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Original Article

Recent and Future Developments in Modified Hemoglobin and Microencapsulated Hemoglobin as Red Blood Cell Substitutes

Pages 1-24 | Published online: 11 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Binglan Yu & Thomas Ming Swi Chang. (2004) Effects of Combined Oral Administration and Intravenous Injection on Maintaining Decreased Systemic Tyrosine Levels in Rats. Artificial Cells, Blood Substitutes, and Biotechnology 32:1, pages 129-148.
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Thomas Ming Swi Chang. (2004) Artificial Cell Bioencapsulation in Macro, Micro, Nano, and Molecular Dimensions: Keynote Lecture. Artificial Cells, Blood Substitutes, and Biotechnology 32:1, pages 1-23.
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Fan‐tao Meng, Wan‐zhong Zhang, Guang‐hui Ma & Zhi‐guo Su. (2003) The Preparation and Characterization of Monomethoxypoly(ethylene glycol)‐b‐poly‐DL‐lactide Microcapsules Containing Bovine Hemoglobin. Artificial Cells, Blood Substitutes, and Biotechnology 31:3, pages 279-292.
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Thomas Ming Swi Chang. (2003) Artificial Cells for Replacement of Metabolic Organ Functions. Artificial Cells, Blood Substitutes, and Biotechnology 31:2, pages 151-161.
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James J. Fischer & Hiroko Yabuki. (1998) Preparation of Red Blood Cells Containing Exogenous Hemoglobin. Artificial Cells, Blood Substitutes, and Biotechnology 26:4, pages 377-387.
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Anil Gulati. (1997) Recent advances in the development of haemoglobin-based blood substitutes. Expert Opinion on Investigational Drugs 6:11, pages 1659-1669.
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Articles from other publishers (53)

Qian Xu, Zeping Zhang, Pauline Po Yee Lui, Liang Lu, Xiaowu Li & Xing Zhang. (2023) Preparation and biomedical applications of artificial cells. Materials Today Bio 23, pages 100877.
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Yixin Chen, Xiuqin Chen, Yong Chen, Hui Wei, Shuo Lin, Houjun Tian, Tao Lin, Jianwei Zhao & Xiaojun Gu. (2018) Preparation, characterisation, and controlled release of sex pheromone-loaded MPEG-PCL diblock copolymer micelles for Spodoptera litura (Lepidoptera: Noctuidae). PLOS ONE 13:9, pages e0203062.
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Takashi Matsuhira, Tomoko Kure, Keizo Yamamoto & Hiromi Sakai. (2018) Analysis of Dimeric αβ Subunit Exchange between PEGylated and Native Hemoglobins (α 2 β 2 Tetramer) in an Equilibrated State by Intramolecular ββ-Cross-Linking . Biomacromolecules 19:8, pages 3412-3420.
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Le Liu, Tuanwei Li, Zheng Ruan & Lifeng Yan. (2018) Polypeptide-based artificial erythrocytes conjugated with near infrared photosensitizers for imaging-guided photodynamic therapy. Journal of Materials Science 53:13, pages 9368-9381.
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Yi Jia, Li Duan & Junbai Li. (2016) Hemoglobin-Based Nanoarchitectonic Assemblies as Oxygen Carriers. Advanced Materials 28:6, pages 1312-1318.
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Yang Liu, Jin Gong, Weiping Wu, Yuting Fang, Qi Wang & Haiying Gu. (2016) A novel bio-nanocomposite based on hemoglobin and carboxyl graphene for enhancing the ability of carrying oxygen. Sensors and Actuators B: Chemical 222, pages 588-597.
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Rahul B. Karyappa, Shivraj. D. Deshmukh & Rochish. M. Thaokar. (2014) Deformation of an elastic capsule in a uniform electric field. Physics of Fluids 26:12.
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Yuping Wei, Chunlong Li, Liang Zhang, Zhiguo Su & Xia Xu. (2014) Inhibition of methemoglobin formation in aqueous solutions under aerobic conditions by the addition of amino acids. International Journal of Biological Macromolecules 64, pages 267-275.
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Thomas Ming Swi Chang. 2013. Biomaterials Science. Biomaterials Science 811 827 .
Donald J. AbrahamStefano Bruno, Luca Ronda, Serena Faggiano, Stefano Bettati & Andrea Mozzarelli. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 609 660 .
Jennifer Rice, Nora Philbin, Rick Light, Françoise Arnaud, Thomas Steinbach, Gerry McGwin, Sarah Collier, Nina Malkevich, Paula Moon-Massatt, Virginia Rentko, L Bruce Pearce, Stephen Ahlers, Richard McCarron, Michael Handrigan & Daniel Freilich. (2008) The Effects of Decreasing Low-Molecular Weight Hemoglobin Components of Hemoglobin-Based Oxygen Carriers in Swine With Hemorrhagic Shock. Journal of Trauma: Injury, Infection & Critical Care 64:5, pages 1240-1257.
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Teruyuki Komatsu, Yubin Huang, Shinobu Wakamoto, Hideki Abe, Mitsuhiro Fujihara, Hiroshi Azuma, Hisami Ikeda, Hisashi Yamamoto, Hirohisa Horinouchi, Koichi Kobayashi & Eishun Tsuchida. (2007) Influence of O2-carrying plasma hemoprotein “albumin-heme” on complement system and platelet activationin vitro and physiological responses to exchange transfusion. Journal of Biomedical Materials Research Part A 81A:4, pages 821-826.
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T M S CHANG. 2007. Artificial Cells, Cell Engineering and Therapy. Artificial Cells, Cell Engineering and Therapy 321 332 .
Sarit Sivan & Noah Lotan. 2006. Wiley Encyclopedia of Biomedical Engineering. Wiley Encyclopedia of Biomedical Engineering.
Teruyuki Komatsu, Yubin Huang, Hisashi Yamamoto, Hirohisa Horinouchi, Koichi Kobayashi & Eishun Tsuchida. 2006. Blood Substitutes. Blood Substitutes 532 539 .
Thomas Ming Swi Chang. 2006. Blood Substitutes. Blood Substitutes 523 531 .
Teruyuki Komatsu & Eishun Tsuchida. 2005. Artificial Oxygen Carrier. Artificial Oxygen Carrier 193 204 .
Thomas Ming Swi Chang. 2005. Applications of Cell Immobilisation Biotechnology. Applications of Cell Immobilisation Biotechnology 249 255 .
Teruyuki Komatsu, Hisashi Yamamoto, Yubin Huang, Hirohisa Horinouchi, Koichi Kobayashi & Eishun Tsuchida. (2004) Exchange transfusion with synthetic oxygen-carrying plasma protein ?albumin-heme? into an acute anemia rat model after seventy-percent hemodilution. Journal of Biomedical Materials Research 71A:4, pages 644-651.
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Yubin Huang, Teruyuki Komatsu, Hisashi Yamamoto, Hirohisa Horinouchi, Koichi Kobayashi & Eishun Tsuchida. (2004) Exchange transfusion with entirely synthetic red‐cell substitute albumin‐heme into rats: Physiological responses and blood biochemical tests. Journal of Biomedical Materials Research Part A 71A:1, pages 63-69.
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I El-Gibaly & M Anwar. (2004) Hemolysate-filled polyethyleneimine and polyurea microcapsules as potential red blood cell substitutes: effect of aqueous monomer type on properties of the prepared microcapsules. International Journal of Pharmaceutics 278:1, pages 25-40.
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Thomas Ming Swi Chang. (2004) Artificial Cells for Cell and Organ Replacements. Artificial Organs 28:3, pages 265-270.
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Ajai K. Malhotra, Michael E. Kelly, Preston R. Miller, J. Craig Hartman, Timothy C. Fabian & Kenneth G. Proctor. (2003) Resuscitation with a Novel Hemoglobin-Based Oxygen Carrier in a Swine Model of Uncontrolled Perioperative Hemorrhage. The Journal of Trauma: Injury, Infection, and Critical Care 54:5, pages 915-924.
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Sarit Sivan & Noah Lotan. (2003) Molecular engineering of proteins with predefined function. Part I: design of a hemoglobin-based oxygen carrier. Biomolecular Engineering 20:3, pages 83-90.
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Eishun Tsuchida, Teruyuki Komatsu, Yasuko Matsukawa, Akito Nakagawa, Hiromi Sakai, Koichi Kobayashi & Makoto Suematsu. (2002) Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging. Journal of Biomedical Materials Research Part A 64A:2, pages 257-261.
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Thomas Ming Swi Chang. 2002. Methods of Tissue Engineering. Methods of Tissue Engineering 965 975 .
G. Kemming, O. Habler & K. Messmer. 1998. Tissue Oxygenation in Acute Medicine. Tissue Oxygenation in Acute Medicine 276 290 .
Junichi Hirayama, Hideki Abe, Naoki Kamo, Kenji Ikebuchi & Hisami Ikeda. (2001) Comparison of the Effects of Different Antiviral Treatments on the Antioxidant Systems of Stroma-free Hemoglobin¶. Photochemistry and Photobiology 74:3, pages 461-464.
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Clara Fronticelli, Daniele Arosio, Kevin M. Bobofchak & Gregory B. Vasquez. (2001) Molecular engineering of a polymer of tetrameric hemoglobins. Proteins: Structure, Function, and Genetics 44:3, pages 212-222.
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Armin Schubert. (2001) Hemoglobin-based oxygen carriers, blood substitutes, and their relevance to high-volume blood loss. Seminars in Anesthesia, Perioperative Medicine and Pain 20:1, pages 78-84.
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Maurizio Gattoni, Maria Cristina Piro, Alberto Boffi, William S. Brinigar, Clara Fronticelli & Emilia Chiancone. (2001) The Heme–Globin and Dimerization Equilibria of Recombinant Human Hemoglobins Carrying Site-Specific β Chains Mutations. Archives of Biochemistry and Biophysics 386:2, pages 172-178.
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Junichi HIRAYAMA, Stephen J. WAGNER, Hideki ABE, Kenji IKEBUCHI & Hisami IKEDA. (2001) Involvement of Reactive Oxygen Species in Hemoglobin Oxidation and Virus Inactivation by 1,9-Dimethylmethylene Blue Phototreatment.. Biological and Pharmaceutical Bulletin 24:4, pages 418-421.
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M. García Caballero, A. Gómez Luque, J. Pavía Molina, J.A. Villalobos Talero, J.J. García Vallejo & M. Muñoz Gómez. (2001) Medidas farmacológicas de ahorro de sangre en cirugía. Cirugía Española 69:2, pages 146-158.
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Gus J. Vlahakes. 2001. Surgical Research. Surgical Research 1037 1046 .
Clive Wilson, Neena Washington & Clive Washington. 2000. Physiological Pharmaceutics. Physiological Pharmaceutics.
Thomas Ming Swi Chang. (2000) Red blood cell substitutes. Best Practice & Research Clinical Haematology 13:4, pages 651-667.
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Junichi Hirayama, Stephen J. Wagner, Charlotte Gomez, Victor W. Macdonald, Hideki Abe, Hisami Ikeda, Kenji Ikebuchi & Sadayoshi Sekiguchi. (2000) Virus Photoinactivation in Stroma-free Hemoglobin with Methylene Blue or 1,9-dimethylmethylene Blue. Photochemistry and Photobiology 71:1, pages 90.
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Junichi Hirayama, Stephen J. Wagner, Charlotte Gomez, Victor W. Macdonald, Hideki Abe, Hisami Ikeda, Kenji Ikebuchi & Sadayoshi Sekiguchi. (2007) Virus Photoinactivation in Stroma-free Hemoglobin with Methylene Blue or 1,9-dimethylmethylene Blue. Photochemistry and Photobiology 71:1, pages 90-93.
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Wilfred Lieberthal, Robert Fuhro, Christopher Andry & C.Robert Valeri. (2000) Effects of hemoglobin-based oxygen-carrying solutions in anesthetized rats with acute ischemic renal failure. Journal of Laboratory and Clinical Medicine 135:1, pages 73-81.
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Thomas Ming Swi Chang. 2000. Principles of Tissue Engineering. Principles of Tissue Engineering 601 610 .
Susanna Herold. (1999) Mechanistic Studies of the Oxidation of Pyridoxalated Hemoglobin Polyoxyethylene Conjugate by Nitrogen Monoxide. Archives of Biochemistry and Biophysics 372:2, pages 393-398.
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K.C. Lowe. (1999) Perfluorinated blood substitutes and artificial oxygen carriers. Blood Reviews 13:3, pages 171-184.
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Klaus F. Waschke & Thomas Frietsch. (1999) Modified haemoglobins and perfluorocarbons. Current Opinion in Anaesthesiology 12:2, pages 195-202.
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Christineh N. Sarkissian, Zhongqi Shao, Françoise Blain, Rosalie Peevers, Hongsheng Su, Robert Heft, Thomas M. S. Chang & Charles R. Scriver. (1999) A different approach to treatment of phenylketonuria: Phenylalanine degradation with recombinant phenylalanine ammonia lyase. Proceedings of the National Academy of Sciences 96:5, pages 2339-2344.
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Thomas Ming Swi Chang. (2002) Artificial Cells with Emphasis on Cell Encapsulation of Genetically Engineered Cells. Artificial Organs 22:11, pages 958-965.
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T. Frietsch, C. Lenz & K. F. Waschke. (1998) Artificial oxygen carriers. European Journal of Anaesthesiology 15:5, pages 571-584.
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Thomas Ming Swi Chang. (1998) Red blood cell substitutes. Seminars in Anesthesia, Perioperative Medicine and Pain 17:3, pages 208-215.
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Daniel H. Doherty, Michael P. Doyle, Shawn R. Curry, Rita J. Vali, Timothy J. Fattor, John S. Olson & Douglas D. Lemon. (1998) Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nature Biotechnology 16:7, pages 672-676.
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T.M.S. Chang. 1998. Biotechnolgy Annual Review. Biotechnolgy Annual Review 75 112 .
Thomas Ming Swi Chang. (1998) Pharmaceutical and therapeutic applications of artificial cells including microencapsulation. European Journal of Pharmaceutics and Biopharmaceutics 45:1, pages 3-8.
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T.M.S. Chang & W.P. Yu. 1998. Blood Substitutes, Present and Future Perspectives. Blood Substitutes, Present and Future Perspectives 161 169 .
THOMAS MING SWI CHANG. (2006) Artificial Cells and Bioencapsulation in Bioartificial Organsa. Annals of the New York Academy of Sciences 831:1, pages 249-259.
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Ronald Kluger & Xianfeng Li. (1997) Efficient Chemical Introduction of a Disulfide Cross-Link and Conjugation Site into Human Hemoglobin at β-Lysine-82 Utilizing a Bifunctional Aminoacyl Phosphate. Bioconjugate Chemistry 8:6, pages 921-926.
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