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Pediatric Hematology and Oncology Volume 27, 2010 - Issue 1
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Case Reports

SUBACUTE METHOTREXATE NEUROTOXICITY AND CEREBRAL VENOUS SINUS THROMBOSIS IN A 12-YEAR OLD WITH ACUTE LYMPHOBLASTIC LEUKEMIA AND METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) C677T POLYMORPHISM: Homocysteine-Mediated Methotrexate Neurotoxicity via Direct Endothelial Injury

Kris M. MahadeoDivision of Pediatric Hematology-Oncology, Children's Hospital at Montefiore, Bronx, New York, USACorrespondence[email protected]
, MD,
Girish DhallDepartment of Pediatric Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles, California, USA
, MD,
Ashok PanigrahyDepartment of Radiology, Childrens Hospital Los Angeles, Los Angeles, California, USA
, MD,
Carlos LastraDepartment of Pediatric Neurology, Saint Peter's University Hospital, New Brunswick, New Jersey, USA
, MD &
Lawrence J. EttingerDivision of Pediatric Hematology-Oncology, All Children's Hospital, St. Petersburg, Florida, USA
, MD
Pages 46-52 | Accepted 16 Sep 2009, Published online: 02 Feb 2010

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