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Original Article

Development of Neo Red Cells(NRC) with the Enyzmatic Reduction System of Methemoglobin

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Pages 417-427 | Published online: 11 Jul 2009

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Vibhudutta Awasthi, Vivek R. Yadav, Beth Goins & William T. Phillips. (2013) Modulation of oxidative stability of haemoglobin inside liposome-encapsulated haemoglobin. Journal of Microencapsulation 30:5, pages 471-478.
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Takatoshi Ito, Mitsuhiro Fujihara, Hideki Abe, Miki Yamaguchi, Shinobu Wakamoto, Shinji Takeoka, Hiromi Sakai, Eishun Tsuchida, Hisami Ikeda & Kenji Ikebuchi. (2001) EFFECTS OF POLY(ETHYLENEGLYCOL)-MODIFIED HEMOGLOBIN VESICLES ON N-FORMYL-METHIONYL-LEUCYL-PHENYLALANINE-INDUCED RESPONSES OF POLYMORPHONUCLEAR NEUTROPHILS IN VITRO. Artificial Cells, Blood Substitutes, and Biotechnology 29:6, pages 427-437.
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Hideki Abe, Kenji Ikebuchi, Koichi Niwa, Osamu Inanami, Mikinori Kuwabara, Mitsuhiro Fujihara, Junichi Hirayama & Hisami Ikeda. (2001) SUPEROXIDE GENERATION FROM HUMAN POLYMORPHONUCLEAR LEUKOCYTES BY LIPOSOME-ENCAPSULATED HEMOGLOBIN. Artificial Cells, Blood Substitutes, and Biotechnology 29:4, pages 275-283.
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H Abe, H Sugawara, J Hirayama, H Ihara, T Kato, H Ikeda & K Ikebuchi. (2000) Removal of Parvovirus B19 from Hemoglobin Solution by Nanofiltration. Artificial Cells, Blood Substitutes, and Biotechnology 28:5, pages 375-383.
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Articles from other publishers (31)

Hiromi Sakai, Naoko Kobayashi, Tomoko Kure & Chie Okuda. (2022) Translational Research of Hemoglobin Vesicles as a Transfusion Alternative. Current Medicinal Chemistry 29:3, pages 591-606.
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Bonpei Takase, Yuko Higashimura, Haruka Asahina, Masayuki Ishihara & Hiromi Sakai. (2021) Liposome‐encapsulated hemoglobin (HbV) transfusion rescues rats undergoing progressive lethal 85% hemorrhage as a result of an anti‐arrhythmogenic effect on the myocardium. Artificial Organs 45:11, pages 1391-1404.
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Clara Coll-Satue, Shahana Bishnoi, Jiantao Chen & Leticia Hosta-Rigau. (2021) Stepping stones to the future of haemoglobin-based blood products: clinical, preclinical and innovative examples. Biomaterials Science 9:4, pages 1135-1152.
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Anirban Sen Gupta & Allan Doctor. 2020. Damage Control Resuscitation. Damage Control Resuscitation 197 222 .
Hiromi Sakai, Bing Li, Wei Lee Lim & Yumika Iga. (2014) Red Blood Cells Donate Electrons to Methylene Blue Mediated Chemical Reduction of Methemoglobin Compartmentalized in Liposomes in Blood. Bioconjugate Chemistry 25:7, pages 1301-1310.
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Shinichi Kaneda, Takanobu Ishizuka, Hiroshi Goto & Hiroaki Kasukawa. 2013. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics. Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics 273 282 .
Yashiro Nogami, Bonpei Takase, Manabu Kinoshita, Satoshi Shono, Shinichi Kaneda, Yoshihiro Tanaka, Satoko Kishimoto, Hidemi Hattori & Masayuki Ishihara. (2012) Liposome-Encapsulated Hemoglobin Attenuates Cardiac Dysfunction and Sympathetic Activity During Hypohemoglobinemic Shock. Shock 38:2, pages 159-164.
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Hitoshi Ikegawa, Yasuyuki Kuwagata, Koichi Hayakawa, Kazuo Noguchi, Hiroshi Ogura & Hisashi Sugimoto. (2011) Effects of Exchange Transfusion With Liposome‐Encapsulated Hemoglobin on VO 2 /DO 2 . Artificial Organs 36:2, pages 130-138.
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Satoshi Shono, Manabu Kinoshita, Bonpei Takase, Yashiro Nogami, Shinichi Kaneda, Masayuki Ishihara, Daizoh Saitoh, Makoto Kikuchi & Shuhji Seki. (2011) Intraosseous Transfusion With Liposome-Encapsulated Hemoglobin Improves Mouse Survival After Hypohemoglobinemic Shock Without Scavenging Nitric Oxide. Shock 35:1, pages 45-52.
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Noriyuki Matsutani, Bonpei Takase, Yashiro Nogami, Yuichi Ozeki, Shinichi Kaneda, Tadaaki Maehara, Makoto Kikuchi & Masayuki Ishihara. (2010) Efficacy of peritoneal oxygenation using a novel artificial oxygen carrier (TRM-645) in a rat respiratory insufficiency model. Surgery Today 40:5, pages 451-455.
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Yashiro Nogami, Bonpei Takase, Manabu Kinoshita, Satoshi Shono, Shinichi Kaneda, Masayuki Ishihara, Makoto Kikuchi & Tadaaki Maehara. (2010) Characteristic Changes in Heart Rate Variability Indices during Hemorrhagic Shock, and Effect of Liposome-Encapsulated Hemoglobin in Rats. Journal of Arrhythmia 26:3, pages 189-198.
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Hrushikesh Agashe & Vibhudutta Awasthi. 2009. 1 28 .
Hiromi Sakai, Keitaro Sou & Eishun Tsuchida. 2009. 363 384 .
Xiaolan Zhang, Changsheng Liu, Yuan Yuan, Xiaoqian Shan, Yan Sheng & Feng Xu. (2008) Reduction and suppression of methemoglobin loaded in the polymeric nanoparticles intended for blood substitutes. Journal of Biomedical Materials Research Part B: Applied Biomaterials 87B:2, pages 354-363.
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Yashiro Nogami, Manabu Kinoshita, Bonpei Takase, Yoshitaka Ogata, Daizoh Saitoh, Makoto Kikuchi, Masayuki Ishihara & Tadaaki Maehara. (2008) Liposome-Encapsulated Hemoglobin Transfusion Rescues Rats Undergoing Progressive Hemodilution From Lethal Organ Hypoxia Without Scavenging Nitric Oxide. Annals of Surgery 248:2, pages 310-319.
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Rei Kansaku, Toshihide Mizuno, Eisuke Tatsumi, Yoshitaka Ogata, Takanobu Ishizuka & Yoshiyuki Taenaka. (2008) Oxygen metabolism during cardiopulmonary bypass with hemodilution using liposome-encapsulated hemoglobin in kid goats. Journal of Artificial Organs 11:1, pages 24-28.
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Vibhudutta Awasthi, Seong-Hwan Yee, Paul Jerabek, Beth Goins & William T. Phillips. (2007) Cerebral oxygen delivery by liposome-encapsulated hemoglobin: a positron-emission tomographic evaluation in a rat model of hemorrhagic shock. Journal of Applied Physiology 103:1, pages 28-38.
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Vibhudutta Awasthi, Beth Goins & William Phillips. 2006. Liposome Technology, Volume II. Liposome Technology, Volume II 63 91 .
Hiromi Sakai, Keitaro Sou, Shinji Takeoka, Koichi Kobayashi & Eishun Tsuchida. 2006. Blood Substitutes. Blood Substitutes 514 522 .
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Teiji Oda, Tetsuhiro Kimura, Yoshitaka Ogata & Yutaka Fujise. (2005) Hemodilution with liposome-encapsulated low-oxygen-affinity hemoglobin does not attenuate hypothermic cerebral ischemia in rats. Journal of Artificial Organs 8:4, pages 263-269.
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Hiromi Sakai, Keitaro Sou, Shinji Takeoka, Koichi Kobayashi & Eishun Tsuchida. 2005. Artificial Oxygen Carrier. Artificial Oxygen Carrier 135 168 .
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V.D. Awasthi, D. Garcia, R. Klipper, W.T. Phillips & B.A. Goins. (2004) Kinetics of liposome-encapsulated hemoglobin after 25% hypovolemic exchange transfusion. International Journal of Pharmaceutics 283:1-2, pages 53-62.
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G. Kemming, O. Habler & K. Messmer. 1998. Tissue Oxygenation in Acute Medicine. Tissue Oxygenation in Acute Medicine 276 290 .
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Yoshitaka OGATA. (2001) The functional design for liposome encapsulated hemoglobin as the biomimetics technology of red blood cell. Oleoscience 1:2, pages 139-146,225.
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S.B. Dev, D.P. Rabussay, G. Widera & G.A. Hofmann. (2000) Medical applications of electroporation. IEEE Transactions on Plasma Science 28:1, pages 206-223.
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Robert O Wright, William J Lewander & Alan D Woolf. (1999) Methemoglobinemia: Etiology, Pharmacology, and Clinical Management. Annals of Emergency Medicine 34:5, pages 646-656.
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Klaus F. Waschke & Thomas Frietsch. (1999) Modified haemoglobins and perfluorocarbons. Current Opinion in Anaesthesiology 12:2, pages 195-202.
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T. Frietsch, C. Lenz & K. F. Waschke. (1998) Artificial oxygen carriers. European Journal of Anaesthesiology 15:5, pages 571-584.
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