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Pediatric Hematology and Oncology Volume 27, 2010 - Issue 1
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Case Reports

SUBACUTE METHOTREXATE NEUROTOXICITY AND CEREBRAL VENOUS SINUS THROMBOSIS IN A 12-YEAR OLD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) C677T POLYMORPHISM: Homocysteine-Mediated Methotrexate Neurotoxicity via Direct Endothelial Injury

Kris M. MahadeoDivision of Pediatric Hematology-Oncology, Children's Hospital at Montefiore, Bronx, New York, USACorrespondence[email protected]
, MD,
Girish DhallDepartment of Pediatric Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles, California, USA
, MD,
Ashok PanigrahyDepartment of Radiology, Childrens Hospital Los Angeles, Los Angeles, California, USA
, MD,
Carlos LastraDepartment of Pediatric Neurology, Saint Peter's University Hospital, New Brunswick, New Jersey, USA
, MD &
Lawrence J. EttingerDivision of Pediatric Hematology-Oncology, All Children's Hospital, St. Petersburg, Florida, USA
, MD
Pages 46-52 | Accepted 16 Sep 2009, Published online: 02 Feb 2010

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Abeer Khalid Al-Ghumlas, Manan A. Alhakbany & Aida A. Korish. (2023) Antiapoptotic and anticoagulant effects of camel milk and camel urine in methotrexate-induced hepatotoxicity. CyTA - Journal of Food 21:1, pages 357-365.
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Michael Benzaquen, Frank Rouby, Mickael Bobot, Dan Lebowitz, Jacques Serratrice & Pauline Belenotti. (2018) Embolie pulmonaire liée au méthotrexate chez un patient présentant une dermatomyosite. Revue du Rhumatisme 85:2, pages 214-215.
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Michael Benzaquen, Frank Rouby, Mickael Bobot, Dan Lebowitz, Jacques Serratrice & Pauline Belenotti. (2017) Pulmonary embolism induced by methotrexate in a dermatomyositis patient. Joint Bone Spine 84:4, pages 501-502.
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Wei Song, Hongbo Ci, Guanglei Tian, Yanjun Zhang & Xiaohu Ge. (2017) Edoxaban improves venous thrombosis via increasing hydrogen sulfide and homocysteine in rat model. Molecular Medicine Reports 16:5, pages 7706-7714.
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Erhan Bayram, Yasemin Topcu, Ozlem Tufekci, Pakize Karaoglu, Uluc Yis, Hale Oren & Semra Hiz Kurul. (2014) The efficacy and safety of levetiracetam in paediatric patients treated with chemotherapeutic agents for haematologic disorders. Journal of Paediatrics and Child Health 50:7, pages 553-556.
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Min Zhang, Jinlin Wen, Xiangjiang Wang & Chun Xiao. (2014) High‑dose folic acid improves endothelial function by increasing tetrahydrobiopterin and decreasing homocysteine levels. Molecular Medicine Reports.
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E. Rueda Arenas, J. García Corzo & L. Franco Ospina. (2013) Hemiparesia y parálisis facial transitorias causadas por metotrexato. Anales de Pediatría 79:6, pages 385-389.
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Alessandro Ferretti, Pasquale Parisi & Maria Pia Villa. (2013) The role of hyperhomocysteinemia in neurological features associated with coeliac disease. Medical Hypotheses 81:4, pages 524-531.
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Jose Manuel Vagace, Maria Dolores de la Maya, Cristina Caceres-Marzal, Silvia Gonzalez de Murillo & Guillermo Gervasini. (2012) Central nervous system chemotoxicity during treatment of pediatric acute lymphoblastic leukemia/lymphoma. Critical Reviews in Oncology/Hematology 84:2, pages 274-286.
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Noha M. EL-Khodary, Sahar M. EL-Haggar, Manal A. Eid & Emad N. Ebeid. (2011) Study of the pharmacokinetic and pharmacogenetic contribution to the toxicity of high-dose methotrexate in children with acute lymphoblastic leukemia. Medical Oncology 29:3, pages 2053-2062.
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Femke EAM Froklage, Jaap C Reijneveld & Jan J Heimans. (2011) Central neurotoxicity in cancer chemotherapy: pharmacogenetic insights. Pharmacogenomics 12:3, pages 379-395.
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Jose Manuel Vagace, Cristina Caceres‐Marzal, Mercedes Jimenez, Maria Soledad Casado, Silvia Gonzalez de Murillo & Guillermo Gervasini. (2010) Methotrexate‐induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis. American Journal of Hematology 86:1, pages 98-101.
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