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Drug Delivery Volume 23, 2016 - Issue 4: Liposome- and lipid-based drug delivery
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Research Article

Co-delivery of doxorubicin and P-gp inhibitor by a reduction-sensitive liposome to overcome multidrug resistance, enhance anti-tumor efficiency and reduce toxicity

Jie TangKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China and ;Department of Pharmaceutical Engineering, School of Bioengineering, Xihua University, Chengdu, China
,
Li ZhangKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China and
,
Huile GaoKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China and
,
Yayuan LiuKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China and
,
Qianyu ZhangKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China and
,
Rui RanKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China and
,
Zhirong ZhangKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China and
&
Qin HeKey Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China and Correspondence[email protected]
 show all
Pages 1130-1143 | Received 03 Oct 2014, Accepted 18 Nov 2014, Published online: 10 Dec 2014

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Qiuxia Ding, Zhi Li, Yi Yang, Gang Guo, Feng Luo, Zhengqiong Chen, Ying Yang, ZhiYong Qian & Shuai Shi. (2016) Preparation and therapeutic application of docetaxel-loaded poly(d,l-lactide) nanofibers in preventing breast cancer recurrence. Drug Delivery 23:8, pages 2677-2685.
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Shian-Ren Lin & Ching-Feng Weng. (2018) PG-Priming Enhances Doxorubicin Influx to Trigger Necrotic and Autophagic Cell Death in Oral Squamous Cell Carcinoma. Journal of Clinical Medicine 7:10, pages 375.
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Ali Raza, Uzma Hayat, Tahir Rasheed, Muhammad Bilal & Hafiz M.N. Iqbal. (2018) Redox-responsive nano-carriers as tumor-targeted drug delivery systems. European Journal of Medicinal Chemistry 157, pages 705-715.
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Sen Lin, Peiling Xie, Mengmeng Luo, Qing Li, Ling Li, Jinzhao Zhang, Qinxiang Zheng, Hao Chen & Kaihui Nan. (2018) Efficiency against multidrug resistance by co-delivery of doxorubicin and curcumin with a legumain-sensitive nanocarrier. Nano Research 11:7, pages 3619-3635.
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Hongxu Lu & Martina H. Stenzel. (2018) Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles. Small 14:13, pages 1702858.
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Eugenia Pugliese, João Q. Coentro & Dimitrios I. Zeugolis. (2018) Advancements and Challenges in Multidomain Multicargo Delivery Vehicles. Advanced Materials 30:13.
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Naveen Chella & Nalini R. Shastri. 2017. Particulate Technology for Delivery of Therapeutics. Particulate Technology for Delivery of Therapeutics 253 289 .

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