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RADIOSENSITIZATION OF LUNG CANCER BY PAENOL

The radiosensitizing effect of Paeonol on lung adenocarcinoma by augmentation of radiation-induced apoptosis and inhibition of the PI3K/Akt pathway

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Pages 1079-1086 | Received 20 Dec 2012, Accepted 04 Jul 2013, Published online: 25 Oct 2013

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Chien-Shan Cheng, Jing-Xian Chen, Jian Tang, Ya-Wen Geng, Lan Zheng, Ling-Ling Lv, Lian-Yu Chen & Zhen Chen. (2020) Paeonol Inhibits Pancreatic Cancer Cell Migration and Invasion Through the Inhibition of TGF-β1/Smad Signaling and Epithelial-Mesenchymal-Transition. Cancer Management and Research 12, pages 641-651.
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Yan Yan, Pengchong Wang, Ruiying Li, Ying Sun, Rui Zhang, Chuanchuan Huo, Jianfeng Xing & Yalin Dong. (2019) Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study. Drug Design, Development and Therapy 13, pages 681-694.
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John E. Moulder. (2019) Chemical radiosensitizers: the Journal history. International Journal of Radiation Biology 95:7, pages 940-944.
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Cong Chen, Feng Jia, Zhibo Hou, Shu Ruan & Qibin Lu. (2017) Delivery of paeonol by nanoparticles enhances its in vitro and in vivo antitumor effects. International Journal of Nanomedicine 12, pages 6605-6616.
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Articles from other publishers (23)

Ying Wang, Bing-Shu Li, Zi-Hui Zhang, Zhi Wang, Yu-Ting Wan, Fu-Wen Wu, Jing-Chun Liu, Jia-Xin Peng, Hao-Yu Wang & Li Hong. (2023) Paeonol repurposing for cancer therapy: From mechanism to clinical translation. Biomedicine & Pharmacotherapy 165, pages 115277.
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Xindi Chang, Xiaoteng Feng, Min Du, Sijin Li, Jiarou Wang, Yiru Wang & Ping Liu. (2023) Pharmacological effects and mechanisms of paeonol on antitumor and prevention of side effects of cancer therapy. Frontiers in Pharmacology 14.
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Jikun Du, Daibo Song, Jinwen Li, Yuanhua Li, Baohong Li & Li Li. (2021) Paeonol triggers apoptosis in HeLa cervical cancer cells: the role of mitochondria-related caspase pathway. Psychopharmacology 239:7, pages 2083-2092.
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Jing Lv, Shibing Zhu, Huiping Chen, Ying Xu, Qingyu Su, Guofen Yu & Wei Ma. (2021) Paeonol inhibits human lung cancer cell viability and metastasis in vitro via miR ‐126‐5p/ ZEB2 axis . Drug Development Research 83:2, pages 432-446.
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Mansi K. Aparnathi, Sami Ul Haq, Zishan Allibhai, Benjamin H. Lok & Anthony M. Brade. 2023. Advances in Radiation Oncology in Lung Cancer. Advances in Radiation Oncology in Lung Cancer 285 302 .
J. J. Zhang, L. J. Cai, K. Pang, Y. Dong, Z. G. Zhang, B. B. Li, R. Li & C. H. Han. (2020) Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells in vitro and in vivo. Clinical and Translational Oncology 23:3, pages 601-611.
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Ho-Sung Lee, In-Hee Lee, Kyungrae Kang, Sang-In Park, Tae-Wook Kwon & Dae-Yeon Lee. (2021) Uncovering the Anti-Lung-Cancer Mechanisms of the Herbal Drug FDY2004 by Network Pharmacology. Evidence-Based Complementary and Alternative Medicine 2021, pages 1-15.
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Xiaoye Fan, Min Xie, Feijie Zhao, Jiajia Li, Changqing Fan, Hao Zheng, Zhentong Wei, Xinxin Ci & Songling Zhang. (2021) Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer. Phytomedicine 82, pages 153465.
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Rui Ma, Zhenhua Zhang, Jin Xu, Xueqi Liang & Qiang Zhao. (2021) Poricoic acid A induces apoptosis and autophagy in ovarian cancer via modulating the mTOR/p70s6k signaling axis. Brazilian Journal of Medical and Biological Research 54:12.
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Haiting Liu, Jian Li, Yinghui Shang, Qiangqiang Zhao, Bin Wu, Xueyuan Huang, Hang Dong, Rong Gui & Rong Huang. (2020) Delivery of the Bioactive Component Paeonol by Dual pH‐Responsive Nanoparticles Enhances Anti‐Metastatic Tumor Efficiency. ChemNanoMat 7:1, pages 50-60.
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Yi-Jen Liao, Yuan-Hsi Wang, Chao-Lien Liu, Cheng-Chieh Fang, Ming-Hua Hsu & Fat-Moon Suk. (2020) 4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt Signaling Pathways. Applied Sciences 10:17, pages 5941.
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Yuqin Jiang, Yanyan Li, Tingting Yang, Xin Shi, Huajun Suo, Weiwei Zhang, Guiqing Xu & Wei Li. (2019) Design, synthesis, and antilung adenocarcinoma activity research of novel paeonol Schiff base derivatives containing a 1,2,3‐triazole moiety. Journal of the Chinese Chemical Society 67:1, pages 165-171.
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Likun Gao, Zhi Wang, Danhua Lu, Jinling Huang, Jin Liu & Li Hong. (2019) Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells. Cell Death & Disease 10:8.
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Liang Zhang, Deng-chang Li & Li-fang Liu. (2019) Paeonol: pharmacological effects and mechanisms of action. International Immunopharmacology 72, pages 413-421.
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Li-Ming Gao, Yue Zheng, Ping Wang, Lei Zheng, Wen-Li Zhang, Ya Di, Lan-Lan Chen, Xiao-Bo Yin, Qi Tian, Shan-Shan Shi & Shu-Feng Xu. (2019) Tumor-suppressive effects of microRNA-181d-5p on non-small-cell lung cancer through the CDKN3-mediated Akt signaling pathway in vivo and in vitro. American Journal of Physiology-Lung Cellular and Molecular Physiology 316:5, pages L918-L933.
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Hai-Mei Zhou, Qin-Xiang Sun & Yan Cheng. (2017) Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor. Experimental and Therapeutic Medicine 14:4, pages 3213-3220.
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Yiling Wang, Jiantao He, Shenghui Zhang & Qingbo Yang. (2017) Intracellular calcium promotes radioresistance of non–small cell lung cancer A549 cells through activating Akt signaling. Tumor Biology 39:3, pages 101042831769597.
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Yu Lei, Bo Zhang, Yaohua Zhang, Yuan Zhao, Jingying Sun, Xuejun Zhang & Sen Yang. (2016) Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma. International Journal of Oncology 49:3, pages 981-990.
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Xing-Mei Luo, Bin Xu, Min-Li Zhou, Yang-Yang Bao, Shui-Hong Zhou, Jun Fan & Zhong-Jie Lu. (2015) Co-Inhibition of GLUT-1 Expression and the PI3K/Akt Signaling Pathway to Enhance the Radiosensitivity of Laryngeal Carcinoma Xenografts In Vivo. PLOS ONE 10:11, pages e0143306.
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Liang Meng, Weidong Xu, Lihong Guo, Wenqi Ning & Xiandong Zeng. (2015) Paeonol Inhibits the Proliferation, Invasion, and Inflammatory Reaction Induced by TNF-α in Vascular Smooth Muscle Cells. Cell Biochemistry and Biophysics 73:2, pages 495-503.
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Kuan-Chuan Pao, Jin-Feng Zhao, Tzong-Shyuan Lee, Ying-Pei Huang, Chien-Chung Han, Lin-Chiang Sherlock Huang, Kou-Hung Wu & Ming-Hua Hsu. (2015) Low-dose paeonol derivatives alleviate lipid accumulation. RSC Advances 5:8, pages 5652-5656.
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Tsurng-Juhn Huang, Hong Chuang, Yu-Chuan Liang, Hui-Hsien Lin, Jia-Cherng Horng, Yu-Cheng Kuo, Chia-Wen Chen, Fu-Yuan Tsai, Shih-Chieh Yen, Shih-Ching Chou & Ming-Hua Hsu. (2015) Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents. European Journal of Medicinal Chemistry 90, pages 428-435.
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Yongfu Ma, Hui Xia, Yang Liu & Min Li. (2014) Silencing miR-21 Sensitizes Non-Small Cell Lung Cancer A549 Cells to Ionizing Radiation through Inhibition of PI3K/Akt. BioMed Research International 2014, pages 1-6.
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