8,914
Views
305
CrossRef citations to date
0
Altmetric
Basic Research Papers

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

, , , , , , , , , , & show all
Pages 1989-2005 | Received 14 Jan 2014, Accepted 21 Aug 2014, Published online: 18 Dec 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (21)

Paloma B. Liton, Kathleen Boesze-Battaglia, Michael E. Boulton, Patricia Boya, Thomas A. Ferguson, Ian G. Ganley, Anu Kauppinnen, Gordon W. Laurie, Noboru Mizushima, Hideaki Morishita, Rossella Russo, Jaya Sadda, Rajalekshmy Shyam, Debasish Sinha, Debra A. Thompson & David N. Zacks. (2023) Autophagy in the eye: from physiology to pathophysiology. Autophagy Reports 2:1.
Read now
Lihua Li, Jun Chen, Yun Zhou, Jiahua Zhang & Lei Chen. (2023) Artesunate alleviates diabetic retinopathy by activating autophagy via the regulation of AMPK/SIRT1 pathway. Archives of Physiology and Biochemistry 129:4, pages 943-950.
Read now
Sayantan Datta, Marisol Cano, Ganesh Satyanarayana, Tongyun Liu, Lei Wang, Jie Wang, Jie Cheng, Kie Itoh, Anjali Sharma, Imran Bhutto, Rangaramanujam Kannan, Jiang Qian, Debasish Sinha & James T. Handa. (2023) Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity. Autophagy 19:3, pages 966-983.
Read now
Ignacio Ramírez-Pardo, Beatriz Villarejo-Zori, Juan Ignacio Jiménez-Loygorri, Elena Sierra-Filardi, Sandra Alonso-Gil, Guillermo Mariño, Pedro de la Villa, Patrick S Fitze, José Manuel Fuentes, Ramón García-Escudero, Deborah A. Ferrington, Raquel Gomez-Sintes & Patricia Boya. (2023) Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration. Autophagy 19:3, pages 784-804.
Read now
Kai Kaarniranta, Janusz Blasiak, Paloma Liton, Michael Boulton, Daniel J. Klionsky & Debasish Sinha. (2023) Autophagy in age-related macular degeneration. Autophagy 19:2, pages 388-400.
Read now
Li Li, Ruoyun Dong, Tao Liu, Yaqian Yang, Hongmei Chang, Xiaojia Meng, Yaxin Deng, Qianqian Wang, Yiman Zhao, Guanling Song & Yunhua Hu. (2023) Nano-titanium dioxide exposure and autophagy: a systematic review and meta-analysis. Toxin Reviews 42:1, pages 407-418.
Read now
Jiangbo Ren, Anli Ren, Xizhi Deng, Zhengrong Huang, Ziyu Jiang, Zhi Li & Yan Gong. (2022) Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration. Journal of Inflammation Research 15, pages 865-880.
Read now
Kirstan A Vessey, Andrew I Jobling, Mai X. Tran, Anna Y. Wang, Ursula Greferath & Erica L. Fletcher. (2022) Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E). Autophagy 18:10, pages 2368-2384.
Read now
Janusz Blasiak & Kai Kaarniranta. (2022) Secretory autophagy: a turn key for understanding AMD pathology and developing new therapeutic targets?. Expert Opinion on Therapeutic Targets 26:10, pages 883-895.
Read now
Erpeng Zhu, Huawei Wu, Wenxian Chen, Yuwei Qin, Jiameng Liu, Shuangqi Fan, Shengming Ma, Keke Wu, Qian Mao, Chaowei Luo, Yixian Qin, Lin Yi, Hongxing Ding, Mingqiu Zhao & Jinding Chen. (2021) Classical swine fever virus employs the PERK- and IRE1-dependent autophagy for viral replication in cultured cells.. Virulence 12:1, pages 130-149.
Read now
Dong Li Li, Lei Mao, Qing Gu, Fang Wei & Yuan-Yuan Gong. (2021) Quercetin protects retina external barrier from oxidative stress injury by promoting autophagy. Cutaneous and Ocular Toxicology 40:1, pages 7-13.
Read now
Jingjing Liu & Dan Liu. (2020) Sirtuin 6 protects human retinal pigment epithelium cells from LPS-induced inflammation and apoptosis partly by regulating autophagy. Bioscience, Biotechnology, and Biochemistry 84:10, pages 2062-2068.
Read now
Saeed Mehrzadi, Karim Hemati, Russel J. Reiter & Azam Hosseinzadeh. (2020) Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment. Expert Opinion on Therapeutic Targets 24:4, pages 359-378.
Read now
Thomas G. McWilliams, Alan R. Prescott, Beatriz Villarejo-Zori, Graeme Ball, Patricia Boya & Ian G. Ganley. (2019) A comparative map of macroautophagy and mitophagy in the vertebrate eye. Autophagy 15:7, pages 1296-1308.
Read now
Xuebin Hu, Zhaojing Lu, Shanshan Yu, James Reilly, Fei Liu, Danna Jia, Yayun Qin, Shanshan Han, Xiliang Liu, Zhen Qu, Yuexia Lv, Jingzhen Li, Yuwen Huang, Tao Jiang, Haibo Jia, Qing Wang, Jingyu Liu, Xinhua Shu, Zhaohui Tang & Mugen Liu. (2019) CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1. Autophagy 15:3, pages 453-465.
Read now
Qingquan Wei, Xiuwei Liang, Ye Peng, Donghui Yu, Ruiling Zhang, Huizi Jin, Jiaqi Fan, Wenting Cai, Chengda Ren & Jing Yu. (2018) 17β-estradiol ameliorates oxidative stress and blue light-emitting diode-induced retinal degeneration by decreasing apoptosis and enhancing autophagy. Drug Design, Development and Therapy 12, pages 2715-2730.
Read now
Sriganesh Ramachandra Rao, Bruce A. Pfeffer, Néstor Más Gómez, Lara A. Skelton, Ueda Keiko, Janet R. Sparrow, Aryn M. Rowsam, Claire H. Mitchell & Steven J. Fliesler. (2018) Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome. Autophagy 14:10, pages 1796-1817.
Read now
Huiling Li, Sumana R. Chintalapudi & Monica M. Jablonski. (2017) Current drug and molecular therapies for the treatment of atrophic age-related macular degeneration: phase I to phase III clinical development. Expert Opinion on Investigational Drugs 26:10, pages 1103-1114.
Read now
Maria Mercedes Campos & Mones S. Abu-Asab. (2017) Loss of endothelial planar cell polarity and cellular clearance mechanisms in age-related macular degeneration. Ultrastructural Pathology 41:5, pages 312-319.
Read now
Ahruem Baek, Soojin Yoon, Jean Kim, Yu Mi Baek, Hanna Park, Daehan Lim, Hyewon Chung & Dong-Eun Kim. (2017) Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress. Autophagy 13:2, pages 248-263.
Read now

Articles from other publishers (284)

Lu Wang, Canyang Zhang, Long Pang & Yan Wang. (2023) Integrated network pharmacology and experimental validation to explore the potential pharmacological mechanism of Qihuang Granule and its main ingredients in regulating ferroptosis in AMD. BMC Complementary Medicine and Therapies 23:1.
Crossref
Agnes Fietz, Sven Schnichels & José Hurst. (2023) Co-cultivation of primary porcine RPE cells and neuroretina induces inflammation: a potential inflammatory AMD-model. Scientific Reports 13:1.
Crossref
Hamid Latifi-Navid, Amir Barzegar Behrooz, Saleh Jamehdor, Maliheh Davari, Masoud Latifinavid, Narges Zolfaghari, Somayeh Piroozmand, Sepideh Taghizadeh, Mahsa Bourbour, Golnaz Shemshaki, Saeid Latifi-Navid, Seyed Shahriar Arab, Zahra-Soheila Soheili, Hamid Ahmadieh & Nader Sheibani. (2023) Construction of an Exudative Age-Related Macular Degeneration Diagnostic and Therapeutic Molecular Network Using Multi-Layer Network Analysis, a Fuzzy Logic Model, and Deep Learning Techniques: Are Retinal and Brain Neurodegenerative Disorders Related?. Pharmaceuticals 16:11, pages 1555.
Crossref
Jie Cheng, Casey J. Keuthan & Noriko Esumi. (2023) The many faces of SIRT6 in the retina and retinal pigment epithelium. Frontiers in Cell and Developmental Biology 11.
Crossref
Keying Chen, Camila Garcia Padilla, Kirill Kiselyov & Takashi D.Y. Kozai. (2023) Cell-specific alterations in autophagy-lysosomal activity near the chronically implanted microelectrodes. Biomaterials 302, pages 122316.
Crossref
Belinda J. Hernandez, Nikolai P. Skiba, Karolina Plössl, Madison Strain, Yutao Liu, Daniel Grigsby, Una Kelly, Martha A. Cady, Vikram Manocha, Arvydas Maminishkis, TeddiJo Watkins, Sheldon S. Miller, Allison Ashley‐Koch, W. Daniel Stamer, Bernhard H. F. Weber, Catherine Bowes Rickman & Mikael Klingeborn. (2023) Polarized desmosome and hemidesmosome shedding via small extracellular vesicles is an early indicator of outer blood‐retina barrier dysfunction. Journal of Extracellular Biology 2:10.
Crossref
Juan Ignacio Jiménez-Loygorri, Rocío Benítez-Fernández, Álvaro Viedma-Poyatos, Juan Zapata-Muñoz, Beatriz Villarejo-Zori, Raquel Gómez-Sintes & Patricia Boya. (2023) Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens. Progress in Retinal and Eye Research 96, pages 101205.
Crossref
Cheng Cao, Yunqing Lu, Bing Li, Yang Chen, Pan Xu, Mengqiu Liu, Ziqiang Zhu, Lei Yuan, Sheng Guo, Hongjie Kang, Jin-ao Duan & Yue Zhu. (2023) Lycii Fructus, a medicine food homology material, attenuates retinal damage in sodium iodate-induced retinal degeneration mice and inhibits oxidation-induced apoptosis of Müller cells via regulating Nrf2-HO1 signaling pathway. Journal of Functional Foods 108, pages 105756.
Crossref
Hanying Wang, Caixia Wang, Yimin Yao, Jialiang Duan, Yuchen Liang & Qingli Shang. (2023) Analysis of long noncoding RNAs in the aqueous humor of wet age-related macular degeneration. Experimental Eye Research 234, pages 109576.
Crossref
Grace A. Borchert, Hoda Shamsnajafabadi, Monica L. Hu, Samantha R. De Silva, Susan M. Downes, Robert E. MacLaren, Kanmin Xue & Jasmina Cehajic-Kapetanovic. (2023) The Role of Inflammation in Age-Related Macular Degeneration—Therapeutic Landscapes in Geographic Atrophy. Cells 12:16, pages 2092.
Crossref
Li Xuan Tan, Colin J. Germer, Thushara Thamban, Nilsa La Cunza & Aparna Lakkaraju. (2023) Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina. Current Biology.
Crossref
Xiaoping Qi, Carolina Francelin, Sayak Mitter, Sanford L. Boye, Hongmei Gu, Judith Quigley, Maria B. Grant & Michael E. Boulton. (2023) β-secretase 1 overexpression by AAV-mediated gene delivery prevents retina degeneration in a mouse model of age-related macular degeneration. Molecular Therapy 31:7, pages 2042-2055.
Crossref
Yuliya Markitantova & Vladimir Simirskii. (2023) Endogenous and Exogenous Regulation of Redox Homeostasis in Retinal Pigment Epithelium Cells: An Updated Antioxidant Perspective. International Journal of Molecular Sciences 24:13, pages 10776.
Crossref
Hanqing Zhu, Hongliang Zhang, Jiahui Guo, Chao Zhang, Quanwu Zhang & Fenghou Gao. (2023) Up-regulated oxidized USP2a can increase Mdm2-p60-p53 to promote cell apoptosis. Experimental Cell Research 427:1, pages 113597.
Crossref
Viivi Karema-Jokinen, Ali Koskela, Maria Hytti, Heidi Hongisto, Taina Viheriälä, Mikko Liukkonen, Tommi Torsti, Heli Skottman, Anu Kauppinen, Soile Nymark & Kai Kaarniranta. (2023) Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients. Journal of Biological Chemistry 299:6, pages 104770.
Crossref
Ying Guo, Na Lu, Qing He, Boyuan Wang, Sai Cao & You Wang. (2023) Autophagy: A newly discovered protective mechanism in the marine rotifer Brachionus plicatilis in response to BDE-47 exposure. Aquatic Toxicology 259, pages 106536.
Crossref
Roberto Pinelli, Michela Ferrucci, Francesca Biagioni, Caterina Berti, Violet Vakunseth Bumah, Carla Letizia Busceti, Stefano Puglisi-Allegra, Gloria Lazzeri, Alessandro Frati & Francesco Fornai. (2023) Autophagy Activation Promoted by Pulses of Light and Phytochemicals Counteracting Oxidative Stress during Age-Related Macular Degeneration. Antioxidants 12:6, pages 1183.
Crossref
Zhibo Si, Yajuan Zheng & Jing Zhao. (2023) The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy. Biomolecules 13:6, pages 901.
Crossref
Roberto Pinelli, Michela Ferrucci, Caterina Berti, Francesca Biagioni, Elena Scaffidi, Violet Vakunseth Bumah, Carla L. Busceti, Paola Lenzi, Gloria Lazzeri & Francesco Fornai. (2023) The Essential Role of Light-Induced Autophagy in the Inner Choroid/Outer Retinal Neurovascular Unit in Baseline Conditions and Degeneration. International Journal of Molecular Sciences 24:10, pages 8979.
Crossref
Zhenzhou Huang & Yanjie Tan. (2023) The Potential of Cylindromatosis (CYLD) as a Therapeutic Target in Oxidative Stress-Associated Pathologies: A Comprehensive Evaluation. International Journal of Molecular Sciences 24:9, pages 8368.
Crossref
Yu. V. Markitantova & V. N. Simirskii. (2023) Conservatism and Variability of the Antioxidant Defense System in the Retinal Pigment Epithelium of Vertebrates. Journal of Evolutionary Biochemistry and Physiology 59:3, pages 655-675.
Crossref
Xiongyi Yang, Zexin Huang, Mei Xu, Yanxia Chen, Mingzhe Cao, Guoguo Yi & Min Fu. (2023) Autophagy in the retinal neurovascular unit: New perspectives into diabetic retinopathy. Journal of Diabetes 15:5, pages 382-396.
Crossref
Yun-Hsiu Tseng, Tien-Li Ma, Dun-Heng Tan, An-Jey A. Su, Kia M. Washington, Chun-Chieh Wang, Yu-Ching Huang, Ming-Chung Wu & Wei-Fang Su. (2023) Injectable Hydrogel Guides Neurons Growth with Specific Directionality. International Journal of Molecular Sciences 24:9, pages 7952.
Crossref
Yu-Qing Chen, Lian-Di Gao, Yi-Lin Liu, Ya Shen, Jia-Le Diao, Wei-Hua Yang & Rui-Li Wei. (2023) Autophagy in graves’ ophthalmopathy. Frontiers in Cell and Developmental Biology 11.
Crossref
Reshal Suri, Tapas C. Nag, Nikita Mehra, Yub Raj Neupane, Sadat Shafi, Devyani Sharma, Kalicharan Sharma, Yasmin Sultana & Kanchan Kohli. (2023) Sirolimus loaded chitosan functionalized PLGA nanoparticles protect against sodium iodate-induced retinal degeneration. Journal of Drug Delivery Science and Technology 82, pages 104369.
Crossref
Alessandro Arrigo, Emanuela Aragona & Francesco Bandello. (2023) The Role of Inflammation in Age-Related Macular Degeneration: Updates and Possible Therapeutic Approaches. Asia-Pacific Journal of Ophthalmology 12:2, pages 158-167.
Crossref
Lili Wei, Jianping Fu, Li He, Hui Wang, Jiming Ruan, Fugui Li & Huadong Wu. (2023) Microcystin-LR-induced autophagy regulates oxidative stress, inflammation, and apoptosis in grass carp ovary cells in vitro. Toxicology in Vitro 87, pages 105520.
Crossref
Liyin Wang, Xin Yu, Dongyan Zhang, Yingying Wen, Liyue Zhang, Yutong Xia, Jinbo Chen, Chen Xie, Hong Zhu, Jianping Tong & Ye Shen. (2023) Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro. Journal of Photochemistry and Photobiology B: Biology 240, pages 112654.
Crossref
Emil Carlsson, Umar Sharif, Wasu Supharattanasitthi & Luminita Paraoan. (2023) Analysis of Wild Type and Variant B Cystatin C Interactome in Retinal Pigment Epithelium Cells Reveals Variant B Interacting Mitochondrial Proteins. Cells 12:5, pages 713.
Crossref
Inês Ramos Rego, Daniela Silvério, Maria Isabel Eufrásio, Sandra Sofia Pinhanços, Bruna Lopes da Costa, José Teixeira, Hugo Fernandes, Yang Kong, Yao Li, Stephen H. Tsang, Paulo J. Oliveira, Rosa Fernandes, Peter M. J. Quinn, Paulo Fernando Santos, António Francisco Ambrósio & Celso Henrique Alves. (2023) TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status. Antioxidants 12:2, pages 381.
Crossref
Yurun Liu, Simin Gu, Yaru Su, Shoubi Wang, Yaqi Cheng, Xuan Sang, Lin Jin, Ying Liu, Chaoyang Li, Weiqin Liu, Minghao Chen, Xiaoran Wang & Zhichong Wang. (2023) Embryonic stem cell extracellular vesicles reverse the senescence of retinal pigment epithelial cells by the p38MAPK pathway. Experimental Eye Research 227, pages 109365.
Crossref
Liwei Wei, Shuang Chai, Chen Yue, Hong Zhang, Jitian Li & Na Qin. (2023) Resveratrol protects osteocytes against oxidative stress in ovariectomized rats through AMPK/JNK1-dependent pathway leading to promotion of autophagy and inhibition of apoptosis. Cell Death Discovery 9:1.
Crossref
Ye Liu, Di Wu, Qiuli Fu, Shengjie Hao, Yuzhou Gu, Wei Zhao, Shuying Chen, Feiyin Sheng, Yili Xu, Zhiqing Chen & Ke Yao. (2023) CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment Epithelial Cells with Oxidative Damage. International Journal of Molecular Sciences 24:2, pages 1582.
Crossref
Meenakshi Maurya, Kiran Bora, AlexandraK Blomfield, MadelineC Pavlovich, Shuo Huang, Chi-Hsiu Liu & Jing Chen. (2023) Oxidative stress in retinal pigment epithelium degeneration: from pathogenesis to therapeutic targets in dry age-related macular degeneration. Neural Regeneration Research 18:10, pages 2173.
Crossref
Hye Mi Cho, Sang Jun Lee & Se-Young Choung. (2023) Protective effects of Panax ginseng berry extract on blue light-induced retinal damage in ARPE-19 cells and mouse retina. Journal of Ginseng Research 47:1, pages 65-73.
Crossref
Shaimaa Eltanani, Thangal Yumnamcha, Andrew Gregory, Mahmoud Elshal, Mohamed Shawky & Ahmed S. Ibrahim. (2022) Relative Importance of Different Elements of Mitochondrial Oxidative Phosphorylation in Maintaining the Barrier Integrity of Retinal Endothelial Cells: Implications for Vascular-Associated Retinal Diseases. Cells 11:24, pages 4128.
Crossref
Cody R. Fisher, Adam A. Shaaeli, Mara C. Ebeling, Sandra R. Montezuma & Deborah A. Ferrington. (2022) Investigating mitochondrial fission, fusion, and autophagy in retinal pigment epithelium from donors with age-related macular degeneration. Scientific Reports 12:1.
Crossref
Kun-Che Chang, Pei-Feng Liu, Chia-Hsuan Chang, Ying-Cheng Lin, Yen-Ju Chen & Chih-Wen Shu. (2022) The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases. Cell & Bioscience 12:1.
Crossref
Tadeusz J. Kaczynski, Elizabeth D. Au & Michael H. Farkas. (2022) Exploring the lncRNA localization landscape within the retinal pigment epithelium under normal and stress conditions. BMC Genomics 23:1.
Crossref
Jasper Weinberg, Mohita Gaur, Anand Swaroop & Allen Taylor. (2022) Proteostasis in aging-associated ocular disease. Molecular Aspects of Medicine 88, pages 101157.
Crossref
Hideaki Morishita. (2022) Role of autophagy in the eye: from physiology to disease. Current Opinion in Physiology 30, pages 100592.
Crossref
Di Zhou, Qiaohui Yang, Jialin Li, Xiao Liu, Jin Li, Wang Zhou, Yujiao Chai & Zhuo Li. (2022) Loss of Hes1 in embryonic stem cells caused developmental disorders in retinal pigment epithelium morphogenesis and specification. Biochemical and Biophysical Research Communications 632, pages 76-84.
Crossref
Ryo Terao, Tazbir Ahmed, Ayana Suzumura & Hiroko Terasaki. (2022) Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration. Antioxidants 11:11, pages 2189.
Crossref
Josephine H. C. Wong, Jessica Y. W. Ma, Andrew I. Jobling, Alice Brandli, Ursula Greferath, Erica L. Fletcher & Kirstan A. Vessey. (2022) Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune system. Frontiers in Neuroscience 16.
Crossref
Hanna Heloterä & Kai Kaarniranta. (2022) A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration. Cells 11:21, pages 3453.
Crossref
Niina Harju. (2022) Regulation of oxidative stress and inflammatory responses in human retinal pigment epithelial cells. Acta Ophthalmologica 100:S273, pages 3-59.
Crossref
Xue Chen, Ying Wang, Jia-Nan Wang, Qiu-Chen Cao, Ru-Xu Sun, Hong-Jing Zhu, Ye-Ran Zhang, Jiang-Dong Ji & Qing-Huai Liu. (2022) m6A modification of circSPECC1 suppresses RPE oxidative damage and maintains retinal homeostasis. Cell Reports 41:7, pages 111671.
Crossref
Lin Lan, Shengyu Wang, Shuhua Duan, Xiangyu Zhou & Yufeng Li. (2022) Cordyceps militaris Carotenoids Protect Human Retinal Endothelial Cells against the Oxidative Injury and Apoptosis Resulting from H2O2. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-12.
Crossref
Xiaojun Wu, Fuwen Yao, Jing-Ying Xu, Jiao Chen, Ying Lu, Wei Li, Jing Deng, Lisha Mou, Qingling Zhang & Zuihui Pu. (2022) The transcriptome profile of RPE cells by the fullerenol against hydrogen peroxide stress. Frontiers in Medicine 9.
Crossref
Zixuan Shao, Marilyn ChwaShari R. AtilanoJohn ParkHampar KarageozianVicken KarageozianM. Cristina Kenney. (2022) The Transcriptome Profile of Retinal Pigment Epithelium and Müller Cell Lines Protected by Risuteganib Against Hydrogen Peroxide Stress. Journal of Ocular Pharmacology and Therapeutics 38:7, pages 513-526.
Crossref
Yibo Gong, Xuechun Wang, Yuchuan Wang, Peng Hao, Hao Wang, Yatu Guo & Wei Zhang. (2022) The effect of a chrysanthemum water extract in protecting the retina of mice from light damage. BMC Complementary Medicine and Therapies 22:1.
Crossref
Mengqi Qin, Zhi Xie, Ting Cao, Zhiruo Wang, Xiaoyu Zhang, Feifei Wang, Wei Wei, Ming Jin, Jingyuan Ma, Ling Zeng, Yanan Wang, Shaonan Pei & Xu Zhang. (2022) Autophagy in Rat Müller Glial Cells Is Modulated by the Sirtuin 4/AMPK/mTOR Pathway and Induces Apoptosis under Oxidative Stress. Cells 11:17, pages 2645.
Crossref
Kai Wang, Yong-Syuan Chen, Hsiang-Wen Chien, Hui-Ling Chiou, Shun-Fa Yang & Yi-Hsien Hsieh. (2022) Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1α/BNIP3-LC3B/mitophagy signaling. Cell & Bioscience 12:1.
Crossref
Zhaoyao Li, Wenxian Chen, Zilong Qiu, Yuwan Li, Jindai Fan, Keke Wu, Xiaowen Li, Mingqiu Zhao, Hongxing Ding, Shuangqi Fan & Jinding Chen. (2022) African Swine Fever Virus: A Review. Life 12:8, pages 1255.
Crossref
Neil Saptarshi, Louise F. Porter & Luminita Paraoan. (2022) PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells. Scientific Reports 12:1.
Crossref
Tori E Rudolph, Crystal M Roach, Lance H Baumgard, Jason W Ross, Aileen F Keating & Josh T Selsby. (2022) The impact of Zearalenone on heat-stressed skeletal muscle in pigs. Journal of Animal Science 100:8.
Crossref
Ling Mei, Minzhi Yu, Yayuan Liu, Eric Weh, Mercy Pawar, Li Li, Cagri G. Besirli & Anna A. Schwendeman. (2022) Synthetic high-density lipoprotein nanoparticles delivering rapamycin for the treatment of age-related macular degeneration. Nanomedicine: Nanotechnology, Biology and Medicine 44, pages 102571.
Crossref
Prajakta Teli, Vaijayanti Kale & Anuradha Vaidya. (2022) Mesenchymal stromal cells-derived secretome protects Neuro-2a cells from oxidative stress-induced loss of neurogenesis. Experimental Neurology 354, pages 114107.
Crossref
T. B. Feldman, A. E. Dontsov, M. A. Yakovleva & M. A. Ostrovsky. (2022) Photobiology of lipofuscin granules in the retinal pigment epithelium cells of the eye: norm, pathology, age. Biophysical Reviews 14:4, pages 1051-1065.
Crossref
Aram Asatryan, Jorgelina M. Calandria, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Khanh V. Do, Surjyadipta Bhattacharjee, Thang L. Pham, Vicente Bermúdez, Melina Valeria Mateos, Jessica Heap & Nicolas G. Bazan. (2022) New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease. Frontiers in Neuroscience 16.
Crossref
Yipin Wang, Nicholas Siu Kay Fung, Wai-Ching Lam & Amy Cheuk Yin Lo. (2022) mTOR Signalling Pathway: A Potential Therapeutic Target for Ocular Neurodegenerative Diseases. Antioxidants 11:7, pages 1304.
Crossref
Min Wang, Fangyuan Hu, Jihong Wu & Shenghai Zhang. (2022) The Effects of Different Degrees of Hypoxia on Retinal Pigment Epithelium. Journal of Biomaterials and Tissue Engineering 12:6, pages 1182-1188.
Crossref
Ajay Kumar, Ravi Prakash, Anas Ahmad, Neha Kumari, Md. Meraj Ansari, Mohsin Ali Khan, Syed Shadab Raza & Rehan Khan. (2022) Nanoparticles mediated localized therapy abrogates autophagy through modulation of Beclin1 and Atg7 for the management of ischemia-reperfusion disorder. Chemical Engineering Journal 438, pages 135557.
Crossref
Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder André & Ari Koskelainen. (2022) Hormetic Heat Shock Enhances Autophagy through HSF1 in Retinal Pigment Epithelium Cells. Cells 11:11, pages 1778.
Crossref
Ravi Prakash, Eram Fauzia, Abu Junaid Siddiqui, Santosh Kumar Yadav, Neha Kumari, Mohammad Tayyab Shams, Abdul Naeem, Prakash P Praharaj, Mohsin Ali Khan, Sujit Kumar Bhutia, Miroslaw Janowski, Johannes Boltze & Syed Shadab Raza. (2022) Oxidative Stress-induced Autophagy Compromises Stem Cell Viability. Stem Cells 40:5, pages 468-478.
Crossref
Yangfei Yi, Ningyin Yang, Qian Luo, Xiaojun Tao & Yufei Li. (2022) Delivery of Chondrocyte-Targeting sh-TTTY15 (Testis-Specific Transcript, Y-Linked 15) Nanoparticles Against LncRNA TTTY15 Improves Osteoarthritis by Regulating Autophagy and Oxidative Stress. Journal of Biomedical Nanotechnology 18:5, pages 1386-1396.
Crossref
Youjian Li, Kepeng Ou, Yuwei Wang, Liying Luo, Zhongzhu Chen & Jiahui Wu. (2022) TLR9 agonist suppresses choroidal neovascularization by restricting endothelial cell motility via ERK/c-Jun pathway. Microvascular Research 141, pages 104338.
Crossref
Cody R. Fisher, Mara C. Ebeling & Deborah A. Ferrington. (2022) Quantification of mitophagy using mKeima-mito in cultured human primary retinal pigment epithelial cells. Experimental Eye Research 217, pages 108981.
Crossref
Lei Zhu, Zhi‐Yang Xie, Zan‐Li Jiang, Xiao‐Hu Wang, Hang Shi, Lu Chen & Xiao‐Tao Wu. (2022) Unfolded protein response alleviates acid‐induced premature senescence by promoting autophagy in nucleus pulposus cells. Cell Biology International 46:4, pages 568-578.
Crossref
Xinyi Xie, Duo Li, Yuqing Cui, Tianhua Xie, Jiping Cai & Yong Yao. (2022) Decorin Protects Retinal Pigment Epithelium Cells from Oxidative Stress and Apoptosis via AMPK-mTOR-Regulated Autophagy. Oxidative Medicine and Cellular Longevity 2022, pages 1-17.
Crossref
Cody R. Fisher, Mara C. Ebeling, Zhaohui Geng, Rebecca J. Kapphahn, Heidi Roehrich, Sandra R. Montezuma, James R. Dutton & Deborah A. Ferrington. (2022) Human iPSC- and Primary-Retinal Pigment Epithelial Cells for Modeling Age-Related Macular Degeneration. Antioxidants 11:4, pages 605.
Crossref
Emilie Heckel, Gael Cagnone, Tapan Agnihotri, Bertan Cakir, Ashim Das, Jin Sung Kim, Nicholas Kim, Geneviève Lavoie, Anu Situ, Sheetal Pundir, Ye Sun, Florian Wünnemann, Kerry A. Pierce, Courtney Dennis, Grant A. Mitchell, Sylvain Chemtob, Flavio A. Rezende, Gregor Andelfinger, Clary B. Clish, Philippe P. Roux, Przemyslaw Sapieha, Lois E.H. Smith & Jean-Sébastien Joyal. (2022) Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation. JCI Insight 7:6.
Crossref
Céline Koster, Koen T. van den Hurk, Jacoline B. ten Brink, Colby F. Lewallen, Boris V. Stanzel, Kapil Bharti & Arthur A. Bergen. (2022) Sodium-Iodate Injection Can Replicate Retinal Degenerative Disease Stages in Pigmented Mice and Rats: Non-Invasive Follow-Up Using OCT and ERG. International Journal of Molecular Sciences 23:6, pages 2918.
Crossref
Lu Liu, Jie Huang, Anlan He, Shuai Zhou, Qianneng Lu, Xiaoning Yu, Xue Bai, Mingrui Li & Ran Huo. (2022) 4,4’-dimethoxychalcone increases resistance of mouse oocytes to postovulatory aging in vitro. Reproductive BioMedicine Online 44:3, pages 411-422.
Crossref
Qingqiu Chen, Li Tang, Yi Zhang, Chengyu Wan, Xiuxian Yu, Yuman Dong, Xiaoting Chen, Xueling Wang, Ning Li, Guang Xin, Meixia Zhang, Zhen Chen, Hai Niu & Wen Huang. (2022) STING up-regulates VEGF expression in oxidative stress-induced senescence of retinal pigment epithelium via NF-κB/HIF-1α pathway. Life Sciences 293, pages 120089.
Crossref
Meng Zhao, Houting Lv, Na Yang & Guang-Hua Peng. (2022) Rapamycin Improved Retinal Function and Morphology in a Mouse Model of Retinal Degeneration. Frontiers in Neuroscience 16.
Crossref
Tomohiro Yako, Wataru Otsu, Shinsuke Nakamura, Masamitsu Shimazawa & Hideaki Hara. (2022) Lipid Droplet Accumulation Promotes RPE Dysfunction. International Journal of Molecular Sciences 23:3, pages 1790.
Crossref
Sumin Son, Ahruem Baek, Jong Hun Lee & Dong-Eun Kim. (2022) Autophagosome–lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process. Cellular and Molecular Life Sciences 79:2.
Crossref
Lin Lin, Mu-Xin Zhang, Lei Zhang, Dan Zhang, Chao Li & Yun-lun Li. (2022) Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis. Frontiers in Cell and Developmental Biology 9.
Crossref
Hao-Yu Tsai, Henkie Isahwan Ahmad Mulyadi Lai, Zhang-Yuan Chen, Tai-Chi Lin, Winnie Khor, Wen-Chuan Kuo, Jia-Pu Syu, Ping-Hsing Tsai, Yi-Ping Yang, Yueh Chien, Shih-Jen Chen, De-Kuang Hwang, Shih-Hwa Chiou & Shih-Jie Chou. (2022) Inhibition of DUSP6 Activates Autophagy and Rescues the Retinal Pigment Epithelium in Sodium Iodate-Induced Retinal Degeneration Models In Vivo and In Vitro. Biomedicines 10:1, pages 159.
Crossref
Yuhong Chen, Xinyue Zhu, Fuxiang Ye, Hong Wang, Xiaoling Wan, Ting Zhang, Yuwei Wang, Yimin Wang, Xiaohuan Zhao, Xinyue Bai, Yushu Xiao & Xiaodong Sun. (2022) Malondialdehyde-Modified Photoreceptor Outer Segments Promote Choroidal Neovascularization in Mice. Translational Vision Science & Technology 11:1, pages 12.
Crossref
Emina Čolak, Lepša Žorić, Miloš Mirković, Jana Mirković, Ilija Dragojević, Dijana Mirić, Bojana Kisić & Ljubinka Nikolić. 2022. Importance of Oxidative Stress and Antioxidant System in Health and Disease [Working Title]. Importance of Oxidative Stress and Antioxidant System in Health and Disease [Working Title].
Li-zhen Cheng, Wei Li, Yi-xin Chen, Yi-jia Lin & Ya Miao. (2022) Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications. Aging and disease 13:2, pages 447.
Crossref
Michael LandowskiCatherine Bowes Rickman. (2022) Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models. Journal of Ocular Pharmacology and Therapeutics 38:1, pages 3-32.
Crossref
Benjamin J. Kim, Tianyu Liu, Dimitrios C. Mastellos & John D. Lambris. (2022) Emerging opportunities for C3 inhibition in the eye. Seminars in Immunology 59, pages 101633.
Crossref
Andreas Koller, Julia Preishuber-Pflügl, Christian Runge, Anja-Maria Ladek, Susanne Maria Brunner, Ludwig Aigner, Herbert Reitsamer & Andrea Trost. (2021) Chronobiological activity of cysteinyl leukotriene receptor 1 during basal and induced autophagy in the ARPE-19 retinal pigment epithelial cell line. Aging 13:24, pages 25670-25693.
Crossref
Nana Ma, Guozhen Wei, Hongzhu Zhang, Hongyu Dai, Animesh Chandra Roy, Xiaoli Shi, Guangjun Chang & Xiangzhen Shen. (2021) Cis-9, Trans-11 CLA Alleviates Lipopolysaccharide-Induced Depression of Fatty Acid Synthesis by Inhibiting Oxidative Stress and Autophagy in Bovine Mammary Epithelial Cells. Antioxidants 11:1, pages 55.
Crossref
David A. Merle, Francesca Provenzano, Mohamed Ali Jarboui, Ellen Kilger, Simon J. Clark, Michela Deleidi, Angela Armento & Marius Ueffing. (2021) mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells. Antioxidants 10:12, pages 1944.
Crossref
Beatriz Villarejo-Zori, Juan Ignacio Jiménez-Loygorri, Juan Zapata-Muñoz, Katharina Bell & Patricia Boya. (2021) New insights into the role of autophagy in retinal and eye diseases. Molecular Aspects of Medicine 82, pages 101038.
Crossref
Ravi Prakash, Eram Fauzia, Abu Junaid Siddiqui, Santosh Kumar Yadav, Neha Kumari, Atin Singhai, Mohsin Ali Khan, Miroslaw Janowski, Sujit Kumar Bhutia & Syed Shadab Raza. (2021) Oxidative Stress Enhances Autophagy-Mediated Death Of Stem Cells Through Erk1/2 Signaling Pathway – Implications For Neurotransplantations. Stem Cell Reviews and Reports 17:6, pages 2347-2358.
Crossref
Chengda Ren, Weinan Hu, Qingquan Wei, Wenting Cai, Huizi Jin, Donghui Yu, Chang Liu, Tianyi Shen, Meijiang Zhu, Xiuwei Liang & Jing Yu. (2021) MicroRNA-27a Promotes Oxidative-Induced RPE Cell Death through Targeting FOXO1. BioMed Research International 2021, pages 1-17.
Crossref
Tapas C. Nag. (2021) Pathogenic mechanisms contributing to the vulnerability of aging human photoreceptor cells. Eye 35:11, pages 2917-2929.
Crossref
Stephanie M. George, Fangfang Lu, Mishal Rao, Lyndsay L. Leach & Jeffrey M. Gross. (2021) The retinal pigment epithelium: Development, injury responses, and regenerative potential in mammalian and non-mammalian systems. Progress in Retinal and Eye Research 85, pages 100969.
Crossref
Miguel Flores‐Bellver, Jason Mighty, Silvia Aparicio‐Domingo, Kang V. Li, Cui Shi, Jing Zhou, Hannah Cobb, Patrick McGrath, German Michelis, Patricia Lenhart, Ganna Bilousova, Søren Heissel, Michael J. Rudy, Christina Coughlan, Andrew E. Goodspeed, S. Patricia Becerra, Stephen Redenti & M. Valeria Canto‐Soler. (2021) Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors. Journal of Extracellular Vesicles 10:13.
Crossref
Ping Li, Yuanzheng Ma, Chengwei Yu, Shoutong Wu, Kai Wang, Hongyang Yi & Weizheng Liang. (2021) Autophagy and Aging: Roles in Skeletal Muscle, Eye, Brain and Hepatic Tissue. Frontiers in Cell and Developmental Biology 9.
Crossref
Matt Trinh, Vincent Khou, Michael Kalloniatis & Lisa Nivison-Smith. (2021) Location-Specific Thickness Patterns in Intermediate Age-Related Macular Degeneration Reveals Anatomical Differences in Multiple Retinal Layers. Investigative Opthalmology & Visual Science 62:13, pages 13.
Crossref
Daniel J Klionsky, Giulia Petroni, Ravi K Amaravadi, Eric H Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo‐San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M K Choi, Mary E Choi, Charleen T Chu, Patrice Codogno, Maria Isabel Colombo, Ana Maria Cuervo, Vojo Deretic, Ivan Dikic, Zvulun Elazar, Eeva‐Liisa Eskelinen, Gian Maria Fimia, David A Gewirtz, Douglas R Green, Malene Hansen, Marja Jäättelä, Terje Johansen, Gábor Juhász, Vassiliki Karantza, Claudine Kraft, Guido Kroemer, Nicholas T Ktistakis, Sharad Kumar, Carlos Lopez‐Otin, Kay F Macleod, Frank Madeo, Jennifer Martinez, Alicia Meléndez, Noboru Mizushima, Christian Münz, Josef M Penninger, Rushika M Perera, Mauro Piacentini, Fulvio Reggiori, David C Rubinsztein, Kevin M Ryan, Junichi Sadoshima, Laura Santambrogio, Luca Scorrano, Hans‐Uwe Simon, Anna Katharina Simon, Anne Simonsen, Alexandra Stolz, Nektarios Tavernarakis, Sharon A Tooze, Tamotsu Yoshimori, Junying Yuan, Zhenyu Yue, Qing Zhong, Lorenzo Galluzzi & Federico Pietrocola. (2021) Autophagy in major human diseases. The EMBO Journal 40:19.
Crossref
Hongtao Shen, Jing Li, Tyler Heisler-Taylor, Ryan Makin, Huan Yang, Timur A. Mavlyutov, Bradley Gelfand, Colleen M. Cebulla & Lian-Wang Guo. (2021) TMEM97 ablation aggravates oxidant-induced retinal degeneration. Cellular Signalling 86, pages 110078.
Crossref
Carolina Francelin, Sayak K. Mitter, Qingwen Qian, Sandeep Kumar Barodia, Colin Ip, Xiaoping Qi, Hongmei Gu, Judith Quigley, Matthew S. Goldberg, Maria B. Grant & Michael E. Boulton. (2021) BACE1 Inhibition Increases Susceptibility to Oxidative Stress by Promoting Mitochondrial Damage. Antioxidants 10:10, pages 1539.
Crossref
Laura CampelloNivedita SinghJayshree AdvaniAnupam K. MondalXimena Corso-DíazAnand Swaroop. (2021) Aging of the Retina: Molecular and Metabolic Turbulences and Potential Interventions. Annual Review of Vision Science 7:1, pages 633-664.
Crossref
Giuseppina Amadoro, Valentina Latina, Bijorn Omar Balzamino, Rosanna Squitti, Monica Varano, Pietro Calissano & Alessandra Micera. (2021) Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration. Frontiers in Neuroscience 15.
Crossref
Shuai Li, Yizhou Jiang, Xingan Xing, Ruohong Lin, Qin Li, Wenshu Zhou, Wei Qiu & Wenhua Zheng. (2021) Protective Mechanism of Berberine on Human Retinal Pigment Epithelial Cells against Apoptosis Induced by Hydrogen Peroxide via the Stimulation of Autophagy. Oxidative Medicine and Cellular Longevity 2021, pages 1-14.
Crossref
Michael H. Guerra, Thangal Yumnamcha, Lalit P. Singh & Ahmed S. Ibrahim. (2021) Relative Contribution of Different Mitochondrial Oxidative Phosphorylation Components to the Retinal Pigment Epithelium Barrier Function: Implications for RPE-Related Retinal Diseases. International Journal of Molecular Sciences 22:15, pages 8130.
Crossref
Song Yang, Jun Zhou & Dengwen Li. (2021) Functions and Diseases of the Retinal Pigment Epithelium. Frontiers in Pharmacology 12.
Crossref
Min-Yen Hsu, Yai-Ping Hsiao, Yu-Ta Lin, Connie Chen, Chee-Ming Lee, Wen-Chieh Liao, Shang-Chun Tsou, Hui-Wen Lin & Yuan-Yen Chang. (2021) Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1α-Sirt1 Pathway. Antioxidants 10:7, pages 1125.
Crossref
Merry Gunawan, Choonbing Low, Kurt Neo, Siawey Yeo, Candice Ho, Veluchamy A. Barathi, Anita Sookyee Chan, Najam A. Sharif & Masaaki Kageyama. (2021) The Role of Autophagy in Chemical Proteasome Inhibition Model of Retinal Degeneration. International Journal of Molecular Sciences 22:14, pages 7271.
Crossref
Janusz Blasiak, Joanna Szczepanska, Michal Fila, Elzbieta Pawlowska & Kai Kaarniranta. (2021) Potential of Telomerase in Age-Related Macular Degeneration—Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α. International Journal of Molecular Sciences 22:13, pages 7194.
Crossref
Zhimin Tang, Yahan Ju, Xiaochan Dai, Ni Ni, Yan Liu, Dandan Zhang, Huiqin Gao, Hao Sun, Jing Zhang & Ping Gu. (2021) HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration. Redox Biology 43, pages 101971.
Crossref
Guanqun Cui, Ziyuan Li, Feifei Cao, Peng Li, Minghua Jin, Shanshan Hou, Xu Yang, Yingwen Mu, Cheng Peng, Hua Shao & Zhongjun Du. (2021) Activation of Nrf2/ HO ‐1 signaling pathway attenuates ROS ‐mediated autophagy induced by silica nanoparticles in H9c2 cells . Environmental Toxicology 36:7, pages 1389-1401.
Crossref
Monica L. Hu, Joel Quinn & Kanmin Xue. (2021) Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration. Life 11:7, pages 635.
Crossref
Carlota Suárez-Barrio, Susana del Olmo-Aguado, Eva García-Pérez, Luis Fernández-Vega-Cueto, Andrés Fernández-Vega Cueto, Begoña Baamonde-Arbaiza, Luis Fernández-Vega & Jesús Merayo-Lloves. (2021) Plasma Rich in Growth Factors Promotes Autophagy in ARPE19 Cells in Response to Oxidative Stress Induced by Blue Light. Biomolecules 11:7, pages 954.
Crossref
Sabrina Carrella, Filomena Massa & Alessia Indrieri. (2021) The Role of MicroRNAs in Mitochondria-Mediated Eye Diseases. Frontiers in Cell and Developmental Biology 9.
Crossref
Po-Min Yang, Kai-Chun Cheng, Jing-Yao Huang, Shih-Yun Wang, Yung-Ni Lin, Yen-Tzu Tseng, Chia-Wen Hsieh & Being-Sun Wung. (2021) Sulforaphane inhibits blue light–induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells. Toxicology and Applied Pharmacology 421, pages 115545.
Crossref
Xiying Lin, Jiayu Tang & Yan-Ru Lou. (2021) Human Pluripotent Stem-Cell-Derived Models as a Missing Link in Drug Discovery and Development. Pharmaceuticals 14:6, pages 525.
Crossref
Jinglong Chen, Danping Wang, Yibo Zong & Xiaojing Yang. (2021) DHA Protects Hepatocytes from Oxidative Injury through GPR120/ERK-Mediated Mitophagy. International Journal of Molecular Sciences 22:11, pages 5675.
Crossref
Nilsa La Cunza, Li Xuan Tan, Thushara Thamban, Colin J. Germer, Gurugirijha Rathnasamy, Kimberly A. Toops & Aparna Lakkaraju. (2021) Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration. JCI Insight 6:9.
Crossref
Ru Fang, Xiaotong Wang, Qiuyuan Xia, Ming Zhao, Hao Zhang, Xuan Wang, Shengbing Ye, Kai Cheng, Yan Liang, Yang Cheng, Yayun Gu & Qiu Rao. (2021) Nuclear translocation of ASPL-TFE3 fusion protein creates favorable metabolism by mediating autophagy in translocation renal cell carcinoma. Oncogene 40:18, pages 3303-3317.
Crossref
Juha M.T. Hyttinen, Janusz Blasiak, Szabolcs Felszeghy & Kai Kaarniranta. (2021) MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy. Ageing Research Reviews 67, pages 101260.
Crossref
Angela Armento, Marius Ueffing & Simon J. Clark. (2021) The complement system in age-related macular degeneration. Cellular and Molecular Life Sciences 78:10, pages 4487-4505.
Crossref
Qitao Zhang, Feriel Presswalla, Robin R. Ali, David N. Zacks, Debra A. Thompson & Jason ML. Miller. (2021) Pharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration. Aging 13:8, pages 10866-10890.
Crossref
Caterina Toma, Stefano De Cillà, Aurelio Palumbo, Divya Praveen Garhwal & Elena Grossini. (2021) Oxidative and Nitrosative Stress in Age-Related Macular Degeneration: A Review of Their Role in Different Stages of Disease. Antioxidants 10:5, pages 653.
Crossref
Marijana Samardzija, Andrea Corna, Raquel Gomez-Sintes, Mohamed Ali Jarboui, Angela Armento, Jerome E. Roger, Eleni Petridou, Wadood Haq, Francois Paquet-Durand, Eberhart Zrenner, Pedro de la Villa, Günther Zeck, Christian Grimm, Patricia Boya, Marius Ueffing & Dragana Trifunović. (2020) HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice. Cell Death & Differentiation 28:4, pages 1317-1332.
Crossref
Marie-France Dorion, Mukandila Mulumba, Shuya Kasai, Ken Itoh, William D. Lubell & Huy Ong. (2021) The CD36 Ligand-Promoted Autophagy Protects Retinal Pigment Epithelial Cells from Oxidative Stress. Oxidative Medicine and Cellular Longevity 2021, pages 1-14.
Crossref
José A. Fernández-Albarral, Esther de Julián-López, Carmen Soler-Domínguez, Rosa de Hoz, Inés López-Cuenca, Elena Salobrar-García, José M. Ramírez, María D. Pinazo-Durán, Juan J. Salazar & Ana I. Ramírez. (2021) The Role of Autophagy in Eye Diseases. Life 11:3, pages 189.
Crossref
Liang Wang & Xiaobo Mao. (2021) Role of Retinal Amyloid-β in Neurodegenerative Diseases: Overlapping Mechanisms and Emerging Clinical Applications. International Journal of Molecular Sciences 22:5, pages 2360.
Crossref
Shiu-Jau Chen, Tzer-Bin Lin, Hsien-Yu Peng, Hsiang-Jui Liu, An-Sheng Lee, Cheng-Hsien Lin & Kuang-Wen Tseng. (2021) Cytoprotective Potential of Fucoxanthin in Oxidative Stress-Induced Age-Related Macular Degeneration and Retinal Pigment Epithelial Cell Senescence In Vivo and In Vitro. Marine Drugs 19:2, pages 114.
Crossref
Chih-Wen Shu, Youn-Shen Bee, Jiunn-Liang Chen, Chui-Lien Tsen, Wei-Lun Tsai & Shwu-Jiuan Sheu. (2021) Detection of Autophagy-Related Gene Expression by Conjunctival Impression Cytology in Age-Related Macular Degeneration. Diagnostics 11:2, pages 296.
Crossref
Janusz Blasiak, Ali Koskela, Elzbieta Pawlowska, Mikko Liukkonen, Johanna Ruuth, Elisa Toropainen, Juha M. T. Hyttinen, Johanna Viiri, John E. Eriksson, Heping Xu, Mei Chen, Szabolcs Felszeghy & Kai Kaarniranta. (2021) Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice. International Journal of Molecular Sciences 22:4, pages 1684.
Crossref
Da Hye Kim, Jeong-Hwan Kim, Hyun Hwangbo, So Young Kim, Seon Yeong Ji, Min Yeong Kim, Hee-Jae Cha, Cheol Park, Su Hyun Hong, Gi-Young Kim, Seh-Kwang Park, Ji-Won Jeong, Mi-Young Kim, Yung Hyun Choi & Hyesook Lee. (2021) Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca2+ Overload in Retinal Pigment Epithelial Cells Independently of ROS. International Journal of Molecular Sciences 22:3, pages 1361.
Crossref
Yue Ruan, Subao Jiang & Adrian Gericke. (2021) Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels. International Journal of Molecular Sciences 22:3, pages 1296.
Crossref
Arunbalaji Pugazhendhi, Margaret Hubbell, Pooja Jairam & Balamurali Ambati. (2021) Neovascular Macular Degeneration: A Review of Etiology, Risk Factors, and Recent Advances in Research and Therapy. International Journal of Molecular Sciences 22:3, pages 1170.
Crossref
Niina Bhattarai, Niina Piippo, Sofia Ranta-aho, Yashavanthi Mysore, Kai Kaarniranta & Anu Kauppinen. (2021) Effects of Resvega on Inflammasome Activation in Conjunction with Dysfunctional Intracellular Clearance in Retinal Pigment Epithelial (RPE) Cells. Antioxidants 10:1, pages 67.
Crossref
Liming Hu, Jia Guo, Li Zhou, Sen Zhu, Chunming Wang, Jiawei Liu, Shanshan Hu, Mulin Yang & Changjun Lin. (2020) Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Apoptosis and Affects Autophagy. Oxidative Medicine and Cellular Longevity 2020, pages 1-15.
Crossref
Marta Martín-Sánchez, Nereida Bravo-Gil, María González-del Pozo, Cristina Méndez-Vidal, Elena Fernández-Suárez, Enrique Rodríguez-de la Rúa, Salud Borrego & Guillermo Antiñolo. (2020) A Multi-Strategy Sequencing Workflow in Inherited Retinal Dystrophies: Routine Diagnosis, Addressing Unsolved Cases and Candidate Genes Identification. International Journal of Molecular Sciences 21:24, pages 9355.
Crossref
Meng Zhang, Nisi Jiang, Yi Chu, Olga Postnikova, Rency Varghese, Anelia Horvath, Amrita K. Cheema & Nady Golestaneh. (2020) Dysregulated metabolic pathways in age-related macular degeneration. Scientific Reports 10:1.
Crossref
Edvinas Cerniauskas, Marzena Kurzawa-Akanbi, Long Xie, Dean Hallam, Marina Moya-Molina, Kathryn White, David Steel, Mary Doherty, Phil Whitfield, Jumana Al-Aama, Lyle Armstrong, David Kavanagh, John D. Lambris, Viktor I. Korolchuk, Claire Harris & Majlinda Lako. (2020) Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function. Stem Cells Translational Medicine 9:12, pages 1585-1603.
Crossref
Janusz Blasiak, Elzbieta Pawlowska, Anna Sobczuk, Joanna Szczepanska & Kai Kaarniranta. (2020) The Aging Stress Response and Its Implication for AMD Pathogenesis. International Journal of Molecular Sciences 21:22, pages 8840.
Crossref
E. F. Barinov. (2020) Molecular Mechanisms of Druze Formation in the Retina in Age-Related Macular Degeneration. Ophthalmology in Russia 17:3s, pages 550-555.
Crossref
Jussi J. Paterno, Ali Koskela, Juha M.T. Hyttinen, Elina Vattulainen, Ewelina Synowiec, Raimo Tuuminen, Cezary Watala, Janusz Blasiak & Kai Kaarniranta. (2020) Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study. Genes 11:11, pages 1318.
Crossref
Shreya Somasundaran, Ian J. Constable, Carla B. Mellough & Livia S. Carvalho. (2020) Retinal pigment epithelium and age‐related macular degeneration: A review of major disease mechanisms. Clinical & Experimental Ophthalmology 48:8, pages 1043-1056.
Crossref
Kai Kaarniranta, Hannu Uusitalo, Janusz Blasiak, Szabolcs Felszeghy, Ram Kannan, Anu Kauppinen, Antero Salminen, Debasish Sinha & Deborah Ferrington. (2020) Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. Progress in Retinal and Eye Research 79, pages 100858.
Crossref
Guadalupe Martínez-Chacón, Francisco Javier Vela, José Luis Campos, Elena Abellán, Sokhna M. S. Yakhine-Diop & Alberto Ballestín. (2020) Autophagy modulation in animal models of corneal diseases: a systematic review. Molecular and Cellular Biochemistry 474:1-2, pages 41-55.
Crossref
Fiona Limanaqi, Francesca Biagioni, Federica Mastroiacovo, Maico Polzella, Gloria Lazzeri & Francesco Fornai. (2020) Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation. Antioxidants 9:10, pages 1022.
Crossref
Andreas Koller, Daniela Bruckner, Ludwig Aigner, Herbert Reitsamer & Andrea Trost. (2020) Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells. Scientific Reports 10:1.
Crossref
Paolo Giuseppe Limoli, Enzo Maria Vingolo, Celeste Limoli & Marcella Nebbioso. (2020) Antioxidant and Biological Properties of Mesenchymal Cells Used for Therapy in Retinitis Pigmentosa. Antioxidants 9:10, pages 983.
Crossref
Li Xuan Tan, Colin J. Germer, Nilsa La Cunza & Aparna Lakkaraju. (2020) Complement activation, lipid metabolism, and mitochondrial injury: Converging pathways in age-related macular degeneration. Redox Biology 37, pages 101781.
Crossref
Alyson Wolk, Mala Upadhyay, Mariya Ali, Jason Suh, Heidi Stoehr, Vera L. Bonilha & Bela Anand-Apte. (2020) The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration. Redox Biology 37, pages 101681.
Crossref
Eloise Keeling, Annabelle J. Culling, David A. Johnston, David S. Chatelet, Anton Page, David A. Tumbarello, Andrew J. Lotery & J. Arjuna Ratnayaka. (2020) An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into RPE Stress Associated with Retinopathy. International Journal of Molecular Sciences 21:18, pages 6647.
Crossref
Young‐Mi Go, Jing Zhang, Jolyn Fernandes, Christopher Litwin, Rui Chen, Theodore G. Wensel, Dean P. Jones, Jiyang Cai & Yan Chen. (2020) MTOR‐initiated metabolic switch and degeneration in the retinal pigment epithelium. The FASEB Journal 34:9, pages 12502-12520.
Crossref
Aparna Lakkaraju, Ankita Umapathy, Li Xuan Tan, Lauren Daniele, Nancy J. Philp, Kathleen Boesze-Battaglia & David S. Williams. (2020) The cell biology of the retinal pigment epithelium. Progress in Retinal and Eye Research 78, pages 100846.
Crossref
Jing-Yao Song, Bin Fan, Lin Che, Yi-Ran Pan, Si-Ming Zhang, Ying Wang, Victoria Bunik & Guang-Yu Li. (2020) Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury. Aging 12:16, pages 16579-16596.
Crossref
Husvinee Sundaramurthi, Sarah L. Roche, Guinevere L. Grice, Ailis Moran, Eugene T. Dillion, Giuseppe Campiani, James A. Nathan & Breandán N. Kennedy. (2020) Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness. Frontiers in Cell and Developmental Biology 8.
Crossref
Camille Keisha Mahendra, Loh Teng Hern Tan, Priyia Pusparajah, Thet Thet Htar, Lay-Hong Chuah, Vannajan Sanghiran Lee, Liang Ee Low, Siah Ying Tang, Kok-Gan Chan & Bey Hing Goh. (2020) Detrimental Effects of UVB on Retinal Pigment Epithelial Cells and Its Role in Age-Related Macular Degeneration. Oxidative Medicine and Cellular Longevity 2020, pages 1-29.
Crossref
Zi-Yuan Zhang, Xiao-Li Bao, Yun-Yi Cong, Bin Fan & Guang-Yu Li. (2020) Autophagy in Age-Related Macular Degeneration: A Regulatory Mechanism of Oxidative Stress. Oxidative Medicine and Cellular Longevity 2020, pages 1-13.
Crossref
Roberto Pinelli, Francesca Biagioni, Fiona Limanaqi, Miorica Bertelli, Elena Scaffidi, Maico Polzella, Carla Letizia Busceti & Francesco Fornai. (2020) A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals. International Journal of Molecular Sciences 21:15, pages 5563.
Crossref
Xia Zhao, Linlin Liu, Yizhou Jiang, Marta Silva, Xuechu Zhen & Wenhua Zheng. (2020) Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway. Oxidative Medicine and Cellular Longevity 2020, pages 1-14.
Crossref
Samuel Abokyi, Sze wan Shan, Chi-ho To, Henry Ho-lung Chan & Dennis Yan-yin Tse. (2020) Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells. Oxidative Medicine and Cellular Longevity 2020, pages 1-18.
Crossref
Janusz Blasiak, Elzbieta Pawlowska, Jan Chojnacki, Joanna Szczepanska, Cezary Chojnacki & Kai Kaarniranta. (2020) Zinc and Autophagy in Age-Related Macular Degeneration. International Journal of Molecular Sciences 21:14, pages 4994.
Crossref
Annamaria Tisi, Vincenzo Flati, Simona Delle Monache, Luca Lozzi, Maurizio Passacantando & Rita Maccarone. (2020) Nanoceria Particles Are an Eligible Candidate to Prevent Age-Related Macular Degeneration by Inhibiting Retinal Pigment Epithelium Cell Death and Autophagy Alterations. Cells 9:7, pages 1617.
Crossref
Madhu Sudhana Saddala, Anton Lennikov, Anthony Mukwaya & Hu Huang. (2020) Transcriptome-Wide Analysis of CXCR5 Deficient Retinal Pigment Epithelial (RPE) Cells Reveals Molecular Signatures of RPE Homeostasis. Biomedicines 8:6, pages 147.
Crossref
Maarten P. Rozing, Jon A. Durhuus, Marie Krogh Nielsen, Yousif Subhi, Thomas BL. Kirkwood, Rudi GJ. Westendorp & Torben Lykke Sørensen. (2020) Age-related macular degeneration: A two-level model hypothesis. Progress in Retinal and Eye Research 76, pages 100825.
Crossref
Yuichi Saito, Tomohiro Yako, Wataru Otsu, Shinsuke Nakamura, Yuki Inoue, Aomi Muramatsu, Yasuhiro Nakagami, Masamitsu Shimazawa & Hideaki Hara. (2020) A triterpenoid Nrf2 activator, RS9, promotes LC3-associated phagocytosis of photoreceptor outer segments in a p62-independent manner. Free Radical Biology and Medicine 152, pages 235-247.
Crossref
Wataru Otsu, Kodai Ishida, Shinsuke Nakamura, Masamitsu Shimazawa, Hideshi Tsusaki & Hideaki Hara. (2020) Blue light-emitting diode irradiation promotes transcription factor EB-mediated lysosome biogenesis and lysosomal cell death in murine photoreceptor-derived cells. Biochemical and Biophysical Research Communications 526:2, pages 479-484.
Crossref
Elena B. Domènech & Gemma Marfany. (2020) The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies. Antioxidants 9:4, pages 347.
Crossref
Xiaoping Qi, Sayak K. Mitter, Yuanqing Yan, Julia V Busik, Maria B Grant & Michael E Boulton. (2020) Diurnal Rhythmicity of Autophagy Is Impaired in the Diabetic Retina. Cells 9:4, pages 905.
Crossref
Sheldon Rowan, Shuhong Jiang, Min-Lee Chang, Jonathan Volkin, Christa Cassalman, Kelsey M. Smith, Matthew D. Streeter, David A. Spiegel, Carlos Moreira-Neto, Naila Rabbani, Paul J. Thornalley, Donald E. Smith, Nadia K. Waheed & Allen Taylor. (2020) A low glycemic diet protects disease-prone Nrf2-deficient mice against age-related macular degeneration. Free Radical Biology and Medicine 150, pages 75-86.
Crossref
Bowen Wang, Li Wang, Sijie Gu, Yankun Yu, Huaxing Huang, Kunlun Mo, He Xu, Fanzhu Zeng, Yichen Xiao, Lulu Peng, Chunqiao Liu, Nan Cao, Yizhi Liu, Jin Yuan & Hong Ouyang. (2020) D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration. Signal Transduction and Targeted Therapy 5:1.
Crossref
Qi Miao, Yufeng Xu, Houfa Yin, Huina Zhang & Juan Ye. (2020) KRT8 phosphorylation regulates the epithelial‐mesenchymal transition in retinal pigment epithelial cells through autophagy modulation. Journal of Cellular and Molecular Medicine 24:5, pages 3217-3228.
Crossref
Parviz Mammadzada, Pablo M. Corredoira & Helder André. (2019) The role of hypoxia-inducible factors in neovascular age-related macular degeneration: a gene therapy perspective. Cellular and Molecular Life Sciences 77:5, pages 819-833.
Crossref
Janusz Blasiak. (2020) Senescence in the pathogenesis of age-related macular degeneration. Cellular and Molecular Life Sciences 77:5, pages 789-805.
Crossref
Samuel Abokyi, Chi-Ho To, Tim T. Lam & Dennis Y. Tse. (2020) Central Role of Oxidative Stress in Age-Related Macular Degeneration: Evidence from a Review of the Molecular Mechanisms and Animal Models. Oxidative Medicine and Cellular Longevity 2020, pages 1-19.
Crossref
Silvia D. Rodrigues, Sabrina S. Santos, Tassiana Meireles, Natalia Romero, Griet Glorieux, Roberto Pecoits-Filho, Donna D. Zhang & Lia S. Nakao. (2020) Uremic toxins promote accumulation of oxidized protein and increased sensitivity to hydrogen peroxide in endothelial cells by impairing the autophagic flux. Biochemical and Biophysical Research Communications 523:1, pages 123-129.
Crossref
Natasha Josifovska, Réka Albert, Richárd Nagymihály, Lyubomyr Lytvynchuk, Morten C. Moe, Kai Kaarniranta, Zoltán J. Veréb & Goran Petrovski. (2020) Resveratrol as Inducer of Autophagy, Pro-Survival, and Anti-Inflammatory Stimuli in Cultured Human RPE Cells. International Journal of Molecular Sciences 21:3, pages 813.
Crossref
Fran M. Pool, Christina Kiel, Luis Serrano & Philip J. Luthert. (2020) Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration. npj Aging and Mechanisms of Disease 6:1.
Crossref
Jong-Jer Lee, Kenji Ishihara, Shoji Notomi, Nikolaos E. Efstathiou, Takashi Ueta, Daniel Maidana, Xiaohong Chen, Yasuhiro Iesato, Alberto Caligiana & Demetrios G. Vavvas. (2020) Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells. Biochemical and Biophysical Research Communications 521:2, pages 414-419.
Crossref
Kai Kaarniranta, Antero Salminen & Anu Kauppinen. 2020. Retinal Pigment Epithelium in Health and Disease. Retinal Pigment Epithelium in Health and Disease 161 171 .
Yun Zhang, Hong-Mei Tang, Chun-Feng Liu, Xie-Fang Yuan, Xiao-Yun Wang, Ning Ma, Guo-Feng Xu, Song-Ping Wang, Jun Deng & Xing Wang. (2019) TGF- β 3 Induces Autophagic Activity by Increasing ROS Generation in a NOX4-Dependent Pathway . Mediators of Inflammation 2019, pages 1-17.
Crossref
Liang Kang, Qian Xiang, Shengfeng Zhan, Yu Song, Kun Wang, Kangcheng Zhao, Shuai Li, Zengwu Shao, Cao Yang & Yukun Zhang. (2019) Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration. Oxidative Medicine and Cellular Longevity 2019, pages 1-27.
Crossref
Jin Young Yang, Sanjar Batirovich Madrakhimov, Dong Hyuck Ahn, Hun Soo Chang, Sang Joon Jung, Seung Kwan Nah, Ha Yan Park & Tae Kwann Park. (2019) mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV. Cell Communication and Signaling 17:1.
Crossref

Displaying 200 of 305 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.