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Platelets Volume 21, 2010 - Issue 4
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Original Article

GPIbα-selective activation of platelets induces platelet signaling events comparable to GPVI activation events

Elizabeth E. Gardiner The Australian Centre for Blood Diseases, Monash University, Melbourne, AustraliaCorrespondence[email protected]
,
Jane F. Arthur The Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
,
Yang Shen The Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
,
Denuja Karunakaran Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
,
Lynley A. Moore Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia
,
Jan Schulte Am Esch II Heinrich Heine University, Duesseldorf, Germany
,
Robert K. Andrews The Australian Centre for Blood Diseases, Monash University, Melbourne, Australia
&
Michael C. Berndt University College Cork, Cork, Ireland
 show all
Pages 244-252 | Received 09 Nov 2009, Accepted 11 Feb 2010, Published online: 06 Apr 2010

Citations (38)

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Read on this site (5)

Mohammad Al-Tamimi, Jianlin Qiao & Elizabeth E. Gardiner. (2022) The utility of platelet activation biomarkers in thrombotic microangiopathies. Platelets 33:4, pages 503-511.
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Jack Yule, Neil V. Morgan & Natalie S. Poulter. (2020) New insights into glycoprotein Ibα desialylation-mediated platelet clearance. Platelets 31:5, pages 621-623.
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Robert K. Andrews & Elizabeth E. Gardiner. (2016) Metalloproteolytic receptor shedding…platelets “acting their age”. Platelets 27:6, pages 512-518.
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Tony G. Walsh, Pat Metharom & Michael C. Berndt. (2015) The functional role of platelets in the regulation of angiogenesis. Platelets 26:3, pages 199-211.
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Robert K Andrews, Jane F Arthur & Elizabeth E Gardiner. (2014) Targeting GPVI as a novel antithrombotic strategy. Journal of Blood Medicine 5, pages 59-68.
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Articles from other publishers (33)

James I. Hearn & Elizabeth E. Gardiner. (2023) Research and Clinical Approaches to Assess Platelet Function in Flowing Blood. Arteriosclerosis, Thrombosis, and Vascular Biology.
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Kristin Klaeske, Anneke Brade, Sandra Eifert, Khalil Jawad, Diyar Saeed, Josephina Haunschild, Franz Sieg, Michael A. Borger & Maja-Theresa Dieterlen. (2023) The Glycoprotein (GP)Ib-IX-V Complex on Platelets: GPIbα Protein Expression Is Reduced in HeartMate 3 Patients with Bleeding Complications within the First 3 Months. International Journal of Molecular Sciences 24:6, pages 5639.
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Sarah M. Hicks, Christine S.M. Lee, Sidra A. Ali, Philip Y. Choi & Elizabeth E. Gardiner. (2020) The molecular basis of immune-based platelet disorders. Clinical Science 134:21, pages 2807-2822.
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Jennifer Yeung, Reheman Adili, Emily N. StringhamRong LuoAlexander VizurragaLuciana K. Rosselli-MuraiHannah M. StovekenMaiya Yu, Xianhua PiaoMichael Holinstat & Gregory G. Tall. (2020) GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force. Proceedings of the National Academy of Sciences 117:45, pages 28275-28286.
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Jian Du, Dongjune Kim, Ghadah Alhawael, David N. Ku & Aaron L. Fogelson. (2020) Clot Permeability, Agonist Transport, and Platelet Binding Kinetics in Arterial Thrombosis. Biophysical Journal 119:10, pages 2102-2115.
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Adela Constantinescu-Bercu, Luigi Grassi, Mattia Frontini, Isabelle I Salles-Crawley, Kevin Woollard & James TB Crawley. (2020) Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2. eLife 9.
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Samantha J. Montague, Yean J. Lim, Woei M. Lee & Elizabeth E. Gardiner. (2020) Imaging Platelet Processes and Function—Current and Emerging Approaches for Imaging in vitro and in vivo. Frontiers in Immunology 11.
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Stephanie Makhoul, Katharina Trabold, Stepan Gambaryan, Stefan Tenzer, Daniele Pillitteri, Ulrich Walter & Kerstin Jurk. (2019) cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets. Cell Communication and Signaling 17:1.
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James A. Giles, Andrew D. Greenhalgh, Adam Denes, Bernhard Nieswandt, Graham Coutts, Barry W. McColl & Stuart M. Allan. (2018) Neutrophil infiltration to the brain is platelet-dependent, and is reversed by blockade of platelet GPIb α . Immunology 154:2, pages 322-328.
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Sarah Luu, Elizabeth Gardiner & Robert Andrews. (2018) Bone Marrow Defects and Platelet Function: A Focus on MDS and CLL. Cancers 10:5, pages 147.
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Elizabeth E. Gardiner. (2018) Proteolytic processing of platelet receptors. Research and Practice in Thrombosis and Haemostasis 2:2, pages 240-250.
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Patrick Andre. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 1341 1357 .
José A. López. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 85 97 .
Elizabeth E. Gardiner & Robert K. Andrews. 2017. Platelets in Thrombotic and Non-Thrombotic Disorders. Platelets in Thrombotic and Non-Thrombotic Disorders 309 319 .
Naadiya Carrim, Jane F. Arthur, Justin R. Hamilton, Elizabeth E. Gardiner, Robert K. Andrews, Niamh Moran, Michael C. Berndt & Pat Metharom. (2015) Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα. Redox Biology 6, pages 640-647.
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R. K. Andrews, J. F. Arthur & E. Gardiner. (2014) Neutrophil extracellular traps (NETs) and the role of platelets in infection. Thrombosis and Haemostasis 112:6.
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M. C. Berndt, P. Metharom & R. K. Andrews. (2014) Primary haemostasis: newer insights. Haemophilia 20, pages 15-22.
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Jianlin Qiao, Yang Shen, Meimei Shi, Yanrong Lu, Jingqiu Cheng & Younan Chen. (2014) Molecular Cloning and Characterization of Rhesus Monkey Platelet Glycoprotein Ibα, a major ligand-binding subunit of GPIb-IX-V complex. Thrombosis Research 133:5, pages 817-825.
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Elizabeth E. Gardiner & Robert K. Andrews. (2014) Platelet Receptor Expression and Shedding: Glycoprotein Ib-IX-V and Glycoprotein VI. Transfusion Medicine Reviews 28:2, pages 56-60.
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Robert Andrews, Jane Arthur & Elizabeth Gardiner. (2017) Neutrophil extracellular traps (NETs) and the role of platelets in infection. Thrombosis and Haemostasis 112:10, pages 659-665.
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Chee W Tan, Christopher M Ward & James P Isbister. 2014. Oh's Intensive Care Manual. Oh's Intensive Care Manual 1003 1016.e3 .
Y. Ozaki, K. Suzuki‐Inoue & O. Inoue. (2013) Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb‐IX‐V, and CLEC‐2. Journal of Thrombosis and Haemostasis 11, pages 330-339.
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Zaverio M. Ruggeri & Shaun P. Jackson. 2013. Platelets. Platelets 399 423 .
Robert K. Andrews & Michael C. Berndt. 2013. Platelets. Platelets 195 213 .
Marc Forestier, Mohammad Al-Tamimi, Elizabeth E. Gardiner, Corinna Hermann, Sara C. Meyer & Juerg H. Beer. (2012) Diesel exhaust particles impair platelet response to collagen and are associated with GPIbα shedding. Toxicology in Vitro 26:6, pages 930-938.
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J.F. ARTHUR, J. QIAO, Y. SHEN, A.K. DAVIS, E. DUNNE, M.C. BERNDT, E.E. GARDINER & R.K. ANDREWS. (2012) ITAM receptor‐mediated generation of reactive oxygen species in human platelets occurs via Syk‐dependent and Syk‐independent pathways. Journal of Thrombosis and Haemostasis 10:6, pages 1133-1141.
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Mohammad Al-TamimiChee Wee TanJianlin QiaoGabrielle J. PenningsAshkan JavadzadeganAndy S. C. YongJane F. ArthurAmanda K. DavisJing JingFi-Tjen MuJustin R. HamiltonShaun P. JacksonAndreas Ludwig, Michael C. Berndt, Christopher M. WardLeonard KritharidesRobert K. AndrewsElizabeth E. Gardiner. (2012) Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood 119:18, pages 4311-4320.
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Desislava BoyanovaSantosh NillaIngvild Birschmann, Thomas Dandekar & Marcus Dittrich. (2012) PlateletWeb: a systems biologic analysis of signaling networks in human platelets. Blood 119:3, pages e22-e34.
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Mohammad Al-Tamimi, Jane F. Arthur, Elizabeth E. Gardiner & Robert K. Andrews. (2017) Focusing on plasma glycoprotein VI. Thrombosis and Haemostasis 107:04, pages 648-655.
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Md. Imtaiyaz Hassan, Aditya Saxena & Faizan Ahmad. (2012) Structure and function of von Willebrand factor. Blood Coagulation & Fibrinolysis 23:1, pages 11-22.
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Elizabeth E. Gardiner, Mohammad Al-Tamimi, Robert K. Andrews & Michael C. Berndt. 2012. Platelets and Megakaryocytes. Platelets and Megakaryocytes 321 339 .
J.F. ARTHUR, Y. SHEN, E.E. GARDINER, L. COLEMAN, D. KENNY, R.K. ANDREWS & M.C. BERNDT. (2011) TNF receptor‐associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. Journal of Thrombosis and Haemostasis 9:1, pages 163-172.
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Matthew Auton, Katie E. Sowa, Scott M. Smith, Erik Sedlák, K. Vinod Vijayan & Miguel A. Cruz. (2010) Destabilization of the A1 Domain in von Willebrand Factor Dissociates the A1A2A3 Tri-domain and Provokes Spontaneous Binding to Glycoprotein Ibα and Platelet Activation under Shear Stress. Journal of Biological Chemistry 285:30, pages 22831-22839.
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