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ORIGINAL ARTICLE

Concomitant iguratimod therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a randomized, double-blind, placebo-controlled trial

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Pages 430-439 | Received 25 May 2012, Accepted 27 Jun 2012, Published online: 02 Jan 2014

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Kyosuke Hattori, Yuji Hirano, Yasuhide Kanayama, Yosuke Hattori, Takefumi Kato, Nobunori Takahashi, Naoki Ishiguro & Toshihisa Kojima. (2021) Efficacy of add-on iguratimod in patients with rheumatoid arthritis who inadequately respond to either tocilizumab or tumor necrosis factor alpha inhibitors. Modern Rheumatology 31:1, pages 80-87.
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Yuki Arita, Hiroaki Taguchi, Mari Kobayashi, Toshihiro Tono, Yasuo Ohsone & Yutaka Okano. (2018) pneumonia developed in a patient with rheumatoid arthritis after 14 weeks of iguratimod add-on to treatment with methotrexate and etanercept. Modern Rheumatology 28:6, pages 1041-1043.
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Ayaka Yoshikawa, Shuzo Yoshida, Yuko Kimura, Nao Tokai, Yohei Fujiki, Takuya Kotani, Yoko Matsumura, Tohru Takeuchi & Shigeki Makino. (2018) Add-on iguratimod as a therapeutic strategy to achieve remission in patients with rheumatoid arthritis inadequately responding to biological DMARDs: A retrospective study. Modern Rheumatology 28:2, pages 227-234.
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Tsuneyo Mimori, Masayoshi Harigai, Tatsuya Atsumi, Takao Fujii, Masataka Kuwana, Hiroaki Matsuno, Shigeki Momohara, Syuji Takei, Naoto Tamura, Yoshinari Takasaki, Satoshi Ikeuchi, Satoru Kushimoto & Takao Koike. (2017) Safety and effectiveness of 24-week treatment with iguratimod, a new oral disease-modifying antirheumatic drug, for patients with rheumatoid arthritis: interim analysis of a post-marketing surveillance study of 2679 patients in Japan. Modern Rheumatology 27:5, pages 755-765.
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Koichi Okamura, Yukio Yonemoto, Takahito Suto, Chisa Okura & Kenji Takagishi. (2015) Efficacy at 52 weeks of daily clinical use of iguratimod in patients with rheumatoid arthritis. Modern Rheumatology 25:4, pages 534-539.
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Keiichi Tanaka, Tomonobu Yamaguchi & Masako Hara. (2015) Iguratimod for the treatment of rheumatoid arthritis in Japan. Expert Review of Clinical Immunology 11:5, pages 565-573.
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Koichi Okamura, Yukio Yonemoto, Chisa Okura, Tsutomu Kobayashi & Kenji Takagishi. (2015) Efficacy of the clinical use of iguratimod therapy in patients with rheumatoid arthritis. Modern Rheumatology 25:2, pages 235-240.
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Masako Hara, Naoki Ishiguro, Kou Katayama, Masakazu Kondo, Takayuki Sumida, Tsuneyo Mimori, Satoshi Soen, Kota Nagai, Tomonobu Yamaguchi & Kazuhiko Yamamoto. (2014) Safety and efficacy of combination therapy of iguratimod with methotrexate for patients with active rheumatoid arthritis with an inadequate response to methotrexate: An open-label extension of a randomized, double-blind, placebo-controlled trial. Modern Rheumatology 24:3, pages 410-418.
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Tianqi Zhang, Qin Shu, Huaijun Zhu, Min Wang, Na Yang, Huayong Zhang & Weihong Ge. (2023) Serum proteomics analysis of biomarkers for evaluating clinical response to MTX/IGU therapy in early rheumatoid arthritis. Molecular Immunology 153, pages 119-125.
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L.-J. Chen, Y.-J. Zhou, Z.-H. Wen, F. Tian & J.-Y. Li. (2020) Efficacy and safety of iguratimod combined with methotrexate vs. methotrexate alone in rheumatoid arthritisWirksamkeit und Sicherheit von Iguratimod in Kombination mit Methotrexat vs. Methotrexat allein bei rheumatoider Arthritis. Zeitschrift für Rheumatologie 80:5, pages 432-446.
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Yuji Nozaki. (2021) Iguratimod: Novel Molecular Insights and a New csDMARD for Rheumatoid Arthritis, from Japan to the World. Life 11:5, pages 457.
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Masao Tanaka. (2021) Conflict between efficacy and economy in rheumatoid arthritis treatment: Iguratimod is found at a compromise. The Lancet Regional Health - Western Pacific 10, pages 100144.
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Rong Mu, Chun Li, Xiaomei Li, Yao Ke, Ling Zhao, Lin Chen, Rui Wu, Zhenbiao Wu, Xiaoxia Zuo, Yanli Xie, Jinwei Chen, Wei Wei, Yi Liu, Zhijun Li, Lie Dai, Lingyun Sun, Xiangyuan Liu & Zhanguo Li. (2021) Effectiveness and safety of iguratimod treatment in patients with active rheumatoid arthritis in Chinese: A nationwide, prospective real-world study. The Lancet Regional Health - Western Pacific 10, pages 100128.
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Wei Jiang, Lingshu Zhang, Yi Zhao, Xiong He, Chunrong Hu & Yi Liu. (2020) The efficacy and mechanism for action of iguratimod in primary Sjögren’s syndrome patients. International Ophthalmology 40:11, pages 3059-3065.
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Asuka Inoue, Yuji Nozaki, Yasuaki Hirooka, Koji Kinoshita, Yasutaka Chiba, Masanori Funauchi & Itaru Matsumura. (2020) The Effectiveness and Retention Rate of Iguratimod in Japanese Rheumatoid Arthritis Patients with/without Methotrexate in Daily Medical Care. Life 10:11, pages 261.
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Adam Kilian, Yu Pei Chock, Irvin J. Huang, Elizabeth R. Graef, Laura A. Upton, Aneka Khilnani, Sonia D. Silinsky Krupnikova, Ibrahim Almaghlouth, Laura C. Cappelli, Ruth Fernandez-Ruiz, Brittany A. Frankel, Jourdan Frankovich, Carly Harrison, Bharat Kumar, Kanika Monga, Jorge A. Rosario Vega, Namrata Singh, Jeffrey A. Sparks, Elaine Sullo, Kristen J. Young, Ali Duarte-Garcia, Michael Putman, Sindhu Johnson, Rebecca Grainger, Zachary S. Wallace, Jean W. Liew & Aruni Jayatilleke. (2020) Acute respiratory viral adverse events during use of antirheumatic disease therapies: A scoping review. Seminars in Arthritis and Rheumatism 50:5, pages 1191-1201.
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Magdalena Massalska, Wlodzimierz Maslinski & Marzena Ciechomska. (2020) Small Molecule Inhibitors in the Treatment of Rheumatoid Arthritis and Beyond: Latest Updates and Potential Strategy for Fighting COVID-19. Cells 9:8, pages 1876.
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Huihui Jiang, Hongyan Gao, Qin Wang, Miao Wang & Bin Wu. (2020) Molecular mechanisms and clinical application of Iguratimod: A review. Biomedicine & Pharmacotherapy 122, pages 109704.
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Jie Li, Jun Bao, Jian Zeng, Aizhu Yan, Chunqiu Zhao & Qiang Shu. (2019) Iguratimod: a valuable remedy from the Asia Pacific region for ameliorating autoimmune diseases and protecting bone physiology. Bone Research 7:1.
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Ying Xia, Shunbo Zhao, Meng Gong & Li Ding. (2018) A rapid and sensitive LC-MS/MS method for analysis of iguratimod in human plasma: Application to a pharmacokinetic study in Chinese healthy volunteers. Biomedical Chromatography 32:9, pages e4277.
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Yoshitaka Morita. (2018) Treatment Update on Rheumatoid Arthritis関節リウマチの治療update. The Japanese Journal of Rehabilitation Medicine 55:4, pages 334-339.
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Feng Xiao, Feng Zhang, Ling-ling Zhang & Wei Wei. (2017) A randomized phase I study to evaluate the safety, tolerability, pharmacokinetics and food-effect of Iguratimod in healthy adult volunteers. European Journal of Clinical Pharmacology 74:1, pages 69-77.
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K. Morimoto, A. Miura & Keiichi Tanaka. (2017) Anti-allodynic action of the disease-modifying anti-rheumatic drug iguratimod in a rat model of neuropathic pain. Inflammation Research 66:10, pages 855-862.
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Z. Xia, J. Lyu, N. Hou, L. Song, X. Li & H. Liu. (2015) Iguratimod in combination with methotrexate in active rheumatoid arthritisIguratimod in Kombination mit Methotrexat bei aktiver rheumatoider Arthritis. Zeitschrift für Rheumatologie 75:8, pages 828-833.
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Tetsuya YamamotoKyoko HasegawaMakoto OnodaKeiichi Tanaka. (2016) Pharmacokinetic and Pharmacodynamic Analyses of Drug-Drug Interactions between Iguratimod and Warfarinイグラチモドとワルファリンとの薬物相互作用に対する薬物動態学的及び薬力学的解析. YAKUGAKU ZASSHI 136:6, pages 905-911.
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Jun Shiota, Hidetoshi Murao, Akihiko Miura, Masaaki Mikami & Keiichi Tanaka. (2016) Iguratimod, a Disease-Modifying Anti-Rheumatic Drug, Inhibits Osteoclastogenesis and Bone Resorption through Suppression of the Nuclear Factor of Activated T Cells Signaling Pathway. Open Journal of Rheumatology and Autoimmune Diseases 06:04, pages 106-119.
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Keiichi Tanaka, Jun Shiota, Masaaki Mikami, Yoko Inoue, Takayuki Sumida, Isao Matsumoto & Kenzo Muramoto. (2014) The combined effects of iguratimod with anti-TNF^|^alpha; antibody on experimental arthritis models in mice. Inflammation and Regeneration 34:3, pages 157-164.
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