Citations (56)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (3)
Xiao-Yu Cheng, Zou Liu, Li Shang, Hong-Qing Cai, Yu Zhang, Yan Cai, Xin Xu, Jia-Jie Hao & Ming-Rong Wang. (2017) Deletion and downregulation of MTAP contribute to the motility of esophageal squamous carcinoma cells. OncoTargets and Therapy 10, pages 5855-5862.
Read now
Read now
Baiqing Tang, Joseph R. Testa & Warren D. Kruger. (2012) Increasing the therapeutic index of 5-fluorouracil and 6-thioguanine by targeting loss of MTAP in tumor cells. Cancer Biology & Therapy 13:11, pages 1082-1090.
Read now
Read now
Joseph R. Bertino, William R. Waud, William B. Parker & Martin Lubin. (2011) Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity. Cancer Biology & Therapy 11:7, pages 627-632.
Read now
Read now
Articles from other publishers (53)
Sanhong Yu, Leona A. Doyle, Jason L. Hornick & Jeffrey K. Mito. (2023) The diagnostic utility of methylthioadenosine phosphorylase immunohistochemistry for pancreatic ductal adenocarcinoma in FNA and small biopsy specimens. Cancer Cytopathology.
Crossref
Crossref
Yina Jiang, Yinying Wu, Liwen Zhang, Yan Wang, Guiping Xu, Yuan Deng, Liang Han, Enxiao Li, Qingyong Ma, Mian Xu, Zheng Wu & Zheng Wang. (2023) Loss of chromosome 9p21 is associated with a poor prognosis in adenosquamous carcinoma of the pancreas. Precision Clinical Medicine 6:4.
Crossref
Crossref
Jae W. Lee, Ralph H. Hruban & Laura D. Wood. 2023. The Pancreas. The Pancreas
912
920
.
Alexander Varshavsky, Kim Lewis & Shun‐Jia Chen. (2023) Deletions of DNA in cancer and their possible uses for therapy. BioEssays 45:7.
Crossref
Crossref
C. Pawan K. Patro, Nupur Biswas, Sandeep C. Pingle, Feng Lin, Misa Anekoji, Lawrence D. Jones, Santosh Kesari, Feng Wang & Shashaanka Ashili. (2022) MTAP loss: a possible therapeutic approach for glioblastoma. Journal of Translational Medicine 20:1.
Crossref
Crossref
Xiang Zhang, Shangyou Zheng, Chonghui Hu, Guolin Li, Hongcao Lin, Renpeng Xia, Yuancheng Ye, Rihua He, Zhihua Li, Qing Lin, Rufu Chen & Quanbo Zhou. (2022) Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair. Oncogene 41:16, pages 2372-2389.
Crossref
Crossref
Simone Terra, Anja C Roden, Eunhee S Yi, Marie Christine Aubry & Jennifer M Boland. (2022) Loss of Methylthioadenosine Phosphorylase by Immunohistochemistry Is Common in Pulmonary Sarcomatoid Carcinoma and Sarcomatoid Mesothelioma. American Journal of Clinical Pathology 157:1, pages 33-39.
Crossref
Crossref
Qiangsheng Hu, Yi Qin, Shunrong Ji, Xiuhui Shi, Weixing Dai, Guixiong Fan, Shuo Li, Wenyan Xu, Wensheng Liu, Mengqi Liu, Zheng Zhang, Zeng Ye, Zhijun Zhou, Jingxuan Yang, Qifeng Zhuo, Xianjun Yu, Min Li & Xiaowu Xu. (2021)
MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting
De Novo
Purine Synthesis and Glycolysis in Pancreatic Cancer
. Cancer Research 81:19, pages 4964-4980.
Crossref
Crossref
Kaishi Satomi, Makoto Ohno, Yuko Matsushita, Masamichi Takahashi, Yasuji Miyakita, Yoshitaka Narita, Koichi Ichimura & Akihiko Yoshida. (2021) Utility of methylthioadenosine phosphorylase immunohistochemical deficiency as a surrogate for CDKN2A homozygous deletion in the assessment of adult-type infiltrating astrocytoma. Modern Pathology 34:4, pages 688-700.
Crossref
Crossref
Chiara Bazzichetto, Fabiana Conciatori, Claudio Luchini, Francesca Simionato, Raffaela Santoro, Vanja Vaccaro, Vincenzo Corbo, Italia Falcone, Gianluigi Ferretti, Francesco Cognetti, Davide Melisi, Aldo Scarpa, Ludovica Ciuffreda & Michele Milella. (2020) From Genetic Alterations to Tumor Microenvironment: The Ariadne’s String in Pancreatic Cancer. Cells 9:2, pages 309.
Crossref
Crossref
Jingsun Wei, Rongbo Han, Xinyu Su, Yuetong Chen, Junfeng Shi, Xiaowen Cui, Honghong Zhang, Yang Gong, Xia Chu & Jinfei Chen. (2019) Identification of biomarkers and their functions in dasatinib‑resistant pancreatic cancer using bioinformatics analysis. Oncology Letters.
Crossref
Crossref
Baiqing Tang, Hyung-Ok Lee, Serim S. An, Kathy Q. Cai & Warren D. Kruger. (2018)
Specific Targeting of
MTAP
-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine
. Cancer Research 78:15, pages 4386-4395.
Crossref
Crossref
Kaavya Jayaramayya, Vellingiri Balachandar & Kumaran Sivanandan Santhy. (2018) Ampullary carcinoma—A genetic perspective. Mutation Research/Reviews in Mutation Research 776, pages 10-22.
Crossref
Crossref
Laura D. Wood & Ralph H. Hruban. 2018. The Pancreas. The Pancreas
679
687
.
Jennifer H. Choe & James L. Abbruzzese. 2018. Pancreatic Cancer. Pancreatic Cancer
1613
1641
.
V.S. Pokrovskii, D.Zh. Davydov, N.V. Davydov, D.D. Zhdanov, S.V. Revtovich, E.A. Morozova, T.V. Demidkina & E.M. Treshchalina. (2017) Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy. Clinical oncohematology 10:3, pages 324-332.
Crossref
Crossref
Waki Hosoda & Laura D. Wood. (2016) Molecular Genetics of Pancreatic Neoplasms. Surgical Pathology Clinics 9:4, pages 685-703.
Crossref
Crossref
Gregory V. KryukovFrederick H. WilsonJason R. RuthJoshiawa PaulkAviad TsherniakSara E. MarlowFrancisca VazquezBarbara A. WeirMark E. FitzgeraldMinoru TanakaCraig M. BielskiJustin M. ScottCourtney DennisGlenn S. CowleyJesse S. BoehmDavid E. RootTodd R. GolubClary B. ClishJames E. BradnerWilliam C. HahnLevi A. Garraway. (2016)
MTAP
deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells
. Science 351:6278, pages 1214-1218.
Crossref
Crossref
Jennifer H. Choe & James L. Abbruzzese. 2017. Pancreatic Cancer. Pancreatic Cancer
1
29
.
Hong-Lin He, Ying-En Lee, Yow-Ling Shiue, Sung-Wei Lee, Tzu-Ju Chen & Chien-Feng Li. (2015) Characterization and Prognostic Significance of Methylthioadenosine Phosphorylase Deficiency in Nasopharyngeal Carcinoma. Medicine 94:49, pages e2271.
Crossref
Crossref
Alexis L. Norris, Hirohiko Kamiyama, Alvin Makohon-Moore, Aparna Pallavajjala, Laura A. Morsberger, Kurt Lee, Denise Batista, Christine A. Iacobuzio-Donahue, Ming-Tseh Lin, Alison P. Klein, Ralph H. Hruban, Sarah J. Wheelan & James R. Eshleman. (2015) Transflip mutations produce deletions in pancreatic cancer. Genes, Chromosomes and Cancer 54:8, pages 472-481.
Crossref
Crossref
Wenwen Chien, Qiao-Yang Sun, Kian Leong Lee, Ling-Wen Ding, Peer Wuensche, Lucia A. Torres-Fernandez, Siew Zhuan Tan, Itay Tokatly, Norazean Zaiden, Lorenz Poellinger, Seiichi Mori, Henry Yang, Jeffrey W. Tyner & H. Phillip Koeffler. (2015) Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer. Molecular Oncology 9:4, pages 889-905.
Crossref
Crossref
Bona Lee, Kwiyeom Yoon, Sunghoon Lee, Jin Muk Kang, Junil Kim, Sung Han Shim, Hak-Min Kim, Sanghoon Song, Kazuhito Naka, An Keun Kim, Han-Kwang Yang & Seong-Jin Kim. (2015) Homozygous deletions at 3p22, 5p14, 6q15, and 9p21 result in aberrant expression of tumor suppressor genes in gastric cancer. Genes, Chromosomes and Cancer 54:3, pages 142-155.
Crossref
Crossref
Baiqing Tang, Yuwaraj Kadariya, Yibai Chen, Michael Slifker & Warren D Kruger. (2015)
Expression of
MTAP
Inhibits Tumor-Related Phenotypes in HT1080 Cells via a Mechanism Unrelated to Its Enzymatic Function
. G3 Genes|Genomes|Genetics 5:1, pages 35-44.
Crossref
Crossref
C.-Y. Su, Y.-C. Chang, Y.-C. Chan, T.-C. Lin, M.-S. Huang, C.-J. Yang & M. Hsiao. (2014) MTAP is an independent prognosis marker and the concordant loss of MTAP and p16 expression predicts short survival in non-small cell lung cancer patients. European Journal of Surgical Oncology (EJSO) 40:9, pages 1143-1150.
Crossref
Crossref
Paul Zarogoulidis, Paschalis Pavlioglou, Patrick Le Pivert, Nikolaos Machairiotis, Nikolaos Katsikogiannis, Ioanna Kougioumtzi, Konstantinos Tsimogiannis, Stylianos Kakolyris, Nikolaos Courcoutsakis, Theodora Tsiouda, Antonios Sakkas, Dimitra Makrantonaki & Konstantinos Zarogoulidis. (2014) Current and future intratumoral targeted treatment for pancreatic cancer. Therapeutic Delivery 5:8, pages 913-926.
Crossref
Crossref
Pashna N. MunshiMartin Lubin & Joseph R. Bertino. (2014) 6-Thioguanine: A Drug With Unrealized Potential for Cancer Therapy. The Oncologist 19:7, pages 760-765.
Crossref
Crossref
Ingrid Garajová, Tessa Y. Le Large, Adam E. Frampton, Christian Rolfo, Johannes Voortman & Elisa Giovannetti. (2014) Molecular Mechanisms Underlying the Role of MicroRNAs in the Chemoresistance of Pancreatic Cancer. BioMed Research International 2014, pages 1-17.
Crossref
Crossref
Yuwaraj Kadariya, Baiqing Tang, Liqun Wang, Tahseen Al-Saleem, Kyoko Hayakawa, Michael J. Slifker & Warren D. Kruger. (2013) Germline Mutations in Mtap Cooperate with Myc to Accelerate Tumorigenesis in Mice. PLoS ONE 8:6, pages e67635.
Crossref
Crossref
Marco Dal Molin & Anirban Maitra. 2013. Molecular Genetics of Pancreatic Cancer. Molecular Genetics of Pancreatic Cancer
1
26
.
Paul Cavuoto & Michael F. Fenech. (2012) A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treatment Reviews 38:6, pages 726-736.
Crossref
Crossref
Yuwaraj Kadariya, Baiqing Tang, Cynthia B. Myers, Jami Fukui, Jeffrey R. Peterson & Warren D. Kruger. (2011) Chemical Genetic Screening for Compounds That Preferentially Inhibit Growth of Methylthioadenosine Phosphorylase (MTAP)–Deficient Saccharomyces cerevisiae. SLAS Discovery 16:1, pages 44-52.
Crossref
Crossref
D. Matthaios, P. Zarogoulidis, I. Balgouranidou, E. Chatzaki & S. Kakolyris. (2011) Molecular Pathogenesis of Pancreatic Cancer and Clinical Perspectives. Oncology 81:3-4, pages 259-272.
Crossref
Crossref
Beate Haugk. (2010) Pancreatic intraepithelial neoplasia - can we detect early pancreatic cancer?. Histopathology 57:4, pages 503-514.
Crossref
Crossref
Kiran K. Mantripragada, Teresita Díaz de Ståhl, Chris Patridge, Uwe Menzel, Robin Andersson, Nadia Chuzhanova, Lan Kluwe, Abhijit Guha, Victor Mautner, Jan P. Dumanski & Meena Upadhyaya. (2009) Genome‐wide high‐resolution analysis of DNA copy number alterations in NF1‐associated malignant peripheral nerve sheath tumors using 32K BAC array. Genes, Chromosomes and Cancer 48:10, pages 897-907.
Crossref
Crossref
Yuwaraj Kadariya, Bu Yin, Baiqing Tang, Susan A. Shinton, Eoin P. Quinlivan, Xiang Hua, Andres Klein-Szanto, Tahseen I. Al-Saleem, Craig H. Bassing, Richard R. Hardy & Warren D. Kruger. (2009)
Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (
MTAP
) Die Prematurely of T-Cell Lymphoma
. Cancer Research 69:14, pages 5961-5969.
Crossref
Crossref
Aude Legoffic, Ezequiel Luis Calvo, Marc Barthet, Jean-Robert Delpero, Jean Charles Dagom & Juan Lucio Iovanna. (2009) Identification of Genomic Alterations Associated with the Aggressiveness of Pancreatic Cancer Using an Ultra-High-Resolution CGH Array. Pancreatology 9:3, pages 267-272.
Crossref
Crossref
Hedy Lee Kindler, Howard A. BurrisIIIIII, Alan B. Sandler & Ira Anton Oliff. (2008) A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer. Investigational New Drugs 27:1, pages 75-81.
Crossref
Crossref
Wang Cheung, Marlene M. Darfler, Hector Alvarez, Brian L Hood, Thomas P. Conrads, Nils Habbe, David B. Krizman, Jan Mollenhauer, Georg Feldmann & Anirban Maitra. (2008) Application of a Global Proteomic Approach to Archival Precursor Lesions: Deleted in Malignant Brain Tumors 1 and Tissue Transglutaminase 2 Are Upregulated in Pancreatic Cancer Precursors. Pancreatology 8:6, pages 608-616.
Crossref
Crossref
Jan-Bart M. Koorstra, Steven R. Hustinx, G. Johan A. Offerhaus & Anirban Maitra. (2008) Pancreatic Carcinogenesis. Pancreatology 8:2, pages 110-125.
Crossref
Crossref
Anirban MaitraRalph H. Hruban. (2008) Pancreatic Cancer. Annual Review of Pathology: Mechanisms of Disease 3:1, pages 157-188.
Crossref
Crossref
Ralph H. Hruban, Robb E. Wilentz, Noriyoshi Fukushima & Michael Goggins. 2005. The Cancer Handbook. The Cancer Handbook.
A. Varshavsky. (2007) Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy. Proceedings of the National Academy of Sciences 104:38, pages 14935-14940.
Crossref
Crossref
Georg Feldmann, Robert Beaty, Ralph H. Hruban & Anirban Maitra. (2007) Molecular genetics of pancreatic intraepithelial neoplasia. Journal of Hepato-Biliary-Pancreatic Surgery 14:3, pages 224-232.
Crossref
Crossref
Shigeo Hirasaki, Tsuyoshi Noguchi, Koshi Mimori, Junko Onuki, Keiko Morita, Hiroshi Inoue, Kenichi Sugihara, Masaki Mori & Takashi Hirano. (2007) BAC Clones Related to Prognosis in Patients with Esophageal Squamous Carcinoma: An Array Comparative Genomic Hybridization Study. The Oncologist 12:4, pages 406-417.
Crossref
Crossref
Collins A. Karikari, Indrajit Roy, Eric Tryggestad, Georg Feldmann, Clemencia Pinilla, Kate Welsh, John C. Reed, Elwood P. Armour, John Wong, Joseph Herman, Dinesh Rakheja & Anirban Maitra. (2007) Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein. Molecular Cancer Therapeutics 6:3, pages 957-966.
Crossref
Crossref
Wenlin YuanJacqueline E. Payton, Matthew S. HoltDaniel C. LinkMark A. Watson, John F. DiPersioTimothy J. Ley. (2006) Commonly dysregulated genes in murine APL cells. Blood 109:3, pages 961-970.
Crossref
Crossref
Shrikanta Chattopadhyay, Rongbao Zhao, Eugenia Tsai, Vern L. Schramm & I. David Goldman. (2006) The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity. Molecular Cancer Therapeutics 5:10, pages 2549-2555.
Crossref
Crossref
Antonio Jimeno & Manuel Hidalgo. (2006) Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer. Molecular Cancer Therapeutics 5:4, pages 787-796.
Crossref
Crossref
Anirban Maitra, Scott E. Kern & Ralph H. Hruban. (2006) Molecular pathogenesis of pancreatic cancer. Best Practice & Research Clinical Gastroenterology 20:2, pages 211-226.
Crossref
Crossref
Collins A. Karikari, Michael Mullendore, James R. Eshleman, Pedram Argani, Lorenzo M. Leoni, Shrikanta Chattopadhyay, Manuel Hidalgo & Anirban Maitra. (2005) Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. Molecular Cancer Therapeutics 4:12, pages 1860-1866.
Crossref
Crossref
Eric L Powell, Lorenzo M Leoni, Marcia I Canto, Arlene A Forastiere, Christine A Iocobuzio-Donahue, Jean S Wang, Anirban Maitra & Elizabeth Montgomery. (2005) Concordant Loss of MTAP and p16/CDKN2A Expression in Gastroesophageal Carcinogenesis. The American Journal of Surgical Pathology 29:11, pages 1497-1504.
Crossref
Crossref
Steven R Hustinx, Lorenzo M Leoni, Charles J Yeo, Priscilla N Brown, Michael Goggins, Scott E Kern, Ralph H Hruban & Anirban Maitra. (2005) Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion. Modern Pathology 18:7, pages 959-963.
Crossref
Crossref