Advanced search
Publication Cover
Autophagy Volume 10, 2014 - Issue 7
Submit an article Journal homepage
4,042
Views
136
CrossRef citations to date
0
Altmetric
Basic Research Paper

Itraconazole suppresses the growth of glioblastoma through induction of autophagy

Involvement of abnormal cholesterol trafficking

Rui Liu State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, China; State Key Laboratory of Oral Diseases; West China Hospital of Stomatology; Sichuan University; Chengdu, China
,
Jingyi Li School of Biomedical Sciences; Chengdu Medical College; Chengdu, China
,
Tao Zhang School of Biomedical Sciences; Chengdu Medical College; Chengdu, China
,
Linzhi Zou College of Life Sciences; Sichuan University; Chengdu, China
,
Yi Chen Department of Gastrointestinal Surgery; State Key Laboratory of Biotherapy; West China Hospital, Sichuan University, Chengdu, China
,
Kui Wang State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, China
,
Yunlong Lei Department of Biochemistry and Molecular Biology, Molecular Medicine and Cancer Research Center; Chongqing Medical University; Chongqing, China
,
Kefei Yuan State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, China
,
Yi Li State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, China
,
Jiang Lan State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, China
,
Lin Cheng State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, China
,
Na Xie State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, China
,
Rong Xiang School of Medicine/Collaborative Innovation Center of Biotherapy; Nankai University; Tianjin, China
,
Edouard C Nice Department of Biochemistry and Molecular Biology; Monash University; Clayton, Victoria Australia
,
Canhua Huang State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, ChinaCorrespondence[email protected]
&
Yuquan Wei State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy; West China Hospital; Sichuan University; Chengdu, China
 show all
Pages 1241-1255 | Received 02 Jun 2013, Accepted 15 Apr 2014, Published online: 15 May 2014

Citations (136)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Chi Zhang, Yiran Ren, Huiyu Gu, Lu Gao, Yuanwei Zhang & Ling Lu. (2021) Calcineurin-mediated intracellular organelle calcium homeostasis is required for the survival of fungal pathogens upon extracellular calcium stimuli. Virulence 12:1, pages 1091-1110.
Read now
Jingwen Jiang, Lu Zhang, Haining Chen, Yunlong Lei, Tao Zhang, Yuelong Wang, Ping Jin, Jiang Lan, Li Zhou, Zhao Huang, Bowen Li, Yuan Liu, Wei Gao, Ke Xie, Liangxue Zhou, Edouard C. Nice, Yong Peng, Yihai Cao, Yuquan Wei, Kui Wang & Canhua Huang. (2020) Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma. Autophagy 16:1, pages 106-122.
Read now
Ke Li, Dengyang Fang, Zuming Xiong & Runlan Luo. (2019) Inhibition of the hedgehog pathway for the treatment of cancer using Itraconazole. OncoTargets and Therapy 12, pages 6875-6886.
Read now
Chia-Hao Chang, Krikor Bijian, Dominik Wernic, Jie Su, Sabrina Daniela da Silva, Henry Yu, Dinghong Qiu, Mariana Asslan & Moulay A. Alaoui-Jamali. (2019) A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy. Autophagy 15:8, pages 1376-1390.
Read now
Na Xie, Kefei Yuan, Li Zhou, Kui Wang, Hai-Ning Chen, Yunlong Lei, Jiang Lan, Qinqin Pu, Wei Gao, Lu Zhang, Guobo Shen, Qifu Li, Hengyi Xiao, Hong Tang, Rong Xiang, Mingliang He, Pinghui Feng, Edouard C. Nice, Yuquan Wei, Haiyuan Zhang, Jiayin Yang & Canhua Huang. (2016) PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation. Autophagy 12:9, pages 1507-1520.
Read now
Xuejiao Zhao, Yong Fang, Yang Yang, Yu Qin, Peng Wu, Ting Wang, Huiling Lai, Li Meng, Daowen Wang, Zhihui Zheng, Xinhua Lu, Hua Zhang, Qinglei Gao, Jianfeng Zhou & Ding Ma. (2015) Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. Autophagy 11:10, pages 1849-1863.
Read now

Articles from other publishers (130)

Wei Tang, Guanghua Li, Qi Lin, Zhenzhen Zhu, Zhao Wang & Zhixiong Wang. (2023) Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer. Journal of Translational Medicine 21:1.
Crossref
Jia Lu, Siwei Chen, Xuejiao Bai, Minru Liao, Yuling Qiu, Ling-Li Zheng & Haiyang Yu. (2023) Targeting cholesterol metabolism in Cancer: From molecular mechanisms to therapeutic implications. Biochemical Pharmacology 218, pages 115907.
Crossref
Sha Huang, Luping Lin, Yifei Ma, Qing Zhu & Ningna Weng. (2023) Scoparone induces autophagic cell death via the PAK1/AKT axis in colorectal cancer. European Journal of Pharmacology 959, pages 176091.
Crossref
Roohi Mohi-ud-din, Apporva Chawla, Pooja Sharma, Prince Ahad Mir, Faheem Hyder Potoo, Željko Reiner, Ivan Reiner, Dilek Arslan Ateşşahin, Javad Sharifi-Rad, Reyaz Hassan Mir & Daniela Calina. (2023) Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects. European Journal of Medical Research 28:1.
Crossref
Fangquan ChenYanjiao LuJunhao LinRui Kang & Jiao Liu. (2023) Cholesterol Metabolism in Cancer and Cell Death. Antioxidants & Redox Signaling 39:1-3, pages 102-140.
Crossref
Ningna Weng, Zhe Zhang, Yunhan Tan, Xiaoyue Zhang, Xiawei Wei & Qing Zhu. (2023) Repurposing antifungal drugs for cancer therapy. Journal of Advanced Research 48, pages 259-273.
Crossref
Yu Chen, Yanquan Xu, Huakan Zhao, Yu Zhou, Jiangang Zhang, Juan Lei, Lei Wu, Mingyue Zhou, Jingchun Wang, Shuai Yang, Xiao Zhang, Guifang Yan & Yongsheng Li. (2023) Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion. Cancer Letters 564, pages 216208.
Crossref
Israel Diniz-Lima, Leonardo Marques da Fonseca, Jhenifer Santos Dos Reis, Debora Decote-Ricardo, Alexandre Morrot, Jose Osvaldo Previato, Lucia Mendonça Previato, Celio Geraldo Freire-de-Lima & Leonardo Freire-de-Lima. (2023) Non-self glycan structures as possible modulators of cancer progression: would polysaccharides from Cryptococcus spp. impact this phenomenon?. Brazilian Journal of Microbiology 54:2, pages 907-919.
Crossref
Yuanchun Zhao, Xingqi Chen, Jiajia Chen & Xin Qi. (2023) Decoding Connectivity Map-based drug repurposing for oncotherapy. Briefings in Bioinformatics 24:3.
Crossref
Ankur Rakesh Dubey, Ribhav Mishra, Yuvraj Anandrao Jagtap, Sumit Kinger, Prashant Kumar, Rohan Dhiman, Somnath Ghosh, Sarika Singh, Amit Prasad, Nihar Ranjan Jana & Amit Mishra. (2023) Itraconazole Confers Cytoprotection Against Neurodegenerative Disease-Associated Abnormal Protein Aggregation. Molecular Neurobiology 60:5, pages 2397-2412.
Crossref
Ling Qiao, Siyuan Qin, Ningna Weng, Bowen Li, Maochao Luo, Zhe Zhang, Li Zhou, Dong Wang & Canhua Huang. (2023) Discovery of canine drug toceranib phosphate as a repurposed agent against human hepatocellular carcinoma. Liver International 43:4, pages 928-944.
Crossref
Xinyan Wan, Junqi Xiang, Hui Fan, Ying Jiang, Yiting Lu, Chundong Zhang, Ying Zhang, Quanmei Chen & Yunlong Lei. (2023) Ciclopirox Olamine Induces Proliferation Inhibition and Protective Autophagy in Hepatocellular Carcinoma. Pharmaceuticals 16:1, pages 113.
Crossref
Paola Lenzi, Carla L. Busceti, Gloria Lazzeri, Rosangela Ferese, Francesca Biagioni, Alessandra Salvetti, Elena Pompili, Valerio De Franchis, Stefano Puglisi-Allegra, Alessandro Frati, Michela Ferrucci & Francesco Fornai. (2023) Autophagy Activation Associates with Suppression of Prion Protein and Improved Mitochondrial Status in Glioblastoma Cells. Cells 12:2, pages 221.
Crossref
Mariana Nunes, Diana Duarte, Nuno Vale & Sara Ricardo. (2022) The Antineoplastic Effect of Carboplatin Is Potentiated by Combination with Pitavastatin or Metformin in a Chemoresistant High-Grade Serous Carcinoma Cell Line. International Journal of Molecular Sciences 24:1, pages 97.
Crossref
Ping Jin, Jingwen Jiang, Li Zhou, Zhao Huang, Edouard C. Nice, Canhua Huang & Li Fu. (2022) Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management. Journal of Hematology & Oncology 15:1.
Crossref
Mehdi Sanati, Maryam Moradi Binabaj, Seyed Sajad Ahmadi, Samaneh Aminyavari, Hossein Javid, Hamid Mollazadeh, Bahram Bibak, Elmira Mohtashami, Tannaz Jamialahmadi, Amir R. Afshari & Amirhossein Sahebkar. (2022) Recent advances in glioblastoma multiforme therapy: A focus on autophagy regulation. Biomedicine & Pharmacotherapy 155, pages 113740.
Crossref
Joana Cardoso, Joana Freitas-Silva, Fernando Durães, Diogo Teixeira Carvalho, Luís Gales, Madalena Pinto, Emília Sousa & Eugénia Pinto. (2022) Antifungal Activity of a Library of Aminothioxanthones. Antibiotics 11:11, pages 1488.
Crossref
Guiqin Bai, Shangwen Jing, Huimin Cao, Yiqi Qiao, Gongchan Chen, Lining Duan, Yuna Yang, Min Li, Weirong Li, Xiang Chang, Cong Yang & Qi Wang. (2022) Kai-Xin-San Protects Depression Mice Against CORT-Induced Neuronal Injury by Inhibiting Microglia Activation and Oxidative Stress. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-17.
Crossref
Chun-Lan Li, Ze-Xuan Fang, Zheng Wu, Yan-Yu Hou, Hua-Tao Wu & Jing Liu. (2022) Repurposed itraconazole for use in the treatment of malignancies as a promising therapeutic strategy. Biomedicine & Pharmacotherapy 154, pages 113616.
Crossref
Yushan Mao, Hanhan Xie, Dan Shu, Lin Cheng, Jingbin Lan & Kejian Pan. (2022) Moxidectin induces autophagy arrest in colorectal cancer. Medical Oncology 39:12.
Crossref
Mariana Nunes, Diana Duarte, Nuno Vale & Sara Ricardo. (2022) Pitavastatin and Ivermectin Enhance the Efficacy of Paclitaxel in Chemoresistant High-Grade Serous Carcinoma. Cancers 14:18, pages 4357.
Crossref
Nanjing Liu, Chunmei Yang, Li Yang, Ting Li, Maoyuan Gong, Haobiao Wang, Jun Zhang, Hui Zhao, Lin Zou & Xiaoyan He. (2022) Matrine induces autophagy in human neuroblastoma cells via blocking the AKT-mTOR pathway. Medical Oncology 39:11.
Crossref
Mai K. L. Nguyen, Jaimy Jose, Mohamed Wahba, Marc Bernaus-Esqué, Andrew J. Hoy, Carlos Enrich, Carles Rentero & Thomas Grewal. (2022) Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance. International Journal of Molecular Sciences 23:13, pages 7206.
Crossref
Hui Ming, Bowen Li, Hailong Tian, Li Zhou, Jingwen Jiang, Tingting Zhang, Ling Qiao, Peijie Wu, Edouard C. Nice, Wei Zhang, Weifeng He, Canhua Huang & Haiyuan Zhang. (2022) A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer. Materials Today Bio 15, pages 100289.
Crossref
Sarah Lastakchi, Mary Kanyinsola Olaloko & Christopher McConville. (2022) A Potential New Treatment for High-Grade Glioma: A Study Assessing Repurposed Drug Combinations against Patient-Derived High-Grade Glioma Cells. Cancers 14:11, pages 2602.
Crossref
Mirna Jovanović, Ana Podolski-Renić, Mikhail Krasavin & Milica Pešić. (2022) The Role of the Thioredoxin Detoxification System in Cancer Progression and Resistance. Frontiers in Molecular Biosciences 9.
Crossref
Magdalena Cybula & Magdalena Bieniasz. (2022) Patient-derived tumor models are attractive tools to repurpose drugs for ovarian cancer treatment: Pre-clinical updates. Oncotarget 13:1, pages 553-575.
Crossref
Adria Hasan, Suroor Fatima Rizvi, Sana Parveen, Neelam Pathak, Aamir Nazir & Snober S. Mir. (2022) Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted Paradox. Frontiers in Oncology 12.
Crossref
Jingyi Li, Tao Zhang, Tao Ren, Xiaoyu Liao, Yilong Hao, Je Sun Lim, Jong-Ho Lee, Mi Li, Jichun Shao & Rui Liu. (2022) Oxygen-sensitive methylation of ULK1 is required for hypoxia-induced autophagy. Nature Communications 13:1.
Crossref
Hans-Jürgen Tietz. (2022) Onychomykose: State of the Art. hautnah dermatologie 38:2, pages 40-43.
Crossref
Congcong Xu, Yating Zhuo, Yunyao Liu & Hao Chen. (2022) Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis. Frontiers in Pharmacology 13.
Crossref
Leilei Fu, Wenke Jin, Jiahui Zhang, Lingjuan Zhu, Jia Lu, Yongqi Zhen, Lan Zhang, Liang Ouyang, Bo Liu & Haiyang Yu. (2022) Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions. Acta Pharmaceutica Sinica B 12:2, pages 532-557.
Crossref
Amir Barzegar Behrooz, Zahra Talaie, Fatemeh Jusheghani, Marek J. Łos, Thomas Klonisch & Saeid Ghavami. (2022) Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma. International Journal of Molecular Sciences 23:3, pages 1353.
Crossref
Safwan Alomari, Irma Zhang, Adrian Hernandez, Caitlin Y. Kraft, Divyaansh Raj, Jayanidhi Kedda & Betty Tyler. (2021) Drug Repurposing for Glioblastoma and Current Advances in Drug Delivery—A Comprehensive Review of the Literature. Biomolecules 11:12, pages 1870.
Crossref
Yu Wang, Jiang Du, Xuemei Wu, Ahmed Abdelrehem, Yu Ren, Chao Liu, Xuan Zhou & Sinan Wang. (2021) Crosstalk between autophagy and microbiota in cancer progression. Molecular Cancer 20:1.
Crossref
Yunfeng Yuan, Xue He, Xiang Li, Yan Liu, Yueliang Tang, Huiming Deng & Xinyuan Shi. (2021) Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway. BMC Pharmacology and Toxicology 22:1.
Crossref
Rui Liu, Jingyi Li, Jichun Shao, Jong-Ho Lee, Xuemei Qiu, Yanxuan Xiao, Bowen Zhang, Yilong Hao, Mi Li & Qianming Chen. (2021) Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair. Cell Metabolism 33:10, pages 2076-2089.e9.
Crossref
Jiao Zhang, Man-Yuan Li, Xiao Lu, Quan-Xing Liu, Dong Zhou, Gui-Xue Yang, Xiao-Qing Liu, Hong Zheng & Ji-Gang Dai. (2021) CWHM-1008 Induces Apoptosis and Protective Autophagy through the Akt/mTOR Axis in LUAD Cells. Journal of Oncology 2021, pages 1-14.
Crossref
Pei-Wen ShenYu-Mei ChouChia-Ling LiEn-Chih LiaoHung-Sen HuangChun-Hao YinChien-Liang ChenSheng-Jie Yu. (2021) Itraconazole improves survival outcomes in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression. Oncology Letters 22:5.
Crossref
Limin Zhou, Jinyan Wang, Jiaqi Liu, Jiantang Liang, Yansong Wang, Qunfang Cai & Yonghao Huang. (2021) YAP activation attenuates toxicarioside G‑induced lethal autophagy arrest in SW480 colorectal cancer cells. Oncology Reports 46:4.
Crossref
Mark F. Santos, Germana Rappa, Jana Karbanová, Simona Fontana, Maria Antonietta Di Bella, Marshall R. Pope, Barbara Parrino, Stella Maria Cascioferro, Giulio Vistoli, Patrizia Diana, Girolamo Cirrincione, Goffredo O. Arena, Gyunghwi Woo, Kevin Huang, Tony Huynh, Marta Moschetti, Riccardo Alessandro, Denis Corbeil & Aurelio Lorico. (2021) Itraconazole inhibits nuclear delivery of extracellular vesicle cargo by disrupting the entry of late endosomes into the nucleoplasmic reticulum. Journal of Extracellular Vesicles 10:10.
Crossref
Cristiana Correia, Abigail Ferreira, Joana Santos, Rui Lapa, Marjo Yliperttula, Arto Urtti & Nuno Vale. (2021) New In Vitro-In Silico Approach for the Prediction of In Vivo Performance of Drug Combinations. Molecules 26:14, pages 4257.
Crossref
Rui Liu, Jong-Ho Lee, Jingyi Li, Rilei Yu, Lin Tan, Yan Xia, Yanhua Zheng, Xue-Li Bian, Philip L. Lorenzi, Qianming Chen & Zhimin Lu. (2021) Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. Molecular Cell 81:13, pages 2722-2735.e9.
Crossref
Jue Wang, Ting Hu, Qiong Wang, Renwang Chen, Yuxiu Xie, Haiyan Chang & Jing Cheng. (2021) Repression of the AURKA-CXCL5 axis induces autophagic cell death and promotes radiosensitivity in non-small-cell lung cancer. Cancer Letters 509, pages 89-104.
Crossref
Tarapati Rana, Tapan Behl, Aayush Sehgal, Monika Sachdeva, Vineet Mehta, Neelam Sharma, Sukhbir Singh & Simona Bungau. (2021) Exploring Sonic Hedgehog Cell Signaling in Neurogenesis: Its Potential Role in Depressive Behavior. Neurochemical Research 46:7, pages 1589-1602.
Crossref
Don Carlo Ramos Batara, Moon-Chang Choi, Hyeon-Uk Shin, Hyunggee Kim & Sung-Hak Kim. (2021) Friend or Foe: Paradoxical Roles of Autophagy in Gliomagenesis. Cells 10:6, pages 1411.
Crossref
Elisabete Cruz Da Silva, Marie-Cécile Mercier, Nelly Etienne-Selloum, Monique Dontenwill & Laurence Choulier. (2021) A Systematic Review of Glioblastoma-Targeted Therapies in Phases II, III, IV Clinical Trials. Cancers 13:8, pages 1795.
Crossref
Mahdi Ghadi, Seyed Jalal Hosseinimehr, Fereshteh Talebpour Amiri, Alireza Mardanshahi & Zohreh Noaparast. (2021) Itraconazole synergistically increases therapeutic effect of paclitaxel and 99mTc-MIBI accumulation, as a probe of P-gp activity, in HT-29 tumor-bearing nude mice. European Journal of Pharmacology 895, pages 173892.
Crossref
Huanyu Zhang, Zhe Zhang, Yonghao Huang, Siyuan Qin, Li Zhou, Ningna Weng, Jiayang Liu, Mei Yang, Xiaodian Zhang, Yanda Lu, Lin Ma, Shaojiang Zheng & Qifu Li. (2020) Repurposing antitussive benproperine phosphate against pancreatic cancer depends on autophagy arrest. Molecular Oncology 15:2, pages 725-738.
Crossref
Marc-Eric Halatsch, Richard E Kast, Georg Karpel-Massler, Benjamin Mayer, Oliver Zolk, Bernd Schmitz, Angelika Scheuerle, Ludwig Maier, Lars Bullinger, Regine Mayer-Steinacker, Carl Schmidt, Katharina Zeiler, Ziad Elshaer, Patricia Panther, Birgit Schmelzle, Anke Hallmen, Annika Dwucet, Markus D Siegelin, Mike-Andrew Westhoff, Kristine Beckers, Gauthier Bouche & Tim Heiland. (2021) A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3. Neuro-Oncology Advances 3:1.
Crossref
Insa Seck & Filomain Nguemo. (2021) Triazole, imidazole, and thiazole-based compounds as potential agents against coronavirus. Results in Chemistry 3, pages 100132.
Crossref
Shan-Shan Zhang, Sajid Asghar, Jun-Xiu Ye, Ling Lin, Qi-Neng Ping, Zhi-Peng Chen, Feng Shao & Yan-Yu Xiao. (2020) A combination of receptor mediated transcytosis and photothermal effect promotes BBB permeability and the treatment of meningitis using itraconazole. Nanoscale 12:46, pages 23709-23720.
Crossref
Valdenizia R. Silva, Sara P. Neves, Luciano de S. Santos, Rosane B. Dias & Daniel P. Bezerra. (2020) Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy. Cancers 12:11, pages 3461.
Crossref
Wenping Wang, XiaoXv Dong, Yi Liu, Boran Ni, Na Sai, Longtai You, Mingyi Sun, Yu Yao, Changhai Qu, Xingbin Yin & Jian Ni. (2020) Itraconazole exerts anti-liver cancer potential through the Wnt, PI3K/AKT/mTOR, and ROS pathways. Biomedicine & Pharmacotherapy 131, pages 110661.
Crossref
Larisa Ryskalin, Francesca Biagioni, Carla L. Busceti, Gloria Lazzeri, Alessandro Frati & Francesco Fornai. (2020) The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent Effects. Molecules 25:20, pages 4839.
Crossref
Mariana Nunes, Miguel Henriques Abreu, Carla Bartosch & Sara Ricardo. (2020) Recycling the Purpose of Old Drugs to Treat Ovarian Cancer. International Journal of Molecular Sciences 21:20, pages 7768.
Crossref
Gricelis P. Martinez, Mercedes E. Zabaleta, Camilo Di Giulio, Jaime E. Charris & Michael R. Mijares. (2020) The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases. Current Pharmaceutical Design 26:35, pages 4467-4485.
Crossref
Qin Xia, Mengchuan Xu, Pei Zhang, Liqun Liu, Xinyi Meng & Lei Dong. (2020) Therapeutic Potential of Autophagy in Glioblastoma Treatment With Phosphoinositide 3-Kinase/Protein Kinase B/Mammalian Target of Rapamycin Signaling Pathway Inhibitors. Frontiers in Oncology 10.
Crossref
Berna KAVAKCIOĞLU YARDIMCI. (2020) Imidazole Antifungals: A Review of Their Action Mechanisms on Cancerous CellsImidazole Antifungals: A Review of Their Action Mechanisms on Cancerous Cells. International Journal of Secondary Metabolite 7:3, pages 139-159.
Crossref
Dong Liang, Ezra K. Osoro, Shuai Tan, Xi Lan, Wenhua Zhu, Litao Wu, Xiaojuan Du, Dongmin Li & Shemin Lu. (2020) Effects and Mechanisms of Autophagy Induced by Solubilized-Cholesterol in Hepatocytes: A Comparative Study Among Solvents. Cell Biochemistry and Biophysics 78:3, pages 357-366.
Crossref
Liuxian Ban, Ting Mei, Qiao Su, Wuguo Li, Zhexun Huang, Lin Liu, Yu Wu, Shaowen Lv, Anxun Wang & Su Li. (2020) Anti-fungal drug itraconazole exerts anti-cancer effects in oral squamous cell carcinoma via suppressing Hedgehog pathway. Life Sciences 254, pages 117695.
Crossref
Huanji Xu, Sheng Zhou, Qiulin Tang, Hongwei Xia & Feng Bi. (2020) Cholesterol metabolism: New functions and therapeutic approaches in cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1874:1, pages 188394.
Crossref
ZhaoMin Lin, ZhaoYang Wang, XueWen Zhou, Ming Zhang, DongFang Gao, Lu Zhang, Peng Wang, Yuan Chen, YuXing Lin, BaoXiang Zhao, JunYing Miao & Feng Kong. (2020) Discovery of new fluorescent thiazole–pyrazoline derivatives as autophagy inducers by inhibiting mTOR activity in A549 human lung cancer cells. Cell Death & Disease 11:7.
Crossref
Huiming Deng, Ling Huang, Zhongkai Liao, Mi Liu, Qiang Li & Ronghua Xu. (2020) Itraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells. Cell Death & Disease 11:7.
Crossref
Rosangela Ferese, Paola Lenzi, Federica Fulceri, Francesca Biagioni, Cinzia Fabrizi, Stefano Gambardella, Pietro Familiari, Alessandro Frati, Fiona Limanaqi & Francesco Fornai. (2020) Quantitative Ultrastructural Morphometry and Gene Expression of mTOR-Related Mitochondriogenesis within Glioblastoma Cells. International Journal of Molecular Sciences 21:13, pages 4570.
Crossref
Shanshan Zhang, Sajid Asghar, Liu Yang, Ziyi Hu, Zhipeng Chen, Feng Shao & Yanyu Xiao. (2020) Borneol and poly (ethylene glycol) dual modified BSA nanoparticles as an itraconazole vehicle for brain targeting. International Journal of Pharmaceutics 575, pages 119002.
Crossref
Xin Wei, Wu Liu, Jia Qi Wang & Zeyao Tang. (2020) “Hedgehog pathway”: a potential target of itraconazole in the treatment of cancer. Journal of Cancer Research and Clinical Oncology 146:2, pages 297-304.
Crossref
Romina Armando, Diego Mengual G�mez & Daniel Gomez. (2020) New drugs are not enough‑drug repositioning in oncology: An update. International Journal of Oncology.
Crossref
Linyan Shen, Yanyun Gu, Yixuan Qiu, Tingting Cheng, Aifang Nie, Canqi Cui, Chenyang Fu, Tingting Li, Xuelin Li, Lihong Fu, Yanqiu Wang, Qicheng Ni, Qidi Wang, Weiqing Wang & Bo Feng. (2020) Atorvastatin Targets the Islet Mevalonate Pathway to Dysregulate mTOR Signaling and Reduce β-Cell Functional Mass. Diabetes 69:1, pages 48-59.
Crossref
Runhong Lei, Liben Yan, Yulin Deng, Jin Xu, Tuo Zhao, M. Umer Farooq Awan, Qiang Li, Guangming Zhou, Xiao Wang & Hong Ma. (2020) HMGB1 mediated autophagy protects glioblastoma cells from carbon-ion beam irradiation injury. Acta Astronautica 166, pages 628-634.
Crossref
Tomomi Takano, Misuzu Akiyama, Tomoyoshi Doki & Tsutomu Hohdatsu. (2019) Antiviral activity of itraconazole against type I feline coronavirus infection. Veterinary Research 50:1.
Crossref
Xiao Ding, Kexia Fan, Jintao Hu, Zhenle Zang, Shunli Zhang, Yin Zhang, Zhichao Lin, Xiangdong Pei, Xin Zheng, Feng Zhu, Hui Yang & Song Li. (2019) SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation. Journal of Experimental & Clinical Cancer Research 38:1.
Crossref
Peter Halcrow, Gaurav Datta, Joyce E. Ohm, Mahmoud L. Soliman, Xuesong Chen & Jonathan D. Geiger. (2019) Role of endolysosomes and pH in the pathogenesis and treatment of glioblastoma. CANCER REPORTS 2:6.
Crossref
Rodrigo Rollin-Pinheiro, Victor Pereira Rochetti, Mariana Ingrid Dutra da Silva Xisto, Livia Cristina Liporagi-Lopes, Beatriz Bastos, Antonella Rella, Ashutosh Singh, Sonia Rozental, Maurizio Del Poeta & Eliana Barreto-Bergter. (2019) Sphingolipid biosynthetic pathway is crucial for growth, biofilm formation and membrane integrity of Scedosporium boydii . Future Medicinal Chemistry 11:22, pages 2905-2917.
Crossref
Junya Ning, Zhaomin Lin, Xuan Zhao, Baoxiang Zhao & Junying Miao. (2019) Inhibiting lysine 353 oxidation of GRP78 by a hypochlorous probe targeting endoplasmic reticulum promotes autophagy in cancer cells. Cell Death & Disease 10:11.
Crossref
Kang Yang, Long Niu, Yijing Bai & Weidong Le. (2019) Glioblastoma: Targeting the autophagy in tumorigenesis. Brain Research Bulletin 153, pages 334-340.
Crossref
Yuta Kouyama, Takaaki Masuda, Atsushi Fujii, Yushi Ogawa, Kuniaki Sato, Taro Tobo, Hiroaki Wakiyama, Yukihiro Yoshikawa, Miwa Noda, Yusuke Tsuruda, Yousuke Kuroda, Hidetoshi Eguchi, Fumio Ishida, Shin‐ei Kudo & Koshi Mimori. (2019) Oncogenic splicing abnormalities induced by DEAD ‐Box Helicase 56 amplification in colorectal cancer . Cancer Science 110:10, pages 3132-3144.
Crossref
Larisa Ryskalin, Anderson Gaglione, Fiona Limanaqi, Francesca Biagioni, Pietro Familiari, Alessandro Frati, Vincenzo Esposito & Francesco Fornai. (2019) The Autophagy Status of Cancer Stem Cells in Gliobastoma Multiforme: From Cancer Promotion to Therapeutic Strategies. International Journal of Molecular Sciences 20:15, pages 3824.
Crossref
Sung-Won Yoon, Dae Hwan Shin & Jin-Seok Kim. (2019) Liposomal itraconazole formulation for the treatment of glioblastoma using inclusion complex with HP-β-CD. Journal of Pharmaceutical Investigation 49:4, pages 477-483.
Crossref
Matthew A. Taylor, Firas Khathayer & Swapan K. Ray. (2019) Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy. Neurochemical Research 44:7, pages 1715-1725.
Crossref
Faming Deng, Qian Xu, Juan Long & Hongfu Xie. (2018) Suppressing ROS‐TFE3‐dependent autophagy enhances ivermectin‐induced apoptosis in human melanoma cells. Journal of Cellular Biochemistry 120:2, pages 1702-1715.
Crossref
Yusuke Kobayashi, Kouji Banno, Haruko Kunitomi, Eiichiro Tominaga & Daisuke Aoki. (2019) Current state and outlook for drug repositioning anticipated in the field of ovarian cancer. Journal of Gynecologic Oncology 30:1.
Crossref
Raquel Lima, Diana Sousa, Ana Gomes, Nuno Mendes, Rune Matthiesen, Madalena Pedro, Franklim Marques, Madalena Pinto, Emília Sousa & M. Vasconcelos. (2018) The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization. Molecules 23:12, pages 3301.
Crossref
Hong Qiao, Yong-Bo Wang, Yu-Mei Gao & Li-Li Bi. (2018) Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway. BMC Neurology 18:1.
Crossref
Qiyuan An, Wenkai Yan, Yi Zhao & Keqiang Yu. (2018) Enhanced neutrophil autophagy and increased concentrations of IL-6, IL-8, IL-10 and MCP-1 in rheumatoid arthritis. International Immunopharmacology 65, pages 119-128.
Crossref
Matthew A. Taylor, Bhaskar C. Das & Swapan K. Ray. (2018) Targeting autophagy for combating chemoresistance and radioresistance in glioblastoma. Apoptosis 23:11-12, pages 563-575.
Crossref
Lei Zhan, Jun Li & Bing Wei. (2018) Autophagy therapeutics: preclinical basis and initial clinical studies. Cancer Chemotherapy and Pharmacology 82:6, pages 923-934.
Crossref
Xuping Feng, Jing Zhou, Jingyi Li, Xueyan Hou, Longhao Li, Yongmin Chen, Shuyue Fu, Li Zhou, Changlong Li & Yunlong Lei. (2018) Tubeimoside I induces accumulation of impaired autophagolysosome against cervical cancer cells by both initiating autophagy and inhibiting lysosomal function. Cell Death & Disease 9:11.
Crossref
Yan Kang, Peiheng He, Hua Wang, Yibiao Ye, Xing Li, Peigen Xie & Bowen Wu. (2018) Brazilin induces FOXO3A-dependent autophagic cell death by disturbing calcium homeostasis in osteosarcoma cells. Cancer Chemotherapy and Pharmacology 82:3, pages 479-491.
Crossref
Xian Zeng & Dianwen Ju. (2018) Hedgehog Signaling Pathway and Autophagy in Cancer. International Journal of Molecular Sciences 19:8, pages 2279.
Crossref
Yong-Hao Huang, Jing Lei, Guo-Hui Yi, Feng-Ying Huang, Yue-Nan Li, Cai-Chun Wang, Yan Sun, Hao-Fu Dai & Guang-Hong Tan. (2018) Coroglaucigenin induces senescence and autophagy in colorectal cancer cells. Cell Proliferation 51:4, pages e12451.
Crossref
Haidong Sun, Qian Liu, Hai Hu, Yisheng Jiang, Wentao Shao, Qihan Wang, Zhaoyan Jiang & Aihua Gu. (2018) Berberine ameliorates blockade of autophagic flux in the liver by regulating cholesterol metabolism and inhibiting COX2-prostaglandin synthesis. Cell Death & Disease 9:8.
Crossref
João Basso, Ana Miranda, João Sousa, Alberto Pais & Carla Vitorino. (2018) Repurposing drugs for glioblastoma: From bench to bedside. Cancer Letters 428, pages 173-183.
Crossref
Wing-Hin Lee, Ching-Yee Loo, Maliheh Ghadiri, Chean-Ring Leong, Paul M. Young & Daniela Traini. (2018) The potential to treat lung cancer via inhalation of repurposed drugs. Advanced Drug Delivery Reviews 133, pages 107-130.
Crossref
Ke Lan, Ron Yan, Kun Zhu, Wenhan Li, Zisen Xu, Chengxue Dang & Kang Li. (2018) Itraconazole inhibits the proliferation of gastric cancer cells in�vitro and improves patient survival. Oncology Letters.
Crossref
Simon J.A. Buczacki, Semiramis Popova, Emma Biggs, Chrysa Koukorava, Jon Buzzelli, Louis Vermeulen, Lee Hazelwood, Hayley Francies, Mathew J. Garnett & Douglas J. Winton. (2018) Itraconazole targets cell cycle heterogeneity in colorectal cancer. Journal of Experimental Medicine 215:7, pages 1891-1912.
Crossref
Lian Zhang, Yunlong Lei, Ying Zhang, Yi Li, Youquan Bu, Fangzhou Song & Chundong Zhang. (2018) Silencing of PRR11 suppresses cell proliferation and induces autophagy in NSCLC cells. Genes & Diseases 5:2, pages 158-166.
Crossref
Yi Lin, Xiaodan He, Dinglun Zhou, Li Li, Jiawei Sun & Xuehua Jiang. (2018) Co-delivery of doxorubicin and itraconazole by Pluronic® P123 coated liposomes to enhance the anticancer effect in breast cancers. RSC Advances 8:42, pages 23768-23779.
Crossref
Jae Eun Cheong, Michela Zaffagni, Ivy Chung, Yingjie Xu, Yiqiang Wang, Finith E. Jernigan, Bruce R. Zetter & Lijun Sun. (2018) Synthesis and anticancer activity of novel water soluble benzimidazole carbamates. European Journal of Medicinal Chemistry 144, pages 372-385.
Crossref
Hans-Jürgen Tietz & Ulrike Gunkel. (2018) Chancen auf Heilung sind besser denn je. Der Deutsche Dermatologe 66:1, pages 38-47.
Crossref
Tara L. Hogenson, Rachel L. O. Olson & Martin E. Fernandez-Zapico. 2018. Pancreatic Cancer. Pancreatic Cancer 409 430 .
Chao Dong, Runxiang Yang, Hongjian Li, Kunbin Ke, Chunxiang Luo, Fang Yang, Xi-Nan Shi, Ying Zhu, Xu Liu, Man-Hon Wong, Guimiao Lin, Xiaomei Wang, Kwong-Sak Leung, Hsiang-Fu Kung, Ceshi Chen & Marie Chia-mi Lin. (2017) Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells. Scientific Reports 7:1.
Crossref
Sho Nambara, Takaaki Masuda, Miki Nishio, Shotaro Kuramitsu, Taro Tobo, Yushi Ogawa, Qingjiang Hu, Tomohiro Iguchi, Yousuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Keishi Sugimachi, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Akira Suzuki & Koshi Mimori. (2017) Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer. Oncotarget 8:64, pages 107666-107677.
Crossref
Ri‑Su Na, Cong Ma, Qiao‑Rui Liu, Li‑Ming Wu, Xu‑Lei Zheng & Zhi‑Wen Liu. (2017) Itraconazole attenuates hepatic gluconeogenesis and promotes glucose uptake by regulating AMPK pathway. Experimental and Therapeutic Medicine.
Crossref
Qiang Hu, Yi-Chao Hou, Jiao Huang, Jing-Yuan Fang & Hua Xiong. (2017) Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells. Journal of Experimental & Clinical Cancer Research 36:1.
Crossref
Yuqiong Xie, Chunchun Li, Yali Huang, Zhenyu Jia & Jiang Cao. (2017) A novel multikinase inhibitor R8 exhibits potent inhibition on cancer cells through both apoptosis and autophagic cell death. Oncotarget 8:50, pages 87209-87220.
Crossref
Linda Sleire, Hilde Elise Førde, Inger Anne Netland, Lina Leiss, Bente Sandvei Skeie & Per Øyvind Enger. (2017) Drug repurposing in cancer. Pharmacological Research 124, pages 74-91.
Crossref
Naoshad Muhammad, Robert Steele, T. Scott Isbell, Nancy Philips & Ratna B. Ray. (2017) Bitter melon extract inhibits breast cancer growth in preclinical model by inducing autophagic cell death. Oncotarget 8:39, pages 66226-66236.
Crossref
Manasi P. Jogalekar, Leigh G. Cooper & Elba E. Serrano. (2017) Hydrogel Environment Supports Cell Culture Expansion of a Grade IV Astrocytoma. Neurochemical Research 42:9, pages 2610-2624.
Crossref
Yong-Hao Huang, Yan Sun, Feng-Ying Huang, Yue-Nan Li, Cai-Chun Wang, Wen-Li Mei, Hao-Fu Dai, Guang-Hong Tan & Canhua Huang. (2017) Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells. Oncotarget 8:32, pages 52783-52791.
Crossref
Hiroshi Tsubamoto, Tomoko Ueda, Kayo Inoue, Kazuko Sakata, Hiroaki Shibahara & Takashi Sonoda. (2017) Repurposing itraconazole as an anticancer agent. Oncology Letters 14:2, pages 1240-1246.
Crossref
Tasleem Arif, Yakov Krelin, Itay Nakdimon, Daniel Benharroch, Avijit Paul, Daniela Dadon-Klein & Varda Shoshan-Barmatz. (2017) VDAC1 is a molecular target in glioblastoma, with its depletion leading to reprogrammed metabolism and reversed oncogenic properties. Neuro-Oncology 19:7, pages 951-964.
Crossref
J-Y Chuang, W-L Lo, C-Y Ko, S-Y Chou, R-M Chen, K-Y Chang, J-J Hung, W-C Su, W-C Chang & T-I Hsu. (2017) Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma. Oncogenesis 6:5, pages e339-e339.
Crossref
Michela Ferrucci, Francesca Biagioni, Paola Lenzi, Stefano Gambardella, Rosangela Ferese, Maria Teresa Calierno, Alessandra Falleni, Alfonso Grimaldi, Alessandro Frati, Vincenzo Esposito, Cristina Limatola & Francesco Fornai. (2017) Rapamycin promotes differentiation increasing βIII-tubulin, NeuN, and NeuroD while suppressing nestin expression in glioblastoma cells. Oncotarget 8:18, pages 29574-29599.
Crossref
Sita Sharan Patel, Sunil Tomar, Diksha Sharma, Neeraj Mahindroo & Malairaman Udayabanu. (2017) Targeting sonic hedgehog signaling in neurological disorders. Neuroscience & Biobehavioral Reviews 74, pages 76-97.
Crossref
F.T. LimS.M. LimK. Ramasamy. (2017) Pediococcus acidilactici LAB4 and Lactobacillus plantarum LAB12 assimilate cholesterol and modulate ABCA1 , CD36 , NPC1L1 and SCARB1 in vitro . Beneficial Microbes 8:1, pages 97-109.
Crossref
婉瑞 付. (2017) The Research Progress on Occurrence of Candida Drug Resistance. Advances in Microbiology 06:04, pages 98-107.
Crossref
Larisa Ryskalin, Gloria Lazzeri, Marina Flaibani, Francesca Biagioni, Stefano Gambardella, Alessandro Frati & Francesco Fornai. (2017) mTOR-Dependent Cell Proliferation in the Brain. BioMed Research International 2017, pages 1-14.
Crossref
Takashi Ode, Katarzyna A. Podyma-Inoue, Kazue Terasawa, Jin-ichi Inokuchi, Toshihide Kobayashi, Tetsuro Watabe, Yuichi Izumi & Miki Hara-Yokoyama. (2017) PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum. Experimental Cell Research 350:1, pages 103-114.
Crossref
Xiaoya Wang, Sanhua Wei, Yong Zhao, Changhong Shi, Peijuan Liu, Caiqin Zhang, Yingfeng Lei, Bo Zhang, Bing Bai, Yong Huang & Hai Zhang. (2017) Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death. Cancer Letters 385, pages 128-136.
Crossref
Shugang Xu, Xing Guo, Xiao Gao, Hao Xue, Jinsen Zhang, Xiaofan Guo, Wei Qiu, Ping Zhang & Gang Li. (2016) Macrophage migration inhibitory factor enhances autophagy by regulating ROCK1 activity and contributes to the escape of dendritic cell surveillance in glioblastoma. International Journal of Oncology 49:5, pages 2105-2115.
Crossref
Soha Jawhari, Marie-Hélène Ratinaud & Mireille Verdier. (2016) Glioblastoma, hypoxia and autophagy: a survival-prone ‘ménage-à-trois’. Cell Death & Disease 7:10, pages e2434-e2434.
Crossref
Qianhui Dou, Hai-Ning Chen, Kui Wang, Kefei Yuan, Yunlong Lei, Kai Li, Jiang Lan, Yan Chen, Zhao Huang, Na Xie, Lu Zhang, Rong Xiang, Edouard C. Nice, Yuquan Wei & Canhua Huang. (2016) Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer. Cancer Research 76:15, pages 4457-4469.
Crossref
Jeong-Jun Lee, Aeri Shim, Jae Young Jeong, Song Yi Lee, Hyun-Jeong Ko & Hyun-Jong Cho. (2016) Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection. Colloids and Surfaces B: Biointerfaces 143, pages 336-341.
Crossref
Feixiong Cheng, Huixiao Hong, Shengyong Yang & Yuquan Wei. (2016) Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era. Briefings in Bioinformatics, pages bbw051.
Crossref
Yi Chen, Xiaoyan Xie, Xinyi Li, Peiqi Wang, Qian Jing, Jiaqi Yue, Yang Liu, Zhong Cheng, Jingyi Li, Haixing Song, Guoyu Li, Rui Liu & Jinhui Wang. (2016) FGFR antagonist induces protective autophagy in FGFR1-amplified breast cancer cell. Biochemical and Biophysical Research Communications 474:1, pages 1-7.
Crossref
Aeri Shim, Jae-Hyoung Song, Bo-Eun Kwon, Jeong-Jun Lee, Jae-Hee Ahn, Yeon-Jeong Kim, Ki-Jong Rhee, Sun-Young Chang, Younggil Cha, Yong-Soo Lee, Mi-Na Kweon, Kwi Sung Park, Dong-Eun Kim, Sungchan Cho, Hyun-Jong Cho & Hyun-Jeong Ko. (2016) Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model. Scientific Reports 6:1.
Crossref
Roberto Würth, Stefano Thellung, Adriana Bajetto, Michele Mazzanti, Tullio Florio & Federica Barbieri. (2016) Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds. Drug Discovery Today 21:1, pages 190-199.
Crossref
Qing Li, Mi Zhou & Renxiao Wang. 2016. Targeting Autophagy in Cancer Therapy. Targeting Autophagy in Cancer Therapy 39 57 .
Tara L. Hogenson, Rachel L. O. Olson & Martin E. Fernandez-Zapico. 2017. Pancreatic Cancer. Pancreatic Cancer 1 22 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.