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Review Article

Phage antibody display libraries: a powerful antibody discovery platform for immunotherapy

, , , &
Pages 276-289 | Received 27 Mar 2014, Accepted 24 Jul 2014, Published online: 14 Nov 2014

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Lilian Rumi Tsuruta, Mariana Lopes dos & Ana Maria Moro. 2018. Antibody Engineering. Antibody Engineering.
Daniela Teixeira & Maria Gonzalez-Pajuelo. 2018. Biomedical Applications of Functionalized Nanomaterials. Biomedical Applications of Functionalized Nanomaterials 67 88 .
Arnaud Avril, Sebastian Miethe, Michael Hust & Thibaut Pelat. 2018. Phage Display. Phage Display 83 112 .
Roghaye Arezumand, Abbas Alibakhshi, Javad Ranjbari, Ali Ramazani & Serge Muyldermans. (2017) Nanobodies As Novel Agents for Targeting Angiogenesis in Solid Cancers. Frontiers in Immunology 8.
Crossref
William R. Strohl. 2017. Protein Therapeutics. Protein Therapeutics 113 159 .
Kathryn E. Tiller, Ratul Chowdhury, Tong Li, Seth D. Ludwig, Sabyasachi Sen, Costas D. Maranas & Peter M. Tessier. (2017) Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis. Frontiers in Immunology 8.
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Mohammad R. Tohidkia, Maryam Sepehri, Shirin Khajeh, Jaleh Barar & Yadollah Omidi. (2017) Improved Soluble ScFv ELISA Screening Approach for Antibody Discovery Using Phage Display Technology. SLAS Discovery 22:8, pages 1026-1034.
Crossref
Patrick J. Kennedy, Carla Oliveira, Pedro L. Granja & Bruno Sarmento. (2017) Antibodies and associates: Partners in targeted drug delivery. Pharmacology & Therapeutics 177, pages 129-145.
Crossref
Parvin Samadi Pakchin, Sattar Akbari Nakhjavani, Reza Saber, Hossein Ghanbari & Yadollah Omidi. (2017) Recent advances in simultaneous electrochemical multi-analyte sensing platforms. TrAC Trends in Analytical Chemistry 92, pages 32-41.
Crossref
Tiansen Li, Meiling Huang, Hongran Xiao, Guoqi Zhang, Jinhua Ding, Peng Wu, Hui Zhang, Jinliang Sheng & Chuangfu Chen. (2017) Selection and characterization of specific nanobody against bovine virus diarrhea virus (BVDV) E2 protein. PLOS ONE 12:6, pages e0178469.
Crossref
Andre ten Haaf, Johannes Kohl, Sibylle Pscherer, Hans-Peter Hamann, Hans Ulrich Eskens, Max Bastian, Stefan Gattenlöhner & Mehmet Kemal Tur. (2017) Development of a monoclonal sandwich ELISA for direct detection of bluetongue virus 8 in infected animals. Journal of Virological Methods 243, pages 172-176.
Crossref
Leili Aghebati-Maleki, Vahid Younesi, Behzad Baradaran, Jalal Abdolalizadeh, Morteza Motallebnezhad, Hamid Nickho, Dariush Shanehbandi, Jafar Majidi & Mehdi Yousefi. (2017) Antiproliferative and Apoptotic Effects of Novel Anti-ROR1 Single-Chain Antibodies in Hematological Malignancies. SLAS Discovery 22:4, pages 408-417.
Crossref
Farnaz Fahimi, Mohammad Reza Tohidkia, Mehdi Fouladi, Reza Aghabeygi, Naser Samadi & Yadollah Omidi. (2017) Pleiotropic cytotoxicity of VacA toxin in host cells and its impact on immunotherapy. BioImpacts 7:1, pages 59-71.
Crossref
Ying-Yu Ma, Ke-Tao Jin, Shi-Bing Wang, Hui-Ju Wang, Xiang-Min Tong, Dong-Sheng Huang & Xiao-Zhou Mou. (2017) Molecular Imaging of Cancer with Nanoparticle-Based Theranostic Probes. Contrast Media & Molecular Imaging 2017, pages 1-11.
Crossref
Nicole H. Trier & Gunnar Houen. 2017. 43 96 .
Leili Aghebati-Maleki, Babak Bakhshinejad, Behzad Baradaran, Morteza Motallebnezhad, Ali Aghebati-Maleki, Hamid Nickho, Mehdi Yousefi & Jafar Majidi. (2016) Phage display as a promising approach for vaccine development. Journal of Biomedical Science 23:1.
Crossref
Yue Cui. (2016) Engineered phages for electronics. Biosensors and Bioelectronics 85, pages 964-976.
Crossref
Anna Säll, Maria Walle, Christer Wingren, Susanne Müller, Tomas Nyman, Andrea Vala, Mats Ohlin, Carl A. K. Borrebaeck & Helena Persson. (2016) Generation and analyses of human synthetic antibody libraries and their application for protein microarrays. Protein Engineering Design and Selection 29:10, pages 427-437.
Crossref
Saeideh Same, Ayuob Aghanejad, Sattar Akbari Nakhjavani, Jaleh Barar & Yadollah Omidi. (2016) Radiolabeled theranostics: magnetic and gold nanoparticles. Bioimpacts 6:3, pages 169-181.
Crossref
Valencio Salema, Ana López-Guajardo, Carlos Gutierrez, Mario Mencía & Luis Ángel Fernández. (2016) Characterization of nanobodies binding human fibrinogen selected by E. coli display. Journal of Biotechnology 234, pages 58-65.
Crossref
Reza Safdari, Reza Ferdousi, Kamal Aziziheris, Sharareh R. Niakan-Kalhori & Yadollah Omidi. (2016) Computerized techniques pave the way for drug-drug interaction prediction and interpretation. BioImpacts 6:2, pages 71-78.
Crossref
Yanyan Zhao, Ying Liang, Yuan Liu, Xiao Zhang, Xiaodan Hu, Sicong Tu, Aihua Wu, Cunzheng Zhang, Jianfeng Zhong, Shengming Zhao, Xianjin Liu & Kang Tu. (2016) Isolation of broad-specificity domain antibody from phage library for development of pyrethroid immunoassay. Analytical Biochemistry 502, pages 1-7.
Crossref
Antonia P. Sagona, Aurelija M. Grigonyte, Paul R. MacDonald & Alfonso Jaramillo. (2016) Genetically modified bacteriophages. Integrative Biology 8:4, pages 465-474.
Crossref
Kannan Natarajan, Michael G Mage & David H Margulies. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences 1 7 .
Kaoru Nagato, Timothy T. Spear & Michael I. Nishimura. 2015. Developments in T Cell Based Cancer Immunotherapies. Developments in T Cell Based Cancer Immunotherapies 75 98 .

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