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Haemostatic and metabolic impact of estradiol pills and drospirenone-containing ethinylestradiol pills vs. levonorgestrel-containing ethinylestradiol pills: A literature review

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Kristina Gemzell-Danielsson, Angelo Cagnacci, Nathalie Chabbert-Buffet, Jonathan Douxfils, Jean-Michel Foidart, Ali Kubba, Luis Ignacio Lete Lasa, Diana Mansour, Joseph Neulen, Jaoquim Neves, Fátima Palma, Thomas Römer, Robert Spaczyński & Vera Tóth. (2022) A novel estetrol-containing combined oral contraceptive: European expert panel review. The European Journal of Contraception & Reproductive Health Care 27:5, pages 373-383.
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Suzanne Reed, Carol Koro, Julia DiBello, Kerstin Becker, Anja Bauerfeind, Christian Franke & Klaas Heinemann. (2021) Prospective controlled cohort study on the safety of a monophasic oral contraceptive containing nomegestrol acetate (2.5mg) and 17β-oestradiol (1.5mg) (PRO-E2 study): risk of venous and arterial thromboembolism. The European Journal of Contraception & Reproductive Health Care 26:6, pages 439-446.
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Santiago Palacios, Enrico Colli & Pedro A. Regidor. (2021) Metabolic and laboratory effects of a progestin-only pill containing drospirenone 4 mg in comparison to desogestrel 75 µg: a double-blind, double-dummy, prospective, randomised study. The European Journal of Contraception & Reproductive Health Care 26:6, pages 454-461.
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Iñaki Lete. (2021) Combined hormonal contraception and COVID-19. The European Journal of Contraception & Reproductive Health Care 26:2, pages 128-131.
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Giovanni Grandi, Maria Chiara Del Savio & Fabio Facchinetti. (2021) The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism. Expert Review of Clinical Pharmacology 14:2, pages 211-224.
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Giovanni Grandi, Fabio Barra, Simone Ferrero & Fabio Facchinetti. (2019) Estradiol in non-oral hormonal contraception: a “long and winding road”. Expert Review of Endocrinology & Metabolism 14:3, pages 153-155.
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Angelo Cagnacci, Carlo Bastianelli, Manuela Neri, Antonio Cianci, Chiara Benedetto, Luana Calanni, Michele Vignali, Vincenzo De Leo, Ettore Cicinelli, Giuseppe Borrelli & Annibale Volpe. (2018) Treatment continuation and satisfaction in women using combined oral contraception with nomegestrol acetate and oestradiol: a multicentre, prospective cohort study (BOLERO). The European Journal of Contraception & Reproductive Health Care 23:6, pages 393-399.
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Manuela Neri, Maria Elena Malune, Valentina Corda, Bruno Piras, Pierina Zedda, Monica Pilloni, Maria Paola Orani, Valerio Vallerino, Gian Benedetto Melis & Anna Maria Paoletti. (2017) Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC). Gynecological Endocrinology 33:12, pages 958-962.
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Manuela Farris, Carlo Bastianelli, Elena Rosato, Ivo Brosens & Giuseppe Benagiano. (2017) Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. effects on hemostasis. Expert Review of Clinical Pharmacology 10:10, pages 1129-1144.
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Giovanni Grandi, Fabio Facchinetti & Johannes Bitzer. (2017) Estradiol in hormonal contraception: real evolution or just same old wine in a new bottle?. The European Journal of Contraception & Reproductive Health Care 22:4, pages 245-246.
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Giovanni Grandi, Antonella Napolitano & Angelo Cagnacci. (2016) Metabolic impact of combined hormonal contraceptives containing estradiol. Expert Opinion on Drug Metabolism & Toxicology 12:7, pages 779-787.
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Anita L Nelson. (2015) An update on new orally administered contraceptives for women. Expert Opinion on Pharmacotherapy 16:18, pages 2759-2772.
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Alessandra Graziottin, Angela Cuccarollo, Massimo P. Franchi & Stefano Uccella. (2022) Patologie mestruali e contraccezione: principi di personalizzazione della scelta terapeutica. L'Endocrinologo.
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I. Lete. (2022) Evolución del estrógeno en la anticoncepción hormonal combinada: del etinilestradiol al estetrol pasando por el estradiol. Clínica e Investigación en Ginecología y Obstetricia 49:3, pages 100755.
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İlkin Seda CAN. (2022) EVALUATION OF CONTRACEPTIVE METHOD USAGE CHANGES AND SATISFACTION OF WOMEN DURING THE COVID-19 PANDEMICCovid-19 Pandemisi Sırasında Kadınların Kontraseptif Yöntem Kullanım Değişimlerinin ve Memnuniyetlerinin Değerlendirilmesi. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 24:1, pages 118-127.
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Rossella Nappi, Lara Tiranini, Simona Sacco, Eleonora De Matteis, Roberto De Icco & Cristina Tassorelli. (2022) Role of Estrogens in Menstrual Migraine. Cells 11:8, pages 1355.
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Thierry Habyarimana, Callixte Yadufashije, Vestine Mukantwali, Alexis Nshimiyinana, Francois Niyonzima, Clementine Yamukujije & Joseph Mucumbitsi. (2022) Association between hormonal contraceptive use and derangement of lipid profile among women attending Muhoza Health Center, Rwanda. Sahel Medical Journal 25:2, pages 47.
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Nelleke van der Weerd, Hine J. A. van Os, Mariam Ali, Jan W. Schoones, Arn M. J. M. van den Maagdenberg, Nyika D. Kruyt, Bob Siegerink & Marieke J. H. Wermer. (2021) Sex Differences in Hemostatic Factors in Patients With Ischemic Stroke and the Relation With Migraine—A Systematic Review. Frontiers in Cellular Neuroscience 15.
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Gerda Venter, Carien L. van der Berg, Francois H. van der Westhuizen & Elardus Erasmus. (2021) Health Status Is Affected, and Phase I/II Biotransformation Activity Altered in Young Women Using Oral Contraceptives Containing Drospirenone/Ethinyl Estradiol. International Journal of Environmental Research and Public Health 18:20, pages 10607.
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T.F. Tatarchuk, Z.M. Dubossarska, V.I. Pyrohova, N.Y. Pedachenko, T.M. Tutchenko, O.О. Yefimenko, N.V. Kosei, Y.O. Dubossarska, K.L. Shatylovych, V.M. Zaporozhan, V.V. Kaminskyi, G.V. Zaichenko, S.A. Dubrov & L.M. Chernukha. (2021) On the use of sex steroids in women during the COVID-19 pandemic. REPRODUCTIVE ENDOCRINOLOGY:58, pages 9-16.
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Angelo Cagnacci & Anna Biasioli. 2021. Female and Male Contraception. Female and Male Contraception 299 317 .
Jonathan Douxfils, Laure Morimont & Céline Bouvy. (2020) Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk. Seminars in Thrombosis and Hemostasis 46:08, pages 872-886.
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Anne Gompel, Olivier Fain, Isabelle Boccon-Gibod, Delphine Gobert & Laurence Bouillet. (2020) Exogenous hormones and hereditary angioedema. International Immunopharmacology 78, pages 106080.
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P. Leusink. 2020. Urogynaecologie. Urogynaecologie 91 103 .
. (2019) FSRH Guideline (January 2019, amended October 2023) Combined Hormonal Contraception. BMJ Sexual & Reproductive Health 45:Suppl 1, pages 1-93.
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Roshni Kakaiya, Lia L. Lopez & Anita L. Nelson. (2017) Women’s perceptions of contraceptive efficacy and safety. Contraception and Reproductive Medicine 2:1.
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Nicolás Mendoza, Esperanza Soto & Rafael Sánchez-Borrego. (2016) Do women aged over 40 need different counseling on combined hormonal contraception?. Maturitas 87, pages 79-83.
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