715
Views
37
CrossRef citations to date
0
Altmetric
Research Article

Treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone is beneficial but toxic in very elderly patients with diffuse large B-cell lymphoma: a population-based cohort study on treatment, toxicity and outcome

, , , , , , , , , , & show all
Pages 526-532 | Received 25 Feb 2013, Accepted 29 May 2013, Published online: 29 Jul 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Anna Asklid, Sandra Eketorp Sylvan, Agnes Mattsson, Maria Winqvist, Hemming Johansson, Anders Österborg & Lotta Hansson. (2020) A real-world study of first-line therapy in 280 consecutive Swedish patients ≥80 years with newly diagnosed diffuse large B-cell lymphoma: very elderly (≥85 years) do well on curative intended therapy. Leukemia & Lymphoma 61:9, pages 2136-2144.
Read now
Jaime Shaw, Christopher Harvey, Catherine Richards & Christopher Kim. (2019) Temporal trends in treatment and survival of older adult diffuse large B-Cell lymphoma patients in the SEER-Medicare linked database. Leukemia & Lymphoma 60:13, pages 3235-3243.
Read now
Gustaf Hedström, Oskar Hagberg, Mats Jerkeman & Gunilla Enblad. (2015) The impact of age on survival of diffuse large B-cell lymphoma – a population-based study. Acta Oncologica 54:6, pages 916-923.
Read now
Ab A. Aaldriks, Erik J. Giltay, Johan W. R. Nortier, Lydia G. M. van der Geest, Bea C. Tanis, Paula Ypma, Saskia le Cessie & Ed Maartense. (2015) Prognostic significance of geriatric assessment in combination with laboratory parameters in elderly patients with aggressive non-Hodgkin lymphoma. Leukemia & Lymphoma 56:4, pages 927-935.
Read now
Thomas Melchardt, Lukas Weiss, Clemens Hufnagl, Daniel Neureiter, Ralf Kemmerling, Patrick Morre, Ann Boekstegers, Georg Hopfinger, Jutta Auberger, Susanne Steinkirchner, Lisa Pleyer, Richard Greil & Alexander Egle. (2015) Treatment of aggressive B-cell lymphoma in elderly patients: influence of single nucleotide polymorphisms affecting pharmacodynamics of chemotherapeutics. Leukemia & Lymphoma 56:2, pages 353-360.
Read now

Articles from other publishers (32)

B Sağlam, M Albayrak, A Yıldız, P Tığlıoğlu, M Tığlıoğlu, MR Aras, F Yılmaz, S Maral & HBA Öztürk. (2023) The Prognostic Impact of Comorbidity, Nutritional and Performance Status on Patients with Diffuse Large B Cell Lymphoma. Nigerian Journal of Clinical Practice 26:10, pages 1512-1518.
Crossref
Lingke Zhang, Hongmei Jing, Shuhan Tang, Jing Wang & Ping Yang. (2023) Benefits of Dynamic Nomogram Models for Elderly Diffuse Large B-Cell Lymphoma Patients’ Early Death Prediction and Clinical Application. Mediators of Inflammation 2023, pages 1-11.
Crossref
Emanuele Cencini, Alessandra Tucci, Benedetta Puccini, Federica Cavallo, Stefano Luminari, Sara Veronica Usai, Alberto Fabbri, Elsa Pennese, Dario Marino, Vittorio Ruggero Zilioli, Monica Balzarotti, Luigi Petrucci, Agostino Tafuri, Annalisa Arcari, Barbara Botto, Manuela Zanni, Stefan Hohaus, Roberto Sartori, Michele Merli, Guido Gini, Wael Al Essa, Gerardo Musurca, Monica Tani, Luca Nassi, Rosa Daffini, Caterina Mammi, Luigi Marcheselli, Monica Bocchia, Michele Spina & Francesco Merli. (2022) The elderly prognostic index predicts early mortality in older patients with diffuse large B‐cell lymphoma. An ad hoc analysis of the elderly project by the Fondazione Italiana Linfomi. Hematological Oncology 41:1, pages 78-87.
Crossref
Yangyang Wang, Xiyang Ren, Keke Huang, Xue Liang, Lianfang Pu, Linhui Hu & Zhimin Zhai. (2023) Comparison of first-line treatments for elderly patients with diffuse large B-cell lymphoma: A systematic review and network meta-analysis. Frontiers in Immunology 13.
Crossref
Will Harris, Edward J. Bataillard, Yoonha Choi, Tarec C. El-Galaly, Vaikunth Cuchelkar, Carsten Henneges, Antonia Kwan, Daniel J. Schneider, Joseph N. Paulson & Tina G. Nielsen. (2022) TRAIL Score: A Simple Model to Predict Immunochemotherapy Tolerability in Patients With Diffuse Large B-Cell Lymphoma. JCO Clinical Cancer Informatics:6.
Crossref
Marguerite Briand, Stephane Gerard, Martin Gauthier, Marie Garric, Zara Steinmeyer & Laurent Balardy. (2021) Impact of therapeutic management and geriatric evaluation on patient of eighty years and older with diffuse large B‐cell lymphoma on survival: A systematic review. European Journal of Haematology 108:1, pages 3-17.
Crossref
Felix Freudenberger, Anke Ohler, Matthias Theobald & Georg Hess. (2021) Cure rate in the elderly patients with diffuse large B cell lymphoma deteriorates after the age of 80—results from a single-center survey. Annals of Hematology 100:4, pages 1013-1021.
Crossref
Roberto Castelli, Antonio Gidaro, Giorgio L. Deliliers & Luigi Bergamaschini. (2021) Bendamustine in association with rituximab for first-line treatment of diffuse large B-cell lymphoma in frail patients ineligible for R-CHOP/R-CHOP-like treatments. Anti-Cancer Drugs 32:3, pages 323-329.
Crossref
Charlotte IJsbrandy, Petronella B. Ottevanger, Winald R. Gerritsen, Wim H. van Harten & Rosella P. M. G. Hermens. (2020) Determinants of adherence to physical cancer rehabilitation guidelines among cancer patients and cancer centers: a cross-sectional observational study. Journal of Cancer Survivorship 15:1, pages 163-177.
Crossref
Kristina Sonnevi, Tove Wästerlid, Christopher M. Melén, Sara Harrysson, Karin E. Smedby & Björn E. Wahlin. (2020) Survival of very elderly patients with diffuse large B‐cell lymphoma according to treatment intensity in the immunochemotherapy era: a Swedish Lymphoma Register study. British Journal of Haematology 192:1, pages 75-81.
Crossref
Shing Fung Lee, Miguel Angel Luque-Fernandez, Yu Hui Chen, Paul J. Catalano, Chi Leung ChiangEric Yuk-Fai Wan, Ian Chi-Kei Wong, Ming Hui Chen & Andrea K. Ng. (2020) Doxorubicin and subsequent risk of cardiovascular diseases among survivors of diffuse large B-cell lymphoma in Hong Kong. Blood Advances 4:20, pages 5107-5117.
Crossref
Vanja Zeremski, Kathleen Jentsch-Ullrich, Christoph Kahl, Martin Mohren, Judith Eberhardt, Thomas Fischer & Enrico Schalk. (2019) Is bendamustine-rituximab a reasonable treatment in selected older patients with diffuse large B cell lymphoma? Results from a multicentre, retrospective study. Annals of Hematology 98:12, pages 2729-2737.
Crossref
Yasir Khan & Elizabeth A. Brem. (2019) Considerations for the Treatment of Diffuse Large B Cell Lymphoma in the Elderly. Current Hematologic Malignancy Reports 14:4, pages 228-238.
Crossref
H.T. van der Galiën, M. Hoogendoorn, R.E. Kibbelaar, T. van Meerten & R.S. van Rijn. (2019) Progression-free survival at 24 months (PFS24) and subsequent outcome for patients with diffuse large B-cell lymphoma (DLBCL) in the real-world setting. Annals of Oncology 30:1, pages 151-152.
Crossref
Abhijeet Kumar, Muhammad Asad Fraz, Muhammad Usman, Saad Ullah Malik, Awais Ijaz, Ceren Durer, Seren Durer, Muhammad Junaid Tariq, Ali Younas Khan, Anum Qureshi, Warda Faridi, Aboo Nasar & Faiz Anwer. (2018) Treating Diffuse Large B Cell Lymphoma in the Very Old or Frail Patients. Current Treatment Options in Oncology 19:10.
Crossref
Maja Bech Juul, Pernille Hammershoej Jensen, Henriette Engberg, Sonja Wehberg, Andriette Dessau-Arp, Donika Haziri, Helene Bjoerg Kristensen, Joachim Baech, Lene Schurmann, Michael Roost Clausen, Rebecca Valentin, Lene Meldgaard Knudsen, Lars Munksgaard, Tarec Christoffer El-Galaly, Henrik Frederiksen & Thomas Stauffer Larsen. (2018) Treatment strategies and outcomes in diffuse large B-cell lymphoma among 1011 patients aged 75 years or older: A Danish population-based cohort study. European Journal of Cancer 99, pages 86-96.
Crossref
Darko Antic, Jelena Jelicic, Goran Trajkovic, Milena Todorovic Balint, Jelena Bila, Olivera Markovic, Ivan Petkovic, Vesna Nikolic, Bosko Andjelic, Vladislava Djurasinovic, Aleksandra Sretenovic, Mihailo Smiljanic, Vojin Vukovic & Biljana Mihaljevic. (2017) Is it possible to improve prognostic value of NCCN-IPI in patients with diffuse large B cell lymphoma? The prognostic significance of comorbidities. Annals of Hematology 97:2, pages 267-276.
Crossref
Richard J. Lin, Madhusmita Behera, Catherine S. Diefenbach & Christopher R. Flowers. (2017) Role of anthracycline and comprehensive geriatric assessment for elderly patients with diffuse large B-cell lymphoma. Blood 130:20, pages 2180-2185.
Crossref
R.E. Kibbelaar, B.E. Oortgiesen, A.M. van der Wal-Oost, K. Boslooper, J.W. Coebergh, N.J.G.M. Veeger, P. Joosten, H. Storm, E.N. van Roon & M. Hoogendoorn. (2017) Bridging the gap between the randomised clinical trial world and the real world by combination of population-based registry and electronic health record data: A case study in haemato-oncology. European Journal of Cancer 86, pages 178-185.
Crossref
Karin Boslooper, Mels Hoogendoorn, Eric N. van Roon, Robby E. Kibbelaar, Huib Storm, Sjoerd Hovenga, Gerhard Woolthuis, Bas P. van Rees, Bart Klijs, Nic J.G.M. Veeger, Hanneke C. Kluin-Nelemans & Geertruida H. de Bock. (2017) No outcome disparities in patients with diffuse large B-cell lymphoma and a low socioeconomic status. Cancer Epidemiology 48, pages 110-116.
Crossref
B. E. Oortgiesen, E.N. van Roon, P. Joosten, R. E. Kibbelaar, H. Storm, S. Hovenga, B. van Rees, G. Woolthuis, N. Veeger, E.G. de Waal & M. Hoogendoorn. (2017) The role of initial clinical presentation, comorbidity and treatment in multiple myeloma patients on survival: a detailed population-based cohort study. European Journal of Clinical Pharmacology 73:6, pages 771-778.
Crossref
Dai Chihara, Jason R. Westin, Yasuhiro Oki, Mohamed A. Ahmed, Bryan Do, Luis E. Fayad, Fredrick B. Hagemeister, Jorge E. Romaguera, Michelle A. Fanale, Hun J. Lee, Francesco Turturro, Felipe Samaniego, Sattva S. Neelapu, M. Alma Rodriguez, Nathan H. Fowler, Michael Wang, Richard E. Davis & Loretta J. Nastoupil. (2016) Management strategies and outcomes for very elderly patients with diffuse large B-cell lymphoma. Cancer 122:20, pages 3145-3151.
Crossref
Kamel Laribi, Nathalie Denizon, Delphine Bolle, Catherine Truong, Anne Besançon, Jeremy Sandrini, Andreaa Anghel, Jonathan Farhi, Habib Ghnaya & Alix Baugier de Materre. (2016) R-CVP regimen is active in frail elderly patients aged 80 or over with diffuse large B cell lymphoma. Annals of Hematology 95:10, pages 1705-1714.
Crossref
Sridhar Chaganti, Tim Illidge, Sally Barrington, Pam Mckay, Kim Linton, Kate Cwynarski, Andrew McMillan, Andy Davies, Simon Stern & Karl Peggs. (2016) Guidelines for the management of diffuse large B-cell lymphoma. British Journal of Haematology 174:1, pages 43-56.
Crossref
Jozette J.C. Stienen, Rosella P.M.G. Hermens, Lianne Wennekes, Saskia A.M. van de Schans, Richard W.M. van der Maazen, Helena M. Dekker, Janine Liefers, Johan H.J.M. van Krieken, Nicole M.A. Blijlevens & Petronella B. Ottevanger. (2015) Variation in guideline adherence in non-Hodgkin’s lymphoma care: impact of patient and hospital characteristics. BMC Cancer 15:1.
Crossref
M. W. M. van der Poel, W. J. Mulder, G. J. Ossenkoppele, E. Maartense, M. Hoogendoorn, P. Wijermans & H. C. Schouten. (2015) Factors that influence treatment decision-making in elderly DLBCL patients: a case vignette study. Annals of Hematology 94:8, pages 1373-1379.
Crossref
Caiguo Zhang & Yan Liu. (2015) Targeting cancer with sesterterpenoids: the new potential antitumor drugs. Journal of Natural Medicines 69:3, pages 255-266.
Crossref
Sung-Hoon Jung, Je-Jung Lee, Won Seog Kim, Won-Sik Lee, Young Rok Do, Sung Yong Oh, Min Kyoung Kim, Yeung-Chul Mun, Ho-Jin Shin, Jae-Yong Kwak, Hye Jin Kang, Jong Ho Won, Jung Hye Kwon, Eunkyung Park, Cheolwon Suh & Deok-Hwan Yang. (2015) Weekly rituximab consolidation following four cycles of R-CHOP induction chemotherapy in very elderly patients with diffuse large B-cell lymphoma: Consortium for improving survival of lymphoma study (CISL). European Journal of Haematology 94:6, pages 504-510.
Crossref
Jessica N. Williams, Ashish Rai, Joseph Lipscomb, Jean L. Koff, Loretta J. Nastoupil & Christopher R. Flowers. (2015) Disease characteristics, patterns of care, and survival in very elderly patients with diffuse large B-cell lymphoma. Cancer 121:11, pages 1800-1808.
Crossref
Christine C. Davis, Jonathon B. Cohen, Katherine S. Shah, Don A. Hutcherson, Minal J. Surati, Kelly Valla, Elyse H. Panjic, Caitlin E. Handler, Jeffrey M. Switchenko & Christopher R. Flowers. (2015) Efficacy and Tolerability of Anthracycline-Based Therapy in Elderly Patients With Diffuse Large B-Cell Lymphoma. Clinical Lymphoma Myeloma and Leukemia 15:5, pages 270-277.
Crossref
Stephan Kreher, Felicitas Lammer, Dieter Augustin, Antonio Pezzutto & Claudia D. Baldus. (2014) R‐split‐ CHOP chemotherapy for elderly patients with diffuse large B‐cell lymphoma . European Journal of Haematology 93:1, pages 70-76.
Crossref
Tanya M. WildesValentin GoedePaul Hamlin. (2014) Personalizing Therapy for Older Adults with Lymphoid Malignancies: Options and Obstacles. American Society of Clinical Oncology Educational Book:34, pages e240-e248.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.