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Review Article

Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

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Pages 83-119 | Received 07 Jan 2013, Accepted 14 Aug 2013, Published online: 19 Nov 2013

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Crossref
Shujie Liu, Taisuke Kawamoto, Osamu Morita, Kouichi Yoshinari & Hiroshi Honda. (2017) Discriminating between adaptive and carcinogenic liver hypertrophy in rat studies using logistic ridge regression analysis of toxicogenomic data: The mode of action and predictive models. Toxicology and Applied Pharmacology 318, pages 79-87.
Crossref
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Crossref
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Crossref
Jia-Ching Wu, Ching-Shu Lai, Mei-Ling Tsai, Chi-Tang Ho, Ying-Jan Wang & Min-Hsiung Pan. (2017) Chemopreventive effect of natural dietary compounds on xenobiotic-induced toxicity. Journal of Food and Drug Analysis 25:1, pages 176-186.
Crossref
Heidi Q. Xie, Tuan Xu, Yangsheng Chen, Yunping Li, Yingjie Xia, Sherry L. Xu, Lingyun Wang, Karl W.K. Tsim & Bin Zhao. (2016) New perspectives for multi-level regulations of neuronal acetylcholinesterase by dioxins. Chemico-Biological Interactions 259, pages 286-290.
Crossref
Ashwini S. Phadnis-Moghe, Weimin Chen, Jinpeng Li, Robert B. Crawford, Anthony Bach, Shawna D’Ingillo, Natalia Kovalova, Jose E. Suarez-Martinez, Barbara L.F. Kaplan, Joshua A. Harrill, Robert Budinsky, J. Craig Rowlands, Russell S. Thomas & Norbert E. Kaminski. (2016) Immunological characterization of the aryl hydrocarbon receptor (AHR) knockout rat in the presence and absence of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD). Toxicology 368-369, pages 172-182.
Crossref
Joshua A. Harrill, Debra Layko, Abraham Nyska, Renee R. Hukkanen, Rosa Anna Manno, Andrea Grassetti, Marie Lawson, Greg Martin, Robert A. Budinsky, J. Craig Rowlands & Russell S. Thomas. (2016) Aryl hydrocarbon receptor knockout rats are insensitive to the pathological effects of repeated oral exposure to 2,3,7,8-tetrachlorodibenzo- p -dioxin . Journal of Applied Toxicology 36:6, pages 802-814.
Crossref
D. Schrenk & E. Richling. (2016) Aus den Hochschulstandorten. Lebensmittelchemie 70:2, pages 26-32.
Crossref
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Crossref
Graciela H. Gonzalez, Tasnia Tahsin, Britton C. Goodale, Anna C. Greene & Casey S. Greene. (2016) Recent Advances and Emerging Applications in Text and Data Mining for Biomedical Discovery. Briefings in Bioinformatics 17:1, pages 33-42.
Crossref
K.T. Bogen. 2016. 1 53 .
Brian G. Lake & Roger J. Price. 2015. New Horizons in Predictive Drug Metabolism and Pharmacokinetics. New Horizons in Predictive Drug Metabolism and Pharmacokinetics 309 332 .
Zemin Wang, Barbara H. Neal, James C. Lamb & James E. Klaunig. (2015) Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors. Toxicological Sciences 147:2, pages 549-561.
Crossref
Richard A. Becker, Grace Patlewicz, Ted W. Simon, J. Craig Rowlands & Robert A. Budinsky. (2015) The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor. Regulatory Toxicology and Pharmacology 73:1, pages 172-190.
Crossref
Charles E. Wood, Renee R. Hukkanen, Radhakrishna Sura, David Jacobson-Kram, Thomas Nolte, Marielle Odin & Samuel M. Cohen. (2015) Scientific and Regulatory Policy Committee (SRPC) Review*. Toxicologic Pathology 43:6, pages 760-775.
Crossref
Ted W. Simon, Robert A. Budinsky & J. Craig Rowlands. (2015) A Model for Aryl Hydrocarbon Receptor-Activated Gene Expression Shows Potency and Efficacy Changes and Predicts Squelching Due to Competition for Transcription Co-Activators. PLOS ONE 10:6, pages e0127952.
Crossref
Zhiwei Hu, Samira A. Brooks, Valérian Dormoy, Chia-Wen Hsu, Hsue-Yin Hsu, Liang-Tzung Lin, Thierry Massfelder, W.Kimryn Rathmell, Menghang Xia, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Dustin G. Brown, Kalan R. Prudhomme, Anna Maria Colacci, Roslida A. Hamid, Chiara Mondello, Jayadev Raju, Elizabeth P. Ryan, Jordan Woodrick, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Rabindra Roy, Stefano Forte, Lorenzo Memeo, Hosni K. Salem, Leroy Lowe, Lasse Jensen, William H. Bisson & Nicole Kleinstreuer. (2015) Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis. Carcinogenesis 36:Suppl 1, pages S184-S202.
Crossref
Brian G Lake, Roger J Price & Thomas G Osimitz. (2015) Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk. Pest Management Science 71:6, pages 829-834.
Crossref
Grace Patlewicz, Ted W. Simon, J. Craig Rowlands, Robert A. Budinsky & Richard A. Becker. (2015) Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes. Regulatory Toxicology and Pharmacology 71:3, pages 463-477.
Crossref
Joshua A. Harrill, Bethany B Parks, Eliane Wauthier, J. Craig Rowlands, Lola M. Reid & Russell S. Thomas. (2015) Lineage‐dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis. Hepatology 61:2, pages 548-560.
Crossref
D. P. Jackson, A. D. Joshi & C. J. Elferink. (2015) Ah receptor pathway intricacies; signaling through diverse protein partners and DNA-motifs. Toxicology Research 4:5, pages 1143-1158.
Crossref
Jun Maeda, Aki Kijima, Kaoru Inoue, Yuji Ishii, Ryohei Ichimura, Shinji Takasu, Ken Kuroda, Kohei Matsushita, Yukio Kodama, Naoaki Saito, Takashi Umemura & Midori Yoshida. (2014) In Vivo Genotoxicity of Ginkgo Biloba Extract in gpt Delta Mice and Constitutive Androstane Receptor Knockout Mice. Toxicological Sciences 140:2, pages 298-306.
Crossref
M.E. Andersen, S. Bhattacharya & W. Hanneman. 2014. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
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