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Clinical Focus: Diabetes and Concomitant Disorders

Safety and Tolerability of Canagliflozin in Patients With Type 2 Diabetes Mellitus: Pooled Analysis of Phase 3 Study Results

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Emir Muzurović & Dimitri P Mikhailidis. (2020) Impact of glucagon-like peptide 1 receptor agonists and sodium-glucose transport protein 2 inhibitors on blood pressure and lipid profile. Expert Opinion on Pharmacotherapy 21:17, pages 2125-2135.
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Katherine Merton, Michael J. Davies, Ujjwala Vijapurkar, Doreen Inman & Gary Meininger. (2018) Achieving the composite endpoint of HbA1c, body weight, and systolic blood pressure reduction with canagliflozin in patients with type 2 diabetes. Current Medical Research and Opinion 34:2, pages 313-318.
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Rong Qiu, Dainius Balis, John Xie, Michael J. Davies, Mehul Desai & Gary Meininger. (2017) Longer-term safety and tolerability of canagliflozin in patients with type 2 diabetes: a pooled analysis. Current Medical Research and Opinion 33:3, pages 553-562.
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Puneet Gupta & William B. White. (2017) Cardiovascular safety of therapies for type 2 diabetes. Expert Opinion on Drug Safety 16:1, pages 13-25.
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Thomas C. Blevins & Azeez Farooki. (2017) Bone effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, in patients with type 2 diabetes mellitus. Postgraduate Medicine 129:1, pages 159-168.
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Matthew R. Weir. (2016) The kidney and type 2 diabetes mellitus: therapeutic implications of SGLT2 inhibitors. Postgraduate Medicine 128:3, pages 290-298.
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Vlado Perkovic, Meg Jardine, Ujjwala Vijapurkar & Gary Meininger. (2015) Renal effects of canagliflozin in type 2 diabetes mellitus. Current Medical Research and Opinion 31:12, pages 2219-2231.
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Lawrence Blonde, Vincent Woo, Chantal Mathieu, Jacqueline Yee, Ujjwala Vijapurkar, William Canovatchel & Gary Meininger. (2015) Achievement of treatment goals with canagliflozin in patients with type 2 diabetes mellitus: a pooled analysis of randomized controlled trials. Current Medical Research and Opinion 31:11, pages 1993-2000.
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Jaime A. Davidson & Louis Kuritzky. (2014) Sodium Glucose Co-Transporter 2 Inhibitors and Their Mechanism for Improving Glycemia in Patients with Type 2 Diabetes. Postgraduate Medicine 126:6, pages 33-48.
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Stephen Brunton & Timothy S. Reid. (2014) Canagliflozin, a Sodium Glucose Co-transporter 2 Inhibitor, for the Management of Type 2 Diabetes. Hospital Practice 42:3, pages 96-108.
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Articles from other publishers (64)

Tanvi Patil, Morgan Cook, Jesse Hobson, Alamdeep Kaur & Aliza Lee. (2023) Evaluating the Safety of Sodium-Glucose Cotransporter-2 Inhibitors in a Nationwide Veterans Health Administration Observational Cohort Study. The American Journal of Cardiology 201, pages 281-293.
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Sanobia Yousuf & Muhammad Yakoob Ahmedani. (2022) Efficacy and safety of empagliflozin in people with type 2 diabetes during Ramadan fasting. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 16:11, pages 102633.
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Sumanth KHAKDE, Hafsa JAWAID, Farah YASMIN, Mashal BINTE ALI & Abdur REHMAN. (2022) Is there a paradigm shift in preventing diabetic heart failure? A review of SGLT2 inhibitors. Minerva Endocrinology 47:3.
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Wajd Alkabbani, Arsène Zongo, Jasjeet K. Minhas-Sandhu, Dean T. Eurich, Baiju R. Shah, Mhd Wasem Alsabbagh & John-Michael Gamble. (2022) Sodium-Glucose Cotransporter-2 Inhibitors and Urinary Tract Infections: A Propensity Score–matched Population-based Cohort Study. Canadian Journal of Diabetes 46:4, pages 392-403.e13.
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Gang Chen, Xiaolin Li, Quexuan Cui, Yangzhong Zhou, Bin Zhao, Dan Mei & Xuemei. (2022) Acute kidney injury following SGLT2 inhibitors among diabetic patients: a pharmacovigilance study. International Urology and Nephrology 54:11, pages 2949-2957.
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Yi-Hsuan Lin, Chia-Hung Lin, Yu-Yao Huang, An-Shun Tai, Shih-Chen Fu, Szu-Tah Chen & Sheng-Hsuan Lin. (2022) Risk factors of first and recurrent genitourinary tract infection in patients with type 2 diabetes treated with SGLT2 inhibitors: A retrospective cohort study. Diabetes Research and Clinical Practice 186, pages 109816.
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Jie Yu, Jingwei Li, Phillip J Leaver, Clare Arnott, Mark D Huffman, Jacob A Udell, Vlado Perkovic, Kenneth W Mahaffey, Dick de Zeeuw, Greg Fulcher, David R Matthews, Wayne Shaw, Norman Rosenthal, Bruce Neal & Gemma A Figtree. (2022) Effects of canagliflozin on myocardial infarction: a post hoc analysis of the CANVAS programme and CREDENCE trial . Cardiovascular Research 118:4, pages 1103-1114.
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M. V. Shestakova, A. S. Ametov, M. B. Antsiferov, T. P. Bardymova, F. V. Valeeva, G. R. Galstyan, T. Yu. Demidova, I. A. Karpova, T. P. Kiseleva, A. Yu. Mayorov, A. M. Mkrtumyan, S. V. Nedogoda, N. А. Petunina, L. A. Ruyatkina, L. A. Suplotova, O. Yu. Sukhareva, V. V. Fadeev & M. S. Shamkhalova. (2022) Canagliflozin: from glycemic control to improvement of cardiovascular and renal prognosis in patients with type 2 diabetes mellitus. Resolution of Advisory Board. Diabetes mellitus 24:5, pages 479-486.
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Mohamed A. Morsy, Hanaa M. Khalaf, Rehab A. Rifaai, Asmaa M.A. Bayoumi, Esraa M.M.A. Khalifa & Yasmine F. Ibrahim. (2021) Canagliflozin, an SGLT-2 inhibitor, ameliorates acetic acid-induced colitis in rats through targeting glucose metabolism and inhibiting NOX2. Biomedicine & Pharmacotherapy 141, pages 111902.
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Daniele Scoccimarro, Giacomo Cipani, Ilaria Dicembrini & Edoardo Mannucci. (2021) Cigarette Smoking as a Predictor of Sodium–Glucose Cotransporter 2 Inhibitor–Associated Genital Infections: A Retrospective Cohort Study. Diabetes Care 44:6, pages e127-e128.
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Jawad H. Butt, Kieran F. Docherty, Mark C. Petrie, Morten Schou, Mikhail N. Kosiborod, Eileen O’Meara, Tzvetana Katova, Charlotta E. A. Ljungman, Mirta Diez, Modele O. Ogunniyi, Anna Maria Langkilde, Mikaela Sjöstrand, Daniel Lindholm, Olof Bengtsson, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Scott D. Solomon, Pardeep S. Jhund, John J. V. McMurray & Lars Køber. (2021) Efficacy and Safety of Dapagliflozin in Men and Women With Heart Failure With Reduced Ejection Fraction. JAMA Cardiology 6:6, pages 678.
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Matthew R Weir, April Slee, Tao Sun, Dainius Balis, Richard Oh, Dick de Zeeuw & Vlado Perkovic. (2021) Effects of canagliflozin on serum potassium in the CANagliflozin cardioVascular Assessment Study (CANVAS) Program. Clinical Kidney Journal 14:5, pages 1396-1402.
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Sutthichai Sae-Tia & Bettina C. Fries. 2021. Encyclopedia of Mycology. Encyclopedia of Mycology 719 725 .
Richard Pratley, Samuel Dagogo‐Jack, Bernard Charbonnel, Shrita Patel, Anne Hickman, Jie Liu, Lisa Tarasenko, Annpey Pong, Misoo C. Ellison, Susan Huyck, Ira Gantz & Steven G. Terra. (2020) Efficacy and safety of ertugliflozin in older patients with type 2 diabetes: A pooled analysis of phase III studies . Diabetes, Obesity and Metabolism 22:12, pages 2276-2286.
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Srikanth Yandrapalli, Aaqib Malik, Adam Horblitt, Gayatri Pemmasani, Wilbert S. Aronow & William H. Frishman. (2020) Cardiovascular Safety and Benefits of Noninsulin Antihyperglycemic Drugs for the Treatment of Type 2 Diabetes Mellitus: Part 2. Cardiology in Review 28:5, pages 219-235.
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Shrita Patel, Anne Hickman, Robert Frederich, Susan Johnson, Susan Huyck, James P. Mancuso, Ira Gantz & Steven G. Terra. (2020) Safety of Ertugliflozin in Patients with Type 2 Diabetes Mellitus: Pooled Analysis of Seven Phase 3 Randomized Controlled Trials. Diabetes Therapy 11:6, pages 1347-1367.
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Jaspreet Kalra, Suresh Babu Mangali, Deepika Dasari, Audesh Bhat, Srashti Goyal, Indu Dhar, Dharamrajan Sriram & Arti Dhar. (2019) SGLT1 inhibition boon or bane for diabetes‐associated cardiomyopathy. Fundamental & Clinical Pharmacology 34:2, pages 173-188.
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Salvatore Carbone & Dave L. Dixon. (2019) The CANVAS Program: implications of canagliflozin on reducing cardiovascular risk in patients with type 2 diabetes mellitus. Cardiovascular Diabetology 18:1.
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Vishal Gupta, Michael Willis, Pierre Johansen, Andreas Nilsson, Manan Shah, Amey Mane & Cheryl Neslusan. (2019) Long-Term Clinical Benefits of Canagliflozin 100 mg Versus Sulfonylurea in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin in India. Value in Health Regional Issues 18, pages 65-73.
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Brecht Claerhout, Dipak Kalra, Christina Mueller, Gurparkash Singh, Nadir Ammour, Laura Meloni, Juuso Blomster, Mark Hopley, George Kafatos, Almenia Garvey, Peter Kuhn, Martine Lewi, Bart Vannieuwenhuyse, Benoît Marchal, Ketan Patel, Christoph Schindler & Mats Sundgren. (2019) Federated electronic health records research technology to support clinical trial protocol optimization: Evidence from EHR4CR and the InSite platform. Journal of Biomedical Informatics 90, pages 103090.
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Michael J. Davies, Katherine Merton, Ujjwala Vijapurkar, Jacqueline Yee & Rong Qiu. (2017) Efficacy and safety of canagliflozin in patients with type 2 diabetes based on history of cardiovascular disease or cardiovascular risk factors: a post hoc analysis of pooled data. Cardiovascular Diabetology 16:1.
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Michael Pfeifer, Raymond R. Townsend, Michael J. Davies, Ujjwala Vijapurkar & Jimmy Ren. (2017) Effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure and markers of arterial stiffness in patients with type 2 diabetes mellitus: a post hoc analysis. Cardiovascular Diabetology 16:1.
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Mohamed Hassanein, Akram Echtay, Ahmed Hassoun, Monira Alarouj, Bachar Afandi, Raffi Poladian, Abdullah Bennakhi, Maciej Nazar, Paul Bergmans, Sofia Keim, Gill Hamilton & Sami T. Azar. (2017) Tolerability of canagliflozin in patients with type 2 diabetes mellitus fasting during Ramadan: Results of the Canagliflozin in Ramadan Tolerance Observational Study (CRATOS). International Journal of Clinical Practice 71:10, pages e12991.
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Richard E. Pratley & Eugenio Cersosimo. (2017) Use of Canagliflozin in Combination With and Compared to Incretin-Based Therapies in Type 2 Diabetes. Clinical Diabetes 35:3, pages 141-153.
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