2,861
Views
87
CrossRef citations to date
0
Altmetric
Basic Research Paper

Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells

, , , &
Pages 1193-1211 | Received 21 Jun 2013, Accepted 03 Apr 2014, Published online: 09 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Paloma B. Liton, Kathleen Boesze-Battaglia, Michael E. Boulton, Patricia Boya, Thomas A. Ferguson, Ian G. Ganley, Anu Kauppinnen, Gordon W. Laurie, Noboru Mizushima, Hideaki Morishita, Rossella Russo, Jaya Sadda, Rajalekshmy Shyam, Debasish Sinha, Debra A. Thompson & David N. Zacks. (2023) Autophagy in the eye: from physiology to pathophysiology. Autophagy Reports 2:1.
Read now
Shahid Y. Khan, Muhammad Ali, Firoz Kabir, Chan Hyun Na, Michael Delannoy, Yinghong Ma, Caihong Qiu, M. Joseph Costello, J. Fielding Hejtmancik & S. Amer Riazuddin. (2022) The role of FYCO1-dependent autophagy in lens fiber cell differentiation. Autophagy 18:9, pages 2198-2215.
Read now
Chaofeng Tu, Haiyu Li, Xuyang Liu, Ying Wang, Wei Li, Lanlan Meng, Weili Wang, Yong Li, Dongyan Li, Juan Du, Guangxiu Lu, Ge Lin & Yue-Qiu Tan. (2021) TDRD7 participates in lens development and spermiogenesis by mediating autophagosome maturation. Autophagy 17:11, pages 3848-3864.
Read now
Xiyuan Ping, Jiancheng Liang, Kexin Shi, Jing Bao, Jing Wu, Xiaoning Yu, Xiajing Tang, Jian Zou & Xingchao Shentu. (2021) Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish. Autophagy 17:11, pages 3323-3337.
Read now
Yu Cao, Pengfei Li, Guowei Zhang, Lihua Kang, Tianqiu Zhou, Jian Wu, Yong Wang, Ying Wang, Xiaojuan Chen & Huaijin Guan. (2021) MicroRNA Let-7c-5p-Mediated Regulation of ERCC6 Disrupts Autophagic Flux in Age-Related Cataract via the Binding to VCP. Current Eye Research 46:9, pages 1353-1362.
Read now
Clare Rogerson, Daniele Bergamaschi & Ryan F. L. O'Shaughnessy. (2018) Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues. Nucleus 9:1, pages 56-64.
Read now
Seda Avcioglu Barutcu, Nomeda Girnius, Santiago Vernia & Roger J. Davis. (2018) Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy. Autophagy 14:9, pages 1586-1595.
Read now
Andreas Struchtrup, Antonia Wiegering, Björn Stork, Ulrich Rüther & Christoph Gerhardt. (2018) The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts. Autophagy 14:4, pages 567-583.
Read now
D. J. Sidjanin, Anna K. Park, Adam Ronchetti, Jamaria Martins & William T. Jackson. (2016) TBC1D20 mediates autophagy as a key regulator of autophagosome maturation. Autophagy 12:10, pages 1759-1775.
Read now

Articles from other publishers (78)

Lisa Brennan, Joshua Disatham, A. Sue Menko & Marc Kantorow. (2023) Multiomic analysis implicates FOXO4 in genetic regulation of chick lens fiber cell differentiation. Developmental Biology 504, pages 25-37.
Crossref
Rifah Gheyas & A. Sue Menko. (2023) Examining PI3K-signaling-dependent regulation of lens organelle free zone formation via immunolocalization and immunoblotting in chick embryos. STAR Protocols 4:4, pages 102569.
Crossref
Rifah Gheyas & A. Sue Menko. (2023) The involvement of caspases in the process of nuclear removal during lens fiber cell differentiation. Cell Death Discovery 9:1.
Crossref
Da Eun Hong, Ji Eun Yu, Seung Sik Yoo, In Jun Yeo, Dong Ju Son, Jaesuk Yun, Sang-Bae Han & Jin Tae Hong. (2023) CHI3L1 induces autophagy through the JNK pathway in lung cancer cells. Scientific Reports 13:1.
Crossref
Jing Zhang, Ning Jiang, Chunxiao Du, Hongzan Guo, Ranqi Meng, Xinyu Hou, Mugen Liu, Yanzhong Hu & Xiukun Cui. (2023) HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation. Investigative Opthalmology & Visual Science 64:7, pages 5.
Crossref
Imran Tarique, Tong Lu & Mansoor Tariq. (2023) Cellular activity of autophagy and multivesicular bodies in lens fiber cells during early lens development in rbm24a mutant of zebrafish: Ultrastructure analysis. Micron 169, pages 103446.
Crossref
Hongyu Li, Lixiong Gao, Jinlin Du, Tianju Ma, Wen Li, Zi Ye & Zhaohui Li. (2023) Impacts of autophagy on the formation of organelle-free zone during the lens development. Molecular Biology Reports 50:5, pages 4551-4564.
Crossref
Joshua Disatham, Lisa Brennan, Ales Cvekl & Marc Kantorow. (2023) Multiomics Analysis Reveals Novel Genetic Determinants for Lens Differentiation, Structure, and Transparency. Biomolecules 13:4, pages 693.
Crossref
Verónica A. Bahamondes Lorca & Shiyong Wu. (2023) Ultraviolet Light, Unfolded Protein Response and Autophagy † . Photochemistry and Photobiology 99:2, pages 498-508.
Crossref
Allen Taylor, Yumei Gu, Min-Lee Chang, Wenxin Yang, Sarah Francisco, Sheldon Rowan, Eloy Bejarano, Steven Pruitt, Liang Zhu, Grant Weiss, Lisa Brennan, Marc Kantorow & Elizabeth A. Whitcomb. (2023) Repurposing a Cyclin-Dependent Kinase 1 (CDK1) Mitotic Regulatory Network to Complete Terminal Differentiation in Lens Fiber Cells. Investigative Opthalmology & Visual Science 64:2, pages 6.
Crossref
Lisa Brennan, M. Joseph Costello, J. Fielding Hejtmancik, A. Sue Menko, S. Amer Riazuddin, Alan Shiels & Marc Kantorow. (2023) Autophagy Requirements for Eye Lens Differentiation and Transparency. Cells 12:3, pages 475.
Crossref
Xiao Cui, Fangyan Chen, Jingya Zhao, Dingchen Li, Mandong Hu, Xue Chen, Yulin Zhang & Li Han. (2023) Involvement of JNK signaling in Aspergillus fumigatus-induced inflammatory factors release in bronchial epithelial cells. Scientific Reports 13:1.
Crossref
Zongbo Wei, Caili Hao, Jian-Kang Chen, Lin Gan & Xingjun Fan. (2023) A tamoxifen-inducible Cre knock-in mouse for lens-specific gene manipulation. Experimental Eye Research 226, pages 109306.
Crossref
Xiujuan Zhang, Peipei Ma, Ting Shao, Yingli Xiong, Qian Du, Songbiao Chen, Bichen Miao, Xuezhi Zhang, Xiaoya Wang, Yong Huang & Dewen Tong. (2022) Porcine parvovirus triggers autophagy through the AMPK/Raptor/mTOR pathway to promote viral replication in porcine placental trophoblasts. Veterinary Research 53:1.
Crossref
Jiyuan Ma, Wei Ye, Yunshu Yang, Tong Wu, Yafen Wang, Ji Li, Rui Pei, Mengmei He, Luning Zhang & Jian Zhou. (2022) The interaction between autophagy and the epithelial-mesenchymal transition mediated by NICD/ULK1 is involved in the formation of diabetic cataracts. Molecular Medicine 28:1.
Crossref
Hideaki Morishita. (2022) Role of autophagy in the eye: from physiology to disease. Current Opinion in Physiology 30, pages 100592.
Crossref
Jiani Li, Xuhua Tan, Qihang Sun, Xuri Li, Rongyuan Chen & Lixia Luo. (2022) Deficiency of Jamc Leads to Congenital Nuclear Cataract and Activates the Unfolded Protein Response in Mouse Lenses . Investigative Opthalmology & Visual Science 63:10, pages 1.
Crossref
Mengqi Qin, Zhi Xie, Ting Cao, Zhiruo Wang, Xiaoyu Zhang, Feifei Wang, Wei Wei, Ming Jin, Jingyuan Ma, Ling Zeng, Yanan Wang, Shaonan Pei & Xu Zhang. (2022) Autophagy in Rat Müller Glial Cells Is Modulated by the Sirtuin 4/AMPK/mTOR Pathway and Induces Apoptosis under Oxidative Stress. Cells 11:17, pages 2645.
Crossref
Romell B. Gletten, Lee S. Cantrell, Sujoy Bhattacharya & Kevin L. Schey. (2022) Lens Aquaporin-5 Inserts Into Bovine Fiber Cell Plasma Membranes Via Unconventional Protein Secretion. Investigative Opthalmology & Visual Science 63:8, pages 5.
Crossref
Jae-Won Lee, Mun-Ock Kim, Yu Na Song, Jae-Hong Min, Seong-Man Kim, Myung-Ji Kang, Eun Sol Oh, Ro Woon Lee, Sunin Jung, Hyunju Ro, Jae Kyoung Lee, Hyung Won Ryu, Dae Young Lee & Su Ui Lee. (2022) Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo. Journal of Ginseng Research 46:3, pages 496-504.
Crossref
Yu Zhang, Chen Liu, Yu Li & Hongguang Xu. (2022) Mechanism of the Mitogen-Activated Protein Kinases/Mammalian Target of Rapamycin Pathway in the Process of Cartilage Endplate Stem Cell Degeneration Induced by Tension Load. Global Spine Journal, pages 219256822210852.
Crossref
Lin YangPeng YuMei ChenBo Lei. (2022) Mammalian Target of Rapamycin Inhibitor Rapamycin Alleviates 7-Ketocholesterol Induced Inflammatory Responses and Vascular Endothelial Growth Factor Elevation by Regulating MAPK Pathway in Human Retinal Pigment Epithelium Cells. Journal of Ocular Pharmacology and Therapeutics 38:2, pages 189-200.
Crossref
Rifah Gheyas, Ramon Ortega-Alvarez, Daniel Chauss, Marc Kantorow & A. Sue Menko. (2022) Suppression of PI3K signaling is linked to autophagy activation and the spatiotemporal induction of the lens organelle free zone. Experimental Cell Research 412:2, pages 113043.
Crossref
Sheng-Yu Lu, Song Guo, Shao-Bin Chai, Jia-Qi Yang, Yuan Yue, Hao Li, Hong-Feng Yan, Tao Zhang, Pei-Ming Sun, Hong-Wei Sun, Jin-Lian Zhou, Jian-Wu Yang, Zheng-Peng Li & Yan Cui. (2022) Proteomic analysis of the effects of simulated microgravity in human gastric mucosal cells. Life Sciences in Space Research 32, pages 26-37.
Crossref
Joshua Disatham, Lisa Brennan, Daniel Chauss, Jason Kantorow, Behdad Afzali & Marc Kantorow. (2021) A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis. BMC Genomics 22:1.
Crossref
Lisa Brennan, Joshua Disatham & Marc Kantorow. (2021) Mechanisms of organelle elimination for lens development and differentiation. Experimental Eye Research 209, pages 108682.
Crossref
Hideaki Morishita, Tomoya Eguchi, Satoshi Tsukamoto, Yuriko Sakamaki, Satoru Takahashi, Chieko Saito, Ikuko Koyama-Honda & Noboru Mizushima. (2021) Organelle degradation in the lens by PLAAT phospholipases. Nature 592:7855, pages 634-638.
Crossref
Junfa Yang, Lei Xu, Meifei Wu, Hui Fang, Yuchen Lu, Congjian Shi, Yang Wang, Shaowei Jiang, Qiang Ma, Zeng Li, Lingling Zhang & Lei Zhang. (2021) Paeonol derivative-6 attenuates inflammation by activating ZEB2 in acute liver injury. International Immunopharmacology 91, pages 107235.
Crossref
Cheng-hsiung Chen, Yi-Rong Li, Sheng-Hao Lin, Hsiu-Hui Chang, Woei-Horng Chai, Po-Chiang Chan & Ching-Hsiung Lin. (2020) Tiotropium/Olodaterol treatment reduces cigarette smoke extract-induced cell death in BEAS-2B bronchial epithelial cells. BMC Pharmacology and Toxicology 21:1.
Crossref
Teng Liu, Qian-Nan Di, Jia-Hui Sun, Meng Zhao, Qian Xu & Yang Shen. (2020) Effects of nonylphenol induced oxidative stress on apoptosis and autophagy in rat ovarian granulosa cells. Chemosphere 261, pages 127693.
Crossref
Bolin Hou, Shuchun Liu, Erwei Li & Xuejun Jiang. (2020) Different Role of Raptor and Rictor in Regulating Rasfonin‐Induced Autophagy and Apoptosis in Renal Carcinoma Cells. Chemistry & Biodiversity 17:12.
Crossref
M. Joseph Costello, Kurt O. Gilliland, Ashik Mohamed, Kevin L. Schey, Sönke Johnsen, Lisa A. Brennan & Marc Kantorow. (2020) Novel mitochondrial derived Nuclear Excisosome degrades nuclei during differentiation of prosimian Galago (bush baby) monkey lenses. PLOS ONE 15:11, pages e0241631.
Crossref
Ji Li, Wei Ye, Wenqin Xu, Tianfang Chang, Luning Zhang, Jiyuan Ma, Rui Pei, Mengmei He & Jian Zhou. (2020) Activation of autophagy inhibits epithelial to mesenchymal transition process of human lens epithelial cells induced by high glucose conditions. Cellular Signalling 75, pages 109768.
Crossref
Lisa Brennan, Joshua Disatham & Marc Kantorow. (2020) Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a. Experimental Eye Research 198, pages 108129.
Crossref
Rohit Sahai, Arindam Bhattacharjee, Vishwa Nath Shukla, Pragya Yadav, Mohammad Hasanain, Jayanta Sarkar, T. Narender & Kalyan Mitra. (2020) Gedunin isolated from the mangrove plant Xylocarpus granatum exerts its anti-proliferative activity in ovarian cancer cells through G2/M-phase arrest and oxidative stress-mediated intrinsic apoptosis. Apoptosis 25:7-8, pages 481-499.
Crossref
Hu Yang, Yang Xuefeng, Wu Shandong & Xiao Jianhua. (2020) COX-2 in liver fibrosis. Clinica Chimica Acta 506, pages 196-203.
Crossref
Qiang Zheng, Yu-chang Wang, Qin-xin Liu, Xi-jie Dong, Zhen-xing Xie, Xing-hua Liu, Wei Gao, Xiang-jun Bai & Zhan-fei Li. (2020) FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy. Life Sciences 250, pages 117551.
Crossref
Jing Zhang, Wen-wen Cui, Chunxiao Du, Yuwen Huang, Xiahui Pi, Wenya Guo, Jungai Wang, Weikang Huang, Danling Chen, Jing Li, Hui Li, Jun Zhang, Yuanfang Ma, Hongmei Mu, Shuman Zhang, Mugen Liu, Xiukun Cui & Yanzhong Hu. (2020) Knockout of DNase1l1l abrogates lens denucleation process and causes cataract in zebrafish. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1866:5, pages 165724.
Crossref
Yuhan Liu, Jinxing Hou, Meng Zhang, Emeline Seleh‐Zo, Jiangang Wang, Binyun Cao & Xiaopeng An. (2019) circ‐016910 sponges miR‐574‐5p to regulate cell physiology and milk synthesis via MAPK and PI3K/AKT–mTOR pathways in GMECs. Journal of Cellular Physiology 235:5, pages 4198-4216.
Crossref
Yubiao Zhang, Siqi Zhou, Weisong Cai, Guangtao Han, Jianping Li, Mao Chen & Haohuan Li. (2020) Hypoxia/reoxygenation activates the JNK pathway and accelerates synovial senescence. Molecular Medicine Reports 22:1, pages 265-276.
Crossref
Ankur Garg, Abdul Hannan, Qian Wang, Neoklis Makrides, Jian Zhong, Hongge Li, Sungtae Yoon, Yingyu Mao & Xin Zhang. (2020) Etv transcription factors functionally diverge from their upstream FGF signaling in lens development. eLife 9.
Crossref
Liqing Huang, Peng Yin, Fenghua Liu, Yilin Liu, Yanhan Liu & Zhaofei Xia. (2019) Protective effects of L‐arginine on the intestinal epithelial barrier under heat stress conditions in rats and IEC‐6 cell line. Journal of Animal Physiology and Animal Nutrition 104:1, pages 385-396.
Crossref
Íria Gabriela Dias dos Santos, Tiago Antônio de Oliveira Mendes, Gerluza Aparecida Borges Silva, Amanda Maria Sena Reis, Cláudia Barros Monteiro-Vitorello, Patricia Dayane Carvalho Schaker, Roberto Hirochi Herai, André Brait Carneiro Fabotti, Luiz Lehmann Coutinho & Erika Cristina Jorge. (2019) Didelphis albiventris: an overview of unprecedented transcriptome sequencing of the white-eared opossum. BMC Genomics 20:1.
Crossref
Caitlin M Logan & A Sue Menko. (2019) Microtubules: Evolving roles and critical cellular interactions. Experimental Biology and Medicine 244:15, pages 1240-1254.
Crossref
Antonia Wiegering, Ulrich Rüther & Christoph Gerhardt. (2019) The Role of Primary Cilia in the Crosstalk between the Ubiquitin–Proteasome System and Autophagy. Cells 8:3, pages 241.
Crossref
Chen Wu, Michelle E. Watts & Lee L. Rubin. (2019) MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis. Cell Reports 26:5, pages 1143-1156.e5.
Crossref
Yilin Zhao, Deyou Zheng & Ales Cvekl. (2018) A comprehensive spatial-temporal transcriptomic analysis of differentiating nascent mouse lens epithelial and fiber cells. Experimental Eye Research 175, pages 56-72.
Crossref
Xin Zhang, Gang Zhao, Ya Zhang, Jian Wang, Yapeng Wang, Long Cheng, Minxuan Sun & Yongjun Rui. (2018) Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis. Biochemical and Biophysical Research Communications 504:4, pages 771-776.
Crossref
Lisa A. Brennan, Rebecca McGreal-Estrada, Caitlin M. Logan, Ales Cvekl, A. Sue Menko & Marc Kantorow. (2018) BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation. Experimental Eye Research 174, pages 173-184.
Crossref
Martin Gauster, Sabine Maninger, Monika Siwetz, Alexander Deutsch, Amin El-Heliebi, Dagmar Kolb-Lenz, Ursula Hiden, Gernot Desoye, Florian Herse & Andreas Prokesch. (2017) Downregulation of p53 drives autophagy during human trophoblast differentiation. Cellular and Molecular Life Sciences 75:10, pages 1839-1855.
Crossref
Huan-huan Sha, Zhen Wang, Shu-chen Dong, Tian-mu HuSi-wen Liu, Jun-ying Zhang, Yang Wu, Rong Ma, Jian-zhong Wu, Dan Chen & Ji-feng Feng. (2018) 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound. Bioscience Reports 38:1.
Crossref
Abhishek Kumar Mishra, Saumya Mishra, Charul Rajput, Mohd Sami ur Rasheed, Devendra Kumar Patel & Mahendra Pratap Singh. (2017) Cypermethrin Activates Autophagosome Formation Albeit Inhibits Autophagy Owing to Poor Lysosome Quality: Relevance to Parkinson’s Disease. Neurotoxicity Research 33:2, pages 377-387.
Crossref
Caitlin M. Logan, Caitlin J. Bowen & A. Sue Menko. (2018) Functional role for stable microtubules in lens fiber cell elongation. Experimental Cell Research 362:2, pages 477-488.
Crossref
W. Qiu, B. Sun, F. He & Y. Zhang. (2017) MTA-induced Notch activation enhances the proliferation of human dental pulp cells by inhibiting autophagic flux. International Endodontic Journal 50, pages e52-e62.
Crossref
Qiuli Fu, Zhenwei Qin, Lifang Zhang, Danni Lyu, Qiaomei Tang, Houfa Yin, Zhijian Chen & Ke Yao. (2017) A New Long Noncoding RNA ALB Regulates Autophagy by Enhancing the Transformation of LC3BI to LC3BII during Human Lens Development. Molecular Therapy - Nucleic Acids 9, pages 207-217.
Crossref
Biao Liang, Ting Xiao, Junrong Long, Maojun Liu, Zining Li, Shengquan Liu & Jun Yang. (2017) Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy. International Journal of Molecular Medicine.
Crossref
Ales Cvekl & Xin Zhang. (2017) Signaling and Gene Regulatory Networks in Mammalian Lens Development. Trends in Genetics 33:10, pages 677-702.
Crossref
Jilong Zhou, Wang Yao, Chengyu Li, Wangjun Wu, Qifa Li & Honglin Liu. (2017) Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1α in mouse granulosa cells. Cell Death & Disease 8:8, pages e3001-e3001.
Crossref
Caitlin M. Logan, Suren Rajakaruna, Caitlin Bowen, Glenn L. Radice, Michael L. Robinson & A. Sue Menko. (2017) N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Developmental Biology 428:1, pages 118-134.
Crossref
Enshuang Guo, Renlong Li, Jiankun Yang, Jun Zhang, Anyi Li, Yan Yang, Shenpei Liu, Anding Liu & Xiaojing Jiang. (2017) FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy. Scientific Reports 7:1.
Crossref
Hanruo Liu, Andrew JO Smith, Simon SR Ball, Yongping Bao, Richard P Bowater, Ningli Wang & I. Michael Wormstone. (2017) Sulforaphane promotes ER stress, autophagy, and cell death: implications for cataract surgery. Journal of Molecular Medicine 95:5, pages 553-564.
Crossref
Bruce A. Boswell, Anna Korol, Judith A. West-Mays & Linda S. Musil. (2017) Dual function of TGFβ in lens epithelial cell fate: implications for secondary cataract. Molecular Biology of the Cell 28:7, pages 907-921.
Crossref
Yan-Fang Tao, Zhi-Heng Li, Wei-Wei Du, Li-Xiao Xu, Jun-Li Ren, Xiao-Lu Li, Fang Fang, Yi Xie, Mei Li, Guang-Hui Qian, Yan-Hong Li, Yi-Ping Li, Gang Li, Yi Wu, Xing Feng, Jian Wang, Wei-Qi He, Shao-Yan Hu, Jun Lu & Jian Pan. (2017) Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation. Oncology Reports 37:3, pages 1419-1429.
Crossref
Wei-Jian Sun, He Huang, Bin He, Dan-Hong Hu, Pi-Hong Li, Yao-Jun Yu, Xiao-Hu Zhou, Zhen Lv, Lei Zhou, Tian-Ye Hu, Zhi-Chao Yao, Ming-Dong Lu, Xian Shen & Zhi-Qiang Zheng. (2017) Romidepsin induces G2/M phase arrest via Erk/cdc25C/cdc2/cyclinB pathway and apoptosis induction through JNK/c-Jun/caspase3 pathway in hepatocellular carcinoma cells. Biochemical Pharmacology 127, pages 90-100.
Crossref
Jie Li, Yang Li, Ying Zhang, Dan Hu, Yonghong Gao, Hongcai Shang & Yanwei Xing. (2017) The Inhibitory Effect of WenxinKeli on H9C2 Cardiomyocytes Hypertrophy Induced by Angiotensin II through Regulating Autophagy Activity. Oxidative Medicine and Cellular Longevity 2017, pages 1-11.
Crossref
Camilla Palumbo, Anastasia De Luca, Nicola Rosato, Mariantonietta Forgione, Dante Rotili & Anna Maria Caccuri. (2016) c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition. Journal of Translational Medicine 14:1.
Crossref
Patricia Boya, Lorena Esteban-Martínez, Ana Serrano-Puebla, Raquel Gómez-Sintes & Beatriz Villarejo-Zori. (2016) Autophagy in the eye: Development, degeneration, and aging. Progress in Retinal and Eye Research 55, pages 206-245.
Crossref
M. Joseph Costello, Lisa A. Brennan, Ashik Mohamed, Kurt O. Gilliland, Sönke Johnsen & Marc Kantorow. (2016) Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells. PLOS ONE 11:8, pages e0160785.
Crossref
Shuying He, Saima Limi, Rebecca S. McGreal, Qing Xie, Lisa A. Brennan, Wanda Lee Kantorow, Juraj Kokavec, Romit Majumdar, Harry HouJrJr, Winfried Edelmann, Wei Liu, Ruth Ashery-Padan, Jiri Zavadil, Marc Kantorow, Arthur I. Skoultchi, Tomas Stopka & Ales Cvekl. (2016) Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation. Development 143:11, pages 1937-1947.
Crossref
Hideaki Morishita & Noboru Mizushima. (2016) Autophagy in the lens. Experimental Eye Research 144, pages 22-28.
Crossref
Peng Duan, Chunhui Hu, Chao Quan, Tingting Yu, Wei Zhou, Meng Yuan, Yuqin Shi & Kedi Yang. (2016) 4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways. Toxicology 341-343, pages 28-40.
Crossref
Daniel Chauss, Lisa A. Brennan, Olga Bakina & Marc Kantorow. (2015) Integrin αVβ5-mediated Removal of Apoptotic Cell Debris by the Eye Lens and Its Inhibition by UV Light Exposure. Journal of Biological Chemistry 290:51, pages 30253-30266.
Crossref
Lindsay Perusek, Bhubanananda Sahu, Tanu Parmar, Hiroshi Maeno, Eisuke Arai, Yun-Zheng Le, Carlos S. Subauste, Yu Chen, Krzysztof Palczewski & Akiko Maeda. (2015) Di-retinoid-pyridinium-ethanolamine (A2E) Accumulation and the Maintenance of the Visual Cycle Are Independent of Atg7-mediated Autophagy in the Retinal Pigmented Epithelium. Journal of Biological Chemistry 290:48, pages 29035-29044.
Crossref
Paul A. Ney. (2015) Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1853:10, pages 2775-2783.
Crossref
Heather L. Chandler, Kristen J. Gervais, Elizabeth A. Lutz, Elizabeth M. Curto, Rachel B. Matusow, David A. Wilkie & Anne J. Gemensky-Metzler. (2015) Cyclosporine A prevents ex vivo PCO formation through induction of autophagy-mediated cell death. Experimental Eye Research 134, pages 63-72.
Crossref
Ales Cvekl, Rebecca McGreal & Wei Liu. 2015. Molecular Biology of Eye Disease. Molecular Biology of Eye Disease 129 167 .
Aleš Cvekl & Ruth Ashery-Padan. (2014) The cellular and molecular mechanisms of vertebrate lens development. Development 141:23, pages 4432-4447.
Crossref
Daniel Chauss, Subhasree Basu, Suren Rajakaruna, Zhiwei Ma, Victoria Gau, Sara Anastas, Lisa A Brennan, J Fielding Hejtmancik, A Sue Menko & Marc Kantorow. (2014) Differentiation State-Specific Mitochondrial Dynamic Regulatory Networks Are Revealed by Global Transcriptional Analysis of the Developing Chicken Lens. G3 Genes|Genomes|Genetics 4:8, pages 1515-1527.
Crossref