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Clinical Focus: Diabetes

A Systematic Assessment of Cardiovascular Outcomes in the Saxagliptin Drug Development Program for Type 2 Diabetes

, MD, PhD, Director, , MD, MHS, FACC, , MD, , PhD, , BSc, , MS, , MD, , MD & , MD show all
Pages 16-27 | Published online: 13 Mar 2015

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Kazuki Orime & Yasuo Terauchi. (2020) Efficacy and safety of saxagliptin for the treatment of type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 21:17, pages 2101-2114.
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Vasilios G. Athyros, Konstantinos Imprialos, Konstantinos Stavropoulos, Alexandros Sahinidis & Michael Doumas. (2019) Understanding the cardiovascular risk with non-insulin antidiabetic drugs. Expert Opinion on Drug Safety 18:3, pages 241-251.
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Sooyoung Shin & Hyunah Kim. (2016) The effect of sitagliptin on cardiovascular risk profile in Korean patients with type 2 diabetes mellitus: a retrospective cohort study. Therapeutics and Clinical Risk Management 12, pages 435-444.
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Simona Cernea, Avivit Cahn & Itamar Raz. (2016) Saxagliptin for the treatment of diabetes - a focus on safety. Expert Opinion on Drug Safety 15:5, pages 697-707.
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Rose Anderson, Jennifer Hayes & Jeffrey W. Stephens. (2016) Pharmacokinetic, pharmacodynamic and clinical evaluation of saxagliptin in type 2 diabetes. Expert Opinion on Drug Metabolism & Toxicology 12:4, pages 467-473.
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Brian Tomlinson, Miao Hu, Yuzhen Zhang, Paul Chan & Zhong-Min Liu. (2016) An overview of new GLP-1 receptor agonists for type 2 diabetes. Expert Opinion on Investigational Drugs 25:2, pages 145-158.
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André J Scheen. (2015) Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opinion on Drug Safety 14:4, pages 505-524.
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Amir Hanna, Kim A Connelly, Robert G Josse & Roger S McIntyre. (2015) The non-glycemic effects of incretin therapies on cardiovascular outcomes, cognitive function and bone health. Expert Review of Endocrinology & Metabolism 10:1, pages 101-114.
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Hiroyuki Konya, Yuzo Yano, Satoshi Matsutani, Taku Tsunoda, Takashi Ikawa, Yoshiki Kusunoki, Toshihiro Matsuo, Masayuki Miuchi, Tomoyuki Katsuno, Tomoya Hamaguchi, Jun-ichiro Miyagawa & Mitsuyoshi Namba. (2014) Profile of saxagliptin in the treatment of type 2 diabetes: focus on Japanese patients. Therapeutics and Clinical Risk Management 10, pages 547-558.
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Jennifer B. Green. (2014) Understanding the Type 2 Diabetes Mellitus and Cardiovascular Disease Risk Paradox. Postgraduate Medicine 126:3, pages 190-204.
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Sheila A Doggrell & Simon B Dimmitt. (2014) Gliptins – do they increase cardiovascular risk or benefit?. Expert Opinion on Drug Safety 13:5, pages 675-680.
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Karoline von Websky, Christoph Reichetzeder & Berthold Hocher. (2013) Linagliptin as add-on therapy to insulin for patients with type 2 diabetes. Vascular Health and Risk Management 9, pages 681-694.
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Carolyn F Deacon & Jens J Holst. (2013) Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety. Expert Opinion on Pharmacotherapy 14:15, pages 2047-2058.
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Sana Khan, Saba Khan, Mohammed Imran, Krishna Kolappa Pillai, Mohd Akhtar & Abul Kalam Najmi. (2013) Effects of pioglitazone and vildagliptin on coagulation cascade in diabetes mellitus – targeting thrombogenesis. Expert Opinion on Therapeutic Targets 17:6, pages 627-639.
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Robert Chilton. (2013) Linagliptin versus glimepiride add-on for the long-term treatment of Type 2 diabetes mellitus. Expert Review of Endocrinology & Metabolism 8:4, pages 345-349.
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Stephanie Aleskow Stein, Elizabeth Mary Lamos & Stephen N Davis. (2013) A review of the efficacy and safety of oral antidiabetic drugs. Expert Opinion on Drug Safety 12:2, pages 153-175.
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Shamsa Ali & Vivian Fonseca. (2013) Saxagliptin overview: special focus on safety and adverse effects. Expert Opinion on Drug Safety 12:1, pages 103-109.
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Elizabeth Mary Lamos, Stephanie Aleskow Stein & Stephen N Davis. (2012) Combination of glibenclamide–metformin HCl for the treatment of type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 13:17, pages 2545-2554.
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Jennifer B. Green. (2012) The Dipeptidyl Peptidase-4 Inhibitors in Type 2 Diabetes Mellitus: Cardiovascular Safety. Postgraduate Medicine 124:4, pages 54-61.
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Edoardo Mannucci & Ilaria Dicembrini. (2012) Incretin-based therapies and cardiovascular risk. Current Medical Research and Opinion 28:5, pages 715-721.
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Sherwyn L. Schwartz. (2012) Saxagliptin for the treatment of type 2 diabetes mellitus: Focus on recent studies. Annals of Medicine 44:2, pages 157-169.
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Carolyn F Deacon & Nikolaus Marx. (2012) Potential cardiovascular effects of incretin-based therapies. Expert Review of Cardiovascular Therapy 10:3, pages 337-351.
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André J Scheen. (2012) Saxagliptin plus metformin combination in patients with type 2 diabetes and renal impairment. Expert Opinion on Drug Metabolism & Toxicology 8:3, pages 383-394.
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André J Scheen. (2012) A review of gliptins in 2011. Expert Opinion on Pharmacotherapy 13:1, pages 81-99.
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Caroline M Apovian. (2011) Management of diabetes across the course of disease: minimizing obesity-associated complications. Diabetes, Metabolic Syndrome and Obesity 4, pages 353-369.
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Matteo Monami, Ilaria Dicembrini, Daniele Martelli & Edoardo Mannucci. (2011) Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials. Current Medical Research and Opinion 27:sup3, pages 57-64.
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Isabelle Bourdel-Marchasson, Anja Schweizer & Sylvie Dejager. (2011) Incretin Therapies in the Management of Elderly Patients with Type 2 Diabetes Mellitus. Hospital Practice 39:1, pages 7-21.
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Paul S. Jellinger. (2011) Focus on Incretin-Based Therapies: Targeting the Core Defects of Type 2 Diabetes. Postgraduate Medicine 123:1, pages 53-65.
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Antonio R Chacra. (2010) Saxagliptin for type 2 diabetes. Diabetes, Metabolic Syndrome and Obesity 3, pages 325-335.
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