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Research Article

Protective effect of astragaloside IV on lipopolysaccharide-induced cardiac dysfunction via downregulation of inflammatory signaling in mice

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Pages 428-433 | Received 27 May 2015, Accepted 03 Jul 2015, Published online: 16 Sep 2015

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Lin Li, Yuwei Zhang, Yudan Luo, Xianghui Meng, Guixiang Pan, Han Zhang, Yuhong Li & Boli Zhang. (2023) The Molecular Basis of the Anti-Inflammatory Property of Astragaloside IV for the Treatment of Diabetes and Its Complications. Drug Design, Development and Therapy 17, pages 771-790.
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Qiuning Wang, Weiying Chen, Xuefeng Yang, Ying Song, Xiaowei Sun, Guizhou Tao, Hong Wang, Nan Zhao, Yue Huang, Erqing Chai & Futian Tang. (2022) Inhibition of miRNA-1-Mediated Inflammation and Autophagy by Astragaloside IV Improves Lipopolysaccharide-Induced Cardiac Dysfunction in Rats. Journal of Inflammation Research 15, pages 2617-2629.
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Xiaoqing Zhang, Huiyan Qu, Tao Yang, Qian Liu & Hua Zhou. (2022) Astragaloside IV attenuate MI-induced myocardial fibrosis and cardiac remodeling by inhibiting ROS/caspase-1/GSDMD signaling pathway. Cell Cycle 21:21, pages 2309-2322.
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Wei Yan, Yao Xu, Yanhong Yuan, Lei Tian, Qin Wang, Yuanyuan Xie, Xinghua Shao, Ming Zhang, Zhaohui Ni & Shan Mou. (2017) Renoprotective mechanisms of Astragaloside IV in cisplatin-induced acute kidney injury. Free Radical Research 51:7-8, pages 669-683.
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Jinfeng Li, Lifeng Huang, Shuzhen Wang, Yongming Yao & Zhenyu Zhang. (2016) Astragaloside IV attenuates inflammatory reaction via activating immune function of regulatory T-cells inhibited by HMGB1 in mice. Pharmaceutical Biology 54:12, pages 3217-3225.
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Chunkun Yang, Qingquan Pan, Kui Ji, Zhuang Tian, Hongyuan Zhou, Shuanghong Li, Chuanchao Luo & Jun Li. (2023) Review on the protective mechanism of astragaloside IV against cardiovascular diseases. Frontiers in Pharmacology 14.
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Lin Zhang, Bin Li, Wei Li, Jingbo Jiang, Wei Chen, Huayun Yang & Diguang Pan. (2023) miR-107 Attenuates Sepsis-Induced Myocardial Injury by Targeting PTEN and Activating the PI3K/AKT Signaling Pathway. Cells Tissues Organs 212:6, pages 523-534.
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Maria Theresa Voelker, Nadine Hechaichi, Bernadin Ndongson-Dongmo, Jana Lemm, Regine Heller, Reinhardt Bauer, Edward M. Conway, Gregor Theilmeier & Sebastian N. Stehr. (2022) Role of the lectin-like domain of thrombomodulin in septic cardiomyopathy. Life Sciences 306, pages 120830.
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Goutami G. Ambati, Kamalender Yadav, Ruchika Maurya, K.K. Kondepudi, Mahendra Bishnoi & Sanjay M. Jachak. (2022) Evaluation of the in vitro and in vivo anti-inflammatory activity of Gymnosporia montana (Roth). Benth leaves. Journal of Ethnopharmacology 297, pages 115539.
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Danial Taherzadeh, Vafa Baradaran Rahimi, Hamed Amiri, Sajjad Ehtiati, Roghayeh Yahyazadeh, Seyed Isaac Hashemy & Vahid Reza Askari. (2022) Acetyl-11-Keto-β-Boswellic Acid (AKBA) Prevents Lipopolysaccharide-Induced Inflammation and Cytotoxicity on H9C2 Cells. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-10.
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Xin Huang, Min-zhou Zhang, Bo Liu, Shi-yu Ma, Xin Yin & Li-heng Guo. (2021) Astragaloside IV Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction in Rats via IKK/NF-κB Pathway. Chinese Journal of Integrative Medicine 27:11, pages 825-831.
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Afsaneh Bagherzadeh, Hamidreza Vaziri, Fatemeh Sokouti Nasimi, Shahin Ahmadian, Adel Feyzi, Mehrdad Farhadi, Fariba Yahyavi, Behnam Hashemi, Reza Rahbarghazi & Mahdi Mahdipour. (2021) Bacterial Lipase Neutralized Toxicity of Lipopolysaccharide on Chicken Embryo Cardiac Tissue. Cardiovascular Toxicology 21:7, pages 582-591.
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Hui‐fei Su, Sharpkate Shaker, Yi Kuang, Meng Zhang, Min Ye & Xue Qiao. (2021) Phytochemistry and cardiovascular protective effects of Huang‐Qi (Astragali Radix). Medicinal Research Reviews 41:4, pages 1999-2038.
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Jie Sun, Shanzhai Wei, Yilai Zhang & Jia Li. (2021) Protective Effects of Astragalus Polysaccharide on Sepsis-Induced Acute Kidney Injury. Analytical Cellular Pathology 2021, pages 1-13.
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Shufang Hu, Weihong Zheng & Li Jin. (2020) Astragaloside IV inhibits cell proliferation and metastasis of breast cancer via promoting the long noncoding RNA TRHDE-AS1. Journal of Natural Medicines 75:1, pages 156-166.
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Ruirui Lu, Junqi Chen, Bihao Liu, Hua Lin, Lixia Bai, Peichun Zhang, Dandan Chen, Honglian Li, Jicheng Li, Yu Pang, Yuan Zhou, Jiuyao Zhou & Junbiao Wu. (2020) Protective role of Astragaloside IV in chronic glomerulonephritis by activating autophagy through PI3K / AKT / AS160 pathway . Phytotherapy Research 34:12, pages 3236-3248.
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Ekaterina Proshkina, Sergey Plyusnin, Tatyana Babak, Ekaterina Lashmanova, Faniya Maganova, Liubov Koval, Elena Platonova, Mikhail Shaposhnikov & Alexey Moskalev. (2020) Terpenoids as Potential Geroprotectors. Antioxidants 9:6, pages 529.
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Yan-gu Tao, Xiu-Fang Huang, Jun-yan Wang, Meng-ru Kang, Ling-jun Wang & Shao-xiang Xian. (2020) Exploring Molecular Mechanism of Huangqi in Treating Heart Failure Using Network Pharmacology. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-17.
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Shuhua Xie, Tao Yang, Zhifen Wang, Man Li, Ling Ding, Xiaotong Hu & Licheng Geng. (2020) Astragaloside IV attenuates sepsis-induced intestinal barrier dysfunction via suppressing RhoA/NLRP3 inflammasome signaling. International Immunopharmacology 78, pages 106066.
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Suxiao Wu & Zilan Chen. (2019) Astragaloside IV alleviates the symptoms of experimental ulcerative colitis in vitro and in vivo. Experimental and Therapeutic Medicine.
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Yong Luo, Qing Wan, Min Xu, Qing Zhou, Xuepiao Chen, Dong Yin, Huan He & Ming He. (2019) Nutritional preconditioning induced by astragaloside Ⅳ on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2-mediated mitochondrial function. Chemico-Biological Interactions 309, pages 108723.
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Jianping Liu, Jianhua Li, Peigang Tian, Bahaer Guli, Guopeng Weng, Lei Li & Qinghong Cheng. (2019) H2S attenuates sepsis‑induced cardiac dysfunction via a PI3K/Akt‑dependent mechanism. Experimental and Therapeutic Medicine.
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He Bao, Danyu Sun, Peng Qi & Shixian Jiang. (2019) RETRACTED: Astragaloside protects oxygen and glucose deprivation induced injury by regulation of microRNA-21 in retinal ganglion cell line RGC-5. Biomedicine & Pharmacotherapy 109, pages 1826-1833.
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Bingshu He, Zhonghua Wang, Lulu Chen, Zhi Zhou & Zeper Abliz. (2018) A rapid, sensitive, and selective liquid chromatography–mass spectrometry method for simultaneous quantification of astragaloside IV and cycloastragenol in mouse plasma and its application to a pharmacokinetic study. International Journal of Mass Spectrometry 434, pages 130-135.
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Bin Tang, Jin-Guo Zhang, Hong-Yong Tan & Xi-Qing Wei. (2018) Astragaloside IV inhibits ventricular remodeling and improves fatty acid utilization in rats with chronic heart failure. Bioscience Reports 38:3.
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Yaling Li, Yun Ye & Hongyan Chen. (2018) Astragaloside IV inhibits cell migration and viability of hepatocellular carcinoma cells via suppressing long noncoding RNA ATB. Biomedicine & Pharmacotherapy 99, pages 134-141.
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Guizhi Jia, Bin Leng, Hongxin Wang & Hongliang Dai. (2017) Inhibition of cardiotrophin-1 overexpression is involved in the anti-fibrotic effect of Astrogaloside IV. Molecular Medicine Reports 16:6, pages 8365-8370.
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Qiang Zhang, Jingjing Huang, Junping Yu, Zhongmin Xu, Liang Liu, Yajing Song, Xiaomei Sun, Anding Zhang & Meilin Jin. (2017) HP1330 Contributes to Streptococcus suis Virulence by Inducing Toll-Like Receptor 2- and ERK1/2-Dependent Pro-inflammatory Responses and Influencing In Vivo S. suis Loads. Frontiers in Immunology 8.
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Hongliang Dai, Guizhi Jia, Meili Lu, Chunguang Liang, Yue Wang & Hongxin Wang. (2017) Astragaloside IV inhibits isoprenaline‑induced cardiac fibrosis by targeting the reactive oxygen species/mitogen‑activated protein kinase signaling axis. Molecular Medicine Reports.
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Liu Xianchu, Professor Zheng Lan, Li Qiufang, Liu Yi, Ruan Xiangcheng, Hou Wenqi & Ding Yang. (2016) Naringin protects against lipopolysaccharide-induced cardiac injury in mice. Environmental Toxicology and Pharmacology 48, pages 1-6.
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Huili Sun, Wenjing Wang, Pengxun Han, Mumin Shao, Gaofeng Song, Heng Du, Tiegang Yi & Shunmin Li. (2016) Astragaloside IV ameliorates renal injury in db/db mice. Scientific Reports 6:1.
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Birgit Waltenberger, Andrei Mocan, Karel Šmejkal, Elke Heiss & Atanas Atanasov. (2016) Natural Products to Counteract the Epidemic of Cardiovascular and Metabolic Disorders. Molecules 21:6, pages 807.
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RONGFENG ZHU, JIANJUN ZHENG, LIZHEN CHEN, BIN GU & SHENGLI HUANG. (2016) Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK/IκBα pathway. International Journal of Molecular Medicine 37:6, pages 1697-1705.
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Maria Theresa Voelker, Nadine Hechaichi, Bernadin Ndongson-Dongmo, Jana Lemm, Regine Heller, Reinhardt Bauer, Edward M. Conway, Gregor Theilmeier & Sebastian Stehr. (2022) Role of the Lectin-Like Domain of Thrombomodulin in Septic Cardiomyopathy. SSRN Electronic Journal.
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Maria Theresa Voelker, Nadine Hechaichi, Bernadin Ndongson-Dongmo, Jana Lemm, Regine Heller, Reinhardt Bauer, Edward M. Conway, Gregor Theilmeier & Sebastian N. Stehr. (2022) Role of the Lectin-Like Domain of Thrombomodulin in Septic Cardiomyopathy Thrombomodulin in Septic Cardiomyopathy. SSRN Electronic Journal.
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