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Research Article

Design of a pectin-based microparticle formulation using zinc ions as the cross-linking agent and glutaraldehyde as the hardening agent for colonic-specific delivery of resveratrol: In vitro and in vivo evaluations

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Pages 446-457 | Received 07 May 2010, Accepted 11 Jun 2010, Published online: 05 Aug 2010

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Read on this site (6)

Himanshu Gandhi, Charul Rathore, Kamal Dua, Samar Vihal, Murtaza M. Tambuwala & Poonam Negi. (2020) Efficacy of resveratrol encapsulated microsponges delivered by pectin based matrix tablets in rats with acetic acid-induced ulcerative colitis. Drug Development and Industrial Pharmacy 46:3, pages 365-375.
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Rosario Pignatello, Tiziana M. G. Pecora, Giuseppa G. Cutuli, Alfio Catalfo, Guido De Guidi, Barbara Ruozi, Giovanni Tosi, Simona Cianciolo & Teresa Musumeci. (2019) Antioxidant activity and photostability assessment of trans-resveratrol acrylate microspheres. Pharmaceutical Development and Technology 24:2, pages 222-234.
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Wenping Wang, Yaya Lei, Hong Sui, Wenping Zhang, Rongyue Zhu, Jun Feng & Hong Wang. (2017) Fabrication and evaluation of nanoparticle-assembled BSA microparticles for enhanced liver delivery of glycyrrhetinic acid. Artificial Cells, Nanomedicine, and Biotechnology 45:4, pages 740-747.
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Rudra Pangeni, Jasjeet K Sahni, Javed Ali, Shrestha Sharma & Sanjula Baboota. (2014) Resveratrol: review on therapeutic potential and recent advances in drug delivery. Expert Opinion on Drug Delivery 11:8, pages 1285-1298.
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Thiruganesh Ramasamy, Hima Bindu Ruttala, Suresh Shanmugam & Subbiah Kandasamy Umadevi. (2013) Eudragit-coated aceclofenac-loaded pectin microspheres in chronopharmacological treatment of rheumatoid arthritis. Drug Delivery 20:2, pages 65-77.
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Li-Xin Sun, Zhi-Bin Lin, Xin-Suo Duan, Jie Lu, Zhi-Hua Ge, Xue-Fei Li, Xue-Jun Li, Min Li, En-Hong Xing, You-Xin Song, Jing Jia & Wei-Dong Li. (2012) Enhanced MHC class I and costimulatory molecules on B16F10 cells by Ganoderma lucidum polysaccharides. Journal of Drug Targeting 20:7, pages 582-592.
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Articles from other publishers (33)

Javier Martínez-Sabando, Francesco Coin, Jorge H. Melillo, Silvia Goyanes & Silvina Cerveny. (2023) A Review of Pectin-Based Material for Applications in Water Treatment. Materials 16:6, pages 2207.
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Zonish Saleem, Kanwal Rehman & Muhammad Sajid Hamid Akash. (2022) Role of Drug Delivery System in Improving the Bioavailability of Resveratrol. Current Pharmaceutical Design 28:20, pages 1632-1642.
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Keila Gutierrez-Alvarado, Randall Chacón-Cerdas & Ricardo Starbird-Perez. (2022) Pectin Microspheres: Synthesis Methods, Properties, and Their Multidisciplinary Applications. Chemistry 4:1, pages 121-136.
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Irina Popescu, Mihail Lupei, Marieta Constantin, Geanina Voicu, Manuela Calin, Anca Irina Prisacaru & Gheorghe Fundueanu. (2021) Double cross-linked pectin beads stable in physiological environment as potential support for biomedical applications. Journal of Polymer Research 28:11.
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Boxu Ren, Marabeth Xin-Yi Kwah, Cuiliu Liu, Zhaowu Ma, Muthu K. Shanmugam, Lingwen Ding, Xiaoqiang Xiang, Paul Chi-Lui Ho, Lingzhi Wang, Pei Shi Ong & Boon Cher Goh. (2021) Resveratrol for cancer therapy: Challenges and future perspectives. Cancer Letters 515, pages 63-72.
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Surajit Das. (2021) Pectin based multi-particulate carriers for colon-specific delivery of therapeutic agents. International Journal of Pharmaceutics 605, pages 120814.
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De-qiang Li, Jun Li, Hui-lin Dong, Xin Li, Jia-qi Zhang, Shri Ramaswamy & Feng Xu. (2021) Pectin in biomedical and drug delivery applications: A review. International Journal of Biological Macromolecules 185, pages 49-65.
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Milica Atanacković Krstonošić, Mira Mikulić & Jelena Cvejić. 2021. A Centum of Valuable Plant Bioactives. A Centum of Valuable Plant Bioactives 349 378 .
Brijesh M. Shah, Sushesh Srivatsa Palakurthi, Tripti Khare, Sharad Khare & Srinath Palakurthi. (2020) Natural proteins and polysaccharides in the development of micro/nano delivery systems for the treatment of inflammatory bowel disease. International Journal of Biological Macromolecules 165, pages 722-737.
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Rohitas Deshmukh. (2020) Bridging the Gap of Drug Delivery in Colon Cancer: The Role of Chitosan and Pectin Based Nanocarriers System. Current Drug Delivery 17:10, pages 911-924.
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Surajit Das, Sie Huey Lee, Pui Shan Chow & Calum Macbeath. (2020) Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. Colloids and Surfaces B: Biointerfaces 194, pages 111161.
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Kun Feng, Yun-shan Wei, Teng-gen Hu, Robert J. Linhardt, Min-hua Zong & Hong Wu. (2020) Colon-targeted delivery systems for nutraceuticals: A review of current vehicles, evaluation methods and future prospects. Trends in Food Science & Technology 102, pages 203-222.
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Hsi-Yang Tang, Zhongxiang Fang & Ken Ng. (2020) Dietary fiber-based colon-targeted delivery systems for polyphenols. Trends in Food Science & Technology 100, pages 333-348.
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Randall Chacón-Cerdas, Alejandro Medaglia-Mata, Dora Flores-Mora & Ricardo Starbird-Pérez. (2019) Synthesis of chitosan, pectin, and chitosan/pectin microspheres by two water-in-oil emulsion crosslinking methods. Chemical Papers 74:2, pages 509-520.
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Poonam Devi, Pratibha Sharma, Charul Rathore & Poonam Negi. 2019. Resveratrol - Adding Life to Years, Not Adding Years to Life. Resveratrol - Adding Life to Years, Not Adding Years to Life.
Pamela Krug, Marta Bartel, Paulina Głowala, Barbara Wysocka, Ilona Mojzych, Marta Kwiatkowska, Aleksandra Skiba, Agata Wójtowicz & Maciej Mazur. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 59 111 .
Leena Kumari & Hemant Ramachandra Badwaik. 2019. Polysaccharide Carriers for Drug Delivery. Polysaccharide Carriers for Drug Delivery 497 557 .
Chun Y. Wong, Jorge Martinez, Hani Al-Salami & Crispin R. Dass. (2018) Quantification of BSA-loaded chitosan/oligonucleotide nanoparticles using reverse-phase high-performance liquid chromatography. Analytical and Bioanalytical Chemistry 410:27, pages 6991-7006.
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Ofosua Adi-Dako, Kwabena Ofori-Kwakye, Seth Kwabena Amponsah, Isaac Boamah, Noble Kuntworbe & Esther Eshun Oppong. (2018) Potential of Cocoa Pod Husk Pectin-Based Modified Release Capsules as a Carrier for Chronodelivery of Hydrocortisone in Sprague-Dawley Rats. Journal of Drug Delivery 2018, pages 1-8.
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Meriem Jouini, Amal Abdelhamid, Mohamed Aymen Chaouch, Didier le Cerf, Abderrahman Bouraoui, Hatem Majdoub & Hichem Ben Jannet. (2018) Physico-chemical characterization and pharmacological activities of polysaccharides from Opuntia microdasys var. rufida cladodes. International Journal of Biological Macromolecules 107, pages 1330-1338.
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Fabíola Prezotti, Fernanda Boni, Natália Ferreira, Daniella Silva, Sérgio Campana-Filho, Andreia Almeida, Teófilo Vasconcelos, Maria Gremião, Beatriz Cury & Bruno Sarmento. (2018) Gellan Gum/Pectin Beads Are Safe and Efficient for the Targeted Colonic Delivery of Resveratrol. Polymers 10:1, pages 50.
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Taoran Wang, Jingyi Xue, Qiaobin Hu, Mingyong Zhou & Yangchao Luo. (2017) Preparation of lipid nanoparticles with high loading capacity and exceptional gastrointestinal stability for potential oral delivery applications. Journal of Colloid and Interface Science 507, pages 119-130.
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Fedor V. Vityazev, Maiia I. Fedyuneva, Victoria V. Golovchenko, Olga A. Patova, Elena U. Ipatova, Eugene A. Durnev, Ekaterina A. Martinson & Sergey G. Litvinets. (2017) Pectin-silica gels as matrices for controlled drug release in gastrointestinal tract. Carbohydrate Polymers 157, pages 9-20.
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Haogang Duan, Shaoyu Lü, Hongyan Qin, Chunmei Gao, Xiao Bai, Yuhui Wei, Xin’an Wu, Mingzhu Liu, Xinyu Zhang & Zhen Liu. (2017) Co-delivery of zinc and 5-aminosalicylic acid from alginate/N-succinyl-chitosan blend microspheres for synergistic therapy of colitis. International Journal of Pharmaceutics 516:1-2, pages 214-224.
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Chityal Ganesh Kumar, Yedla Poornachandra & Sujitha Pombala. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 1 61 .
Taoran Wang, Xiaoyu Ma, Yu Lei & Yangchao Luo. (2016) Solid lipid nanoparticles coated with cross-linked polymeric double layer for oral delivery of curcumin. Colloids and Surfaces B: Biointerfaces 148, pages 1-11.
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Franceline Reynaud, Nicolas Tsapis, Silvia S. Guterres, Adriana R. Pohlmann & Elias Fattal. (2015) Pectin beads loaded with chitosan?iron microspheres for specific colonic adsorption of ciprofloxacin. Journal of Drug Delivery Science and Technology 30, pages 494-500.
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Ah Ra Cho, Yong Gi Chun, Bum Keun Kim & Dong June Park. (2014) Preparation of Chitosan-TPP Microspheres as Resveratrol Carriers. Journal of Food Science 79:4, pages E568-E576.
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Teng Ma, Meng-Shan Tan, Jin-Tai Yu & Lan Tan. (2014) Resveratrol as a Therapeutic Agent for Alzheimer’s Disease. BioMed Research International 2014, pages 1-13.
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Mary Ann Augustin, Luz Sanguansri & Trevor Lockett. (2013) Nano- and micro-encapsulated systems for enhancing the delivery of resveratrol. Annals of the New York Academy of Sciences 1290:1, pages 107-112.
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Maxim A. Mironov, Iliya D. Shulepov, Vladislav S. Ponomarev & Vasily A. Bakulev. (2013) Synthesis of polyampholyte microgels from colloidal salts of pectinic acid and their application as pH-responsive emulsifiers. Colloid and Polymer Science 291:7, pages 1683-1691.
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A. Amri, J.C. Chaumeil, S. Sfar & C. Charrueau. (2012) Administration of resveratrol: What formulation solutions to bioavailability limitations?. Journal of Controlled Release 158:2, pages 182-193.
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Shyam S. Bansal, Mehak Goel, Farrukh Aqil, Manicka V. Vadhanam & Ramesh C. Gupta. (2011) Advanced Drug Delivery Systems of Curcumin for Cancer Chemoprevention. Cancer Prevention Research 4:8, pages 1158-1171.
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