2,765
Views
66
CrossRef citations to date
0
Altmetric
Commentary

Crosstalk between ERK, AKT, and cell survival

Pages 245-246 | Received 13 Dec 2013, Accepted 13 Dec 2013, Published online: 14 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Said M. Afify, Aung Ko Ko Oo, Ghmkin Hassan, Akimasa Seno & Masaharu Seno. (2021) How can we turn the PI3K/AKT/mTOR pathway down? Insights into inhibition and treatment of cancer. Expert Review of Anticancer Therapy 21:6, pages 605-619.
Read now
Juan-Juan Yin, Stepan P Shumyak, Christopher Burgess, Zhi-Wei Zhou, Zhi-Xu He, Xue-Ji Zhang, Shu-Ting Pan, Tian-Xin Yang, Wei Duan, Jia-Xuan Qiu & Shu-Feng Zhou. (2015) Controllable drug uptake and nongenomic response through estrogen-anchored cyclodextrin drug complex. International Journal of Nanomedicine 10, pages 4717-4730.
Read now
Beatrice Rubin, Halenya Monticelli, Marco Redaelli, Carla Mucignat, Susi Barollo, Loris Bertazza, Caterina Mian, Corrado Betterle, Maurizio Iacobone, Ambrogio Fassina, Marco Boscaro, Raffaele Pezzani & Franco Mantero. (2015) Mitogen-Activated Protein Kinase Pathway: Genetic Analysis of 95 Adrenocortical Tumors. Cancer Investigation 33:10, pages 526-531.
Read now
Wen-Fen Yan, Qian-Hang Shao, Dong-Ming Zhang, Yu-He Yuan & Nai-Hong Chen. (2015) The molecular mechanism of polygalasaponin F-mediated decreases in TNFα: emphasizing the role of the TLR4-PI3K/AKT-NF-κB pathway. Journal of Asian Natural Products Research 17:6, pages 662-670.
Read now

Articles from other publishers (62)

Mustafa C. Beker, Fatmagul I. Aydinli, Ahmet B. Caglayan, Merve Beker, Oguzhan Baygul, Aysun Caglayan, Aurel Popa-Wagner, Thorsten R. Doeppner, Dirk M. Hermann & Ertugrul Kilic. (2023) Age-Associated Resilience Against Ischemic Injury in Mice Exposed to Transient Middle Cerebral Artery Occlusion. Molecular Neurobiology 60:8, pages 4359-4372.
Crossref
Xiaoqian Zhai, Dan Pu, Rulan Wang, Jiabi Zhang, Yiyun Lin, Yuqing Wang, Ni Zhai, Xuan Peng, Qinghua Zhou & Lu Li. (2023) Gas6/AXL pathway: immunological landscape and therapeutic potential. Frontiers in Oncology 13.
Crossref
Zhicheng Gu, Shuxian Lin, Wanli Yan, Di Chen, Ziwei Zeng, Lei Chen, Yan Li & Bin He. (2022) Enhanced Water Solubility and Anti-Tumor Activity of Oleanolic Acid through Chemical Structure Modification. International Journal of Molecular Sciences 23:21, pages 13291.
Crossref
Runbo Li, Hirohito Kato, Yoichiro Taguchi, Xin Deng, Emika Minagawa, Takaya Nakata & Makoto Umeda. (2022) Glucose Starvation-Caused Oxidative Stress Induces Inflammation and Autophagy in Human Gingival Fibroblasts. Antioxidants 11:10, pages 1907.
Crossref
Iva Potočnjak, Lidija Šimić, Iva Vukelić, Lara Batičić & Robert Domitrović. (2022) Oleanolic acid induces HCT116 colon cancer cell death through the p38/FOXO3a/Sirt6 pathway. Chemico-Biological Interactions 363, pages 110010.
Crossref
Amita Arora, Juuso H. Taskinen & Vesa M. Olkkonen. (2022) Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins. Progress in Lipid Research 86, pages 101146.
Crossref
Vesa M. Olkkonen. (2022) The emerging roles of OSBP-related proteins in cancer: Impacts through phosphoinositide metabolism and protein–protein interactions. Biochemical Pharmacology 196, pages 114455.
Crossref
Subum Lee & Kyoung-Tae Kim. 2022. Diagnosis and Treatment of Spinal Cord Injury. Diagnosis and Treatment of Spinal Cord Injury 425 435 .
Usuma Jermnak, Wachiraphan Supsavhad, Sunee Kunakornsawat, Tassanee Jaroensong, Piyajit Watcharasit, Daranee Visitnonthachai, Selapoom Pairor & Napasorn Phaochoosak. (2021) Anti‐cancer potentials of Gynura procumbens leaves extract against two canine mammary cancer cell lines . Veterinary Medicine and Science 8:1, pages 69-84.
Crossref
Chao-Yue Sun, Di Cao, Qian-Nan Ren, Shan-Shan Zhang, Ning-Ning Zhou, Shi-Juan Mai, Bing Feng & Hui-Yun Wang. (2021) Combination Treatment With Inhibitors of ERK and Autophagy Enhances Antitumor Activity of Betulinic Acid in Non–small-Cell Lung Cancer In Vivo and In Vitro. Frontiers in Pharmacology 12.
Crossref
Geoffrey I. Shapiro, Patricia LoRusso, Daniel C. Cho, Luna Musib, Yibing Yan, Matthew Wongchenko, Ilsung Chang, Premal Patel, Iris T. Chan, Sandra Sanabria-Bohorquez, Raymond D. Meng & Johanna C. Bendell. (2020) A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors. Investigational New Drugs 39:1, pages 163-174.
Crossref
Teru Hideshima & Kenneth C. Anderson. (2021) Signaling Pathway Mediating Myeloma Cell Growth and Survival. Cancers 13:2, pages 216.
Crossref
Lillian Lai, Toshio Moritani, Satsuki Matsumoto, Mariko Sato, Jeremy D. Greenlee & John M. Buatti. 2021. Diffusion-Weighted MR Imaging of the Brain, Head and Neck, and Spine. Diffusion-Weighted MR Imaging of the Brain, Head and Neck, and Spine 627 713 .
Xin-Xing Li, Xiaoting Zheng, Zhenjie Liu, Qiongming Xu, Hongzhen Tang, Jianfang Feng, Shilin Yang, Chi Teng Vong, Hongwei Gao & Yitao Wang. (2020) Cryptotanshinone from Salvia miltiorrhiza Bunge (Danshen) inhibited inflammatory responses via TLR4/MyD88 signaling pathway. Chinese Medicine 15:1.
Crossref
Yunxiang Zhou, Yihan Yao, Yongchuan Deng & Anwen Shao. (2020) Regulation of efferocytosis as a novel cancer therapy. Cell Communication and Signaling 18:1.
Crossref
Aadhya Tiwari, Mari Iida, Corinna Kosnopfel, Mahyar Abbariki, Apostolos Menegakis, Birgit Fehrenbacher, Julia Maier, Martin Schaller, Sara Y. Brucker, Deric L. Wheeler, Paul M. Harari, Ulrich Rothbauer, Birgit Schittek, Daniel Zips & Mahmoud Toulany. (2020) Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers. Cancers 12:10, pages 2795.
Crossref
Masaharu Noi, Ken‐ichi Mukaisho, Shoko Murakami, Shinya Koshinuma, Yoshisato Machida, Masashi Yamori, Takahisa Nakayama, Takao Ogawa, Yusuke Nakata, Takeshi Shimizu, Gaku Yamamoto & Hiroyuki Sugihara. (2020) Expressions of ezrin, ERK , STAT3 , and AKT in tongue cancer and association with tumor characteristics and patient survival . Clinical and Experimental Dental Research 6:4, pages 420-427.
Crossref
Kyuri Jo, Beatriz Santos-Buitrago, Minsu Kim, Sungmin Rhee, Carolyn Talcott & Sun Kim. (2020) Logic-based analysis of gene expression data predicts association between TNF, TGFB1 and EGF pathways in basal-like breast cancer. Methods 179, pages 89-100.
Crossref
Sungjin Park, Youngeun Hong, Soomin Lee, Ah Young Lee, Quangdon Tran, Hyunji Lee, Minhee Kim, Jisoo Park, Myung-Haing Cho & Jongsun Park. (2020) FCHO1560−571 peptide, a PKB kinase motif, inhibits tumor progression. Biochemical and Biophysical Research Communications 528:3, pages 478-484.
Crossref
Zhi-ye Zhang, Xiao-hui Gao, Ming-ying Ma, Chun-ling Zhao, Ya-li Zhang & Shuang-shuang Guo. (2020) CircRNA_101237 promotes NSCLC progression via the miRNA-490-3p/MAPK1 axis. Scientific Reports 10:1.
Crossref
Chenjing Zhu, Huashan Shi, Min Wu & Xiawei Wei. (2020) A dual MET/AXL small‐molecule inhibitor exerts efficacy against gastric carcinoma through killing cancer cells as well as modulating tumor microenvironment. MedComm 1:1, pages 103-118.
Crossref
Rajani Rai, Kathleen Gong Essel, Doris Mangiaracina Benbrook, Justin Garland, Yan Daniel Zhao & Vishal Chandra. (2020) Preclinical Efficacy and Involvement of AKT, mTOR, and ERK Kinases in the Mechanism of Sulforaphane against Endometrial Cancer. Cancers 12:5, pages 1273.
Crossref
Jennifer A. Rohrs, Elizabeth L. Siegler, Pin Wang & Stacey D. Finley. (2020) ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation. iScience 23:4, pages 101023.
Crossref
Chenjing Zhu, Yuquan Wei & Xiawei Wei. (2019) AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications. Molecular Cancer 18:1.
Crossref
Zhuang Gui Chen, Zhao Ni Wang, Yan Yan, Jing Liu, Ting Ting He, Kim Thye Thong, Yew Kwang Ong, Vincent T. K. Chow, Kai Sen Tan & De Yun Wang. (2019) Upregulation of cell-surface mucin MUC15 in human nasal epithelial cells upon influenza A virus infection. BMC Infectious Diseases 19:1.
Crossref
Thomas B. Davis, Mingli Yang, Heiman Wang, Changgong Lee, Timothy J. Yeatman & W. Jack Pledger. (2019) PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC. Oncotarget 10:63, pages 6768-6780.
Crossref
Hassan Bjeije, Bahram Mohammad Soltani, Mehrdad Behmanesh & Mohammad Reza Zali. (2019) YWHAE long non-coding RNA competes with miR-323a-3p and miR-532-5p through activating K-Ras/Erk1/2 and PI3K/Akt signaling pathways in HCT116 cells. Human Molecular Genetics 28:19, pages 3219-3231.
Crossref
Junrong Zou, Tingting Lei, Pei Guo, Jason Yu, Qichao Xu, Yunfei Luo, Rong Ke & Deqiang Huang. (2018) Mechanisms shaping the role of ERK1/2 in cellular sene scence (Review). Molecular Medicine Reports.
Crossref
Xiaoge Gao, Lanqi Cen, Fangyuan Li, Ren Wen, Hongru Yan, Hong Yao & Songlei Zhu. (2018) Oral administration of indole substituted dipyrido[2,3-d]pyrimidine derivative exhibits anti-tumor activity via inhibiting AKT and ERK1/2 on hepatocellular carcinoma. Biochemical and Biophysical Research Communications 505:3, pages 761-767.
Crossref
Yan Zhang, Jianbo Feng, Haijuan Fu, Changhong Liu, Zhibin Yu, Yingnan Sun, Xiaoling She, Peiyao Li, Chunhua Zhao, Yang Liu, Tao Liu, Qiang Liu, Qing Liu, Guiyuan Li & Minghua Wu. (2018) Coagulation Factor X Regulated by CASC2c Recruited Macrophages and Induced M2 Polarization in Glioblastoma Multiforme. Frontiers in Immunology 9.
Crossref
Ibis M. Agosto-Marlin, Nicole L. Nichols & Gordon S. Mitchell. (2018) Systemic inflammation inhibits serotonin receptor 2-induced phrenic motor facilitation upstream from BDNF/TrkB signaling. Journal of Neurophysiology 119:6, pages 2176-2185.
Crossref
Juciano Gasparotto, Carolina S. Girardi, Nauana Somensi, Camila T. Ribeiro, José C.F. Moreira, Monique Michels, Beatriz Sonai, Mariane Rocha, Amanda V. Steckert, Tatiana Barichello, JoΔo Quevedo, Felipe Dal-Pizzol & Daniel P. Gelain. (2018) Receptor for advanced glycation end products mediates sepsis-triggered amyloid-β accumulation, Tau phosphorylation, and cognitive impairment. Journal of Biological Chemistry 293:1, pages 226-244.
Crossref
Amitabha Ray & Margot P. Cleary. (2017) The potential role of leptin in tumor invasion and metastasis. Cytokine & Growth Factor Reviews 38, pages 80-97.
Crossref
Triparna Sen, Pan Tong, Lixia Diao, Lerong Li, Youhong Fan, Jennifer Hoff, John V. Heymach, Jing Wang & Lauren Averett Byers. (2017) Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer. Clinical Cancer Research 23:20, pages 6239-6253.
Crossref
Jingwei Shao, Guirong Zheng, Hongning Chen, Jian Liu, Aixiao Xu, Fan Chen, Tao Li, Yusheng Lu, Jianguo Xu, Ning Zheng & Lee Jia. (2017) Metapristone (RU486 metabolite) suppresses NSCLC by targeting EGFR-mediated PI3K/AKT pathway. Oncotarget 8:45, pages 78351-78364.
Crossref
Terruzzi Ileana, Montesano Anna, Senesi Pamela, Vacante Fernanda, Benedini Stefano & Luzi Livio. (2016) Ranolazine promotes muscle differentiation and reduces oxidative stress in C2C12 skeletal muscle cells. Endocrine 58:1, pages 33-45.
Crossref
Hiromi Sato, Miaki Uzu, Tatsuro Kashiba, Rina Suzuki, Takuya Fujiwara, Hiroko Okuzawa & Koichi Ueno. (2017) Sodium butyrate enhances the growth inhibitory effect of sunitinib in human renal cell carcinoma cells. Oncology Letters 14:1, pages 937-943.
Crossref
Pranav Chintamani Joshi, Ramesh Samineni, Dwaipayan Bhattacharya, Bommana Raghunath Reddy, Lenin Veeraval, Tapatee Das, Swati Maitra, Abhipradnya Bipin Wahul, Shailaja Karri, Srihari Pabbaraja, Goverdhan Mehta, Arvind Kumar & Sumana Chakravarty. (2017) A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic. Scientific Reports 7:1.
Crossref
Songpol Srinual, Pithi Chanvorachote & Varisa Pongrakhananon. (2017) Suppression of cancer stem-like phenotypes in NCI-H460 lung cancer cells by vanillin through an Akt-dependent pathway. International Journal of Oncology 50:4, pages 1341-1351.
Crossref
Susanna Fraguas, Yoshihiko Umesono, Kiyokazu Agata & Francesc Cebrià. 2017. ERK Signaling. ERK Signaling 303 315 .
Ingeborg Elisabeth Cernaj. (2016) Simultaneous dual targeting of Par-4 and G6PD: a promising new approach in cancer therapy? Quintessence of a literature review on survival requirements of tumor cells. Cancer Cell International 16:1.
Crossref
Leslie Calapre, Elin S. Gray, Sandrine Kurdykowski, Anthony David, Prue Hart, Pascal Descargues & Mel Ziman. (2016) Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo. BMC Dermatology 16:1.
Crossref
Manish Kumar Gupta & Krishna Misra. (2016) A holistic approach for integration of biological systems and usage in drug discovery. Network Modeling Analysis in Health Informatics and Bioinformatics 5:1.
Crossref
Xueling Kang, Xiangxiang Wei, Li Jiang, Cong Niu, Jianyi Zhang, Sifeng Chen & Dan Meng. (2016) Nox2 and Nox4 regulate self-renewal of murine induced-pluripotent stem cells. IUBMB Life 68:12, pages 963-970.
Crossref
David W. Howell, Camille L. Duran, Shang-Pu Tsai, Sarah E. Bondos & Kayla J. Bayless. (2016) Functionalization of Ultrabithorax Materials with Vascular Endothelial Growth Factor Enhances Angiogenic Activity. Biomacromolecules 17:11, pages 3558-3569.
Crossref
Robert P. Feehan & Lisa M. Shantz. (2016) Molecular signaling cascades involved in nonmelanoma skin carcinogenesis. Biochemical Journal 473:19, pages 2973-2994.
Crossref
Anup S. Pathania, Santosh K. Guru, Suresh Kumar, Ashok Kumar, Masroor Ahmad, Shashi Bhushan, Parduman R. Sharma, Priya Mahajan, Bhahwal A. Shah, Simmi Sharma, Amit Nargotra, Ram Vishwakarma, Hasan Korkaya & Fayaz Malik. (2016) Interplay between cell cycle and autophagy induced by boswellic acid analog. Scientific Reports 6:1.
Crossref
Lei Zhu, Guangang Tian, Qin Yang, Gejing De, Zhigang Zhang, Yahui Wang, Huizhen Nie, Yanli Zhang, Xiaomei Yang & Jun Li. (2016) Thyroid hormone receptor β1 suppresses proliferation and migration by inhibiting PI3K/Akt signaling in human colorectal cancer cells. Oncology Reports.
Crossref
Jing Qian, Weiyou Zhu, Keming Wang, Lin Ma, Jin Xu, Tongpeng Xu, Oluf Dimitri Røe, Aiping Li, Jianwei Zhou & Yongqian Shu. (2016) JWA loss promotes cell migration and cytoskeletal rearrangement by affecting HER2 expression and identifies a high-risk subgroup of HER2-positive gastric carcinoma patients. Oncotarget 7:24, pages 36865-36884.
Crossref
XIAOHONG JIN & YI SHI. (2016) Isobavachalcone induces the apoptosis of gastric cancer cells via inhibition of the Akt and Erk pathways. Experimental and Therapeutic Medicine 11:2, pages 403-408.
Crossref
Thérèse Keravis, Laure Favot, Abdurrazag A. Abusnina, Anita Anton, Hélène Justiniano, Raffaella Soleti, Eid Alabed Alibrahim, Gilles Simard, Ramaroson Andriantsitohaina & Claire Lugnier. (2015) Delphinidin Inhibits Tumor Growth by Acting on VEGF Signalling in Endothelial Cells. PLOS ONE 10:12, pages e0145291.
Crossref
Xin Wang, Longzhi Han, Jianjun Zhang & Qiang Xia. (2015) Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma. Digestive Diseases and Sciences 60:10, pages 3011-3018.
Crossref
Shiyi Yu, Xiuxiu Cai, Chenxi Wu, Lele Wu, Yuzhi Wang, Yan Liu, Zhenghong Yu, Sheng Qin, Fei Ma, Jean Paul Thiery & Liming Chen. (2014) Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression. Oncotarget 6:5, pages 2951-2965.
Crossref
Ying Zhang, Ying He, Yi Zong, Jiazhi Guo, Lin Sun, Yunbing Ma, Wei Dong & Li Gui. (2015) 17β-estradiol attenuates homocysteine-induced oxidative stress and inflammatory response as well as MAPKs cascade via activating PI3-K/Akt signal transduction pathway in Raw 264.7 cells. Acta Biochimica et Biophysica Sinica 47:2, pages 65-72.
Crossref
Marion Weber-Boyvat, Henriikka Kentala, Johanna Lilja, Terhi Vihervaara, Raisa Hanninen, You Zhou, Johan Peränen, Tuula A. Nyman, Johanna Ivaska & Vesa M. Olkkonen. (2015) OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity. Experimental Cell Research 331:2, pages 278-291.
Crossref
Shunzeng Lv, Congxin Dai, Yuting Liu, Bowen Sun, Ranran Shi, Mingzhi Han, Ruixiang Bian & Renzhi Wang. (2014) Cell Surface Protein C23 Affects EGF-EGFR Induced Activation of ERK and PI3K-AKT Pathways. Journal of Molecular Neuroscience 55:2, pages 519-524.
Crossref
Javier A. García-Vilas, Ana R. Quesada & Miguel A. Medina. (2015) Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells. Scientific Reports 5:1.
Crossref
Yu Seok SongMarie Carmel BalcosHye-Young YunKwang Jin BaekNyoun Soo KwonMyo-Kyoung KimDong-Seok Kim. (2015) ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells. The Korean Journal of Physiology & Pharmacology 19:1, pages 29.
Crossref
William Damsky, Goran Micevic, Katrina Meeth, Viswanathan Muthusamy, David P. Curley, Manjula Santhanakrishnan, Ildiko Erdelyi, James T. Platt, Laura Huang, Nicholas Theodosakis, M. Raza Zaidi, Scott Tighe, Michael A. Davies, David Dankort, Martin McMahon, Glenn Merlino, Nabeel Bardeesy & Marcus Bosenberg. (2015) mTORC1 Activation Blocks BrafV600E-Induced Growth Arrest but Is Insufficient for Melanoma Formation. Cancer Cell 27:1, pages 41-56.
Crossref
Oxana V. Denisova, Sandra Söderholm, Salla Virtanen, Carina Von Schantz, Dmitrii Bychkov, Elena Vashchinkina, Jens Desloovere, Janne Tynell, Niina Ikonen, Linda L. Theisen, Tuula A. Nyman, Sampsa Matikainen, Olli Kallioniemi, Ilkka Julkunen, Claude P. Muller, Xavier Saelens, Vladislav V. Verkhusha & Denis E. Kainov. (2014) Akt Inhibitor MK2206 Prevents Influenza pH1N1 Virus Infection In Vitro . Antimicrobial Agents and Chemotherapy 58:7, pages 3689-3696.
Crossref
Claudia Penna, Mara Brancaccio, Francesca Tullio, Cristina Rubinetto, Maria-Giulia Perrelli, Carmelina Angotti, Pasquale Pagliaro & Guido Tarone. (2014) Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury. Basic Research in Cardiology 109:4.
Crossref
Sihoon SonKyoung-Tae KimDae-Chul ChoHye-Jeong KimJoo-Kyung SungJae-Sung Bae. (2014) Curcumin Stimulates Proliferation of Spinal Cord Neural Progenitor Cells via a Mitogen-Activated Protein Kinase Signaling Pathway. Journal of Korean Neurosurgical Society 56:1, pages 1.
Crossref