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Review Article

Ochratoxin A and its effects on immunity

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Pages 11-20 | Received 15 May 2014, Accepted 22 Aug 2014, Published online: 22 Sep 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Ahrar Khan, Muhammad Mustjab Aalim, Muhammad Zargham Khan, M. Kashif Saleemi, Cheng He, Aisha Khatoon & Shafia Tehseen Gul. (2017) Amelioration of immunosuppressive effects of aflatoxin and ochratoxin A in White Leghorn layers with distillery yeast sludge. Toxin Reviews 36:4, pages 275-281.
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Yan Zhao, Li-Hong Wan, Xiao-Lin Bai, Yi-Ming Liu, Feng-Ping Zhang, Yao-Min Liu & Xun Liao. (2017) Quantification of mycotoxins in vegetable oil by UPLC-MS/MS after magnetic solid-phase extraction. Food Additives & Contaminants: Part A 34:7, pages 1201-1210.
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Tao Zhao, Xiao Li Shen, Wenying Chen, Xin Liao, Jieyeqi Yang, Yan Wang, Yan Zou & Cuilan Fang. (2017) Advances in research of nephrotoxicity and toxic antagonism of ochratoxin A. Toxin Reviews 36:1, pages 39-44.
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Articles from other publishers (29)

Weiqing Ma, Yang Fu, Shanshan Zhu, Daiyang Xia, Shuangshuang Zhai, Deqin Xiao, Yongwen Zhu, Michel Dione, Lukuyu Ben, Lin Yang & Wence Wang. (2023) Ochratoxin A induces abnormal tryptophan metabolism in the intestine and liver to activate AMPK signaling pathway. Journal of Animal Science and Biotechnology 14:1.
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Danielle Cardoso Gimenes, Mario Augusto Ono, Igor Massahiro de Souza Suguiura, Rafaela Macagnan, Daniele Sartori, Dionisio Borsato, Maria Helena Pelegrinelli Fungaro & Elisabete Yurie Sataque Ono. (2023) Yeasts as sustainable biocontrol agents against ochratoxigenic Aspergillus species and in vitro optimization of ochratoxin A detoxification . Journal of Applied Microbiology 134:8.
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A. CimbaloM. FrangiamoneM. LozanoL. EscriváP. Vila-DonatL. Manyes. (2023) Protective role of fermented whey and pumpkin extract against aflatoxin B 1 and ochratoxin A toxicity in Jurkat T-cells . World Mycotoxin Journal 16:2, pages 165-178.
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Kseniya V. Serebrennikova, Alexey V. Samokhvalov, Anatoly V. Zherdev & Boris B. Dzantiev. (2022) A fluorescence immunosensor for ochratoxin A based on resonance energy transfer between fluorescein derivative and gold nanoparticles. Journal of Food Composition and Analysis 114, pages 104806.
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Daniela Eliza Marin, Gina Cecilia Pistol, Cristina Valeria Procudin & Ionelia Taranu. (2022) Co-Contamination of Food and Feed with Mycotoxin and Bacteria and Possible Implications for Health. Agriculture 12:11, pages 1970.
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L.E. Carter, S. Bugiel, A. Nunnikhoven, A.J. Verster, G.S. Bondy & I.H.A. Curran. (2022) Genomic analysis of Fisher F344 rat kidneys from a reproductive study following dietary ochratoxin A exposure. Food and Chemical Toxicology 167, pages 113302.
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Rui Zheng, Hanrui Qing, Qiugang Ma, Xueting Huo, Shimeng Huang, Lihong Zhao, Jianyun Zhang & Cheng Ji. (2022) A Newly Isolated Alcaligenes faecalis ANSA176 with the Capability of Alleviating Immune Injury and Inflammation through Efficiently Degrading Ochratoxin A. Toxins 14:8, pages 569.
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Gengan Du, Shuaidan Chang, Qi Guo, Xiaohai Yan, Hong Chen, Kehan Shi, Yahong Yuan & Tianli Yue. (2022) Protective effects of Tibetan kefir in mice with ochratoxin A-induced cecal injury. Food Research International 158, pages 111551.
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Wen-Chao Liu, Karthika Pushparaj, Arun Meyyazhagan, Vijaya Anand Arumugam, Manikantan Pappuswamy, Haripriya Kuchi Bhotla, Rathinasamy Baskaran, Utthapon Issara, Balamuralikrishnan Balasubramanian & Amin Mousavi Khaneghah. (2022) Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis. Toxicon 213, pages 59-75.
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Lan Wang, Xia Hua, Jie Shi, Ninghao Jing, Ting Ji, Bing Lv, Lijun Liu & Yun Chen. (2022) Ochratoxin A: Occurrence and recent advances in detoxification. Toxicon 210, pages 11-18.
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Mikela Vlachou, Andreana Pexara, Nikolaos Solomakos & Alexander Govaris. (2022) Ochratoxin A in Slaughtered Pigs and Pork Products. Toxins 14:2, pages 67.
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Rehab E. Abdelrahman, Abdel Azeim A. Khalaf, Mohamed A. Elhady, Marwa A. Ibrahim, Eman I. Hassanen & Peter A. Noshy. (2022) Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway. Chemico-Biological Interactions 351, pages 109720.
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Ramesh C. Gupta, Robin B. Doss, Rajiv Lall, Ajay Srivastava & Anita Sinha. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 983 1002 .
Iulian Alexandru Grosu, Ana Elena Cismileanu, Daniela Eliza Marin & Ionelia Taranu. (2021) The effects of a low dose OTA exposure on weanling piglet gut microbiota. Archiva Zootechnica 24:1, pages 31-43.
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Avinash Kumar Singh, G. B. V. S. Lakshmi, Tarun Kumar Dhiman, Ajeet Kaushik & Pratima R. Solanki. (2021) Bio-Active Free Direct Optical Sensing of Aflatoxin B1 and Ochratoxin A Using a Manganese Oxide Nano-System. Frontiers in Nanotechnology 2.
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Roua Gabriela Popescu, Cristina Bulgaru, Arabela Untea, Mihaela Vlassa, Miuta Filip, Anca Hermenean, Daniela Marin, Ionelia Țăranu, Sergiu Emil Georgescu & Anca Dinischiotu. (2021) The Effectiveness of Dietary Byproduct Antioxidants on Induced CYP Genes Expression and Histological Alteration in Piglets Liver and Kidney Fed with Aflatoxin B1 and Ochratoxin A. Toxins 13:2, pages 148.
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Kamal Niaz, Syed Zahid Ali Shah, Fazlullah Khan & Mohammed Bule. (2020) Ochratoxin A–induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies. Environmental Science and Pollution Research 27:36, pages 44673-44700.
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Pradeep Kumar, Dipendra Kumar Mahato, Bharti Sharma, Rituraj Borah, Shafiul Haque, M.M. Chayan Mahmud, Ajay Kumar Shah, Deepaksshi Rawal, Himashree Bora & Sukni Bui. (2020) Ochratoxins in food and feed: Occurrence and its impact on human health and management strategies. Toxicon 187, pages 151-162.
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Ajwad A. M. Assumaidaee, Nathera M. Ali & Shahad W. Ahmed. (2020) Zearalenone Mycotoxicosis: Pathophysiology and Immunotoxicity. The Iraqi Journal of Veterinary Medicine 44:1, pages 29-38.
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Chen Li, Wenying Chen, Lirong Zheng, Boyang Zhang, Xuqin Yang, Qipeng Zhang, Ning Wang, Yan Wang, Jieyeqi Yang, Jingzhou Sha, Zheng Zhou, Xiaohong Li, Yuzhe Li & Xiao Li Shen. (2019) Ameliorative effect of ursolic acid on ochratoxin A-induced renal cytotoxicity mediated by Lonp1/Aco2/Hsp75. Toxicon 168, pages 141-146.
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Sheraz Ahmed Bhatti, Muhammad Zargham Khan, Muhammad Kashif Saleemi & Zahoor Ul Hassan. (2019) Impact of dietary Trichosporon mycotoxinivorans on ochratoxin A induced immunotoxicity; In vivo study. Food and Chemical Toxicology 132, pages 110696.
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Zsolt Csenki, Edina Garai, Anita Risa, Mátyás Cserháti, Katalin Bakos, Dalma Márton, Zoltán Bokor, Balázs Kriszt & Béla Urbányi. (2019) Biological evaluation of microbial toxin degradation by microinjected zebrafish (Danio rerio) embryos. Chemosphere 227, pages 151-161.
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Wenying Chen, Chen Li, Boyang Zhang, Zheng Zhou, Yingbin Shen, Xin Liao, Jieyeqi Yang, Yan Wang, Xiaohong Li, Yuzhe Li & Xiao L. Shen. (2018) Advances in Biodetoxification of Ochratoxin A-A Review of the Past Five Decades. Frontiers in Microbiology 9.
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Ramesh C. Gupta, Ajay Srivastava & Rajiv Lall. 2018. Veterinary Toxicology. Veterinary Toxicology 1019 1027 .
Daniela E. Marin, Gina C. Pistol, Mihai A. Gras, Mihai L. Palade & Ionelia Taranu. (2017) Comparative effect of ochratoxin A on inflammation and oxidative stress parameters in gut and kidney of piglets. Regulatory Toxicology and Pharmacology 89, pages 224-231.
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Daniela Eliza Marin, Cornelia Braicu, Mihai Alexandru Gras, Gina Cecilia Pistol, Roxana Cojocneanu Petric, Ioana Berindan Neagoe, Mihai Palade & Ionelia Taranu. (2017) Low level of ochratoxin A affects genome-wide expression in kidney of pig. Toxicon 136, pages 67-77.
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Alexey V. Samokhvalov, Irina V. Safenkova, Sergei A. Eremin, Anatoly V. Zherdev & Boris B. Dzantiev. (2017) Use of anchor protein modules in fluorescence polarisation aptamer assay for ochratoxin A determination. Analytica Chimica Acta 962, pages 80-87.
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Ramesh C. Gupta, Michelle A. Lasher, Ida R. Miller Mukherjee, Ajay Srivastava & Rajiv Lall. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 945 962 .
Youssef Darif, Driss Mountassif, Abdelkarim Belkebir, Younes Zaid, Kaustuv Basu, Walid Mourad & Mounia Oudghiri. (2016) Ochratoxin A mediates MAPK activation, modulates <i>IL-2</i> and <i>TNF-α</i> mRNA expression and induces apoptosis by mitochondria-dependent and mitochondria-independent pathways in human H9 T cells. The Journal of Toxicological Sciences 41:3, pages 403-416.
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