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Review Article

Efficacy, Safety and Mechanism of Cyclodextrins as Absorption Enhancers in Nasal Delivery of Peptide and Protein Drugs

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Pages 17-36 | Received 12 Jun 1997, Published online: 26 Jun 2009

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Toktam Salehi, Mohammad Amin Raeisi Estabragh, Soodeh Salarpour, Mandana Ohadi & Gholamreza Dehghannoudeh. (2023) Absorption enhancer approach for protein delivery by various routes of administration: a rapid review. Journal of Drug Targeting 31:9, pages 950-961.
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Chandrabose Leelasabari, Rajaram Rajamohan, Yong Rok Lee, Angaiah Subramania, Krishnamoorthy Sivakumar, Moorthiraman Murugan & Govindasamy Manigandan. (2023) Characterization and Molecular Docking Analysis for the Supramolecular Interaction of Lidocaine with β-Cyclodextrin. Polycyclic Aromatic Compounds 43:2, pages 1202-1218.
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Mark A. Strege, Siyuan Huang & Donald S. Risley. (2019) Quantitative determination of beta-cyclodextrin in a powder insulin formulation for nasal delivery using hydrophilic interaction chromatography with evaporative light scattering detection. Journal of Liquid Chromatography & Related Technologies 42:3-4, pages 74-78.
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Hailong Zhang, Xiaoyan Huang, Yongjing Zhang & Yang Gao. (2017) Efficacy, safety and mechanism of HP-β-CD-PEI polymers as absorption enhancers on the intestinal absorption of poorly absorbable drugs in rats. Drug Development and Industrial Pharmacy 43:3, pages 474-482.
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Amrish Kumar, Aditya Nath Pandey & Sunil Kumar Jain. (2016) Nasal-nanotechnology: revolution for efficient therapeutics delivery. Drug Delivery 23:3, pages 671-683.
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Sonal Gupta, Arushi Jain, Mainak Chakraborty, Jasjeet K Sahni, Javed Ali & Shweta Dang. (2013) Oral delivery of therapeutic proteins and peptides: a review on recent developments. Drug Delivery 20:6, pages 237-246.
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Takayuki Anno, Taishi Higashi, Keiichi Motoyama, Fumitoshi Hirayama, Kaneto Uekama & Hidetoshi Arima. (2012) Potential use of glucuronylglucosyl-β-cyclodextrin/dendrimer conjugate (G2) as a DNA carrier in vitro and in vivo. Journal of Drug Targeting 20:3, pages 272-280.
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Kalpana S. Paudel, Dana C. Hammell, Remigius U. Agu, Satyanarayana Valiveti & Audra L. Stinchcomb. (2010) Cannabidiol bioavailability after nasal and transdermal application: effect of permeation enhancers. Drug Development and Industrial Pharmacy 36:9, pages 1088-1097.
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Thorsteinn Loftsson, Pekka Jarho, Már Másson & Tomi Järvinen. (2005) Cyclodextrins in drug delivery. Expert Opinion on Drug Delivery 2:2, pages 335-351.
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T. Mahesh Kumar & A. Misra. (2004) Pulmonary Absorption Enhancement of Salmon Calcitonin. Journal of Drug Targeting 12:3, pages 135-144.
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