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REVIEW ARTICLE

Integrating toxicogenomics into human health risk assessment: Lessons learned from the benzo[a]pyrene case study

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Pages 44-52 | Received 21 Jan 2014, Accepted 03 Oct 2014, Published online: 21 Jan 2015

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Julie K. Buick & Carole L. Yauk. 2016. Toxicogenomics in Predictive Carcinogenicity. Toxicogenomics in Predictive Carcinogenicity 76 112 .
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