Advanced search
Publication Cover
Autophagy Volume 10, 2014 - Issue 6
Submit an article Journal homepage
6,807
Views
203
CrossRef citations to date
0
Altmetric
Basic Research Paper

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer

Wenjie Guo State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China; School of Pharmacy; Jiangsu University; Zhenjiang, China
,
Yang Sun State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, ChinaCorrespondence[email protected] [email protected] [email protected]
,
Wen Liu State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China
,
Xingxin Wu State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China
,
Lele Guo State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China
,
Peifen Cai Department of Oncology; First Affiliated Hospital of Nanjing Medical University; Nanjing, China
,
Xuefeng Wu State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China
,
Xudong Wu State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China
,
Yan Shen State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, China
,
Yongqian Shu Department of Oncology; First Affiliated Hospital of Nanjing Medical University; Nanjing, China
,
Yanhong Gu Department of Oncology; First Affiliated Hospital of Nanjing Medical University; Nanjing, ChinaCorrespondence[email protected] [email protected] [email protected]
&
Qiang Xu State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing, ChinaCorrespondence[email protected] [email protected] [email protected]
 show all
Pages 972-985 | Received 18 May 2013, Accepted 27 Feb 2014, Published online: 01 Apr 2014

Citations (203)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (9)

Xuanhong Jin, Liangkun You, Jincheng Qiao, Weidong Han & Hongming Pan. (2023) Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development. Autophagy 0:0, pages 1-17.
Read now
Aarti Pant, Xiaomin Yao, Aude Lavedrine, Christophe Viret, Jacob Dockterman, Swati Chauhan, Chong-Shan Shi, Ravi Manjithaya, Ken Cadwell, Thomas A. Kufer, John H. Kehrl, Jörn Coers, L. David Sibley, Mathias Faure, Gregory A. Taylor & Santosh Chauhan. (2022) Interactions of Autophagy and the Immune System in Health and Diseases. Autophagy Reports 1:1, pages 438-515.
Read now
Xiaofei Li, Mingjie Lu, Manman Yuan, Jing Ye, Wei Zhang, Lingyan Xu, Xiaohan Wu, Bingqing Hui, Yuchen Yang, Bin Wei, Ciliang Guo, Min Wei, Jie Dong, Xingxin Wu & Yanhong Gu. (2022) CXCL10-armed oncolytic adenovirus promotes tumor-infiltrating T-cell chemotaxis to enhance anti-PD-1 therapy. OncoImmunology 11:1.
Read now
Xiaomin Cai, Bin Wei, Lele Li, Xiaofeng Chen, Jing Yang, Xiaofei Li, Xiaozheng Jiang, Mu Lv, Mingyang Li, Yumeng Lin, Qiang Xu, Wenjie Guo & Yanhong Gu. (2020) Therapeutic Potential of Apatinib Against Colorectal Cancer by Inhibiting VEGFR2-Mediated Angiogenesis and β-Catenin Signaling. OncoTargets and Therapy 13, pages 11031-11044.
Read now
Anaïs Larabi, Nicolas Barnich & Hang Thi Thu Nguyen. (2020) New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD. Autophagy 16:1, pages 38-51.
Read now
Ye Xu, Jun Shen & Zhihua Ran. (2020) Emerging views of mitophagy in immunity and autoimmune diseases. Autophagy 16:1, pages 3-17.
Read now
Xiaojuan Han, Sifan Sun, Yiming Sun, Qiqi Song, Jialei Zhu, Nanshan Song, Miaomiao Chen, Ting Sun, Meiling Xia, Jianhua Ding, Ming Lu, Honghong Yao & Gang Hu. (2019) Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease. Autophagy 15:11, pages 1860-1881.
Read now
Jingyu Yao, Lin Jia, Naheed Khan, Chengmao Lin, Sayak K Mitter, Michael E Boulton, Joshua L Dunaief, Daniel J Klionsky, Jun-Lin Guan, Debra A Thompson & David N Zacks. (2015) Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium. Autophagy 11:6, pages 939-953.
Read now
Nandan Dixit, Harsha Motwani, Saumya K. Patel, Rakesh M. Rawal & Hiteshkumar A. Solanki. Decoding the mechanism of andrographolide to combat hepatocellular carcinoma: a network pharmacology integrated molecular docking and dynamics approach. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-19.
Read now

Articles from other publishers (194)

Elias Kouroumalis, Ioannis Tsomidis & Argyro Voumvouraki. (2023) Autophagy and Apoptosis in Inflammatory Bowel Disease. Gastroenterology Insights 14:4, pages 598-636.
Crossref
Dan Wang, Yongjian Zheng, Junjing Xie, Wenwen Yu, Zhongteng Lu, Wenping Zhang, Yanling Hu, Jianyuan Fu, Qing Sheng & Zhengbing Lv. (2023) Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia. Metabolic Brain Disease.
Crossref
Tingting Wan, Yalong Wang, Kaixin He & Shu Zhu. (2023) Microbial sensing in the intestine. Protein & Cell 14:11, pages 824-860.
Crossref
Chen Zhang, Bin Tang, Xuwei Zheng, Qianqian Luo, Yang Bi, Hao Deng, Jingjie Yu, Yue Lu, Ling Han, Haiming Chen & Chuanjian Lu. (2023) Analysis of the potential pyroptosis mechanism in psoriasis and experimental validation of NLRP3 in vitro and in vivo. International Immunopharmacology 124, pages 110811.
Crossref
Marisol Villalva, Juan José Martínez-García, Laura Jaime, Susana Santoyo, Pablo Pelegrín & Jara Pérez-Jiménez. (2023) Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review of in vivo studies . Food & Function 14:21, pages 9534-9553.
Crossref
Huachun Cui, Sami Banerjee, Na Xie, Tapan Dey, Rui-Ming Liu, Yan Y. Sanders & Gang Liu. (2023) MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages. Communications Biology 6:1.
Crossref
Matthew Hunt, Monica Torres, Etty Bachar-Wikström & Jakob D. Wikström. (2023) Multifaceted roles of mitochondria in wound healing and chronic wound pathogenesis. Frontiers in Cell and Developmental Biology 11.
Crossref
Xinyue Yang, Qing Wang, Xinghai Zhang, Lingling Li, Xingyue Cao, Li Zhou, Yefei Huang, Guixiang Sun & Yansu Chen. (2023) Purple Yam Polyphenol Extracts Exert Anticolitis and Anticolitis-Associated Colorectal Cancer Effects through Inactivation of NF-κB/p65 and STAT3 Signaling Pathways. Journal of Agricultural and Food Chemistry 71:32, pages 12177-12189.
Crossref
Zhongbo Bian, Qiuyu Zhang, Yong Qin, Xiaodie Sun, Lulin Liu, Huahuan Liu, Lianzhi Mao, Yiran Yan, Wenzhen Liao, Longying Zha & Suxia Sun. (2023) Sodium Butyrate Inhibits Oxidative Stress and NF-κB/NLRP3 Activation in Dextran Sulfate Sodium Salt-Induced Colitis in Mice with Involvement of the Nrf2 Signaling Pathway and Mitophagy. Digestive Diseases and Sciences 68:7, pages 2981-2996.
Crossref
Wan-di Feng, Yao Wang, Tong Luo, Xin Jia, Cui-qin Cheng, Hao-jia Wang, Mei-qi Zhang, Qi-qi Li, Xue-jiao Wang, Yi-ying Li, Jin-yong Wang, Guang-rui Huang, Ting Wang & An-long Xu. (2022) Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases. Acta Pharmacologica Sinica 44:6, pages 1238-1251.
Crossref
Yuka Ikeda & Satoru Matsuda. (2023) Gut Protective Effect from D-Methionine or Butyric Acid against DSS and Carrageenan-Induced Ulcerative Colitis. Molecules 28:11, pages 4392.
Crossref
Shuang-Lan Chen, Chun-Meng Li, Wei Li, Qing-Song Liu, Shuang-Yuan Hu, Mao-Yuan Zhao, Dong-Sen Hu, Yan-Wei Hao, Jin-Hao Zeng & Yi Zhang. (2023) How autophagy, a potential therapeutic target, regulates intestinal inflammation. Frontiers in Immunology 14.
Crossref
Qingdan Gu, Jiazhen Zou, Ying Zhou & Qiuchan Deng. (2023) Mechanism of inflammasomes in cancer and targeted therapies. Frontiers in Oncology 13.
Crossref
Ziqi Zhang, Xue Li, Yang Wang, Yuquan Wei & Xiawei Wei. (2023) Involvement of inflammasomes in tumor microenvironment and tumor therapies. Journal of Hematology & Oncology 16:1.
Crossref
Yi Huang, Yun Guo, Yan Zhou, Qian Huang, Yi Ru, Yingli Luo & Wen Xu. (2023) Tivantinib alleviates inflammatory diseases by directly targeting NLRP3. iScience 26:3, pages 106062.
Crossref
Roxana Zaharie, Dan Valean, Calin Popa, Alin Fetti, Claudiu Zdrehus, Aida Puia, Lia Usatiuc, Diana Schlanger & Florin Zaharie. (2023) The Multifaceted Role and Regulation of Nlrp3 Inflammasome in Colitis-Associated Colo-Rectal Cancer: A Systematic Review. International Journal of Molecular Sciences 24:4, pages 3472.
Crossref
Bhesh Raj Sharma & Thirumala-Devi Kanneganti. (2023) Inflammasome signaling in colorectal cancer. Translational Research 252, pages 45-52.
Crossref
Jiang Xin. (2023) Critical signaling pathways governing colitis-associated colorectal cancer: Signaling, therapeutic implications, and challenges. Digestive and Liver Disease 55:2, pages 169-177.
Crossref
Zuman Zhou, Wanying He, Honglei Tian, Ping Zhan & Jianshu Liu. (2023) Thyme ( Thymus vulgaris L.) polyphenols ameliorate DSS-induced ulcerative colitis of mice by mitigating intestinal barrier damage, regulating gut microbiota, and suppressing TLR4/NF-κB-NLRP3 inflammasome pathways . Food & Function 14:2, pages 1113-1132.
Crossref
Jinguang Yang, Lili Miao, Ye Xue & Xiaoyan Wang. (2023) Yiyi Fuzi Baijiang Powder Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats via Inhibiting the TLR4/NF-κB/NLRP3 Inflammasome Signaling Pathway to Repair the Intestinal Epithelial Barrier, and Modulating Intestinal Microbiota. Oxidative Medicine and Cellular Longevity 2023, pages 1-20.
Crossref
Yixuan Wang, Jian Gao, Ying Yu, Lin Zhou, Miao Wang, Wenwen Xue, Bo Liu, Xudong Wu, Xuefeng Wu, Huiyuan Gao, Yan Shen & Qiang Xu. (2022) A plant‐derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy. British Journal of Pharmacology 180:2, pages 194-213.
Crossref
Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, Ying Zheng, Richard D Ye, Chris Soon Heng TAN, Yitao Wang & Jia-Hong Lu. (2023) Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease. Burns & Trauma 11.
Crossref
Jinxiang Wu, Lei Wang & Jianwei Xu. (2022) The role of pyroptosis in modulating the tumor immune microenvironment. Biomarker Research 10:1.
Crossref
Wen Liu, Jiashu Yang, Shihao Fang, Chenyang Jiao, Jianhua Gao, Aihua Zhang, Tiancong Wu, Renxiang Tan, Qiang Xu & Wenjie Guo. (2022) Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC. Journal of Biological Chemistry 298:12, pages 102696.
Crossref
Zhiyong Zhang, Ying Chen, Yuxin Yin, Yuxi Chen, Qianyu Chen, Ziqian Bing, Yaojun Zheng, Yayi Hou, Sunan Shen, Yitian Chen & Tingting Wang. (2022) Candida tropicalis induces NLRP3 inflammasome activation via glycogen metabolism-dependent glycolysis and JAK-STAT1 signaling pathway in myeloid-derived suppressor cells to promote colorectal carcinogenesis. International Immunopharmacology 113, pages 109430.
Crossref
Yuyu Zhu, Zijun Ouyang, Haojie Du, Meijing Wang, Jiaojiao Wang, Haiyan Sun, Lingdong Kong, Qiang Xu, Hongyue Ma & Yang Sun. (2022) New opportunities and challenges of natural products research: When target identification meets single-cell multiomics. Acta Pharmaceutica Sinica B 12:11, pages 4011-4039.
Crossref
Guoliang Deng, Lisha Zhou, Binglin Wang, Xiaofan Sun, Qinchang Zhang, Hongqi Chen, Ning Wan, Hui Ye, Xiaoqi Wu, Dongdong Sun, Yang Sun & Haibo Cheng. (2022) Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation. Journal for ImmunoTherapy of Cancer 10:10, pages e004874.
Crossref
Xiaohong Li, Weichen Yuan, Jibiao Wu, Jianhua Zhen, Qihui Sun & Minmin Yu. (2022) Andrographolide, a natural anti-inflammatory agent: An Update. Frontiers in Pharmacology 13.
Crossref
Jun Qian, Xiangdong Wang, Guanghui Su, Xiaolin Shu, Zucheng Huang, Huaji Jiang & Qingan Zhu. (2022) Platelet-rich plasma-derived exosomes attenuate intervertebral disc degeneration by promoting NLRP3 autophagic degradation in macrophages. International Immunopharmacology 110, pages 108962.
Crossref
Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Chandra Sekhar Bhol, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Srimanta Patra, Amruta Singh, Shankargouda Patil, Rohan Dhiman, Samir Kumar Patra & Sujit Kumar Bhutia. (2022) Inflammasomes in cancer: Effect of epigenetic and autophagic modulations. Seminars in Cancer Biology 83, pages 399-412.
Crossref
Feng Zhou, Fanxuan Zhao, Qianmeng Huang, Xiang Lin, Songying Zhang & Yongdong Dai. (2022) NLRP3 activated macrophages promote endometrial stromal cells migration in endometriosis. Journal of Reproductive Immunology 152, pages 103649.
Crossref
Huang Hong, Weilan Cao, Quanpeng Wang, Changbao Liu & Chongjie Huang. (2022) Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer. Medical Oncology 39:8.
Crossref
Yanting Sun, Hao Xu, Bin Tan, Qin Yi, Huiwen Liu, Tangtian Chen, Han Xiang, Rui Wang, Qiumin Xie, Jie Tian & Jing Zhu. (2022) Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway. Stem Cell Research & Therapy 13:1.
Crossref
Aekkhaluck Intharuksa, Warunya Arunotayanun, Wipawadee Yooin & Panee Sirisa-ard. (2022) A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery. Molecules 27:14, pages 4479.
Crossref
Wen Liu, Yi Zou, Kaiming Li, Haiqing Zhong, Longbo Yu, Shushan Ge, Yisheng Lai, Xianchi Dong, Qiang Xu & Wenjie Guo. (2022) Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy. The Journal of Immunology 209:1, pages 180-191.
Crossref
Hallie M. Blevins, Yiming Xu, Savannah Biby & Shijun Zhang. (2022) The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases. Frontiers in Aging Neuroscience 14.
Crossref
Somayeh Vafaei, Hamed Taheri, Yasamin Hajimomeni, Amirhossein Fakhre Yaseri & Firoozeh Abolhasani Zadeh. (2022) The role of NLRP3 inflammasome in colorectal cancer: potential therapeutic target. Clinical and Translational Oncology 24:10, pages 1881-1889.
Crossref
Hiroko Nagao-Kitamoto, Sho Kitamoto & Nobuhiko Kamada. (2022) Inflammatory bowel disease and carcinogenesis. Cancer and Metastasis Reviews 41:2, pages 301-316.
Crossref
Srimanta Patra, Soumya R. Mishra, Bishnu P. Behera, Kewal K. Mahapatra, Debasna P. Panigrahi, Chandra S. Bhol, Prakash P. Praharaj, Gautam Sethi, Samir K. Patra & Sujit K. Bhutia. (2022) Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives. Seminars in Cancer Biology 80, pages 205-217.
Crossref
Xia Wu, Nana Xu, Ziqi Ye, Qingwei Zhao, Jian Liu, Jichen Li, Minglan Wu, Yunliang Zheng, Xiaodong Li, Weifen Li, Tianfang Zhang, Xingjiang Hu & Qiao Zhang. (2022) Polysaccharide from Scutellaria barbata D. Don attenuates inflammatory response and microbial dysbiosis in ulcerative colitis mice. International Journal of Biological Macromolecules 206, pages 1-9.
Crossref
Jiao Qu, Qianqian Liu, Guoquan You, Ling Ye, Yiguang Jin, Lingdong Kong, Wenjie Guo, Qiang Xu & Yang Sun. (2021) Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective. Medicinal Research Reviews 42:3, pages 1147-1178.
Crossref
Jiawei Sun, Qili Yang, Enping Liu, Dahua Chen & Qinmiao Sun. (2022) KIZ/GM114 Balances the NF-ĸB Signaling by Antagonizing the Association of TRAF2/6 With Their Upstream Adaptors. Frontiers in Cell and Developmental Biology 10.
Crossref
Pei Li, Guoping Chen, Jiaxian Zhang, Chaoying Pei, Ying Chen, Jing Gong, Song Deng, Kaiwei Cai, Haiyan Li, Dawei Wang, Baochun Shen, Zhiyong Xie & Qiongfeng Liao. (2022) Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis . Food & Function 13:5, pages 2985-2997.
Crossref
Rui Wang, Yanming Wang, Jimin Wu, Yanli Guo, Han Xiao, Youyi Zhang & Ketao Ma. (2022) Resveratrol Targets AKT1 to Inhibit Inflammasome Activation in Cardiomyocytes Under Acute Sympathetic Stress. Frontiers in Pharmacology 13.
Crossref
Zhiyong Zhang, Yuxi Chen, Yaojun Zheng, Lei Wang, Sunan Shen, Geliang Yang, Yufei Yang & Tingting Wang. (2022) Quxie Capsule Alleviates Colitis-associated Colorectal Cancer Through Modulating the Gut Microbiota and Suppressing A. fumigatus -induced Aerobic Glycolysis . Integrative Cancer Therapies 21, pages 153473542211385.
Crossref
Yuanyuan Wang, Bin Wei, Danping Wang, Jingjing Wu, Jianhua Gao, Haiqing Zhong, Yang Sun, Qiang Xu, Wen Liu, Yanhong Gu & Wenjie Guo. (2022) DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis. Acta Pharmaceutica Sinica B 12:1, pages 262-273.
Crossref
Li Guo, Yi Yang, Yongjia Sheng, Jin Wang, Wenyan Li, Xiaohong Zhou, Shuiliang Ruan & Chenyang Han. (2021) Galloflavin Relieves the Malignant Behavior of Colorectal Cancer Cells in the Inflammatory Tumor Microenvironment. Frontiers in Pharmacology 12.
Crossref
Bin Han, Wei Jiang, Pan Cui, Kai Zheng, Chun Dang, Junjie Wang, He Li, Lin Chen, Rongxin Zhang, Qing Mei Wang, Zhenyu Ju & Junwei Hao. (2021) Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation. Genome Medicine 13:1.
Crossref
Britney N. Lizama & Charleen T. Chu. (2021) Neuronal autophagy and mitophagy in Parkinson's disease. Molecular Aspects of Medicine 82, pages 100972.
Crossref
Huahuan Liu, Zhongbo Bian, Qiuyu Zhang, Zhipeng Xiao, Yu Cao, Xiaodie Sun, Yong Qin, Lianzhi Mao, Xinwei Chu, Wenzhen Liao, Longying Zha & Suxia Sun. (2021) Sodium butyrate inhibits colitis-associated colorectal cancer through preventing the gut microbiota dysbiosis and reducing the expression of NLRP3 and IL-1β. Journal of Functional Foods 87, pages 104862.
Crossref
Yang Zheng, Yang Yu, Xu-Feng Chen, Sheng-Lan Yang, Xiao-Long Tang & Zheng-Guo Xiang. (2021) Intestinal Macrophage Autophagy and its Pharmacological Application in Inflammatory Bowel Disease. Frontiers in Pharmacology 12.
Crossref
Silpita Paul, Dia Roy, Subhadip Pati & Gaurisankar Sa. (2021) The Adroitness of Andrographolide as a Natural Weapon Against Colorectal Cancer. Frontiers in Pharmacology 12.
Crossref
Lingyan Xu, Peifen Cai, Xiaofei Li, Xiaohan Wu, Jian Gao, Wen Liu, Jiashu Yang, Qiang Xu, Wenjie Guo & Yanhong Gu. (2021) Inhibition of NLRP3 inflammasome activation in myeloid-derived suppressor cells by andrographolide sulfonate contributes to 5-FU sensitization in mice. Toxicology and Applied Pharmacology 428, pages 115672.
Crossref
Tao Li, Bin Fu, Xin Zhang, Yunjiang Zhou, Mengdi Yang, Mengran Cao, Yaxin Chen, Yingying Tan & Rong Hu. (2021) Overproduction of Gastrointestinal 5-HT Promotes Colitis-Associated Colorectal Cancer Progression via Enhancing NLRP3 Inflammasome Activation. Cancer Immunology Research 9:9, pages 1008-1023.
Crossref
Qi Lv, Yao Xing, Jian Liu, Dong Dong, Yue Liu, Hongzhi Qiao, Yinan Zhang & Lihong Hu. (2021) Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation. Acta Pharmaceutica Sinica B 11:9, pages 2880-2899.
Crossref
Ying Li, Jiao Lv, Weikai Shi, Jia Feng, Mingxi Liu, Shenao Gan, Hongjin Wu, Weiwei Fan & Ming Shi. (2021) Inflammasome Signaling: A Novel Paradigm of Hub Platform in Innate Immunity for Cancer Immunology and Immunotherapy. Frontiers in Immunology 12.
Crossref
Danyang Li & Minghua Wu. (2021) Pattern recognition receptors in health and diseases. Signal Transduction and Targeted Therapy 6:1.
Crossref
Ilandarage Menu Neelaka Molagoda, Athapaththu Mudiyanselage Gihan Kavinda Athapaththu, Yung Hyun Choi, Cheol Park, Cheng-Yung Jin, Chang-Hee Kang, Mi-Hwa Lee & Gi-Young Kim. (2021) Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production. Antioxidants 10:8, pages 1215.
Crossref
Rongliang Wang, Jiawei Li, Xingquan Xu, Jia Xu, Huiming Jiang, Zhongyang Lv, Rui Wu, Ziying Sun, Wenjie Guo, Yang Sun, Shiro Ikegawa, Qing Jiang & Dongquan Shi. (2021) Andrographolide attenuates synovial inflammation of osteoarthritis by interacting with tumor necrosis factor receptor 2 trafficking in a rat model. Journal of Orthopaedic Translation 29, pages 89-99.
Crossref
Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Srimanta Patra, Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, Prakash Priyadarshi Praharaj, Amruta Singh, Shankargouda Patil, Rohan Dhiman & Sujit Kumar Bhutia. (2021) Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics. The International Journal of Biochemistry & Cell Biology 136, pages 106013.
Crossref
Qiang-Qiang Shi, Yu Zhang, Ting-Ting Wang, Feng Xiong, Rui-Han Zhang, Xiao-Li Li, Xu Ji, Xing-Jie Zhang, Wei-Guang Wang & Wei-Lie Xiao. (2021) Euphopias D–F from Euphorbia L.: quantum chemical calculation-based structure elucidation and their bioactivity of inhibiting NLRP3 inflammasome activation . Organic Chemistry Frontiers 8:12, pages 3041-3046.
Crossref
Akhila H. Shrungeswara & Mazhuvancherry K. Unnikrishnan. (2021) Energy Provisioning and Inflammasome Activation: The Pivotal Role of AMPK in Sterile Inflammation and Associated Metabolic Disorders. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 20:2, pages 107-117.
Crossref
Qun Zhao, Yun Bi, Jian Guo, Ying-xiang Liu, Jing Zhong, Long-rui Pan, Yan Tan & Xian-jun Yu. (2020) Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation. Acta Pharmacologica Sinica 42:6, pages 975-986.
Crossref
Qiu-Ling Chen, Hao-Ran Yin, Qing-Yu He & Ying Wang. (2021) Targeting the NLRP3 inflammasome as new therapeutic avenue for inflammatory bowel disease. Biomedicine & Pharmacotherapy 138, pages 111442.
Crossref
Sonia Missiroli, Mariasole Perrone, Caterina Boncompagni, Chiara Borghi, Alberto Campagnaro, Francesco Marchetti, Gabriele Anania, Pantaleo Greco, Francesco Fiorica, Paolo Pinton & Carlotta Giorgi. (2021) Targeting the NLRP3 Inflammasome as a New Therapeutic Option for Overcoming Cancer. Cancers 13:10, pages 2297.
Crossref
Bhesh Raj Sharma & Thirumala-Devi Kanneganti. (2021) NLRP3 inflammasome in cancer and metabolic diseases. Nature Immunology 22:5, pages 550-559.
Crossref
Michele Aventaggiato, Enza Vernucci, Federica Barreca, Matteo A. Russo & Marco Tafani. (2021) Sirtuins' control of autophagy and mitophagy in cancer. Pharmacology & Therapeutics 221, pages 107748.
Crossref
Weiwei Qin, Xiyang Tong, Rongyao Liang, Kai Tang, Xingdong Wu, Yuning Jia & Ninghua Tan. (2021) Preservation of mitochondrial homeostasis is responsible for the ameliorative effects of Suhuang antitussive capsule on non-resolving inflammation via inhibition of NF-κB signaling and NLRP3 inflammasome activation. Journal of Ethnopharmacology 271, pages 113827.
Crossref
Feng Shi, Bo Wei, Tian Lan, Yang Xiao, Xin Quan, Jun Chen, Chong Zhao & Jinhang Gao. (2021) Low NLRP3 expression predicts a better prognosis of colorectal cancer. Bioscience Reports 41:4.
Crossref
Chin King Looi, Ling-Wei Hii, Felicia Fei-Lei Chung, Chun-Wai Mai, Wei-Meng Lim & Chee-Onn Leong. (2021) Roles of Inflammasomes in Epstein–Barr Virus-Associated Nasopharyngeal Cancer. Cancers 13:8, pages 1786.
Crossref
Yanpin Gu, Yongcheng Zhu, Guoliang Deng, Songjun Liu, Yang Sun & Wen Lv. (2021) Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation. International Immunopharmacology 93, pages 107375.
Crossref
Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Saeideh Momtaz, Negar Ghanaatian, Parichehr Kohansal, Mohammad Hosein Farzaei, Khashayar Afshari, Amirhossein Sahebkar & Amir Hossein Abdolghaffari. (2021) Targeting Mammalian Target of Rapamycin: Prospects for the Treatment of Inflammatory Bowel Diseases. Current Medicinal Chemistry 28:8, pages 1605-1624.
Crossref
Mark J. McVey, Benjamin E. Steinberg & Neil M. Goldenberg. (2021) Inflammasome activation in acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology 320:2, pages L165-L178.
Crossref
Sridhar Muthusami, Ileng Kumaran Ramachandran, Kokelavani Nampalli Babu, Sneha Krishnamoorthy, Akash Guruswamy, Lurdes Queimado, Gautam Chaudhuri & Ilangovan Ramachandran. (2021) Role of Inflammation in the Development of Colorectal Cancer. Endocrine, Metabolic & Immune Disorders - Drug Targets 21:1, pages 77-90.
Crossref
Zhen Dai, Xiao-yi Chen, Lu-yan An, Cui-cui Li, Ni Zhao, Fan Yang, Song-tao You, Chen-zhi Hou, Kan Li, Cheng Jiang, Qi-dong You, Bin Di & Li-li Xu. (2020) Development of Novel Tetrahydroquinoline Inhibitors of NLRP3 Inflammasome for Potential Treatment of DSS-Induced Mouse Colitis. Journal of Medicinal Chemistry 64:1, pages 871-889.
Crossref
梦馨 杨. (2021) Research Progress of Autophagy in the Mechanism of Periodontal Disease. Advances in Clinical Medicine 11:02, pages 567-574.
Crossref
Jian Cui, Yan Li, Chenyang Jiao, Jianhua Gao, Yingxue He, Beibei Nie, Lingdong Kong, Wenjie Guo & Qiang Xu. (2021) Improvement of magnesium isoglycyrrhizinate on DSS-induced acute and chronic colitis. International Immunopharmacology 90, pages 107194.
Crossref
Sahabuddin Ahmed, Mohit Kwatra, Samir Ranjan Panda, U.S.N Murty & V.G.M. Naidu. (2021) Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease. Brain, Behavior, and Immunity 91, pages 142-158.
Crossref
Hong Wu, Tao Wang, Yiqiang Liu, Xin Li, Senlin Xu, Changtao Wu, Hongbo Zou, Mianfu Cao, Guoxiang Jin, Jinyi Lang, Bin Wang, Baohua Liu, Xiaolin Luo & Chuan Xu. (2020) Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis. Journal of Experimental & Clinical Cancer Research 39:1.
Crossref
Chaeuk Chung, Wonhyoung Seo, Prashanta Silwal & Eun-Kyeong Jo. (2020) Crosstalks between inflammasome and autophagy in cancer. Journal of Hematology & Oncology 13:1.
Crossref
Yinjuan Song, Yang Zhou & Xiangmei Zhou. (2020) The role of mitophagy in innate immune responses triggered by mitochondrial stress. Cell Communication and Signaling 18:1.
Crossref
Jian Cui, Jian Gao, Yan Li, Ting Fan, Jiao Qu, Yang Sun, Wen Liu, Wenjie Guo & Qiang Xu. (2020) Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice. Journal of Pharmacological Sciences 144:4, pages 189-196.
Crossref
Weigang He, Jinxia Sun, Qingwen Zhang, Yinhong Li, Yan Fu, Yuejuan Zheng & Xin Jiang. (2020) Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis -infected macrophages by regulating the Notch1/Akt/NF-κB axis . Journal of Leukocyte Biology 108:6, pages 1747-1764.
Crossref
Zhaoxin Zhang, Yun Wang, Yating Shan & Wu Yin. (2020) Acetylharpagide Protects Mice from Staphylococcus Aureus-Induced Acute Lung Injury by Inhibiting NF-κB Signaling Pathway. Molecules 25:23, pages 5523.
Crossref
Yuanyuan Wang, Bin Wei, Jianhua Gao, Xiaomin Cai, Lingyan Xu, Haiqing Zhong, Binglin Wang, Yang Sun, Wenjie Guo, Qiang Xu & Yanhong Gu. (2020) Combination of Fruquintinib and Anti–PD-1 for the Treatment of Colorectal Cancer. The Journal of Immunology 205:10, pages 2905-2915.
Crossref
Wenwen Ding, Zhiquan Ding, Yong Wang, Yan Zhu, Qi Gao, Wangsen Cao & Ronghui Du. (2020) Evodiamine Attenuates Experimental Colitis Injury Via Activating Autophagy and Inhibiting NLRP3 Inflammasome Assembly. Frontiers in Pharmacology 11.
Crossref
Zhaoxin Zhang, Yun Wang, Yating Shan, Ri Zhou & Wu Yin. (2020) Oroxylin A alleviates immunoparalysis of CLP mice by degrading CHOP through interacting with FBXO15. Scientific Reports 10:1.
Crossref
Debasna P. Panigrahi, Prakash P. Praharaj, Chandra S. Bhol, Kewal K. Mahapatra, Srimanta Patra, Bishnu P. Behera, Soumya R. Mishra & Sujit K. Bhutia. (2020) The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics. Seminars in Cancer Biology 66, pages 45-58.
Crossref
Xue Jia, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Ningning Wang, Sen Wei, Ye Tao, Pei Pei, Zhidong Wang, Jingyuan Zhang, Yuhan Zhu, Guang Yang, Xiaofang Liu, Shuang Liu & Xiance Sun. (2020) Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway. Journal of Hazardous Materials 399, pages 123034.
Crossref
Jia Huang, Tengfei Zhu, Rong Rong, Mengling You, Dan Ji & Haibo Li. (2020) FUN14 domain‐containing 1-mediated mitophagy suppresses interleukin-1β production in macrophages. International Immunopharmacology 88, pages 106964.
Crossref
Rui Liang, Wei Chen, Huining Fan, Xiaoyu Chen, Jing Zhang & Jin-Shui Zhu. (2020) Dihydroartemisinin prevents dextran sodium sulphate-induced colitis through inhibition of the activation of NLRP3 inflammasome and p38 MAPK signaling. International Immunopharmacology 88, pages 106949.
Crossref
Xiaomin Cai, Bin Wei, Lele Li, Xiaofeng Chen, Wen Liu, Jian Cui, Yumeng Lin, Yang Sun, Qiang Xu, Wenjie Guo & Yanhong Gu. (2020) Apatinib enhanced anti-PD-1 therapy for colon cancer in mice via promoting PD-L1 expression. International Immunopharmacology 88, pages 106858.
Crossref
Gülçin Tezcan, Ekaterina E. Garanina, Margarita N. Zhuravleva, Shaimaa Hamza, Albert A. Rizvanov & Svetlana F. Khaiboullina. (2020) Rab GTPase Mediating Regulation of NALP3 in Colorectal Cancer. Molecules 25:20, pages 4834.
Crossref
Baptiste Pradel, Véronique Robert-Hebmann & Lucile Espert. (2020) Regulation of Innate Immune Responses by Autophagy: A Goldmine for Viruses. Frontiers in Immunology 11.
Crossref
Zhe Li, Jialong Guo & Liqi Bi. (2020) Role of the NLRP3 inflammasome in autoimmune diseases. Biomedicine & Pharmacotherapy 130, pages 110542.
Crossref
Muhammad Torequl Islam, Sanaa K. Bardaweel, Mohammad S. Mubarak, Wojciech Koch, Katarzyna Gaweł-Beben, Beata Antosiewicz & Javad Sharifi-Rad. (2020) Immunomodulatory Effects of Diterpenes and Their Derivatives Through NLRP3 Inflammasome Pathway: A Review. Frontiers in Immunology 11.
Crossref
Mridula P. Menon & Kuo-Feng Hua. (2020) The Long Non-coding RNAs: Paramount Regulators of the NLRP3 Inflammasome. Frontiers in Immunology 11.
Crossref
Ammad Ahmad Farooqi, Rukset Attar, Uteuliyev Yerzhan Sabitaliyevich, Nada Alaaeddine, Damião Pergentino de Sousa, Baojun Xu & William C. Cho. (2020) The Prowess of Andrographolide as a Natural Weapon in the War against Cancer. Cancers 12:8, pages 2159.
Crossref
Xiaofei Li, Ruifang Tian, Lan Liu, Lihui Wang, Dong He, Ke Cao, John K. Ma & Chenghui Huang. (2020) Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells. Journal of International Medical Research 48:8, pages 030006052094616.
Crossref
Gaohui Mao, Liqin Sun, Jinwen Xu, Yiming Li, Ciren Dunzhu, Liuqiang Zhang & Fei Qian. (2020) Scrodentoids H and I, a Pair of Natural Epimerides from Scrophularia dentata , Inhibit Inflammation through JNK-STAT3 Axis in THP-1 Cells . Evidence-Based Complementary and Alternative Medicine 2020, pages 1-11.
Crossref
Shaima'a Hamarsheh & Robert Zeiser. (2020) NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword. Frontiers in Immunology 11.
Crossref
Jae-Min Yuk, Prashanta Silwal & Eun-Kyeong Jo. (2020) Inflammasome and Mitophagy Connection in Health and Disease. International Journal of Molecular Sciences 21:13, pages 4714.
Crossref
Xuan Wang, Qi-Hui Shao, Hao Zhou, Jun-Lu Wu, Wen-Qiang Quan, Ping Ji, Yi-Wen Yao, Dong Li & Zu-Jun Sun. (2020) RETRACTED ARTICLE: Ginkgolide B inhibits lung cancer cells promotion via beclin-1-dependent autophagy. BMC Complementary Medicine and Therapies 20:1.
Crossref
Jianhua Gao, Jian Cui, Haiqing Zhong, Yan Li, Wen Liu, Chenyang Jiao, Jian Gao, Chunhong Jiang, Wenjie Guo & Qiang Xu. (2020) Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis. International Immunopharmacology 83, pages 106426.
Crossref
Guoliang Dai, Zhitao Jiang, Bingting Sun, Chao Liu, Qinghai Meng, Kang Ding, Wen Jing & Wenzheng Ju. (2020) Caffeic Acid Phenethyl Ester Prevents Colitis-Associated Cancer by Inhibiting NLRP3 Inflammasome. Frontiers in Oncology 10.
Crossref
Wenmin Deng, Zhongjin Yang, Hu Yue, Yitao Ou, Wenhui Hu & Ping Sun. (2020) Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation. Free Radical Biology and Medicine 152, pages 8-17.
Crossref
Wei Shi, Guang Xu, Xiaoyan Zhan, Yuan Gao, Zhilei Wang, Shubin Fu, Nan Qin, Xiaorong Hou, Yongqiang Ai, Chunyu Wang, Tingting He, Hongbin Liu, Yuanyuan Chen, Yan Liu, Jiabo Wang, Ming Niu, Yuming Guo, Xiaohe Xiao & Zhaofang Bai. (2020) Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases. Cell Death & Disease 11:4.
Crossref
Haw-Wen Chen, Chih-Ching Yen, Li-Li Kuo, Chia-Wen Lo, Chin-Shiu Huang, Chih-Chieh Chen & Chong-Kuei Lii. (2020) Benzyl isothiocyanate ameliorates high-fat/cholesterol/cholic acid diet-induced nonalcoholic steatohepatitis through inhibiting cholesterol crystal-activated NLRP3 inflammasome in Kupffer cells. Toxicology and Applied Pharmacology 393, pages 114941.
Crossref
Wen Liu, Ting Fan, Manru Li, Guohui Zhang, Wenjie Guo, Xiaoling Yang, Chunhong Jiang, Xiang Li, Xiangyu Xu, Anshu Tang, Keqin Liu, Lixuan Liu, Lingdong Kong, Qiang Xu & Yang Sun. (2020) Andrographolide potentiates PD-1 blockade immunotherapy by inhibiting COX2-mediated PGE2 release. International Immunopharmacology 81, pages 106206.
Crossref
Mohamed Adil A.A., Shabnam Ameenudeen, Ashok Kumar, S. Hemalatha, Neesar Ahmed, Nemat Ali, Abdullah F. AlAsmari, Mohammad Aashique & Mohammad Waseem. (2020) Emerging Role of Mitophagy in Inflammatory Diseases: Cellular and Molecular Episodes. Current Pharmaceutical Design 26:4, pages 485-491.
Crossref
Shanshan Huang, Jing Che, Qian Chu & Peng Zhang. (2020) The Role of NLRP3 Inflammasome in Radiation-Induced Cardiovascular Injury. Frontiers in Cell and Developmental Biology 8.
Crossref
Minmin Fan, Gang Xiang, Jingwei Chen, Jian Gao, Wenwen Xue, Yixuan Wang, Wuhao Li, Lin Zhou, Ruihua Jiao, Yan Shen & Qiang Xu. (2020) Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S12, protects against DSS-induced colitis via inhibiting both nuclear translocation of NF-κB and NLRP3 inflammasome activation. International Immunopharmacology 80, pages 106144.
Crossref
Xiao Yang, Weinan Pan, Gaosheng Xu & Linxi Chen. (2020) Mitophagy: A crucial modulator in the pathogenesis of chronic diseases. Clinica Chimica Acta 502, pages 245-254.
Crossref
Sonsoles Hortelano, Laura González-Cofrade, Irene Cuadrado & Beatriz de las Heras. (2020) Current status of terpenoids as inflammasome inhibitors. Biochemical Pharmacology 172, pages 113739.
Crossref
Shu-Wei Zhang, Chao-Jun Gong, Ming-Bo Su, Fei Chen, Ting He, Yang-Ming Zhang, Qian-Qian Shen, Yi Su, Jian Ding, Jia Li, Yi Chen & Fa-Jun Nan. (2019) Synthesis and in Vitro and in Vivo Biological Evaluation of Tissue-Specific Bisthiazole Histone Deacetylase (HDAC) Inhibitors. Journal of Medicinal Chemistry 63:2, pages 804-815.
Crossref
Tomoya Iida, Daisuke Hirayama, Naoki Minami, Minoru Matsuura, Kohei Wagatsuma, Kentaro Kawakami, Kanna Nagaishi, Masanori Nojima, Hiroki Ikeuchi, Seiichi Hirota, Ryutaro Shirakawa, Hisanori Horiuchi & Hiroshi Nakase. (2020) Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation. Cellular and Molecular Gastroenterology and Hepatology 9:2, pages 277-293.
Crossref
Jian Gao, Shuang Peng, Xinni Shan, Guoliang Deng, Lihong Shen, Jian Sun, Chunhong Jiang, Xiaoling Yang, Zhigang Chang, Xinchen Sun, Fude Feng, Lingdong Kong, Yanhong Gu, Wenjie Guo, Qiang Xu & Yang Sun. (2019) Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis. Cell Death & Disease 10:12.
Crossref
Shengchao Xu, Xizhe Li, Yuanqi Liu, Yu Xia, Ruimin Chang & Chunfang Zhang. (2019) Inflammasome inhibitors: promising therapeutic approaches against cancer. Journal of Hematology & Oncology 12:1.
Crossref
Mingjiang Yao, Xiaodi Fan, Bo Yuan, Norio Takagi, Sai Liu, Xiao Han, Junguo Ren & Jianxun Liu. (2019) Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell. BMC Complementary and Alternative Medicine 19:1.
Crossref
Ji Geng, Wen Liu, Jian Gao, Chunhong Jiang, Ting Fan, Yang Sun, Zheng‐Hong Qin, Qiang Xu, Wenjie Guo & Jing Gao. (2019) Andrographolide alleviates Parkinsonism in MPTP‐PD mice via targeting mitochondrial fission mediated by dynamin‐related protein 1. British Journal of Pharmacology 176:23, pages 4574-4591.
Crossref
Yumeng Miao, Qi Lv, Simiao Qiao, Ling Yang, Yu Tao, Wenxin Yan, Pengfei Wang, Na Cao, Yue Dai & Zhifeng Wei. (2019) Alpinetin improves intestinal barrier homeostasis via regulating AhR/suv39h1/TSC2/mTORC1/autophagy pathway. Toxicology and Applied Pharmacology 384, pages 114772.
Crossref
Peng Liu, Ziwen Lu, Lanlan Liu, Ruyan Li, Zhiquan Liang, Mingxiang Shen, Han Xu, Dewan Ren, Mengchen Ji, Sirui Yuan, Dongsheng Shang, Yibang Zhang, Hanqing Liu & Zhigang Tu. (2019) NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies. Phytomedicine 64, pages 152925.
Crossref
Yunyun Liu, Yuanpei Zhang, Jialing Peng, Hongxuan Wang, Xiangpen Li, Xiaoyu Li, Xiaoming Rong, Jingrui Pan & Ying Peng. (2019) Autophagy alleviates ethanol-induced memory impairment in association with anti-apoptotic and anti-inflammatory pathways. Brain, Behavior, and Immunity 82, pages 63-75.
Crossref
Yanping Wu, Li Tang, Baikui Wang, Qiming Sun, Pengwei Zhao & Weifen Li. (2019) The role of autophagy in maintaining intestinal mucosal barrier. Journal of Cellular Physiology 234:11, pages 19406-19419.
Crossref
Samantha N Devenport & Yatrik M Shah. (2019) Functions and Implications of Autophagy in Colon Cancer. Cells 8:11, pages 1349.
Crossref
Zhenrui Cao, Yanhao Wang, Zhimin Long & Guiqiong He. (2019) Interaction between autophagy and the NLRP3 inflammasome. Acta Biochimica et Biophysica Sinica 51:11, pages 1087-1095.
Crossref
Zhao-Li Hu, Ting Sun, Ming Lu, Jian-Hua Ding, Ren-Hong Du & Gang Hu. (2019) Kir6.1/K-ATP channel on astrocytes protects against dopaminergic neurodegeneration in the MPTP mouse model of Parkinson’s disease via promoting mitophagy. Brain, Behavior, and Immunity 81, pages 509-522.
Crossref
Ji Geng, Jia Liu, Xiao Yuan, Wen Liu & Wenjie Guo. (2019) Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice. Toxicology and Applied Pharmacology 379, pages 114688.
Crossref
Guorong Zhang, Chunhong Jiang, Ning Xie, Yang Xu, Li Liu & Nan Liu. (2019) Treatment with andrographolide sulfonate provides additional benefits to imipenem in a mouse model of Klebsiella pneumoniae pneumonia. Biomedicine & Pharmacotherapy 117, pages 109065.
Crossref
He, Li, Meng, Wu, Zhao & Zhao. (2019) Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats. Cells 8:8, pages 897.
Crossref
Na An, Yonghong Gao, Zeyu Si, Hanlai Zhang, Liqin Wang, Chao Tian, Mengchen Yuan, Xinyu Yang, Xinye Li, Hongcai Shang, Xingjiang Xiong & Yanwei Xing. (2019) Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel Immune-Inflammatory Marker in Cardiovascular Diseases. Frontiers in Immunology 10.
Crossref
Kuo-Chieh Liao, Christina F. Sandall, David A. Carlson, Annegret Ulke-Lemée, Jaye M. Platnich, Philip F. Hughes, Daniel A. Muruve, Timothy A.J. Haystead & Justin A. MacDonald. (2019) Application of immobilized ATP to the study of NLRP inflammasomes. Archives of Biochemistry and Biophysics 670, pages 104-115.
Crossref
Haibo Xia, Junchao Xue, Hui Xu, Min Lin, Ming Shi, Qian Sun, Tian Xiao, Xiangyu Dai, Lu Wu, Junjie Li, Quanyong Xiang, Huanwen Tang, Qian Bian & Qizhan Liu. (2019) Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIR. Toxicology 422, pages 84-94.
Crossref
Ying Feng, Boyi Liu, Xiang Zheng, Li Chen, Wei Chen & Zhicheng Fang. (2019) The protective role of autophagy in sepsis. Microbial Pathogenesis 131, pages 106-111.
Crossref
Gulcin Tezcan, Ekaterina V. Martynova, Zarema E. Gilazieva, Alan McIntyre, Albert A. Rizvanov & Svetlana F. Khaiboullina. (2019) MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies. Frontiers in Pharmacology 10.
Crossref
Francesca GiampieriSadia AfrinTamara Y. Forbes-HernandezMassimiliano GasparriniDanila CianciosiPatricia Reboredo-RodriguezAlfonso Varela-LopezJose L. QuilesMaurizio Battino. (2019) Autophagy in Human Health and Disease: Novel Therapeutic Opportunities. Antioxidants & Redox Signaling 30:4, pages 577-634.
Crossref
Xuan Zhu, Shasha Xiang, Xiao Feng, Huanhuan Wang, Shiyi Tian, Yuanyuan Xu, Lihua Shi, Lu Yang, Mian Li, Yubiao Shen, Jie Chen, Yuewen Chen & Jianzhong Han. (2018) Impact of Cyanocobalamin and Methylcobalamin on Inflammatory Bowel Disease and the Intestinal Microbiota Composition. Journal of Agricultural and Food Chemistry 67:3, pages 916-926.
Crossref
Chu-Tian Mai, Mei-Mei Wu, Chun-Li Wang, Zi-Ren Su, Yuan-Yuan Cheng & Xiao-Jun Zhang. (2019) Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation. Molecular Immunology 105, pages 76-85.
Crossref
Dev Karan. (2018) Inflammasomes: Emerging Central Players in Cancer Immunology and Immunotherapy. Frontiers in Immunology 9.
Crossref
Patricia Ahechu, Gabriel Zozaya, Pablo Martí, José Luis Hernández-Lizoáin, Jorge Baixauli, Xabier Unamuno, Gema Frühbeck & Victoria Catalán. (2018) NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development. Frontiers in Immunology 9.
Crossref
Si Ming Man. (2018) Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis. Nature Reviews Gastroenterology & Hepatology 15:12, pages 721-737.
Crossref
W.S. Daniel Tan, Wupeng Liao, Hong Yong Peh, Merima Vila, Jinrui Dong, Han-Ming Shen & W.S. Fred Wong. (2018) Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells. Toxicology and Applied Pharmacology 360, pages 120-130.
Crossref
Xinxu Yuan, Owais M. Bhat, Nan Meng, Hannah Lohner & Pin-Lan Li. (2018) Protective Role of Autophagy in Nlrp3 Inflammasome Activation and Medial Thickening of Mouse Coronary Arteries. The American Journal of Pathology 188:12, pages 2948-2959.
Crossref
Agampodi Promoda Perera, Karishma Sajnani, Joanne Dickinson, Rajaraman Eri & Heinrich Körner. (2018) NLRP3 inflammasome in colitis and colitis-associated colorectal cancer. Mammalian Genome 29:11-12, pages 817-830.
Crossref
Yuhui Wu, Junlin Yao, Jiansheng Xie, Zhen Liu, Yubin Zhou, Hongming Pan & Weidong Han. (2018) The role of autophagy in colitis-associated colorectal cancer. Signal Transduction and Targeted Therapy 3:1.
Crossref
Pil-Hoon Park. (2018) Autophagy induction: a critical event for the modulation of cell death/survival and inflammatory responses by adipokines. Archives of Pharmacal Research 41:11, pages 1062-1073.
Crossref
Wen Liu, Wenjie Guo, Yongcheng Zhu, Shuang Peng, Wei Zheng, Chao Zhang, Fenli Shao, Yuyu Zhu, Nan Hang, Lingdong Kong, Xiangbao Meng, Qiang Xu & Yang Sun. (2018) Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice. The Journal of Immunology 201:8, pages 2403-2413.
Crossref
Xiang Li, Tianyi Wang, Dongping Zhang, Haiying Li, Haitao Shen, Xin Ding & Gang Chen. (2018) Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction. Neuropharmacology 141, pages 305-315.
Crossref
Hyunkyung Lee, Seungyeon Lee, Dawoon Jeong & Sun Jung Kim. (2018) Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells. Journal of Ginseng Research 42:4, pages 455-462.
Crossref
Kai Wang, Qi Lv, Yu-meng Miao, Si-miao Qiao, Yue Dai & Zhi-feng Wei. (2018) Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway. Biochemical Pharmacology 155, pages 494-509.
Crossref
Agampodi Promoda Perera, Ruchira Fernando, Tanvi Shinde, Rohit Gundamaraju, Benjamin Southam, Sukhwinder Singh Sohal, Avril A. B. Robertson, Kate Schroder, Dale Kunde & Rajaraman Eri. (2018) MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Scientific Reports 8:1.
Crossref
Muhammad Torequl Islam, Eunüs S. Ali, Shaikh Jamal Uddin, Md. Amirul Islam, Subrata Shaw, Ishaq N. Khan, Seyed Soheil Saeedi Saravi, Saheem Ahmad, Shahnawaz Rehman, Vijai Kumar Gupta, Mihnea-Alexandru Găman, Amelia Maria Găman, Santosh Yele, Asish Kumar Das, João Marcelo de Castro e Sousa, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S. Mubarak, Nagendra Sastry Yarla, Jamil A. Shilpi, Siddhartha Kumar Mishra, Atanas G. Atanasov & Mohammad Amjad Kamal. (2018) Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. Cancer Letters 420, pages 129-145.
Crossref
Sulin Zhang, Bin Hu, Yan You, Zhiwen Yang, Lixin Liu, Huanhuan Tang, Weilian Bao, Yunyun Guan & Xiaoyan Shen. (2018) Sorting nexin 10 acts as a tumor suppressor in tumorigenesis and progression of colorectal cancer through regulating chaperone mediated autophagy degradation of p21Cip1/WAF1. Cancer Letters 419, pages 116-127.
Crossref
Gang Xiang, Minmin Fan, Yuzhu Ma, Miao Wang, Jian Gao, Jingwei Chen, Xin Li, Wenwen Xue, Yixuan Wang, Huiyuan Gao, Yan Shen & Qiang Xu. (2018) Anti-inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator. Biochemical Pharmacology 150, pages 150-159.
Crossref
Qi LV, Kai WANG, Si-Miao QIAO, Yue DAI & Zhi-Feng WEI. (2018) Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome. Chinese Journal of Natural Medicines 16:3, pages 161-174.
Crossref
Michihiro Takahama, Shizuo Akira & Tatsuya Saitoh. (2017) Autophagy limits activation of the inflammasomes. Immunological Reviews 281:1, pages 62-73.
Crossref
Ji Geng, Wen Liu, Yuyun Xiong, Hongqun Ding, Chunhong Jiang, Xiaoling Yang, Xiang Li, Ahmed Elgehama, Yang Sun, Qiang Xu, Wenjie Guo & Jing Gao. (2018) Andrographolide sulfonate improves Alzheimer-associated phenotypes and mitochondrial dysfunction in APP/PS1 transgenic mice. Biomedicine & Pharmacotherapy 97, pages 1032-1039.
Crossref
Daolu Yuwen, Shanwei Mi, Yuzhu Ma, Wenjie Guo, Qiang Xu, Yan Shen & Yongqian Shu. (2017) Andrographolide enhances cisplatin-mediated anticancer effects in lung cancer cells through blockade of autophagy. Anti-Cancer Drugs 28:9, pages 967-976.
Crossref
Wencheng Wei, Meiling Ding, Kai Zhou, Haifeng Xie, Mian Zhang & Chaofeng Zhang. (2017) Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling. Biomedicine & Pharmacotherapy 94, pages 27-36.
Crossref
Xianjun Yu, Qun Zhao, Xixi Zhang, Haiwei Zhang, Yongbo Liu, Xiaoxia Wu, Ming Li, Xiaoming Li, Jingxuan Zhang, Xuzhi Ruan & Haibing Zhang. (2017) Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation. Oncotarget 8:40, pages 67300-67314.
Crossref
Jian Gao, Minmin Fan, Shuang Peng, Minxia Zhang, Gang Xiang, Xin Li, Wenjie Guo, Yang Sun, Xuefeng Wu, Xudong Wu, Guang Liang, Yan Shen & Qiang Xu. (2017) Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer. Cell Death & Disease 8:9, pages e3049-e3049.
Crossref
Jihoon Nah, Shigeki Miyamoto & Junichi Sadoshima. 2011. Comprehensive Physiology. Comprehensive Physiology 1407 1424 .
Wei Zhou, Xiuting Liu, Xin Zhang, Jingjing Tang, Zhiyu Li, Qing Wang & Rong Hu. (2017) Oroxylin A inhibits colitis by inactivating NLRP3 inflammasome. Oncotarget 8:35, pages 58903-58917.
Crossref
N. Zmora, M. Levy, M. Pevsner-Fishcer & E. Elinav. (2017) Inflammasomes and intestinal inflammation. Mucosal Immunology 10:4, pages 865-883.
Crossref
Yong Zhang, Weijia Kong & Jiandong Jiang. (2017) Prevention and treatment of cancer targeting chronic inflammation: research progress, potential agents, clinical studies and mechanisms. Science China Life Sciences 60:6, pages 601-616.
Crossref
Liang Lu, Sulin Zhang, Cuixian Li, Chun Zhou, Dong Li, Peiqing Liu, Min Huang & Xiaoyan Shen. (2017) Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation. Cell Death & Disease 8:5, pages e2767-e2767.
Crossref
Hang Zhou, Lili Feng, Fang Xu, Yi Sun, Yuxiang Ma, Xiong Zhang, Hailiang Liu, Ge Xu, Xuefeng Wu, Yan Shen, Yang Sun, Xudong Wu & Qiang Xu. (2017) Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement. Biomedicine & Pharmacotherapy 89, pages 864-874.
Crossref
Ai Hua Zhang, Wen Liu, Nan Jiang, Xin Lei Wang, Gang Wang, Qiang Xu & Ren Xiang Tan. (2017) Sequestration of Guest Intermediates by Dalesconol Bioassembly Lines in Daldinia eschscholzii . Organic Letters 19:8, pages 2142-2145.
Crossref
Wen Liu, Wenjie Guo, Lihong Shen, Zhen Chen, Qiong Luo, Xiaolin Luo, GenSheng Feng, Yongqian Shu, Yanhong Gu, Qiang Xu & Yang Sun. (2016) T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice. Oncotarget 8:5, pages 7586-7597.
Crossref
Ping Ke, Bo-Zong Shao, Zhe-Qi Xu, Xiong-Wen Chen & Chong Liu. (2017) Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease. Frontiers in Immunology 7.
Crossref
Wencheng Wei, Lei Wang, Kai Zhou, Haifeng Xie, Mian Zhang & Chaofeng Zhang. (2017) Rhapontin ameliorates colonic epithelial dysfunction in experimental colitis through SIRT1 signaling. International Immunopharmacology 42, pages 185-194.
Crossref
Ai Hua Zhang, Wen Liu, Nan Jiang, Qiang Xu & Ren Xiang Tan. (2016) Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor. Organic Letters 18:24, pages 6496-6499.
Crossref
Shuang Peng, Jian Gao, Wen Liu, Chunhong Jiang, Xiaoling Yang, Yang Sun, Wenjie Guo & Qiang Xu. (2016) Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation. Oncotarget 7:49.
Crossref
Jelena Todoric, Laura Antonucci & Michael Karin. (2016) Targeting Inflammation in Cancer Prevention and Therapy. Cancer Prevention Research 9:12, pages 895-905.
Crossref
Weicheng Wang, Wenjie Guo, Lele Li, Zan Fu, Wen Liu, Jian Gao, Yongqian Shu, Qiang Xu, Yang Sun & Yanhong Gu. (2016) Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression. Biochemical Pharmacology 121, pages 8-17.
Crossref
Shanwei Mi, Gang Xiang, Daolu Yuwen, Jian Gao, Wenjie Guo, Xuefeng Wu, Xudong Wu, Yang Sun, Yongqian Su, Yan Shen & Qiang Xu. (2016) Inhibition of autophagy by andrographolide resensitizes cisplatin-resistant non-small cell lung carcinoma cells via activation of the Akt/mTOR pathway. Toxicology and Applied Pharmacology 310, pages 78-86.
Crossref
Je-Wook Yu & Myung-Shik Lee. (2016) Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance. Archives of Pharmacal Research 39:11, pages 1503-1518.
Crossref
Ping Ke, Bo-Zong Shao, Zhe-Qi Xu, Wei Wei, Bin-Ze Han, Xiong-Wen Chen, Ding-Feng Su & Chong Liu. (2016) Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages. PLOS ONE 11:9, pages e0155076.
Crossref
Chao Lin, Honglu Chao, Zheng Li, Xiupeng Xu, Yinlong Liu, Lijun Hou, Ning Liu & Jing Ji. (2016) Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy. Journal of Pineal Research 61:2, pages 177-186.
Crossref
Junlin Yao, Jiansheng Xie, Binbin Xie, Yiran Li, Liming Jiang, Xinbing Sui, Xiaoyun Zhou, Hongming Pan & Weidong Han. (2016) Therapeutic effect of hydroxychloroquine on colorectal carcinogenesis in experimental murine colitis. Biochemical Pharmacology 115, pages 51-63.
Crossref
Fenli Shao, Tao Tan, Yang Tan, Yang Sun, Xingxin Wu & Qiang Xu. (2016) Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88. Biochemical Pharmacology 115, pages 94-103.
Crossref
Bin Lu, Yuchen Sheng, Jiaqi Zhang, Zhiyong Zheng & Lili Ji. (2016) The altered microRNA profile in andrographolide-induced inhibition of hepatoma tumor growth. Gene 588:2, pages 124-133.
Crossref
Tatsuya Saitoh & Shizuo Akira. (2016) Regulation of inflammasomes by autophagy. Journal of Allergy and Clinical Immunology 138:1, pages 28-36.
Crossref
Xiuting Liu, Wei Zhou, Xin Zhang, Ping Lu, Qianming Du, Lei Tao, Yang Ding, Yajing Wang & Rong Hu. (2016) Dimethyl fumarate ameliorates dextran sulfate sodium-induced murine experimental colitis by activating Nrf2 and suppressing NLRP3 inflammasome activation. Biochemical Pharmacology 112, pages 37-49.
Crossref
Wupeng Liao, W. S. Daniel Tan & W. S. Fred Wong. (2016) Andrographolide Restores Steroid Sensitivity To Block Lipopolysaccharide/IFN-γ–Induced IL-27 and Airway Hyperresponsiveness in Mice. The Journal of Immunology 196:11, pages 4706-4712.
Crossref
Wen Liu, Wenjie Guo, Nan Hang, Yuanyuan Yang, Xuefeng Wu, Yan Shen, Jingsong Cao, Yang Sun & Qiang Xu. (2016) MALT1 inhibitors prevent the development of DSS-induced experimental colitis in mice via inhibiting NF-κB and NLRP3 inflammasome activation. Oncotarget 7:21, pages 30536-30549.
Crossref
Shuang Peng, Nan Hang, Wen Liu, Wenjie Guo, Chunhong Jiang, Xiaoling Yang, Qiang Xu & Yang Sun. (2016) Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways. Acta Pharmaceutica Sinica B 6:3, pages 205-211.
Crossref
Hong Wang, Yajing Wang, Qianming Du, Ping Lu, Huimin Fan, Jinrong Lu & Rong Hu. (2016) Inflammasome-independent NLRP3 is required for epithelial-mesenchymal transition in colon cancer cells. Experimental Cell Research 342:2, pages 184-192.
Crossref
Annalisa Marcuzzi, Elisa Piscianz, Claudia Loganes, Liza Vecchi Brumatti, Alessandra Knowles, Sabrine Bilel, Alberto Tommasini, Roberta Bortul & Marina Zweyer. (2015) Innovative Target Therapies Are Able to Block the Inflammation Associated with Dysfunction of the Cholesterol Biosynthesis Pathway. International Journal of Molecular Sciences 17:1, pages 47.
Crossref
Shusaku T Shibutani, Tatsuya Saitoh, Heike Nowag, Christian Münz & Tamotsu Yoshimori. (2015) Autophagy and autophagy-related proteins in the immune system. Nature Immunology 16:10, pages 1014-1024.
Crossref
Jemma GatliffMichelangelo Campanella. (2015) TSPO is a REDOX regulator of cell mitophagy. Biochemical Society Transactions 43:4, pages 543-552.
Crossref

Displaying 200 of 203 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.