652
Views
63
CrossRef citations to date
0
Altmetric
Original Article

Copper oxide nanoparticles aggravate airway inflammation and mucus production in asthmatic mice via MAPK signaling

, , , , , , , , & show all
Pages 445-452 | Received 17 Oct 2014, Accepted 08 Jul 2015, Published online: 15 Oct 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Wells Utembe, Charlene Andraos & Mary Gulumian. (2023) Immunotoxicity of engineered nanomaterials and their role in asthma. Critical Reviews in Toxicology 53:8, pages 491-505.
Read now
Yuanbao Zhang, Yiqun Mo, Jiali Yuan, Yue Zhang, Luke Mo & Qunwei Zhang. (2021) MMP-3 activation is involved in copper oxide nanoparticle-induced epithelial-mesenchymal transition in human lung epithelial cells. Nanotoxicology 15:10, pages 1380-1402.
Read now
Hui He, Zhen Zou, Bin Wang, Ge Xu, Chengzhi Chen, Xia Qin, Chao Yu & Jun Zhang. (2020) Copper Oxide Nanoparticles Induce Oxidative DNA Damage and Cell Death via Copper Ion-Mediated P38 MAPK Activation in Vascular Endothelial Cells. International Journal of Nanomedicine 15, pages 3291-3302.
Read now
Cheng Teng Ng, Liya E Yu, Choon Nam Ong, Boon Huat Bay & Gyeong Hun Baeg. (2019) The use of Drosophila melanogaster as a model organism to study immune-nanotoxicity. Nanotoxicology 13:4, pages 429-446.
Read now
Katherine A. Roach, Aleksandr B. Stefaniak & Jenny R. Roberts. (2019) Metal nanomaterials: Immune effects and implications of physicochemical properties on sensitization, elicitation, and exacerbation of allergic disease. Journal of Immunotoxicology 16:1, pages 87-124.
Read now
In-Chul Lee, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, In-Sik Shin, Changjong Moon, Sung-Ho Kim, Won-Kee Yun, Hyoung-Chin Kim & Jong-Choon Kim. (2018) Copper nanoparticles induce early fibrotic changes in the liver via TGF-β/Smad signaling and cause immunosuppressive effects in rats. Nanotoxicology 12:6, pages 637-651.
Read now
Je-Won Ko, Na-Rae Shin, Ji-Won Park, Sung-Hyeuk Park, In-Chul Lee, Joong-Sun Kim, Jong-Choon Kim, Kyung-Seop Ahn & In-Sik Shin. (2018) Copper oxide nanoparticles induce collagen deposition via TGF-β1/Smad3 signaling in human airway epithelial cells. Nanotoxicology 12:3, pages 239-250.
Read now

Articles from other publishers (56)

Dong Yiming, Abdullah R Alzahrani & Abubucker Peer Mohideen. (2023) Plumbagin Attenuates Ovalbumin-induced Allergic Asthma in Mice through Inhibition of Inflammatory Response. Pharmacognosy Magazine.
Crossref
Qais Jarrar, Mansour Almansour, Bashir Jarrar, Amin Al-Doaiss & Ali Shati. (2023) Hepatic ultrastructural alterations induced by copper oxide nanoparticles: In vivo electron microscopy study. Toxicology and Industrial Health 39:11, pages 651-663.
Crossref
Sudartip Areecheewakul, Andrea Adamcakova-Dodd, Zeb R. Zacharias, Xuefang Jing, David K. Meyerholz, Kevin L. Legge, Jon C. D. Houtman, Patrick T. O’Shaughnessy, Peter S. Thorne & Aliasger K. Salem. (2023) Immunomodulatory Effects of Subacute Inhalation Exposure to Copper Oxide Nanoparticles in House Dust Mite-Induced Asthma. ACS Nano 17:15, pages 14586-14603.
Crossref
Ibraheem Akram Omar Alhirmizi, Fatma Uysal, Seyfullah Oktay Arslan, Saliha Ayşenur Çam Özünlü, Ayşegül Koç, Ali Parlar & Keziban Korkmaz Bayram. (2023) Fenofibrate attenuates asthma features in an ovalbumin-induced mouse model via suppressing NF-κB binding activity. Respiratory Physiology & Neurobiology 314, pages 104083.
Crossref
Mohammad Ehsan Taghavizadeh Yazdi, Mohsen Qayoomian, Sima Beigoli & Mohammad Hossein Boskabady. (2023) Recent advances in nanoparticle applications in respiratory disorders: a review. Frontiers in Pharmacology 14.
Crossref
Chloé Puisney-Dakhli, Evdokia K. Oikonomou, Mickaël Tharaud, Yann Sivry, Jean-François Berret & Armelle Baeza-Squiban. (2023) Effects of brake wear nanoparticles on the protection and repair functions of the airway epithelium. Environmental Pollution 327, pages 121554.
Crossref
Sohi Kang, Hae-June Lee, Yeonghoon Son, Min Ji Bae, Wol Soon Jo, Jun Hong Park, Sohee Jeong, Changjong Moon, In-Sik Shin, Chang Geun Lee & Joong Sun Kim. (2023) Low-dose-rate gamma radiation aggravates titanium dioxide nanoparticle-induced lung injury in mice. Molecular & Cellular Toxicology.
Crossref
Huidan Deng, Song Zhu, Huiru Yang, Hengmin Cui, Hongrui Guo, Junliang Deng, Zhihua Ren, Yi Geng, Ping Ouyang, Zhiwen Xu, Youtian Deng & Yanqiu Zhu. (2022) The Dysregulation of Inflammatory Pathways Triggered by Copper Exposure. Biological Trace Element Research 201:2, pages 539-548.
Crossref
Yu Zheng, Yuxin Zhao, Mengting Bai, Huang Gu & Xiaofang Li. (2022) Metal–organic frameworks as a therapeutic strategy for lung diseases. Journal of Materials Chemistry B 10:30, pages 5666-5695.
Crossref
Sudartip Areecheewakul, Andrea Adamcakova-Dodd, Ezazul Haque, Xuefang Jing, David K. Meyerholz, Patrick T. O’Shaughnessy, Peter S. Thorne & Aliasger K. Salem. (2022) Time course of pulmonary inflammation and trace element biodistribution during and after sub-acute inhalation exposure to copper oxide nanoparticles in a murine model. Particle and Fibre Toxicology 19:1.
Crossref
Mahyar Aghapour, Niki D. Ubags, Dunja Bruder, Pieter S. Hiemstra, Venkataramana Sidhaye, Fariba Rezaee & Irene H. Heijink. (2022) Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD. European Respiratory Review 31:163, pages 210112.
Crossref
Jevin Büttner, Thomas Schneider, Martin Westermann & Michael Glei. (2022) Artificial Digestion of Polydisperse Copper Oxide Nanoparticles: Investigation of Effects on the Human In Vitro Intestinal Co-Culture Model Caco-2/HT29-MTX. Toxics 10:3, pages 130.
Crossref
Hyeon Hwa Nam, Ji Hye Lee, Seung Mok Ryu, Sueun Lee, Sungyu Yang, Pureum Noh, Byung Cheol Moon, Joong Sun Kim & Yun-Soo Seo. (2022) Gekko gecko extract attenuates airway inflammation and mucus hypersecretion in a murine model of ovalbumin-induced asthma. Journal of Ethnopharmacology 282, pages 114574.
Crossref
So-Won Pak, A Yeong Lee, Yun-Soo Seo, Se-Jin Lee, Woong-Il Kim, Dong-Ho Shin, Jong-Choon Kim, Joong-Sun Kim, Je-Oh Lim & In-Sik Shin. (2022) Anti-asthmatic effects of Phlomis umbrosa Turczaninow using ovalbumin induced asthma murine model and network pharmacology analysis. Biomedicine & Pharmacotherapy 145, pages 112410.
Crossref
Gaurang Patel, Chayan Patra, S. P. Srinivas, Mamta Kumawat, P. N. Navya & Hemant Kumar Daima. (2021) Methods to evaluate the toxicity of engineered nanomaterials for biomedical applications: a review. Environmental Chemistry Letters 19:6, pages 4253-4274.
Crossref
Ralph A. Pietrofesa, Kyewon Park, Om P. Mishra, Darrah Johnson-McDaniel, Jacob W. Myerson, Vladimir V. Shuvaev, Evguenia Arguiri, Shampa Chatterjee, Ganesh S. Moorthy, Athena Zuppa, Wei-Ting Hwang & Melpo Christofidou-Solomidou. (2021) Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605). International Journal of Molecular Sciences 22:17, pages 9477.
Crossref
Wenhui Zhang, Yingling Zhang, Simin Chen, Hong Zhang, Man Yuan, Lianbo Xiao, Yue Lu & Hongxi Xu. (2021) Trigonelline, An Alkaloid From Leonurus japonicus Houtt., Suppresses Mast Cell Activation and OVA-Induced Allergic Asthma. Frontiers in Pharmacology 12.
Crossref
Zhihui Wang & Meng Tang. (2020) Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells. Journal of Applied Toxicology 41:5, pages 683-700.
Crossref
Domniki Fragou & Leda Kovatsi. 2021. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure 451 457 .
Ayse Basak Engin. 2021. Protein Kinase-mediated Decisions Between Life and Death. Protein Kinase-mediated Decisions Between Life and Death 165 193 .
Jing Ding, Jin Liu, Xian Bo Chang, Dong Zhu & Simon Bo Lassen. (2020) Exposure of CuO nanoparticles and their metal counterpart leads to change in the gut microbiota and resistome of collembolans. Chemosphere 258, pages 127347.
Crossref
Je-Oh Lim, Je-Won Ko, Tae-Yang Jung, Woong-Il Kim, So-Won Pak, In-Sik Shin, Won-Kee Yun, Hyoung-Chin Kim, Jeong-Doo Heo & Jong-Choon Kim. (2020) Pulmonary inflammation caused by silica dioxide nanoparticles in mice via TXNIP/NLRP3 signaling pathway. Molecular & Cellular Toxicology 16:3, pages 245-252.
Crossref
Nemi Malhotra, Tzong-Rong Ger, Boontida Uapipatanakul, Jong-Chin Huang, Kelvin H.-C. Chen & Chung-Der Hsiao. (2020) Review of Copper and Copper Nanoparticle Toxicity in Fish. Nanomaterials 10:6, pages 1126.
Crossref
Je-Won Ko, Na-Rae Shin, Lim Je-Oh, Tae-Yang Jung, Changjong Moon, Tae-Won Kim, Jungil Choi, In-Sik Shin, Jeong-Doo Heo & Jong-Choon Kim. (2020) Silica dioxide nanoparticles aggravate airway inflammation in an asthmatic mouse model via NLRP3 inflammasome activation. Regulatory Toxicology and Pharmacology 112, pages 104618.
Crossref
Pooja Malaviya, Dhaval Shukal & Abhay R. Vasavada. (2020) Nanotechnology-based Drug Delivery, Metabolism and Toxicity. Current Drug Metabolism 20:14, pages 1167-1190.
Crossref
Anastasios A. Malandrakis, Nektarios Kavroulakis & Constantinos V. Chrysikopoulos. (2020) Synergy between Cu-NPs and fungicides against Botrytis cinerea. Science of The Total Environment 703, pages 135557.
Crossref
Harri Alenius & Kai Savolainen. 2020. Interaction of Nanomaterials with the Immune System. Interaction of Nanomaterials with the Immune System 149 165 .
Marit Ilves, Pia Anneli Sofia Kinaret, Joseph Ndika, Piia Karisola, Veer Marwah, Vittorio Fortino, Yuri Fedutik, Manuel Correia, Nicky Ehrlich, Katrin Loeschner, Alexandros Besinis, Joanne Vassallo, Richard D. Handy, Henrik Wolff, Kai Savolainen, Dario Greco & Harri Alenius. (2019) Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation. Particle and Fibre Toxicology 16:1.
Crossref
Haiyan Cui, Jiawei Huang, Manman Lu, Qian Zhang, Wei Qin, Yun Zhao, Xianxian Lu, Jiting Zhang, Zhuge Xi & Rui Li. (2019) Antagonistic effect of vitamin E on nAl2O3-induced exacerbation of Th2 and Th17-mediated allergic asthma via oxidative stress. Environmental Pollution 252, pages 1519-1531.
Crossref
Han‑Sol Lee, Ji‑Won Park, Ok‑Kyoung Kwon, Yourim Lim, Jung Kim, Soo‑Yong Kim, Nelson Zamora, Kattia Rosales, Sangho Choi, Sei‑Ryang Oh & Kyung‑Seop Ahn. (2019) Anti‑inflammatory effects of ethanol extract from the leaves and shoots of Cedrela odorata L. in cytokine‑stimulated keratinocytes. Experimental and Therapeutic Medicine.
Crossref
Anastasios A. Malandrakis, Nektarios Kavroulakis & Constantinos V. Chrysikopoulos. (2019) Use of copper, silver and zinc nanoparticles against foliar and soil-borne plant pathogens. Science of The Total Environment 670, pages 292-299.
Crossref
Zorawar Singh. (2019) Alteration in Morphological and Toxicological Properties of Copper Oxide Nano-particles: The pH Effect. Journal of Applied Sciences 19:2, pages 148-155.
Crossref
Yubin Li, Jiajun Fan & Dianwen Ju. 2019. Brain Targeted Drug Delivery System. Brain Targeted Drug Delivery System 377 408 .
Ravindra Pratap Singh. 2019. Plant Nanobionics. Plant Nanobionics 115 176 .
Huimin Liang, Aijie Chen, Xuan Lai, Jia Liu, Junrong Wu, Yiyuan Kang, Xinying Wang & Longquan Shao. (2018) Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-κB and MAPK pathways. Particle and Fibre Toxicology 15:1.
Crossref
Jun Zhang, Bin Wang, Hong Wang, Hui He, Qiong Wu, Xia Qin, Xi Yang, Linmu Chen, Ge Xu, Zhiyi Yuan, Qiying Yi, Zhen Zou & Chao Yu. (2018) Disruption of the superoxide anions-mitophagy regulation axis mediates copper oxide nanoparticles-induced vascular endothelial cell death. Free Radical Biology and Medicine 129, pages 268-278.
Crossref
Eugene Baeg, Kanidta Sooklert & Amornpun Sereemaspun. (2018) Copper Oxide Nanoparticles Cause a Dose-Dependent Toxicity via Inducing Reactive Oxygen Species in Drosophila. Nanomaterials 8:10, pages 824.
Crossref
Su-Ui Lee, Hyung Won Ryu, Seoghyun Lee, In-Sik Shin, Ji-Hee Choi, Jae-Won Lee, Jinhyuk Lee, Mun Ock Kim, Hyun-Jun Lee, Kyung-Seop Ahn, Sung-Tae Hong & Sei-Ryang Oh. (2018) Lignans Isolated From Flower Buds of Magnolia fargesii Attenuate Airway Inflammation Induced by Cigarette Smoke in vitro and in vivo. Frontiers in Pharmacology 9.
Crossref
Je-Won Ko, Hae-Jun Lee, Na-Rae Shin, Yun-Soo Seo, Sung-Ho Kim, In-Sik Shin & Joong-Sun Kim. (2018) Silicon Dioxide Nanoparticles Enhance Endotoxin-Induced Lung Injury in Mice. Molecules 23:9, pages 2247.
Crossref
Na-Rae Shin, Sung-Hyeuk Park, Je-Won Ko, Young-Kwon Cho, In-Chul Lee, Jong-Choon Kim, In-Sik Shin & Joong-Sun Kim. (2018) Lobeglitazone Attenuates Airway Inflammation and Mucus Hypersecretion in a Murine Model of Ovalbumin-Induced Asthma. Frontiers in Pharmacology 9.
Crossref
Ewelina Cholewińska, Jerzy Juśkiewicz & Katarzyna Ognik. (2018) Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model. Journal of Trace Elements in Medicine and Biology 48, pages 111-117.
Crossref
Jun Zhang, Zhen Zou, Bin Wang, Ge Xu, Qiong Wu, Yuchan Zhang, Zhiyi Yuan, Xi Yang & Chao Yu. (2018) Lysosomal deposition of copper oxide nanoparticles triggers HUVEC cells death. Biomaterials 161, pages 228-239.
Crossref
Xiaofeng Lai, Hu Zhao, Yong Zhang, Kai Guo, Yuqiao Xu, Suning Chen & Jian Zhang. (2018) Intranasal Delivery of Copper Oxide Nanoparticles Induces Pulmonary Toxicity and Fibrosis in C57BL/6 mice. Scientific Reports 8:1.
Crossref
Ji-Won Park, Ok-Kyoung Kwon, Hyung Ryu, Jin-Hyub Paik, Imam Paryanto, Prasetyawan Yuniato, Sangho Choi, Sei-Ryang Oh & Kyung-Seop Ahn. (2018) Anti-inflammatory effects of Passiflora foetida L. in LPS-stimulated RAW264.7 macrophages. International Journal of Molecular Medicine.
Crossref
Ji‑Won Park, Han‑Sol Lee, Yourim Lim, Jin‑Hyub Paik, Ok‑Kyoung Kwon, Jung‑Hee Kim, Imam Paryanto, Prasetyawan Yunianto, Sangho Choi, Sei‑Ryang Oh & Kyung‑Seop Ahn. (2018) Rhododendron album Blume extract inhibits TNF-α/IFN-γ-induced chemokine production via blockade of NF-κB and JAK/STAT activation in human epidermal keratinocytes. International Journal of Molecular Medicine.
Crossref
Mark D. Ihrie & James C. Bonner. (2018) The Toxicology of Engineered Nanomaterials in Asthma. Current Environmental Health Reports 5:1, pages 100-109.
Crossref
Cezary Pałczyński & Maciej Kupczyk. 2018. Metal Allergy. Metal Allergy 533 544 .
Ji-Won Park, Ok-Kyoung Kwon, Sei-Ryang Oh, Joongku Lee, Sangmi Eum, Samnang Nguon, Sang Ho Choi, Piseth Khiev & Kyung-Seop Ahn. (2017) Dipterocarpus obtusifolius attenuates the effects of lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. Molecular Medicine Reports 16:6, pages 8463-8470.
Crossref
Kirsty Meldrum, Chang Guo, Emma L. Marczylo, Timothy W. Gant, Rachel Smith & Martin O. Leonard. (2017) Mechanistic insight into the impact of nanomaterials on asthma and allergic airway disease. Particle and Fibre Toxicology 14:1.
Crossref
Belinda Shu Ee Wong, Qidong Hu & Gyeong Hun Baeg. (2017) Epigenetic modulations in nanoparticle-mediated toxicity. Food and Chemical Toxicology 109, pages 746-752.
Crossref
Marina A. Dobrovolskaia, Michael R. Shurin, Valerian E. Kagan & Anna A. Shvedova. (2017) Ins and Outs in Environmental and Occupational Safety Studies of Asthma and Engineered Nanomaterials. ACS Nano 11:8, pages 7565-7571.
Crossref
Arturo A. Keller, Adeyemi S. Adeleye, Jon R. Conway, Kendra L. Garner, Lijuan Zhao, Gary N. Cherr, Jie Hong, Jorge L. Gardea-Torresdey, Hilary A. Godwin, Shannon Hanna, Zhaoxia Ji, Chitrada Kaweeteerawat, Sijie Lin, Hunter S. Lenihan, Robert J. Miller, André E. Nel, Jose R. Peralta-Videa, Sharon L. Walker, Alicia A. Taylor, Cristina Torres-Duarte, Jeffrey I. Zink & Nubia Zuverza-Mena. (2017) Comparative environmental fate and toxicity of copper nanomaterials. NanoImpact 7, pages 28-40.
Crossref
Jae-Won Lee, Ji-Won Park, Ok-Kyoung Kwon, Hee Jae Lee, Hye Gwang Jeong, Jae-Hong Kim, Sei-Ryang Oh & Kyoung-Seop Ahn. (2016) NPS2143 Inhibits MUC5AC and Proinflammatory Mediators in Cigarette Smoke Extract (CSE)-Stimulated Human Airway Epithelial Cells. Inflammation 40:1, pages 184-194.
Crossref
Jean Cornier, Andrew Owen, Arno Kwade & Marcel Van de VoordeMarina A. Dobrovolskaia. 2017. Pharmaceutical Nanotechnology: Innovation and Production. Pharmaceutical Nanotechnology: Innovation and Production 425 442 .
Ji-Won Park, Yong-Jae Kim, In-Sik Shin, Ok-Kyoung Kwon, Ju Mi Hong, Na-Rae Shin, Sei-Ryang Oh, Un-Hwan Ha, Jae-Hong Kim & Kyung-Seop Ahn. (2016) Type III Secretion System of Pseudomonas aeruginosa Affects Matrix Metalloproteinase 12 (MMP-12) and MMP-13 Expression via Nuclear Factor κB Signaling in Human Carcinoma Epithelial Cells and a Pneumonia Mouse Model . Journal of Infectious Diseases 214:6, pages 962-969.
Crossref
Daqing Sun, Jing Wang, Niandi Yang & Haixin Ma. (2016) Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice. Biochemical and Biophysical Research Communications 477:1, pages 83-90.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.