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Research Article

Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride

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Pages 399-407 | Received 26 Jan 2010, Accepted 09 Mar 2010, Published online: 30 Apr 2010

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Dan Wang, Yimeng Du, Wenpeng Zhang, Xiaolu Han, Hui Zhang, Zengming Wang, Nan Liu, Meng Li, Xiang Gao, Xiaomei Zhuang, Jing Gao & Aiping Zheng. (2021) Development and in vivo evaluation of intranasal formulations of parathyroid hormone (1-34). Drug Delivery 28:1, pages 487-498.
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Dan Luo, Xiaoqing Ni, Hao Yang, Lu Feng, Zhaoqun Chen & Lan Bai. (2024) A comprehensive review of advanced nasal delivery: Specially insulin and calcitonin. European Journal of Pharmaceutical Sciences 192, pages 106630.
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Chaojie Ren, Danni Zhong, Yuchen Qi, Chaoyi Liu, Xingyu Liu, Shihong Chen, Sheng Yan & Min Zhou. (2023) Bioinspired pH-Responsive Microalgal Hydrogels for Oral Insulin Delivery with Both Hypoglycemic and Insulin Sensitizing Effects. ACS Nano 17:14, pages 14161-14175.
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Emine Kahraman, Sevgi Güngör & Yıldız Özsoy. 2023. Nasal Drug Delivery. Nasal Drug Delivery 253 277 .
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Tosha Pandya, Priyanka Bhatt & Ambikandan Misra. (2022) Development and Evaluation of Exenatide Loaded PLGA Nanoparticles for Intranasal Delivery in the Treatment of Obesity. Drug Delivery Letters 12:2, pages 149-162.
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Paola Mura, Francesca Maestrelli, Marzia Cirri & Natascia Mennini. (2022) Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review. Marine Drugs 20:5, pages 335.
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Francisca Espinoza, Walther Ide, Natalia Saldivia & Diego Zelada. 2022. Polymeric Biomaterials for Healthcare Applications. Polymeric Biomaterials for Healthcare Applications 369 402 .
Már Másson. 2021. Handbook of Hydrocolloids. Handbook of Hydrocolloids 1039 1072 .
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Sanjib Sarkar, Dibyendu Das, Prachurjya Dutta, Jatin Kalita, Sawlang Borsingh Wann & Prasenjit Manna. (2020) Chitosan: A promising therapeutic agent and effective drug delivery system in managing diabetes mellitus. Carbohydrate Polymers 247, pages 116594.
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Bianca-Iustina Andreica, Xinjian Cheng & Luminita Marin. (2020) Quaternary ammonium salts of chitosan. A critical overview on the synthesis and properties generated by quaternization. European Polymer Journal 139, pages 110016.
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Melissa Kirkby, Aaron R.J. Hutton & Ryan F. Donnelly. (2020) Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations. Pharmaceutical Research 37:6.
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Rabinarayan Parhi. (2020) Drug delivery applications of chitin and chitosan: a review. Environmental Chemistry Letters 18:3, pages 577-594.
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V. Nipun Babu, Raju Vivek, Chandrababu Rejeeth & Soundarapandian Kannan. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 33 58 .
Rabinarayan Parhi. 2019. Sustainable Agriculture Reviews 36. Sustainable Agriculture Reviews 36 175 239 .
Wei Wang, Arun Alphonse Ignatius, Satoshi Ohtake & Teng-Chieh Yang. 2018. Challenges in Protein Product Development. Challenges in Protein Product Development 99 123 .
Gauravkumar R. Agrawal, Pravin Wakte & Santosh Shelke. (2017) Formulation, physicochemical characterization and in vitro evaluation of human insulin-loaded microspheres as potential oral carrier. Progress in Biomaterials 6:3, pages 125-136.
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Tehila Mishraki-Berkowitz, Abraham Aserin & Nissim Garti. (2017) Structural properties and release of insulin-loaded reverse hexagonal (HII) liquid crystalline mesophase. Journal of Colloid and Interface Science 486, pages 184-193.
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Suelen P. Facchi, Débora B. Scariot, Pedro V.A. Bueno, Paulo R. Souza, Luana C. Figueiredo, Heveline D.M. Follmann, Cátia S. Nunes, Johny P. Monteiro, Elton G. Bonafé, Celso V. Nakamura, Edvani C. Muniz & Alessandro F. Martins. (2016) Preparation and cytotoxicity of N-modified chitosan nanoparticles applied in curcumin delivery. International Journal of Biological Macromolecules 87, pages 237-245.
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Isabel Schultz, Joel Wurzel & Lorenz Meinel. (2015) Drug delivery of Insulin-like growth factor I. European Journal of Pharmaceutics and Biopharmaceutics 97, pages 329-337.
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Christina Karavasili, Orestis L. Katsamenis, Nikolaos Bouropoulos, Hamde Nazar, Philipp J. Thurner, Susanna M. van der Merwe & Dimitrios G. Fatouros. (2014) Preparation and Characterization of Bioadhesive Microparticles Comprised of Low Degree of Quaternization Trimethylated Chitosan for Nasal Administration: Effect of Concentration and Molecular Weight. Langmuir 30:41, pages 12337-12344.
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Luca Casettari & Lisbeth Illum. (2014) Chitosan in nasal delivery systems for therapeutic drugs. Journal of Controlled Release 190, pages 189-200.
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Ana Fortuna, Gilberto Alves, Ana Serralheiro, Joana Sousa & Amílcar Falcão. (2014) Intranasal delivery of systemic-acting drugs: Small-molecules and biomacromolecules. European Journal of Pharmaceutics and Biopharmaceutics 88:1, pages 8-27.
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Thundiparambil Azeez Sonia & Chandra P. Sharma. 2014. Oral Delivery of Insulin. Oral Delivery of Insulin 59 112 .
H. Nazar, P. Caliceti, B. Carpenter, A. I. El-Mallah, D. G. Fatouros, M. Roldo, S. M. van der Merwe & J. Tsibouklis. (2013) A once-a-day dosage form for the delivery of insulin through the nasal route: in vitro assessment and in vivo evaluation. Biomater. Sci. 1:3, pages 306-314.
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Lidong Na, Juan Wang, Linlin Wang & Shirui Mao. (2013) A novel permeation enhancer: N-succinyl chitosan on the intranasal absorption of isosorbide dinitrate in rats. European Journal of Pharmaceutical Sciences 48:1-2, pages 301-306.
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John Tsibouklis, Andrew M. Middleton, Nisha Patel & Jonathan Pratten. (2013) Toward mucoadhesive hydrogel formulations for the management of xerostomia: The physicochemical, biological, and pharmacological considerations. Journal of Biomedical Materials Research Part A, pages n/a-n/a.
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Hamde Nazar & John Tsibouklis. (2012) Towards the nasal delivery of insulin. Therapeutic Delivery 3:11, pages 1241-1243.
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Yukako Ito, Muneyuki Hirono, Keizo Fukushima, Nobuyuki Sugioka & Kanji Takada. (2012) Two-layered dissolving microneedles formulated with intermediate-acting insulin. International Journal of Pharmaceutics 436:1-2, pages 387-393.
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Lisbeth Illum, Faron Jordan & Andrew L. Lewis. (2012) CriticalSorb™: A novel efficient nasal delivery system for human growth hormone based on Solutol HS15. Journal of Controlled Release 162:1, pages 194-200.
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Hamde Nazar, Marta Roldo, Dimitrios G Fatouros, Susanna M van der Merwe & John Tsibouklis. (2012) Hydrogels in mucosal delivery. Therapeutic Delivery 3:4, pages 535-555.
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Christopher F. van der Walle & Orest Olejnik. 2011. Peptide and Protein Delivery. Peptide and Protein Delivery 1 22 .

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