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Review Article

Epigenetic screening in product safety assessment: are we there yet?

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Pages 298-311 | Published online: 16 Apr 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Mine Senyildiz, Buket Alpertunga & Sibel Ozden. (2017) DNA methylation analysis in rat kidney epithelial cells exposed to 3-MCPD and glycidol. Drug and Chemical Toxicology 40:4, pages 432-439.
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P. A. Schulte, C. Whittaker & C. P. Curran. (2015) Considerations for Using Genetic and Epigenetic Information in Occupational Health Risk Assessment and Standard Setting. Journal of Occupational and Environmental Hygiene 12:sup1, pages S69-S81.
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Goksun Demirel, Buket Alpertunga & Sibel Ozden. (2015) Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells. Pharmaceutical Biology 53:9, pages 1302-1310.
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Articles from other publishers (25)

Anne Le Goff, Séverine Louvel, Henri Boullier & Patrick Allard. (2022) Toxicoepigenetics for Risk Assessment: Bridging the Gap Between Basic and Regulatory Science. Epigenetics Insights 15, pages 251686572211131.
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Iraia Muñoa-Hoyos, Manu Araolaza, Itziar Urizar-Arenaza, Marta Gianzo, Jon Irazusta & Nerea Subiran. (2021) Sex dependent alteration of epigenetic marks after chronic morphine treatment in mice organs. Food and Chemical Toxicology 152, pages 112200.
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Nan Mei, Tao Chen, Baitang Ning & Lei Guo. 2021. Nutraceuticals. Nutraceuticals 299 313 .
Felicia Fei-Lei Chung & Zdenko Herceg. (2020) The Promises and Challenges of Toxico-Epigenomics: Environmental Chemicals and Their Impacts on the Epigenome. Environmental Health Perspectives 128:1.
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Mélanie Blanc, Joëlle Rüegg, Nikolai Scherbak & Steffen H. Keiter. (2019) Environmental chemicals differentially affect epigenetic-related mechanisms in the zebrafish liver (ZF-L) cell line and in zebrafish embryos. Aquatic Toxicology 215, pages 105272.
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Tomoki Kimura, Takuomi Hosaka, Tsuyoshi Nakanishi & Osamu Aozasa. (2019) Long-term cadmium exposure enhances metallothionein-1 induction after subsequent exposure to high concentrations of cadmium in P1798 mouse lymphosarcoma cells. The Journal of Toxicological Sciences 44:4, pages 309-316.
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Jonathan Moggs & Rémi Terranova. (2018) Chromatin dynamics underlying latent responses to xenobiotics. Toxicology Research 7:4, pages 606-617.
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Maria Dusinska, Jana Tulinska, Naouale El Yamani, Miroslava Kuricova, Aurelia Liskova, Eva Rollerova, Elise Rundén-Pran & Bozena Smolkova. (2017) Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?. Food and Chemical Toxicology 109, pages 797-811.
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Isabelle R. Miousse, Lynea A. Murphy, Haixia Lin, Melissa R. Schisler, Jinchun Sun, Marie-Cecile G. Chalbot, Radhakrishna Sura, Kamin Johnson, Matthew J. LeBaron, Ilias G. Kavouras, Laura K. Schnackenberg, Richard D. Beger, Reza J. Rasoulpour & Igor Koturbash. (2017) Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants. Food and Chemical Toxicology 109, pages 690-702.
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Jessica LaRocca, Kamin J. Johnson, Matthew J. LeBaron & Reza J. Rasoulpour. (2017) The interface of epigenetics and toxicology in product safety assessment. Current Opinion in Toxicology 6, pages 87-92.
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Kerry L. Dearfield, B. Bhaskar Gollapudi, Jeffrey C. Bemis, R. Daniel Benz, George R. Douglas, Rosalie K. Elespuru, George E. Johnson, David J. Kirkland, Matthew J. LeBaron, Albert P. Li, Francesco Marchetti, Lynn H. Pottenger, Emiel Rorije, Jennifer Y. Tanir, Veronique Thybaud, Jan van Benthem, Carole L. Yauk, Errol Zeiger & Mirjam Luijten. (2017) Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations. Environmental and Molecular Mutagenesis 58:5, pages 264-283.
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Claudia Knothe, Hiromi Shiratori, Eduard Resch, Alfred Ultsch, Gerd Geisslinger, Alexandra Doehring & Jörn Lötsch. (2016) Disagreement between two common biomarkers of global DNA methylation. Clinical Epigenetics 8:1.
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Manon C. Bouwmeester, Sander Ruiter, Tobias Lommelaars, Josefine Sippel, Hennie M. Hodemaekers, Evert-Jan van den Brandhof, Jeroen L.A. Pennings, Jorke H. Kamstra, Jaroslav Jelinek, Jean-Pierre J. Issa, Juliette Legler & Leo T.M. van der Ven. (2016) Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Toxicology and Applied Pharmacology 291, pages 84-96.
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Senthilkumar P. Kuppusamy, J. Phillip Kaiser & Scott C. Wesselkamper. (2015) Epigenetic Regulation in Environmental Chemical Carcinogenesis and its Applicability in Human Health Risk Assessment. International Journal of Toxicology 34:5, pages 384-392.
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Bozena Smolkova, Naouale El Yamani, Andrew R. Collins, Arno C. Gutleb & Maria Dusinska. (2015) Nanoparticles in food. Epigenetic changes induced by nanomaterials and possible impact on health. Food and Chemical Toxicology 77, pages 64-73.
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Rebecca A. Alyea, B. Bhaskar Gollapudi & Reza J. Rasoulpour. (2014) Are we ready to consider transgenerational epigenetic effects in human health risk assessment?. Environmental and Molecular Mutagenesis 55:3, pages 292-298.
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Jane Muncke. 2014. Toxicants in Food Packaging and Household Plastics. Toxicants in Food Packaging and Household Plastics 265 297 .
Jörn Lötsch, Gisbert Schneider, Daniel Reker, Michael J. Parnham, Petra Schneider, Gerd Geisslinger & Alexandra Doehring. (2013) Common non-epigenetic drugs as epigenetic modulators. Trends in Molecular Medicine 19:12, pages 742-753.
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Steffen Schneider, Heike Marxfeld, Sibylle Gröters, Roland Buesen & Bennard van Ravenzwaay. (2013) Vinclozolin—No transgenerational inheritance of anti-androgenic effects after maternal exposure during organogenesis via the intraperitoneal route. Reproductive Toxicology 37, pages 6-14.
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Frank A Barile. 2013. Principles of Toxicology Testing. Principles of Toxicology Testing 118 127 .
Emmanuel Somm, Christelle Stouder & Ariane Paoloni-Giacobino. (2013) Effect of developmental dioxin exposure on methylation and expression of specific imprinted genes in mice. Reproductive Toxicology 35, pages 150-155.
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Alexandra Doehring, Bruno Georg Oertel, Reinhard Sittl & Jörn Lötsch. (2013) Chronic opioid use is associated with increased DNA methylation correlating with increased clinical pain. Pain 154:1, pages 15-23.
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Igor P. Pogribny & Ivan Rusyn. 2013. Epigenetic Alterations in Oncogenesis. Epigenetic Alterations in Oncogenesis 215 232 .
Rebecca A. Alyea, Nigel P. Moore, Matthew J. LeBaron, B. Bhaskar Gollapudi & Reza J. Rasoulpour. (2012) Is the current product safety assessment paradigm protective for epigenetic mechanisms?. Journal of Pharmacological and Toxicological Methods 66:3, pages 207-214.
Crossref
Harri Lempiäinen, Raphaëlle Luisier, Arne Müller, Philippe Marc, David Heard, Federico Bolognani, Pierre Moulin, Philippe Couttet, Olivier Grenet, Jennifer Marlowe, Jonathan Moggs & Rémi Terranova. 2012. Toxicology and Epigenetics. Toxicology and Epigenetics 365 385 .

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