Advanced search
Publication Cover
Autophagy Volume 9, 2013 - Issue 11
Submit an article Journal homepage
2,438
Views
45
CrossRef citations to date
0
Altmetric
Translational Research Paper

Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress

Tomonori Kimura Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka Japan
,
Atsushi Takahashi Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka Japan
,
Yoshitsugu Takabatake Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka Japan
,
Tomoko Namba Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka Japan
,
Takeshi Yamamoto Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka Japan
,
Jun-ya Kaimori Department of Advanced Technology for Transplantation; Osaka University Graduate School of Medicine; Suita, Osaka Japan
,
Isao Matsui Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka Japan
,
Harumi Kitamura Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka Japan
,
Fumio Niimura Department of Pediatrics; Tokai University School of Medicine; Isehara, Kanagawa Japan
,
Taiji Matsusaka Institute of Medical Science; Tokai University School of Medicine; Isehara, Kanagawa Japan
,
Tomoyoshi Soga Institute for Advanced Biosciences; Keio University; Mizukami, Kakuganji, Tsuruoka, Yamagata Japan
,
Hiromi Rakugi Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka Japan
&
Yoshitaka Isaka Department of Geriatric Medicine and Nephrology; Osaka University Graduate School of Medicine; Suita, Osaka JapanCorrespondence[email protected]
 show all
Pages 1876-1886 | Received 02 Dec 2012, Accepted 14 Jun 2013, Published online: 11 Jul 2013

Citations (45)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Rei Unno, Tsuyoshi Kawabata, Kazumi Taguchi, Teruaki Sugino, Shuzo Hamamoto, Ryosuke Ando, Atsushi Okada, Kenjiro Kohri, Tamotsu Yoshimori & Takahiro Yasui. (2020) Deregulated MTOR (mechanistic target of rapamycin kinase) is responsible for autophagy defects exacerbating kidney stone development. Autophagy 16:4, pages 709-723.
Read now
Satoshi Minami, Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomoko Namba, Jun Matsuda, Tomonori Kimura, Jun-ya Kaimori, Isao Matsui, Takayuki Hamano, Hiroaki Takeda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Taiji Matsusaka, Fumio Niimura & Yoshitaka Isaka. (2017) Lipophagy maintains energy homeostasis in the kidney proximal tubule during prolonged starvation. Autophagy 13:10, pages 1629-1647.
Read now
Tomonori Kimura, Yoshitaka Isaka & Tamotsu Yoshimori. (2017) Autophagy and kidney inflammation. Autophagy 13:6, pages 997-1003.
Read now

Articles from other publishers (42)

Hongping Gu, Jinrong Li & Yuehan Ni. (2023) Sinomenine improves renal fibrosis by regulating mesenchymal stem cell‐derived exosomes and affecting autophagy levels. Environmental Toxicology.
Crossref
Yu Zhao, Chuan Guo, Lianlin Zeng, Jialing Li, Xia Liu, Yiwei Wang, Kun Zhao & Bo Chen. (2022) Mesenchymal Stem Cells Ameliorate Fibrosis by Enhancing Autophagy via Inhibiting Galectin-3/Akt/mTOR Pathway and by Alleviating the EMT via Inhibiting Galectin-3/Akt/GSK3β/Snail Pathway in NRK-52E Fibrosis. International Journal of Stem Cells 16:1, pages 52-65.
Crossref
Yimeng Chen, Congya Zhang, Yingjie Du, Xiying YangMin Liu, Wenjing Yang, Guiyu Lei & Guyan Wang. (2022) Exosomal transfer of microRNA-590-3p between renal tubular epithelial cells after renal ischemia-reperfusion injury regulates autophagy by targeting TRAF6. Chinese Medical Journal 135:20, pages 2467-2477.
Crossref
Hao Li, Yingjian Zhou, Wenchao Xu, Jihong Liu, Shaogang Wang & Hongyang Jiang. (2022) The role of autophagy in calcium oxalate kidney stone: A systematic review of the literature. Frontiers in Physiology 13.
Crossref
Atsushi Hesaka, Yusuke Tsukamoto, Shigeyuki Nada, Masataka Kawamura, Naotsugu Ichimaru, Shinsuke Sakai, Maiko Nakane, Masashi Mita, Daisuke Okuzaki, Masato Okada, Yoshitaka Isaka & Tomonori Kimura. (2021) d-Serine Mediates Cellular Proliferation for Kidney Remodeling. Kidney360 2:10, pages 1611-1624.
Crossref
Martin Schulz, Valentina Diehl, Jonel Trebicka, Malgorzata Wygrecka & Liliana Schaefer. (2021) Biglycan: A regulator of hepatorenal inflammation and autophagy. Matrix Biology 100-101, pages 150-161.
Crossref
Yue Wu, Yang Xun, Jiaqiao Zhang, Henglong Hu, Baolong Qin, Tao Wang, Shaogang Wang, Cong Li & Yuchao Lu. (2021) Resveratrol Attenuates Oxalate-Induced Renal Oxidative Injury and Calcium Oxalate Crystal Deposition by Regulating TFEB-Induced Autophagy Pathway. Frontiers in Cell and Developmental Biology 9.
Crossref
Katharina Bublitz, Sabine Böckmann, Kirsten Peters & Burkhard Hinz. (2020) Cannabinoid-Induced Autophagy and Heme Oxygenase-1 Determine the Fate of Adipose Tissue-Derived Mesenchymal Stem Cells under Stressful Conditions. Cells 9:10, pages 2298.
Crossref
Sabine Böckmann & Burkhard Hinz. (2020) Cannabidiol Promotes Endothelial Cell Survival by Heme Oxygenase-1-Mediated Autophagy. Cells 9:7, pages 1703.
Crossref
Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Masashi Kitagawa, Keiko Tanaka, Yuzuki Kano, Koki Mise, Nozomu Otaka, Katsuyuki Tanabe, Hiroshi Morinaga, Masaru Kinomura, Haruhito A. Uchida & Jun Wada. (2020) Podocyte autophagy is associated with foot process effacement and proteinuria in patients with minimal change nephrotic syndrome. PLOS ONE 15:1, pages e0228337.
Crossref
Xin Ye, Xu-jie Zhou & Hong Zhang. (2019) Autophagy in Immune-Related Renal Disease. Journal of Immunology Research 2019, pages 1-10.
Crossref
Shinsuke SakaiTakeshi YamamotoYoshitsugu Takabatake, Atsushi TakahashiTomoko Namba-Hamano, Satoshi Minami, Ryuta FujimuraHiroaki YonishiJun MatsudaAtsushi HesakaIsao Matsui, Taiji Matsusaka, Fumio NiimuraMotoko Yanagita & Yoshitaka Isaka. (2019) Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes. Journal of the American Society of Nephrology 30:6, pages 929-945.
Crossref
Tomonori Kimura. (2019) Reverse translational research of autophagy and metabolism in kidney disease: Oshima Award Address 2018. Clinical and Experimental Nephrology 23:6, pages 733-738.
Crossref
Jin Xiang, Tingting Jiang, Wenying Zhang, Wei Xie, Xun Tang & Jun Zhang. (2019) Human umbilical cord-derived mesenchymal stem cells enhanced HK-2 cell autophagy through MicroRNA-145 by inhibiting the PI3K/AKT/mTOR signaling pathway. Experimental Cell Research 378:2, pages 198-205.
Crossref
Oskar Zakiyanov, Marta Kalousová, Tomáš Zima & Vladimír Tesař. (2019) Matrix Metalloproteinases in Renal Diseases: A Critical Appraisal. Kidney and Blood Pressure Research 44:3, pages 298-330.
Crossref
Janina Müller-Deile, Tilman Jobst-Schwan & Mario Schiffer. (2019) Moving beyond GWAS and eQTL Analysis to Validated Hits in Chronic Kidney Disease. Cell Metabolism 29:1, pages 9-10.
Crossref
Wolfgang Eberhardt, Usman Nasrullah & Josef Pfeilschifter. (2018) Activation of renal profibrotic TGFβ controlled signaling cascades by calcineurin and mTOR inhibitors. Cellular Signalling 52, pages 1-11.
Crossref
Chengxiang Qiu, Shizheng Huang, Jihwan Park, YoSon Park, Yi-An Ko, Matthew J. Seasock, Joshua S. Bryer, Xiang-Xi Xu, Wen-Chao Song, Matthew Palmer, Jon Hill, Paolo Guarnieri, Julie Hawkins, Carine M. Boustany-Kari, Steven S. Pullen, Christopher D. Brown & Katalin Susztak. (2018) Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease. Nature Medicine 24:11, pages 1721-1731.
Crossref
Yingmei Zhang, Adam T. Whaley-Connell, James R. Sowers & Jun Ren. (2018) Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management. Pharmacology & Therapeutics 191, pages 1-22.
Crossref
Leslie S. Gewin. (2018) Renal fibrosis: Primacy of the proximal tubule. Matrix Biology 68-69, pages 248-262.
Crossref
Xiaolu Duan, Zhenzhen Kong, Xin Mai, Yu Lan, Yang Liu, Zhou Yang, Zhijian Zhao, Tuo Deng, Tao Zeng, Chao Cai, Shujue Li, Wen Zhong, Wenqi Wu & Guohua Zeng. (2018) Autophagy inhibition attenuates hyperoxaluria-induced renal tubular oxidative injury and calcium oxalate crystal depositions in the rat kidney. Redox Biology 16, pages 414-425.
Crossref
Jinyu Chi, Lei Wang, Xiaohui Zhang, Yu Fu, Yue Liu, Wenjia Chen, Wenxiu Liu, Zhiyu Shi & Xinhua Yin. (2018) Cyclosporin A induces autophagy in cardiac fibroblasts through the NRP-2/WDFY-1 axis. Biochimie 148, pages 55-62.
Crossref
Wei Wei, Xing-Rong An, Shi-Jie Jin, Xiao-Xue Li & Ming Xu. (2018) Inhibition of insulin resistance by PGE1 via autophagy-dependent FGF21 pathway in diabetic nephropathy. Scientific Reports 8:1.
Crossref
Shingo Muratsubaki, Atsushi Kuno, Masaya Tanno, Takayuki Miki, Toshiyuki Yano, Hirohito Sugawara, Satoru Shibata, Koki Abe, Satoko Ishikawa, Kouhei Ohno, Yukishige Kimura, Yuki Tatekoshi, Kei Nakata, Wataru Ohwada, Masashi Mizuno & Tetsuji Miura. (2017) Suppressed autophagic response underlies augmentation of renal ischemia/reperfusion injury by type 2 diabetes. Scientific Reports 7:1.
Crossref
Atsushi Takahashi, Yoshitsugu Takabatake, Tomonori Kimura, Ikuko Maejima, Tomoko Namba, Takeshi Yamamoto, Jun Matsuda, Satoshi Minami, Jun-ya Kaimori, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Tamotsu Yoshimori & Yoshitaka Isaka. (2017) Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules. Diabetes 66:5, pages 1359-1372.
Crossref
Takeshi Yamamoto, Yoshitsugu Takabatake, Atsushi Takahashi, Tomonori Kimura, Tomoko Namba, Jun Matsuda, Satoshi Minami, Jun-ya Kaimori, Isao Matsui, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita & Yoshitaka Isaka. (2017) High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney. Journal of the American Society of Nephrology 28:5, pages 1534-1551.
Crossref
Tomoya Iida, Kei Onodera & Hiroshi Nakase. (2017) Role of autophagy in the pathogenesis of inflammatory bowel disease. World Journal of Gastroenterology 23:11, pages 1944.
Crossref
Kirsty M. Hooper, Peter G. Barlow, Craig Stevens & Paul Henderson. (2017) Inflammatory Bowel Disease Drugs: A Focus on Autophagy. Journal of Crohn's and Colitis 11:1, pages 118-127.
Crossref
Qiyuan Kuai, Chunyan Wang, Yanbing Wang, Weijing Li, Gongqing Zhang, Zhixin Qiao, Min He, Xuanlin Wang, Yu Wang, Xingwei Jiang, Lihua Su, Yuezhong He, Suping Ren & Qun Yu. (2016) Energy metabolism regulated by HDAC inhibitor attenuates cardiac injury in hemorrhagic rat model. Scientific Reports 6:1.
Crossref
Wen-Chin LeeChien-Hua ChiuJin-Bor ChenChiu-Hua ChenHsueh-Wei Chang. (2016) Mitochondrial Fission Increases Apoptosis and Decreases Autophagy in Renal Proximal Tubular Epithelial Cells Treated with High Glucose. DNA and Cell Biology 35:11, pages 657-665.
Crossref
Olivia Lenoir, Pierre-Louis Tharaux & Tobias B. Huber. (2016) Autophagy in kidney disease and aging: lessons from rodent models. Kidney International 90:5, pages 950-964.
Crossref
Daisuke Nakano & Akira Nishiyama. (2016) Multiphoton imaging of kidney pathophysiology. Journal of Pharmacological Sciences 132:1, pages 1-5.
Crossref
Edwin K. Jackson, Elizabeth V. Menshikova, Zaichuan Mi, Jonathan D. Verrier, Rashmi Bansal, Keri Janesko-Feldman, Travis C. Jackson & Patrick M. Kochanek. (2016) Renal 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase Is an Important Determinant of AKI Severity after Ischemia-Reperfusion. Journal of the American Society of Nephrology 27:7, pages 2069-2081.
Crossref
Tomonori Kimura, Keiko Yasuda, Ryohei Yamamoto, Tomoyoshi Soga, Hiromi Rakugi, Terumasa Hayashi & Yoshitaka Isaka. (2016) Identification of biomarkers for development of end-stage kidney disease in chronic kidney disease by metabolomic profiling. Scientific Reports 6:1.
Crossref
Andrea Havasi & Zheng Dong. (2016) Autophagy and Tubular Cell Death in the Kidney. Seminars in Nephrology 36:3, pages 174-188.
Crossref
T. Ruppert, A. Schumann, H.J. Gröne, J.G. Okun, S. Kölker, M.A. Morath & S.W. Sauer. (2015) Molecular and biochemical alterations in tubular epithelial cells of patients with isolated methylmalonic aciduria. Human Molecular Genetics, pages ddv405.
Crossref
Tomonori Kimura, Ashish Jain, Seong Won Choi, Michael A. Mandell, Kate Schroder, Terje Johansen & Vojo Deretic. (2015) TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. Journal of Cell Biology 210:6, pages 973-989.
Crossref
LINGYUN BI, RUANLING HOU, DASHENG YANG, SHUJUN LI & DEAN ZHAO. (2015) Erythropoietin protects lipopolysaccharide-induced renal mesangial cells from autophagy. Experimental and Therapeutic Medicine 9:2, pages 559-562.
Crossref
Sophie Fougeray & Nicolas Pallet. (2014) Mechanisms and biological functions of autophagy in diseased and ageing kidneys. Nature Reviews Nephrology 11:1, pages 34-45.
Crossref
Yoshitaka Isaka, Tomonori Kimura, Atsushi Takahashi & Yoshitsugu Takabatake. 2015. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 249 258 .
Tomoko Namba, Yoshitsugu Takabatake, Tomonori Kimura, Atsushi Takahashi, Takeshi Yamamoto, Jun Matsuda, Harumi Kitamura, Fumio Niimura, Taiji Matsusaka, Hirotsugu Iwatani, Isao Matsui, Junya Kaimori, Hidetaka Kioka, Yoshitaka Isaka & Hiromi Rakugi. (2014) Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis. Journal of the American Society of Nephrology 25:10, pages 2254-2266.
Crossref
Y. Takabatake, T. Kimura, A. Takahashi & Y. Isaka. (2014) Autophagy and the kidney: health and disease. Nephrology Dialysis Transplantation 29:9, pages 1639-1647.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.