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Hemoglobin
international journal for hemoglobin research
Volume 1, 1977 - Issue 5
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Original Article

Hemoglobin Mizuho or Beta 68 (E 12) Leucine → Proline, a new Ufistarle Variaiit Associated with Severe Hemolytic Anemia

Y. Ohba Department of Clinical Pathology, Yamaguchi University School of Medicine, Ube, 755, Japan
,
T. Miyaji Department of Clinical Pathology, Yamaguchi University School of Medicine, Ube, 755, Japan
,
M. Matsuoka Department of Clinical Pathology, Yamaguchi University School of Medicine, Ube, 755, Japan
,
K. Sugiyama Department of Pediatrics, Nagoya City University Medical School, Nagoya, 467, Japan
,
T. Suzuki Department of Pediatrics, Nagoya City University Medical School, Nagoya, 467, Japan
&
T. Sugiura Department of Pediatrics, Nagoya City University Medical School, Nagoya, 467, Japan
Pages 467-477 | Published online: 07 Jul 2009

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Ya-ping Chen, Peng Wu, Heng Wang, Jiang-fen Wu, Dan Xie, Lei Wang, Bangquan An & Shengwen Huang. (2023) A Rare Case of Abnormal Hemoglobin Variant Hb Mizuho: [HBB: c.206T > C β 68(E12) Leu-Pro]: A First Report in the Chinese Population. Hemoglobin 47:3, pages 130-134.
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Diksha D. Yadav, Manu Jamwal, Namrata Singh, Ritika Sharma, Reena Das, Amita Trehan, Deepak Bansal, Sanjeev Chhabra & Prashant Sharma. (2021) Hb Mizuho (HBB: c.206T>C): Pitfalls of Screening Tests in an Unstable Hemoglobin Variant Diagnosed after Targeted Next-Generation Sequencing . Hemoglobin 45:5, pages 338-340.
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P. Shiromi Perera, Ishari Silva, Menaka Hapugoda, Merita N. Wickramarathne, Indira Wijesiriwardena, Dimitar G. Efremov, Christopher A. Fisher, David J. Weatherall & Anuja Premawardhena. (2015) Rare Hemoglobin Variants: Hb G-Szuhu (HBB: c.243C>G), Hb G-Coushatta (HBB: c.68A>C) and Hb Mizuho (HBB: c.206T>C) in Sri Lankan Families. Hemoglobin 39:1, pages 62-65.
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D. Hull, P. C. Winter, C. M. McHale, T. R.J. Lappin & E. E. Mayne. (1998) Familial Hemolytic Anemia Due to Hb Sabine [β91(F7)Leu←Pro] Identified BY Polymerase Chain Reaction. Hemoglobin 22:3, pages 263-266.
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M. F. H. Carver & T. H. J. Huisman. (1997) International Hemoglobin Information Center Variant List. Hemoglobin 21:6, pages 505-506.
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. (1996) Variants of the Alpha Chain. Hemoglobin 20:3, pages 215-312.
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E. J. Harthoorn-lasthuizen, F. A. E. Nabben, E. G. Kazanetz, L.-H. Gu, T. P. Molchanova & T. H. J. Huisman. (1995) HB Mizuho or α2β268(E12)LEU→PRO in a Young Dutch Boy. Hemoglobin 19:3-4, pages 203-206.
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. (1994) International Hemoglobin Information Center. Hemoglobin 18:2, pages 77-161.
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H. Wajcman, M. de Montalembert, R. Girot, J. Kister, M. Maier-Redelsperger & F. Galacteros. (1994) The Use of Staphylococcus V8 Protease in the Structural Determination of Hunan Hemoglobin Variants:Hb Valparaiso [α88(F9)ALA-GLY] As Example. Hemoglobin 18:4-5, pages 275-284.
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. (1993) Variants of the Alpea Chain. Hemoglobin 17:2, pages 89-177.
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. (1992) Variants of the Alpha Chain. Hemoglobin 16:3, pages 127-213.
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. (1991) International hemoglobin information center: Variants of the alpha chain. Hemoglobin 15:3, pages 139-217.
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M. M. Keeling, S. J. Bertolone, E. Baysal, Y-C. Gu, B. Cepreganova, J. B. Wilson & T. H. J. Huisman. (1991) HB Mizuho or α2β268(E12)Leu→pro in a Caucasian Boy with high levels of HB F; Identification by Sequencing of Amplified DNA. Hemoglobin 15:6, pages 477-485.
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R. J. Labotka, L. N. Vida & G. R. Honig. (1990) HB Mizuho [β68(E12)LEU-PRO]. Second Occurrence Identified in A Caucasian Child with Hemolytic Anenia and Dense Erythrocyte Inclusions. Hemoglobin 14:2, pages 129-136.
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. (1990) International Hemoglobin Information Center. Hemoglobin 14:3, pages 249-325.
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. (1989) Variants of the Alpha Chain. Hemoglobin 13:3, pages 223-297.
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. (1988) IHIC Variants List. Hemoglobin 12:3, pages 209-282.
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. (1987) IHIC Variants List. Hemoglobin 11:3, pages 243-308.
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. (1986) International Hemoglobin Information Center IHIC Variants List. Hemoglobin 10:3, pages 261-327.
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S. Rahbar & Y. Asmerom. (1986) Functional Studies, Anion-Binding and Effects of Bezafibrate on Three High Affinity Hemoglobin Variants: Hb Olynpia, Hb Great Lakes and Hb North Chicago. Hemoglobin 10:6, pages 643-649.
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. (1985) International Hemoglobin Information Center. Hemoglobin 9:3, pages 229-298.
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. (1984) International Hemoglobin Information Center: Variants of the Alpha Chain. Hemoglobin 8:3, pages 243-300.
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G. Stamatoyannopoulos & P. E. Nute. (1984) Cases of Unstable Hemoglobin and Methemoglobin Produced by De Novo Mutation. Hemoglobin 8:1, pages 85-95.
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. (1983) International Hemoglobin Information Center: Policies—Ihic. Hemoglobin 7:4, pages 331-406.
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Y. Ohba, H. Yoshinaka, Y. Hattori, M. Matsuoka & T. Miyaji. (1983) Hemoglobin J Habana Found in a Cord Blood of a Japanese. Hemoglobin 7:4, pages 327-329.
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. (1983) Two Further Examples of HB Hirose, β37 (C3) Trp→Ser. Hemoglobin 7:2, pages 191-193.
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T. Nakatsuji, B. B. Webber, S. E. N. Johnson & T. H. J. Huisman. (1983) Two Rare α Chain Variants, Hb Dunn Or α26(A4)Asp→Asnβ2 and HB G-Pest or α274(EF3)ASP→ASNβ2 Observed in an indian and a Black Newborn. Hemoglobin 7:6, pages 597-599.
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. (1982) International Hemoglobin Information Center Policies - IHIC. Hemoglobin 6:3, pages 257-346.
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. (1981) International Hemoglobin Information Center Policies - Ihic. Hemoglobin 5:3, pages 259-323.
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K. Fuyuno, T. Torigoe, Y. Ohba#M. Matsuoka & T. Miyaji. (1981) Survey of cord blood Hemoglobin in Japan and Identification of two new γ Chain Variants. Hemoglobin 5:2, pages 139-151.
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Y. Ohba, M. Matsuoka, K. Fuyuno, K. Yamamoto, S. Nishijima & T. Miyaji. (1981) Further Studies on Hemoglobin Hofu, β 126 (H 4) Val ⇒ Glu, with Special Reference to its Stability. Hemoglobin 5:1, pages 89-95.
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T. Nakatsuji, S. Miwa, Y. Ohba, Y. Hattori, T. Miyaji, S. Hino & N. Matsumoto. (1981) A New Unstable Hemoglobin, Hb Yokohama β31(B13)LEU → Pro, Causing Hemolytic Anemia. Hemoglobin 5:7-8, pages 667-678.
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. (1981) Hemoglobin Duan, α75(EF4) ASP→ALA, a New Variant Found in China. Hemoglobin 5:5, pages 481-486.
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S. O. Brennan, R. M. Wells, H. Smith & R. W. Carrell. (1981) Hemoglobin Brisbane: β68 Leu→His. A new High Oxygen Affinity Variant. Hemoglobin 5:4, pages 325-335.
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I. Iuchi, S. Shimasaki, K. Hidaka, S. Ueda, S. Shibata, J. Mizushima & H. Harada. (1981) HB Ube-2 (α68[E-17]ASN→ASP): The Second Instance in Japan. Hemoglobin 5:6, pages 599-603.
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. (1980) Hemoglobin Mizushi (α75[EF4]ASP→GLY): A New Hemoglobin Variant Observed in A Japanese Family. Hemoglobin 4:2, pages 209-214.
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S. Shibata, T. Miyaji & Y. Ohba. (1980) Abnormal Hemoglobins in Japan. Hemoglobin 4:3-4, pages 395-408.
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Y. Ohba, T. Miyaji, Y. Hattori, K. Fuyuno & M. Matsuoka. (1980) Unstable Hemoglobins in Japan. Hemoglobin 4:3-4, pages 307-312.
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. (1979) International Hemoglobin Information Center: Policies -Ihic. Hemoglobin 3:6, pages 481-513.
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. (1979) International Hemoglobin Information Center Policies - Ihic. Hemoglobin 3:5, pages 371-395.
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B. Brimhall, Kenneth Stangland, R. T. Jones, Robert R. Becker & Thomas J. Bailey. (1979) Tryptic Peptide Compositions of Hemoglobins from Mink (Hustela Vison) and Hyena (Hyaenae Hyaenae) and the α-Chain of coatmundi (Nasua Nasua. Hemoglobin 3:4, pages 271-292.
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M. Matsuoka, M. Morito & I. Iuchi. (1978) Short Communications: Characterization of Hb Ube-4: Alpha 116 (Gh4) Glu → Ala. Hemoglobin 2:2, pages 181-186.
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. (1978) International Hemoglobin Information Center. Hemoglobin 2:5, pages 471-491.
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Y. Ohba, T. Miyaji, T. Hirosaki, M. Matsuoka, M. Koresawa & I. Iuchi. (1978) Occurrence of Hemoglobin G Cousha in Japan. Hemoglobin 2:5, pages 437-441.
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Y. Ohba, T. Miyaji, M. Matsuoka & M. Yokoyama. (1978) Further Studies on Hemoglobin Hirosaki: Demonstration of its Presence at Low Concentration. Hemoglobin 2:3, pages 281-286.
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. (1978) Variant Lists. Hemoglobin 2:6, pages 567-598.
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H. F. Bunn, A. J. Altman, K. Stangland, S. I. Firshein, B. Forget, G. J. Schmidt & R. T. Jones. (1978) Hemoglobins AIDA (α64 ASP → ASN) and D-Los Angeles (β121 Glu → Glu) in an Asian-Indian Family. Hemoglobin 2:6, pages 531-540.
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. (1977) International Hemoglobin Information Center. Hemoglobin 1:7, pages 707-733.
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Helene Narvestad-Bøttger, Anne Winther-Larsen, Jens Haugbølle Bjerre, Morten Hanefeld Dziegiel, Anne Todsen Hansen & Henrik Hasle. (2023) Extreme Reticulocytosis After Splenectomy in a Patient With Hemoglobin Mizuho. Journal of Pediatric Hematology/Oncology.
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Tania T. Sarker, Bhavesh Delvadia, Shiyong Li, John D. Roback, Ross M. Fasano, Kari J. Broder, Ashley L. Monsrud & Cassandra D. Josephson. (2021) Mizuho hemoglobinopathy, presenting with severe hemolytic anemia and multisystem organ failure secondary to exertion. Transfusion 61:7, pages 1996-1997.
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Linet Njue, Cesare Medri, Peter Keller, Miriam Diepold, Behrouz Mansouri Taleghani & Alicia Rovó. (2021) The rare hemoglobin variant Hb Mizuho: report of a Swiss family and literature review. Annals of Hematology 100:7, pages 1677-1683.
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Berndt Zur, Bernd Mayer-Hubner, Michael Ludwig & Birgit Stoffel-Wagner. (2012) A 14-Year-Old Boy with Chronic Cyanosis, Mild Anemia, and Limited Physical Resistance to Stress. Clinical Chemistry 58:2, pages 332-335.
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Amber M. Yates, Nicole A. Mortier, Kristina S. Hyde, Jane S. Hankins & Russell E. Ware. (2010) The diagnostic dilemma of congenital unstable hemoglobinopathies. Pediatric Blood & Cancer 55:7, pages 1393-1395.
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Cristina Ferreira, James D. Hoyer, Armandina Miranda, Isabel Picanço, Vanda Almendra, Maria Teresa Seixas, Teresa Almeida, Luísa Romão & Paula Faustino. (2006) Hemoglobin Loves Park [β68 (E12) Leu→Phe]: Report of five cases including one originating from a de novo mutation. American Journal of Hematology 81:4, pages 256-261.
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Ph. Beris, M. N. Kitundu, E. Baysal, C. Öner, K. D. Lanclos, A. J. Dimovski, F. Kutlar & T. H. J. Huisman. (2006) Black β‐thalassemia homozygotes with specific sequence variations in the 5′ hypersensitive site‐2 of the locus control region have high levels of fetal hemoglobin. American Journal of Hematology 41:2, pages 97-101.
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M. R. Waltz, T. N. Pullman, K. Takeda, P. Sobieszczyk & S. Refetoff. (2014) Molecular basis for the properties of the thyroxine-binding globulin-slow variant in American Blacks. Journal of Endocrinological Investigation 13:4, pages 343-349.
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T. Nakatsuji, J. Carver, J. B. Wilson, H. Lam, A. L. Reese, S. Nagle, S. Miwa & T. H. J. Huisman. (1983) Alpha chain and gamma chain abnormal hemoglobins in newborn babies: Structural and genetic aspects. American Journal of Hematology 14:2, pages 121-132.
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Zeng Yi-Tao, M.E. Headlee, J. Henson, H. Lam, J.B. Wilson & T.H.J. Huisman. (1982) Identification of hemoglobin G-Philadelphia (α68 Asn→Lys) and homoglonin matsue-oki (α75 Asp→Asn) in a black infant. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 707:2, pages 206-212.
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William P. Winter, Samir M. Hanash & Donald L. Rucknagel. 1979. Advances in Human Genetics 9. Advances in Human Genetics 9 229 291 .

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