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Original Article

Protection Against Free Radical-Induced and Transition Metal-Mediated Damage: The Use of “Pull” and “Push” Mechanisms

Pages 691-696 | Published online: 07 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Alireza Ghaffarieh & Joseph B. Ciolino. (2021) Potential of Application of Iron Chelating Agents in Ophthalmic Diseases. Seminars in Ophthalmology 36:4, pages 157-161.
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Vladimir Vinokur, Gil Leibowitz, Leonid Grinberg, Ron Eliashar, Eduard Berenshtein & Mordechai Chevion. (2007) Diabetes and the heart: could the diabetic myocardium be protected by preconditioning?. Redox Report 12:6, pages 246-256.
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Somdet Srichairatanakool, Sakaewan Ounjaijean, Chonthida Thephinlap, Udompun Khansuwan, Chada Phisalpong & Suthat Fucharoen. (2006) Iron-Chelating and Free-Radical Scavenging Activities of Microwave-Processed Green Tea in Iron Overload. Hemoglobin 30:2, pages 311-327.
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Mark D. Scott. (2001) Intraerythrocytic Iron Chelation: A New Therapy for Thalassemia?. Hematology 6:1, pages 73-89.
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G. Kocic, D. Pavlovic, T. Jevtovic, R. Kocic, A. Bojic, P. Vlahovic, V. Djordjevic, D. Sokolovic & B. Djindjic. (2001) Oxidative Modification of Rat Liver 5'-Nucleotidase: The Mechanisms for Protection and Re-Activation. Archives of Physiology and Biochemistry 109:4, pages 323-330.
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Kenji Sakamoto, Taishi Suzuki, Kosuke Takahashi, Takumi Koguchi, Tasuku Hirayama, Asami Mori, Tsutomu Nakahara, Hideko Nagasawa & Kunio Ishii. (2018) Iron-chelating agents attenuate NMDA-Induced neuronal injury via reduction of oxidative stress in the rat retina. Experimental Eye Research 171, pages 30-36.
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A.S. Pradeep, G.J. Naga Raju, S. Abdul Sattar, P. Sarita, A. Durga Prasada Rao, Dinesh Kumar Ray, B. Seetharami Reddy & S. Bhuloka Reddy. (2014) Trace elemental distribution in the scalp hair of bipolars using PIXE technique. Medical Hypotheses 82:4, pages 470-477.
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Haim Bibi, Vladimir Vinokur, Dan Waisman, Yigal Elenberg, Amir Landesberg, Anna Faingersh, Moran Yadid, Vera Brod, Jimy Pesin, Eduard Berenshtein, Ron Eliashar & Mordechai Chevion. (2014) Zn/Ga−DFO iron–chelating complex attenuates the inflammatory process in a mouse model of asthma. Redox Biology 2, pages 814-819.
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Xue-Song Dong, Xiao-Yang Xu, Yu-Qiang Sun, Wei-Liu, Zhe-Hui Jiang & Zhi Liu. (2013) Toll-like receptor 4 is involved in myocardial damage following paraquat poisoning in mice. Toxicology 312, pages 115-122.
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Jan NeckářAdéla BoudíkováPetra MandíkováMartin ŠtěrbaOlga PopelováIvan MikšíkLudmila DabrowskáJaroslav MrázVladimír GeršlFrantišek Kolář. (2012) Protective effects of dexrazoxane against acute ischaemia/reperfusion injury of rat hearts. Canadian Journal of Physiology and Pharmacology 90:9, pages 1303-1310.
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Alexey Obolensky, Eduard Berenshtein, Michal Lederman, Baruch Bulvik, Ruslana Alper-Pinus, Ruth Yaul, Efrat Deleon, Itay Chowers, Mordechai Chevion & Eyal Banin. (2011) Zinc–desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa. Free Radical Biology and Medicine 51:8, pages 1482-1491.
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Leandro C. Tabares, Jessica Gätjens & Sun Un. (2010) Understanding the influence of the protein environment on the Mn(II) centers in Superoxide Dismutases using High-Field Electron Paramagnetic Resonance. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1804:2, pages 308-317.
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Mordechai Chevion, Shirley Leibowitz, Nu Nu Aye, Odeya Novogrodsky, Adar Singer, Oded Avizemer, Baruch Bulvik, Abraham M. Konijn & Eduard Berenshtein. (2008) Heart protection by ischemic preconditioning: A novel pathway initiated by iron and mediated by ferritin. Journal of Molecular and Cellular Cardiology 45:6, pages 839-845.
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Ehud BaninAlina LozinskiKeith M. BradyEduard Berenshtein, Phillip W. Butterfield, Maya MosheMordechai Chevion, Everett Peter GreenbergEyal Banin. (2008) The potential of desferrioxamine-gallium as an anti- Pseudomonas therapeutic agent . Proceedings of the National Academy of Sciences 105:43, pages 16761-16766.
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Alexey Obolensky, Eduard Berenshtein, Abraham M. Konijn, Eyal Banin & Mordechai Chevion. (2008) Ischemic preconditioning of the rat retina: Protective role of ferritin. Free Radical Biology and Medicine 44:7, pages 1286-1294.
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Miran K. Rakha, Zohour I. Nabil & Aida A. Hussein. (2008) Cardioactive and Vasoactive Effects of Natural Wild Honey Against Cardiac Malperformance Induced by Hyperadrenergic Activity. Journal of Medicinal Food 11:1, pages 91-98.
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Shlomit Schaal, Itzchak Beiran, Hadas Rozner, Irit Rubinstein, Mordechai Chevion, Benjamin Miller & Ahuva Dovrat. (2007) Desferrioxamine and zinc–desferrioxamine reduce lens oxidative damage. Experimental Eye Research 84:3, pages 561-568.
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Shlomit Schaal, Itzchak Beiran, Elvira Bormusov, Mordechai Chevion & Ahuva Dovrat. (2007) Zinc–desferrioxamine reduces damage to lenses exposed to hyperbaric oxygen and has an ameliorative effect on catalase and Na, K-ATPase activities. Experimental Eye Research 84:3, pages 455-463.
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C. Jung, A.V. Zima, P. Szentesi, I. Jona, L.A. Blatter & E. Niggli. (2007) Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes. Cell Calcium 41:2, pages 187-194.
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Ryan M. Hutcheson, Mark D. Engelmann & I. Francis Cheng. (2005) Voltammetric studies of Zn and Fe complexes of EDTA: Evidence for the push mechanism. BioMetals 18:1, pages 43-51.
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Y. Gozal, M. Chevion, A. Elami, E. Berenshtein, N. Kitrossky & B. Drenger. (2005) Ischaemic preconditioning but not isoflurane prevents post-ischaemic production of hydroxyl radicals in a canine model of ischaemia-reperfusion. European Journal of Anaesthesiology 22:1, pages 49-55.
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Y. Gozal, M. Chevion, A. Elami, E. Berenshtein, N. Kitrossky & B. Drenger. (2005) Ischaemic preconditioning but not isoflurane prevents post-ischaemic production of hydroxyl radicals in a canine model of ischaemia-reperfusion. European Journal of Anaesthesiology 22:1, pages 49-55.
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Maxwell Afari Gyamfi & Yoko Aniya. (2002) Antioxidant properties of Thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea. Biochemical Pharmacology 63:9, pages 1725-1737.
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Dimitrios Galaris & Angelos Evangelou. (2002) The role of oxidative stress in mechanisms of metal-induced carcinogenesis. Critical Reviews in Oncology/Hematology 42:1, pages 93-103.
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Xing-Mei Ouyang, Bao-Li Fei, Taka-aki Okamura, Wei-Yin Sun, Wen-Xia Tang & Norikazu Ueyama. (2002) Synthesis, Crystal Structure and Superoxide Dismutase (SOD) Activity of Novel Seven-Coordinated Manganese(II) Complex with Multidentate Di-Schiff Base Ligands. Chemistry Letters 31:3, pages 362-363.
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Mordechai Chevion, Eduard Berenshtein & Ben-Zhan Zhu. 2002. Reactive Oxygen Species in Biological Systems. Reactive Oxygen Species in Biological Systems 103 131 .
Ben-Zhan Zhu, Svetlana Shechtman & Mordechai Chevion. (2001) Synergistic cytotoxicity between pentachlorophenol and copper in a bacterial model. Chemosphere 45:4-5, pages 463-470.
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Matthias Karck, Satonori Tanaka, Eduard Berenshtein, Christian Sturm, Axel Haverich & Mordechai Chevion. (2001) The push-and-pull mechanism to scavenge redox-active transition metals: A novel concept in myocardial protection. The Journal of Thoracic and Cardiovascular Surgery 121:6, pages 1169-1178.
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Marta Ugarte & Neville N Osborne. (2001) Zinc in the retina. Progress in Neurobiology 64:3, pages 219-249.
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Ben-Zhan Zhu & Mordechai Chevion. (2000) Copper-Mediated Toxicity of 2,4,5-Trichlorophenol: Biphasic Effect of the Copper(I)-Specific Chelator Neocuproine. Archives of Biochemistry and Biophysics 380:2, pages 267-273.
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Eyal Banin, Eduard Berenshtein, Nahum Kitrossky, Jacob Pe’er & Mordechai Chevion. (2000) Gallium-desferrioxamine protects the cat retina against injury after ischemia and reperfusion. Free Radical Biology and Medicine 28:3, pages 315-323.
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Lawrence S Greene. (1999) Asthma, oxidant stress, and diet. Nutrition 15:11-12, pages 899-907.
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Dennis P. Riley. (1999) Functional Mimics of Superoxide Dismutase Enzymes as Therapeutic Agents. Chemical Reviews 99:9, pages 2573-2588.
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Andrea Frustaci, Nicola Magnavita, Cristina Chimenti, Marina Caldarulo, Enrico Sabbioni, Romano Pietra, Carlo Cellini, Gian Federico Possati & Attilio Maseri. (1999) Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction. Journal of the American College of Cardiology 33:6, pages 1578-1583.
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László Virág & Csaba Szabó. (2009) Inhibition of poly(ADP‐ribose) synthetase (PARS) and protection against peroxynitrite‐induced cytotoxicity by zinc chelation. British Journal of Pharmacology 126:3, pages 769-777.
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L. S. Greene. (1998) Nutrients that influence erythrocyte redox status and adaptation at the G6PD locus. International Journal of Anthropology 13:3-4, pages 265-273.
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Mordechai Chevion, Ben-Zhan Zhu & Eduard Berenshtein. 1998. Free Radicals, Oxidative Stress, and Antioxidants. Free Radicals, Oxidative Stress, and Antioxidants 267 283 .
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