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Research Article

Synthesis and carbonic anhydrase inhibitory properties of novel 1,4-dihydropyrimidinone substituted diarylureas

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Pages 18-22 | Received 27 Jul 2012, Accepted 01 Nov 2012, Published online: 16 Jan 2013

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Read on this site (7)

Özcan Güleç, Mustafa Arslan, Nahit Gencer, Adem Ergun, Cigdem Bilen & Oktay Arslan. (2017) Synthesis and carbonic anhydrase inhibitory properties of new spiroindoline-substituted sulphonamide compounds. Archives of Physiology and Biochemistry 123:5, pages 306-312.
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Stanislav Kalinin, Claudiu T. Supuran & Mikhail Krasavin. (2016) Multicomponent chemistry in the synthesis of carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 185-199.
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Soner Kılıcaslan, Mustafa Arslan, Zeynep Ruya, Çigdem Bilen, Adem Ergün, Nahit Gençer & Oktay Arslan. (2016) Synthesis and evaluation of sulfonamide-bearing thiazole as carbonic anhydrase isoforms hCA I and hCA II. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1300-1305.
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Belma Zengin Kurt, Fatih Sönmez, Çiğdem Bilen, Adem Ergun, Nahit Gençer, Oktay Arslan & Mustafa Kucukislamoglu. (2016) Synthesis, antioxidant and carbonic anhydrase I and II inhibitory activities of novel sulphonamide-substituted coumarylthiazole derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 991-998.
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Mert Olgun Karataş, Harun Uslu, Suat Sarı, Mehmet Abdullah Alagöz, Arzu Karakurt, Bülent Alıcı, Cigdem Bilen, Emre Yavuz, Nahit Gencer & Oktay Arslan. (2016) Coumarin or benzoxazinone based novel carbonic anhydrase inhibitors: synthesis, molecular docking and anticonvulsant studies. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 760-772.
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Ahmet Balci, Mustafa Arslan, Arleta Rifati Nixha, Cigdem Bilen, Adem Ergun & Nahit Gençer. (2015) Synthesis and evaluation of N-heteroarylsubstituted triazolosulfonamides as carbonic anhydrase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry 30:3, pages 377-382.
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Nurhan Sarioglu, Cigdem Bilen, Zubeyde Sackes & Nahit Gencer. (2015) The effects of bronchodilator drugs and antibiotics used for respiratory infection on human erythrocyte carbonic anhydrase I and II isozymes. Archives of Physiology and Biochemistry 121:2, pages 56-61.
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Articles from other publishers (14)

Merve Taşcı, Mustafa Arslan, Kübra Çıkrıkcı, Adem Ergun, Nahit Gençer & Oktay Arslan. (2023) Synthesis and Investigation of Carbonic Anhydrase I and II Activity of Dihydrobenzo[h]Quinazolin-2-yl Thiourea Compounds. Pharmaceutical Chemistry Journal 57:6, pages 899-906.
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Ahmad Badreddin Musatat, Alparslan Atahan, Adem Ergün, Kübra Çıkrıkcı, Nahit Gençer, Oktay Arslan & Mustafa Zengin. (2023) Synthesis, enzyme inhibition, and molecular docking studies of a novel chalcone series bearing benzothiazole scaffold. Biotechnology and Applied Biochemistry 70:3, pages 1357-1370.
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Tanya Prasad, Aastha Mahapatra, Tripti Sharma, Chita R. Sahoo & Rabindra Nath Padhy. (2023) Dihydropyrimidinones as potent anticancer agents: Insight into the structure–activity relationship. Archiv der Pharmazie 356:6.
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Murat Bozdag, Lochlin Cravey, Jacob Combs, Anusha Kota, Robert McKenna, Andrea Angeli, Silvia Selleri, Fabrizio Carta & Claudiu T. Supuran. (2022) Small Molecule Alkoxy Oriented Selectiveness on Human Carbonic Anhydrase II and IX Inhibition. ChemMedChem 17:11.
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Gioele Vannozzi, Daniela Vullo, Andrea Angeli, Marta Ferraroni, Jacob Combs, Carrie Lomelino, Jacob Andring, Robert Mckenna, Gianluca Bartolucci, Marco Pallecchi, Laura Lucarini, Silvia Sgambellone, Emanuela Masini, Fabrizio Carta & Claudiu T. Supuran. (2021) One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes. Journal of Medicinal Chemistry 65:1, pages 824-837.
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Nurcan Berber, Mustafa Arslan, Fırat Vural, Adem Ergun, Nahit Gençer & Oktay Arslan. (2020) Synthesis of new series of thiazol‐(2(3 H )‐ylideneamino)benzenesulfonamide derivatives as carbonic anhydrase inhibitors . Journal of Biochemical and Molecular Toxicology 34:12.
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Arleta Rifati‐Nixha, Mustafa Arslan, Nahit Gençer, Kübra Çıkrıkıçı, Başak Gökçe & Oktay Arslan. (2019) Synthesis of carbazole bearing pyridopyrimidine‐substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity. Journal of Biochemical and Molecular Toxicology 33:6.
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Safak Akin, Hasan Ayaloglu, Ergun Gultekin, Ahmet Colak, Olcay Bekircan & Melike Yildirim Akatin. (2019) Synthesis of 1,2,4-triazole-5-on derivatives and determination of carbonic anhydrase II isoenzyme inhibition effects. Bioorganic Chemistry 83, pages 170-179.
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Alparslan AtahanNahit GencerCigdem BilenEmre YavuzHayriye GencFatih SonmezMustafa ZenginMustafa CeylanMustafa Kucukislamoglu. (2018) Synthesis, Biological Activity and Structure-Activity Relationship of Novel Diphenylurea Derivatives Containing Tetrahydroquinoline as Carbonic Anhydrase I and II Inhibitors. ChemistrySelect 3:2, pages 529-534.
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Larizza Hellen Santana Matos, Flávia Teixeira Masson, Luiz Alberto Simeoni & Mauricio Homem-de-Mello. (2018) Biological activity of dihydropyrimidinone (DHPM) derivatives: A systematic review. European Journal of Medicinal Chemistry 143, pages 1779-1789.
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Belma Z. Kurt, Fatih Sonmez, Basak Gokce, Adem Ergun, Nahit Gencer, Taki Demir, Oktay Arslan & Mustafa Kucukislamoglu. (2016) In vitro inhibition effects on erythrocyte carbonic anhydrase I and II and structure-activity relationships of cumarylthiazole derivatives. Russian Journal of Bioorganic Chemistry 42:5, pages 506-511.
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Satish Kumar, Mariangela Ceruso, Tiziano Tuccinardi, Claudiu T. Supuran & Pawan K. Sharma. (2016) Pyrazolylbenzo[ d ]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII. Bioorganic & Medicinal Chemistry 24:13, pages 2907-2913.
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SitaRam, Mariangela Ceruso, Poonam Khloya, Claudiu T. Supuran & Pawan K. Sharma. (2014) 4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII. Bioorganic & Medicinal Chemistry 22:24, pages 6945-6952.
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Hilal Kuday, Fatih Sonmez, Cigdem Bilen, Emre Yavuz, Nahit Gençer & Mustafa Kucukislamoglu. (2014) Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II. BioMed Research International 2014, pages 1-8.
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