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Pediatric Hematology and Oncology Volume 27, 2010 - Issue 5
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Article

ASSOCIATION OF GENETIC POLYMORPHISMS WITH HEPATOTOXICITY IN PATIENTS WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA OR LYMPHOMA

Masanori HorinouchiDivision of Pharmaceutics, Department of Pharmaceutical Health Care, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan
, PhD,
Mariko YagiDepartment of Clinical Evaluation of Pharmacotherapy, and Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
, MD, PhD,
Hiroyuki ImanishiDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
, MD, PhD,
Takeshi MoriDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
, MD,
Tomoko YanaiDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
, MD,
Akira HayakawaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
, MD, PhD,
Yasuhiro TakeshimaDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
, MD, PhD,
Michiyo HijiokaDepartment of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine, Kobe, Japan
, MSc,
Noboru OkamuraDepartment of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine, Kobe, Japan; and Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan
, PhD,
Toshiyuki SakaedaCenter for Integrative Education of Pharmacy Frontier, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
, PhD,
Masafumi MatsuoDepartment of Pediatrics, Kobe University Graduate School of Medicine, Kobe, Japan
, MD, PhD,
Katsuhiko OkumuraDepartment of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine, Kobe, Japan
, PhD &
Tsutomu NakamuraDivision of Pharmaceutics, Department of Pharmaceutical Health Care, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Himeji, Japan; and Department of Clinical Evaluation of Pharmacotherapy, Kobe University Graduate School of Medicine, Kobe, JapanCorrespondence[email protected]
, PhD show all
Pages 344-354 | Received 21 Jul 2009, Accepted 01 Mar 2010, Published online: 29 Jul 2010

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Pingli Yao, Xia He, Rong Zhang, Rongsheng Tong & Hongtao Xiao. (2019) The influence of MTHFR genetic polymorphisms on adverse reactions after methotrexate in patients with hematological malignancies: a meta-analysis. Hematology 24:1, pages 10-19.
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Hai-Rong He, Ping Liu, Gong-Hao He, Wei-Hua Dong, Mao-Yi Wang, Ya-Lin Dong & Jun Lu. (2014) Association between reduced folate carrier G80A polymorphism and methotrexate toxicity in childhood acute lymphoblastic leukemia: a meta-analysis. Leukemia & Lymphoma 55:12, pages 2793-2800.
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Stéphanie Dulucq, Caroline Laverdière, Daniel Sinnett & Maja Krajinovic. (2014) Pharmacogenetic considerations for acute lymphoblastic leukemia therapies. Expert Opinion on Drug Metabolism & Toxicology 10:5, pages 699-719.
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Rohit P. Ojha & James G. Gurney. (2014) Methylenetetrahydrofolate reductase C677T and overall survival in pediatric acute lymphoblastic leukemia: a systematic review. Leukemia & Lymphoma 55:1, pages 67-73.
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Velia D’Angelo, Maria Ramaglia, Adriana Iannotta, Matteo Francese, Elvira Pota, Maria Carmen Affinita, Giulia Pecoraro, Cristiana Indolfi, Martina Di Martino, Daniela Di Pinto, Salvatore Buffardi, Vincenzo Poggi, Paolo Indolfi & Fiorina Casale. (2013) Influence of methylenetetrahydrofolate reductase gene polymorphisms on the outcome of pediatric patients with non-Hodgkin lymphoma treated with high-dose methotrexate. Leukemia & Lymphoma 54:12, pages 2639-2644.
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Tao Shen, Yingdong Song, Xiangting Wang & Haiyang Wang. (2022) Characterizing the molecular heterogeneity of clear cell renal cell carcinoma subgroups classified by miRNA expression profile. Frontiers in Molecular Biosciences 9.
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C Zhu, Y W Liu, S Z Wang, X L Li, X L Nie, X T Yu, L B Zhao & X L Wang. (2017) Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis. The Pharmacogenomics Journal 18:3, pages 450-459.
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Jawad Ahmad & Joseph A. Odin. (2017) Epidemiology and Genetic Risk Factors of Drug Hepatotoxicity. Clinics in Liver Disease 21:1, pages 55-72.
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T. Adam de Beaumais, A. Baruchel & E. Jacqz-Aigrain. (2015) Approches méthodologiques en pharmacogénétique : le modèle des leucémies aiguës lymphoblastiques de l’enfant. Revue d'Oncologie Hématologie Pédiatrique 3:4, pages 215-220.
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Sujatha Suthandiram, Gin-Gin Gan, Shamsul Mohd Zain, Ping-Chong Bee, Lay-Hoong Lian, Kian-Meng Chang, Tee-Chuan Ong & Zahurin Mohamed. (2014) Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies. Pharmacogenomics 15:11, pages 1479-1494.
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Elixabet Lopez-Lopez, Angela Gutierrez-Camino, Nerea Bilbao-Aldaiturriaga, Maria Pombar-Gomez, Idoia Martin-Guerrero & Africa Garcia-Orad. (2014) Pharmacogenetics of childhood acute lymphoblastic leukemia. Pharmacogenomics 15:10, pages 1383-1398.
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Alice Matimba, Fang Li, Alina Livshits, Cher S Cartwright, Stephen Scully, Brooke L Fridley, Gregory Jenkins, Anthony Batzler, Liewei Wang, Richard Weinshilboum & Lynne Lennard. (2014) Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes. Pharmacogenomics 15:4, pages 433-447.
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E Lopez-Lopez, I Martin-Guerrero, J Ballesteros & A Garcia-Orad. (2012) A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia. The Pharmacogenomics Journal 13:6, pages 498-506.
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Elixabet Lopez–Lopez, Javier Ballesteros & Africa Garcia-Orad. (2011) MTHFR 677TT genotype and toxicity of methotrexate: controversial results. Cancer Chemotherapy and Pharmacology 68:5, pages 1369-1370.
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Lucia A. Hindorff, Elizabeth M. Gillanders & Teri A. Manolio. (2011) Genetic architecture of cancer and other complex diseases: lessons learned and future directions. Carcinogenesis 32:7, pages 945-954.
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