, Robin Gunning & Georgina Bingham. (2009) An analogue of piperonyl butoxide facilitates the characterisation of metabolic resistance. Pest Management Science 65:2, pages 150-154.
Crossref
Lionel Perrin, Fran?ois Andr?Caroline Aninat, R?my Ricoux, Jean-Pierre Mahy, Ning Shangguan, Madeleine M. Joulli?Marcel Delaforge. (2009) Intramolecular hydrogen bonding as a determinant of the inhibitory potency of N-unsubstituted imidazole derivatives towards mammalian hemoproteins. Metallomics 1:2, pages 148-156.
Crossref
John Timbrell. 2008. Principles of Biochemical Toxicology, Fourth Edition. Principles of Biochemical Toxicology, Fourth Edition 129 191 .
Sonya M. Billiard, Joel N. Meyer, Deena M. Wassenberg, Peter V. Hodson & Richard T. Di Giulio. (2008) Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment. Toxicological Sciences 105:1, pages 5-23.
Crossref
Helena M. B. Seth-Smith, James Edwards, Susan J. Rosser, Deborah A. Rathbone & Neil C. Bruce. (2008) The Explosive-Degrading Cytochrome P450 System Is Highly Conserved among Strains of Rhodococcus spp.. Applied and Environmental Microbiology 74:14, pages 4550-4552.
Crossref
Stefan A. Laufer, Dominik R. J. Hauser, David M. Domeyer, Katrin Kinkel & Andy J. Liedtke. (2008) Design, Synthesis, and Biological Evaluation of Novel Tri- and Tetrasubstituted Imidazoles as Highly Potent and Specific ATP-Mimetic Inhibitors of p38 MAP Kinase: Focus on Optimized Interactions with the Enzyme’s Surface-Exposed Front Region. Journal of Medicinal Chemistry 51:14, pages 4122-4149.
Crossref
C.G. van Ginkel, R. Geerts, P.D. Nguyen & C.M. Plugge. (2008) Biodegradation pathway of l-glutamatediacetate by Rhizobium radiobacter strain BG-1. International Biodeterioration & Biodegradation 62:1, pages 31-37.
Crossref
Gavin A. Whitlock, Kelly Conlon, Gordon McMurray, Lee R. Roberts, Alan Stobie & Richard J. Thurlow. (2008) Novel 2-imidazoles as potent and selective ?1A adrenoceptor partial agonists. Bioorganic & Medicinal Chemistry Letters 18:9, pages 2930-2934.
Crossref
Marie M. Ahlström & Ismael Zamora. (2008) Characterization of Type II Ligands in CYP2C9 and CYP3A4. Journal of Medicinal Chemistry 51:6, pages 1755-1763.
Crossref
Yasuhiro Imaeda, Toshio Miyawaki, Hiroki Sakamoto, Fumio Itoh, Noriko Konishi, Katsuhiko Hiroe, Masaki Kawamura, Toshimasa Tanaka & Keiji Kubo. (2008) Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors. Bioorganic & Medicinal Chemistry 16:5, pages 2243-2260.
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Alicia R. Timme-Laragy, Crystal J. Cockman, Cole W. Matson & Richard T. Di Giulio. (2007) Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. Aquatic Toxicology 85:4, pages 241-250.
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Jared B.J. Milbank, Christopher S. Knauer, Corinne E. Augelli-Szafran, Annette T. Sakkab-Tan, Kristin K. Lin, Koji Yamagata, Jennifer K. Hoffman, Nian Zhuang, John Thomas, Paul Galatsis, John A. Wendt, John W. Mickelson, Roy D. Schwarz, Jack J. Kinsora, Susan M. Lotarski, Korana Stakich, Kristen K. Gillespie, Wing W. Lam & Abdul E. Mutlib. (2007) Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. Bioorganic & Medicinal Chemistry Letters 17:16, pages 4415-4418.
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Pierre Lafite, Sylvie Dijols, Darryl C. Zeldin, Patrick M. Dansette & Daniel Mansuy. (2007) Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2. Archives of Biochemistry and Biophysics 464:2, pages 155-168.
Crossref
Fabio Bellina, Silvia Cauteruccio & Renzo Rossi. (2007) Synthesis and biological activity of vicinal diaryl-substituted 1H-imidazoles. Tetrahedron 63:22, pages 4571-4624.
Crossref
Christopher J. D. Mau & Rodney Croteau. (2006) Cytochrome P450 oxygenases of monoterpene metabolism. Phytochemistry Reviews 5:2-3, pages 373-383.
Crossref
Keimei Oh, Tadao Asami, Kenji Matsui, Gregg A. Howe & Noboru Murofushi. (2006) Characterization of novel imidazole derivative, JM-8686, a potent inhibitor of allene oxide synthase. FEBS Letters 580:24, pages 5791-5796.
Crossref
Stefan A. Laufer, Simona Margutti & Martina D. Fritz. (2006) Substituted Isoxazoles as Potent Inhibitors of p38 MAP Kinase. ChemMedChem 1:2, pages 197-207.
Crossref
Wayne D. Vaccaro, Rosy Sher, Michael Berlin, Neng-Yang Shih, Robert Aslanian, John H. Schwerdt, Kevin D. McCormick, John J. Piwinski, Robert E. WestJr.Jr., John C. Anthes, Shirley M. Williams, Ren-Long Wu, H. Susan She, Maria A. Rivelli, Jennifer C. Mutter, Michel R. Corboz, John A. Hey & Leonard Favreau. (2006) Novel histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine scaffold. Bioorganic & Medicinal Chemistry Letters 16:2, pages 395-399.
Crossref
Miho Sasaki, Jun-ichi Maki, Ko-ichi Oshiman, Yoshinobu Matsumura & Tetsuaki Tsuchido. (2005) Biodegradation of bisphenol A by cells and cell lysate from Sphingomonas sp. strain AO1. Biodegradation 16:5, pages 449-459.
Crossref
Seiji Miwatashi, Yasuyoshi Arikawa, Etsuo Kotani, Maki Miyamoto, Ken-ichi Naruo, Hiroyuki Kimura, Toshimasa Tanaka, Satoru Asahi & Shigenori Ohkawa. (2005) Novel Inhibitor of p38 MAP Kinase as an Anti-TNF-α Drug:  Discovery of N -[4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a Potent and Orally Active Anti-Rheumatoid Arthritis Agent . Journal of Medicinal Chemistry 48:19, pages 5966-5979.
Crossref
David Schleheck & Alasdair M. Cook. (2005) ω-Oxygenation of the alkyl sidechain of linear alkylbenzenesulfonate (LAS) surfactant in Parvibaculum lavamentivorans T. Archives of Microbiology 183:6, pages 369-377.
Crossref
Christian Wolff, Michel Gillard, Bruno Fuks & Pierre Chatelain. (2005) [3H]linopirdine binding to rat brain membranes is not relevant for M-channel interaction. European Journal of Pharmacology 518:1, pages 10-17.
Crossref
Kotomi Ueno, Yoshiharu Araki, Nobuhiro Hirai, Shigeki Saito, Masaharu Mizutani, Kanzo Sakata & Yasushi Todoroki. (2005) Differences between the structural requirements for ABA 8′-hydroxylase inhibition and for ABA activity. Bioorganic & Medicinal Chemistry 13:10, pages 3359-3370.
Crossref
Etienne Quertemont, Sophie Tambour & Ezio Tirelli. (2005) The role of acetaldehyde in the neurobehavioral effects of ethanol: A comprehensive review of animal studies. Progress in Neurobiology 75:4, pages 247-274.
Crossref
Maria Almira Correia & Paul R. Ortiz de Montellano. 2005. Cytochrome P450. Cytochrome P450 247 322 .
Deena M. Wassenberg & Richard T. Di Giulio. (2004) Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus . Environmental Health Perspectives 112:17, pages 1658-1664.
Crossref
Stefan A. Laufer, Werner Zimmermann & Kathrin J. Ruff. (2004) Tetrasubstituted Imidazole Inhibitors of Cytokine Release:  Probing Substituents in the N-1 Position. Journal of Medicinal Chemistry 47:25, pages 6311-6325.
Crossref
Wolfgang Dekant & Spiridon Vamvakas. 2000. Ullmann's Encyclopedia of Industrial Chemistry. Ullmann's Encyclopedia of Industrial Chemistry.
Andreas Verras, Irwin D. Kuntz & Paul R. Ortiz de Montellano. (2004) Computer-Assisted Design of Selective Imidazole Inhibitors for Cytochrome P450 Enzymes. Journal of Medicinal Chemistry 47:14, pages 3572-3579.
Crossref
Margit Frohlich, Jurgen Burhenne, Meret Martin-Facklam, Johanna Weiss, Michael von Wolff, Thomas Strowitzki, Ingeborg Walter-Sack & Walter E. Haefeli MD. (2004) Oral Contraception Does Not Alter Single Dose Saquinavir Pharmacokinetics in Women. British Journal of Clinical Pharmacology 57:3, pages 244-252.
Crossref
John DiGiovanni & Heather E. Kleiner. 2004. Cancer Chemoprevention. Cancer Chemoprevention 69 84 .
D Parmar, S Yadav, M Dayal, A Johri, A Dhawan & P.K Seth. (2003) Effect of lindane on hepatic and brain cytochrome P450s and influence of P450 modulation in lindane induced neurotoxicity. Food and Chemical Toxicology 41:8, pages 1077-1087.
Crossref
Stefan A. Laufer, Gerd K. Wagner, Dunja A. Kotschenreuther & W. Albrecht. (2003) Novel Substituted Pyridinyl Imidazoles as Potent Anticytokine Agents with Low Activity against Hepatic Cytochrome P450 Enzymes. Journal of Medicinal Chemistry 46:15, pages 3230-3244.
Crossref
Marcus Moreno Horn, Leif-Alexander Garbe, Roland Tressl, Lorenz Adrian & Helmut Görisch. (2003) Biodegradation of bis(1-chloro-2-propyl) ether via initial ether scission and subsequent dehalogenation by Rhodococcus sp. strain DTB. Archives of Microbiology 179:4, pages 234-241.
Crossref
M Trigui, S Pulvin, P Poupin & D Thomas. (2003) Biodegradation of cyclic amines by a Pseudomonas strain involves an amine mono-oxygenase . Canadian Journal of Microbiology 49:3, pages 181-188.
Crossref
M Dayal, D Parmar, A Dhawan, Mohd Ali, U.N Dwivedi & P.K Seth. (2003) Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin. Food and Chemical Toxicology 41:3, pages 431-437.
Crossref
Donald J. AbrahamBernard Testa & William Soine. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 431 498 .
Keimei Oh & Noboru Murofushi. (2002) Design and synthesis of novel imidazole derivatives as potent inhibitors of allene oxide synthase(CYP74). Bioorganic & Medicinal Chemistry 10:12, pages 3707-3711.
Crossref
Toshiyuki Kawamura & Ichiro Yamashita. (2002) Aryl Hydrocarbon Receptor is Required for Prevention of Blood Clotting and for the Development of Vasculature and Bone in the Embryos of Medaka Fish, Oryzias latipes. Zoological Science 19:3, pages 309-319.
Crossref
Masayuki Hara, Yoshiaki Yasuda, Hideki Toyotama, Hideo Ohkawa, Tsunenori Nozawa & Jun Miyake. (2002) A novel ISFET-type biosensor based on P450 monooxygenases. Biosensors and Bioelectronics 17:3, pages 173-179.
Crossref
Andrew T. Pudzianowski. (2002) A protoporphyrin IX‐based model for cytochrome P‐450 iron‐binding inhibitors: SAM1 calculations of structure and complexation enthalpy*. International Journal of Quantum Chemistry 88:1, pages 147-153.
Crossref
David Lewis. 2001. Guide to Cytochromes P450. Guide to Cytochromes P450 164 210 .
T. Miyahara, Y. Tokita & H. Nakatsuji. (2001) SAC/SAC−CI Study of the Ground, Excited, and Ionized States of Cytochromes P450CO. The Journal of Physical Chemistry B 105:30, pages 7341-7352.
Crossref
Helga L George & Hans D VanEtten. (2001) Characterization of Pisatin-Inducible Cytochrome P450s in Fungal Pathogens of Pea That Detoxify the Pea Phytoalexin Pisatin. Fungal Genetics and Biology 33:1, pages 37-48.
Crossref
R.M. Venn, A. Bryant, G.M. Hall & R.M. Grounds. (2001) Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. British Journal of Anaesthesia 86:5, pages 650-656.
Crossref
Finis L. Cavender. 2003. Patty's Toxicology. Patty's Toxicology.
Alison Souter, Kirsty J McLean, W Ewen Smith & Andrew W Munro. (2000) The genome sequence ofMycobacterium tuberculosis reveals cytochromes P450 as novel anti-TB drug targets. Journal of Chemical Technology & Biotechnology 75:10, pages 933-941.
Crossref
Marlène L.N Dubuisson, Bertrand de Wergifosse, André Trouet, Fernand Baguet, Jacqueline Marchand-Brynaert & Jean-François Rees. (2000) Antioxidative properties of natural coelenterazine and synthetic methyl coelenterazine in rat hepatocytes subjected to tert-butyl hydroperoxide-induced oxidative stress. Biochemical Pharmacology 60:4, pages 471-478.
Crossref
Thomas Schräder, Grit Schuffenhauer, Bernhard Sielaff & Jan R. Andreesen. (2000) High morpholine degradation rates and formation of cytochrome P450 during growth on different cyclic amines by newly isolated Mycobacterium sp. strain HE5 The EMBL accession number of the 16S rRNA gene of Mycobacterium sp. strain HE5 is AJ012738.. Microbiology 146:5, pages 1091-1098.
Crossref
Patrick J. Klein, Robert Buckner, Jack Kelly & Roger A. CoulombeJr.Jr.. (2000) Biochemical Basis for the Extreme Sensitivity of Turkeys to Aflatoxin B1. Toxicology and Applied Pharmacology 165:1, pages 45-52.
Crossref
Jaime Padrós, Émilien Pelletier, Stéphanie Reader & Francine Denizeau. (2009) Mutual in vivo interactions between benzo[ a ]pyrene and tributyltin in brook trout ( Salvelinus fontinalis ) . Environmental Toxicology and Chemistry 19:4, pages 1019-1027.
Crossref
Irma Kakko, Tarja Toimela & Hanna Tähti. (2000) Piperonyl butoxide potentiates the synaptosome ATPase inhibiting effect of pyrethrin. Chemosphere 40:3, pages 301-305.
Crossref
Catherine N.S.P. Suurmeijer, Manuela Pérez-Gilabert, Dirk-Jan van Unen, Harry T.W.M. van der Hijden, Gerrit A. Veldink & Johannes F.G. Vliegenthart. (2000) Purification, stabilization and characterization of tomato fatty acid hydroperoxide lyase. Phytochemistry 53:2, pages 177-185.
Crossref
Dai Shiba & Norio Shimamoto. (1999) Attenuation of endogenous oxidative stress?induced cell death by cytochrome P450 inhibitors in primary cultures of rat hepatocytes. Free Radical Biology and Medicine 27:9-10, pages 1019-1026.
Crossref
K.H. Janbaz & A.H. Gilani. (1999) Potentiation of Paracetamol and Carbon Tetrachloride-induced Hepatotoxicity in Rodents by the Food Additive Vanillin. Food and Chemical Toxicology 37:6, pages 603-607.
Crossref
Antje Chang & Thomas Hartmann. (1998) Solubilization and characterization of a senecionine N-oxygenase from Crotalaria scassellatii seedlings. Phytochemistry 49:7, pages 1859-1866.
Crossref
Jerry L. Adams, Jeffrey C. Boehm, Shouki Kassis, Peter D. Gorycki, Edward F. Webb, Ralph Hall, Margaret Sorenson, John C. Lee, Andrew Ayrton, Don E. Griswold & Timothy F. Gallagher. (1998) Pyrimidinylimidazole inhibitors of CSBP/P38 kinase demonstrating decreased inhibition of hepatic cytochrome P450 enzymes. Bioorganic & Medicinal Chemistry Letters 8:22, pages 3111-3116.
Crossref
Maija Dambrova, Staffan Uhlén & Jarl E. S. Wikberg. (1998) Characterization of Guanoxabenz Reducing Activity in Rat Brain. Pharmacology & Toxicology 83:4, pages 158-163.
Crossref
P. Besse, B. Combourieu, P. Poupin, M. Sancelme, N. Truffaut, H. Veschambre & A.M. Delort. (1998) Degradation of morpholine and thiomorpholine by an environmental Mycobacterium involves a cytochrome P450. Direct evidence of intermediates by in situ NMR. Journal of Molecular Catalysis B: Enzymatic 5:1-4, pages 403-409.
Crossref
Gail D Anderson. (2016) A Mechanistic Approach to Antiepileptic Drug Interactions. Annals of Pharmacotherapy 32:5, pages 554-563.
Crossref
P. Poupin, N. Truffaut, B. Combourieu, P. Besse, M. Sancelme, H. Veschambre & A. M. Delort. (1998) Degradation of Morpholine by an EnvironmentalMycobacterium Strain Involves a Cytochrome P-450. Applied and Environmental Microbiology 64:1, pages 159-165.
Crossref
Pia Larsson, Wojciech Cybulski & Hans Tjälve. (2009) Binding of 3 H‐Metronidazole in Olfactory, Respiratory and Alimentary Epithelia in Rats . Pharmacology & Toxicology 81:2, pages 65-73.
Crossref
Maria Norl?n & Per Allard. (1997) []GBR 12935 binding in platelets: A possible association with cytochrome P-450IID6?. European Journal of Pharmacology 332:2, pages 227-230.
Crossref
O Pelkonen & H Raunio. (1997) Metabolic activation of toxins: tissue-specific expression and metabolism in target organs.. Environmental Health Perspectives 105:suppl 4, pages 767-774.
Crossref
Enrique Diez-Barra, Antonio de la Hoz, Ren?I. Rodr?guez-Curiel & Juan Tejeda. (1997) A methylene bridge as protecting group. 1. Selective preparation of 4-alkyl-1,2,4-triazoles. Tetrahedron 53:6, pages 2253-2260.
Crossref
Nicola E. Davidson & Nigel P. Botting. (1997) Oxidation of Isothiocyanates to Isocyanates using Dimethyldioxirane; Relevance to Biological Activity of Isothiocyanates†. Journal of Chemical Research:11, pages 410.
Crossref
Michal Laniado Schwartzman. 1997. Advances in Ocular Toxicology. Advances in Ocular Toxicology 3 20 .
Susannah M. Cantrell, Linda H. Lutz, Donald E. Tillitt & Mark Hannink. (1996) Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Theembryonic vasculature is a physiological target for TCDD-induced DNA damage and apoptotic cell death in medaka (Orizias latipes). Toxicology and Applied Pharmacology 141:1, pages 23-34.
Crossref
Katja S. Salmela, Pertti Kaihovaara, Mikko Salaspuro & Risto P. Roine. (2006) Role of Catalase in Rat Gastric Mucosal Ethanol Metabolism In Vitro. Alcoholism: Clinical and Experimental Research 20:6, pages 1011-1015.
Crossref
Jerry Hefner, Steven M. Rubenstein, Raymond E.B. Ketchum, Donna M. Gibson, Robert M. Williams & Rodney Croteau. (1996) Cytochrome P450-catalyzed hydroxylation of taxa-4(5),11(12)-diene to taxa-4(20),11(12)-dien-5a-o1: the first oxygenation step in taxol biosynthesis. Chemistry & Biology 3:6, pages 479-489.
Crossref
S. Pennanen, A. Kojo, M. Pasanen, J. Liesivuori, RO Juvonen & H. Komulainen. (2016) CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver. Human & Experimental Toxicology 15:5, pages 435-442.
Crossref
Anatolyi A. Buzukov, Valeriya B. Il'asova, Marcel Tabak, Nilce C. Meirelles & Igor A. Degterev. (1996) An ESR and spectrophotometric study of the denitration of nitroheterocyclic drugs by liver homogenates and their metabolic consumption by liver microsomes from cytochrome P-450-induced mice. Chemico-Biological Interactions 100:2, pages 113-124.
Crossref
Helen M. Barham & Ian J. Stratford. (1996) Enzymology of the reduction of the novel fused pyrazine mono-N-oxide bioreductive drug, RB90740 roles for P450 reductase and cytochrome b5 reductase. Biochemical Pharmacology 51:6, pages 829-837.
Crossref
G. Feuee & F. A. Iglesia. 1996. Drug-Induced Hepatotoxicity. Drug-Induced Hepatotoxicity 43 73 .
Arnold R. Goeptar, Johan M. te Koppele, Hansruedi R. Glatt, Ed J. Groot, Albrecht Seidel, Martine Barrenscheen, Catherine Wölfel, Johannes Doehmer & Nico P.E. Vermeulen. (1995) The cytotoxicity of mitomycin C and Adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes. Chemico-Biological Interactions 97:2, pages 149-168.
Crossref
A. A. Buzukov, V. B. Il'yasova, M. Tabak, N. K. Tatarskaya & I. A. Degterev. (1995) Metabolic denitrification of quinifuryl and nitracrine in mouse liver homogenate. Pharmaceutical Chemistry Journal 29:7, pages 445-450.
Crossref
J. S. Uotila, V. H. Kitunen, T. Coote, T. Saastamoinen, M. Salkinoja-Salonen & J. H. A. Apajalahti. (1995) Metabolism of halohydroquinones inRhodococcus chlorophenolicus PCP-1. Biodegradation 6:2, pages 119-126.
Crossref
N. Takahashi, C.L. Miranda, M.C. Henderson, D.R. Buhler, D.E. Williams & G.S. Bailey. (1995) Inhibition of in vitro aflatoxin B1-DNA binding in rainbow trout by CYP1A inhibitors: α-naphthoflavone, β-naphthoflavone and trout CYP1A1 peptide antibody. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 110:3, pages 273-280.
Crossref
Richard A. Smallwood, Roger G. Berlin, Neal Castagnoli, Henk P. M. Festen, Christopher J. Hawkey, S. K. Lam, Michael J. S. Langman, Per Lundborg & Andrew Parkinson. (1995) Safety of acid-suppressing drugs. Digestive Diseases and Sciences 40:S2, pages 63S-80S.
Crossref
I TomasiI ArtaudY BertheauD Mansuy. (1995) Metabolism of polychlorinated phenols by Pseudomonas cepacia AC1100: determination of the first two steps and specific inhibitory effect of methimazole. Journal of Bacteriology 177:2, pages 307-311.
Crossref
Paul R. Ortiz de Montellano & Maria Almira Correia. 1995. Cytochrome P450. Cytochrome P450 305 364 .
V.S. Haritos, J.R.J. French & J.T. Ahokas. (1994) Cytochrome P450 monooxygenase and glutathione S-transferase activity of two Australian termites: Mastotermes darwiniensis and Coptotermes acinaciformis. Insect Biochemistry and Molecular Biology 24:9, pages 929-935.
Crossref
Iain G.C. Robertson & Ranjith S.K.A. Gamage. (1994) Methadone: a potent inhibitor of rat liver aldehyde oxidase. Biochemical Pharmacology 47:3, pages 584-587.
Crossref
E. Ershov, A. Shlosberg, V. Hanji & J. Kagan. (1994) THE ROLE OF MICROSOMAL MIXED FUNCTION OXIDASES IN THE METABOLISM AND MECHANISM OF ACTION OF CERTAIN ORGANOPHOSPHORUS INSECTICIDES. Drug Metabolism and Drug Interactions 11:2.
Crossref
L K Pershing, J Corlett & C Jorgensen. (1994) In vivo pharmacokinetics and pharmacodynamics of topical ketoconazole and miconazole in human stratum corneum.. Antimicrobial Agents and Chemotherapy 38:1, pages 90-95.
Crossref
TADASHI ASAKURA, MAKOTO MATSUDA, SATOSHI MATSUDA & HITOSHI SHICHI. (1994) Synthesis of 12(R)- and 12(S)-Hydroxyeicosatetraenoic Acid by Porcine Ocular Tissues. Journal of Ocular Pharmacology and Therapeutics 10:3, pages 525-535.
Crossref
ROBERT A. STOLTZ, MICHAEL S. CONNERS, MICHAEL W. DUNN & MICHAL LANIADO SCHWARTZMAN. (1994) Effect of Metabolic Inhibitors on Arachidonic Acid Metabolism in the Corneal Epithelium: Evidence for Cytochrome P450-Mediated Reactions. Journal of Ocular Pharmacology and Therapeutics 10:1, pages 307-317.
Crossref
Per Allard, Jan O. Marcusson & Svante B. Ross. (2008) [3H] GBR-12935 Binding to Cytochrome P450 in the Human Brain. Journal of Neurochemistry 62:1, pages 342-348.
Crossref
O. Pelkonen & D. D. Breimer. 1994. Pharmacokinetics of Drugs. Pharmacokinetics of Drugs 289 332 .
M.M.A. Elmazar, R.-S. Hauck & H. Nau. (1993) Anticonvulsant and Neurotoxic Activities of Twelve Analogues of Valproic Acid. Journal of Pharmaceutical Sciences 82:12, pages 1255-1258.
Crossref
Kelly W. Beers, Derek W. Nicoll, Dianne K. Anestis, Patrick I. Brown & Gary O. Rankin. (1993) Effect of microsomal enzyme modulators on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)-induced nephrotoxicity in the Fischer 344 rat. Toxicology 84:1-3, pages 141-155.
Crossref
M. Duverger-van Bogaert, P.J. Dierickx, C. Stecca & M.-C. Crutzen. (1993) Metabolic activation by a supernatant from human hepatoma cells: a possible alternative in mutagenic tests. Mutation Research/Environmental Mutagenesis and Related Subjects 292:2, pages 199-204.
Crossref
Tom Werner, Lars Gawell & Svante B. Ross. (2006) Synthesis of [ 3 H]proadifen for studying binding to liver membranes . Journal of Labelled Compounds and Radiopharmaceuticals 33:7, pages 627-631.
Crossref
Iain G.C. Robertson & Tony J. Bland. (1993) Inhibition by SKF-525A of the aldehyde oxidase-mediated metabolism of the experimental antitumour agent acridine carboxamide. Biochemical Pharmacology 45:10, pages 2159-2162.
Crossref
Malle Jurima‐Romet, Barry H. Thomas, G. Solomonraj, Charles J. Paul & Hide Huang. (2006) Metabolism of phenazopyridine by isolated rat hepatocytes. Biopharmaceutics & Drug Disposition 14:2, pages 171-179.
Crossref
JAY GANDY, STEPHEN K. DURHAM & TOSHIKO IMAMURA. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 153 163 .
Françlois P. Monnet, Guy Debonnel & Claude de Montigny. (2004) The cytochromes P‐450 are not involved in the modulation of the N ‐methyl‐D‐aspartate response by sigma ligands in the rat CA 3 dorsal hippocampus . Synapse 13:1, pages 30-38.
Crossref
Kurt A. Black, Deborah L. Novicki, Jack L. Vincent & Gary J. Smith. (2005) Flow cytometric analysis of xenobiotic metabolism activity in isolated rat hepatocytes. Cytometry 14:3, pages 334-338.
Crossref
Lena Dahlstr?m-King, Johanne Couture & Gabriel L. Plaa. (1992) Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis. Toxicology Letters 63:3, pages 243-252.
Crossref
J. L. Riviere. (1992) Hepatic microsomal monooxygenase activities in natural populations of the Mallard DuckAnas platyrhynchos, the Tufted DuckAythya fuligula and the Great Crested GrebePodiceps cristatus. Ecotoxicology 1:2, pages 117-135.
Crossref
Rina Varsano, Haim D. Rabinowitch & Baruch Rubin. (1992) Mode of action of piperonyl butoxide as herbicide synergist of atrazine and terbutryn in maize. Pesticide Biochemistry and Physiology 44:3, pages 174-182.
Crossref
Pia Larsson, Steven Ngethe, Kristian Ingebrigtsen & Hans Tjälve. (2009) Extrahepatic Disposition of 3 H‐Aflatoxin B 1 in the Rainbow Trout ( Oncorhynchus mykiss ) . Pharmacology & Toxicology 71:4, pages 262-271.
Crossref
P. F. Dowd, F. C. Peng, J. W. Chen & K. H. Ling. (2011) Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea . Entomologia Experimentalis et Applicata 65:1, pages 57-64.
Crossref
K. Gill, J. F. Menez, D. Lucas & R. A. Deitrich. (2006) Enzymatic Production of Acetaldehyde from Ethanol in Rat Brain Tissue. Alcoholism: Clinical and Experimental Research 16:5, pages 910-915.
Crossref
Bernd Clement & Thomas Kunze. (1992) The reduction of 6-N-hydroxylaminopurine to adenine by xanthine oxidase. Biochemical Pharmacology 44:8, pages 1501-1509.
Crossref
F.S. LaBella, G. Queen, G. Glavin, G. Durant, D. Stein & L.J. Brandes. (2012) H 3 receptor antagonist, thioperamide, inhibits adrenal steroidogenesis and histamine binding to adrenocortical microsomes and binds to cytochrome P450 . British Journal of Pharmacology 107:1, pages 161-164.
Crossref
Anthony S. Basile, Ian A. Paul & Brian de Costa. (1992) Differential effects of cytochrome P-450 induction on ligand binding to σ receptors. European Journal of Pharmacology: Molecular Pharmacology 227:1, pages 95-98.
Crossref
A. Castonguay & G. Rossignol. (1992) Modulation of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by hamster liver microsomes to protein alkylating species. Toxicology in Vitro 6:5, pages 397-404.
Crossref
Tadashi Asakura & Hitoshi Shichi. (1992) Cytochrome P450-mediated prostaglandin ??-1 hydroxylase activities in porcine ciliary body epithelial cells. Experimental Eye Research 55:2, pages 377-384.
Crossref
Arnold R. Goeptar, Johan M. Te Koppele, Etienne P.A. Neve & Nico P.E. Vermeulen. (1992) Reductase and oxidase activity of rat liver cytochrome P450 with 2,3,5,6-tetramethylbenzoquinone as substrate. Chemico-Biological Interactions 83:3, pages 249-269.
Crossref
Nancy Eddy Hopkins, Maryam K. Foroozesh & William L. Alworth. (1992) Suicide inhibitors of cytochrome P450 1A1 and P450 2B1. Biochemical Pharmacology 44:4, pages 787-796.
Crossref

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