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Research Paper

Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis.

Pages 382-390 | Published online: 15 Feb 2009

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Qing Zhang, Ruzhen Yang, Phaik Eem Lim, Yaoxian Chin, Sainan Zhou, Yuan Gao & Qingjuan Tang. (2022) Sun-Dried and Air-Dried Kappaphycus alvarezii Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice. Nutrition and Cancer 74:6, pages 2113-2121.
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A. Hudita, I. C. Radu, B. Galateanu, O. Ginghina, H. Herman, C. Balta, M. Rosu, C. Zaharia, M. Costache, E. Tanasa, K. Velonia, A. Tsatsakis & A. Hermenean. (2021) Bioinspired silk fibroin nano-delivery systems protect against 5-FU induced gastrointestinal mucositis in a mouse model and display antitumor effects on HT-29 colorectal cancer cells in vitro. Nanotoxicology 15:7, pages 973-994.
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Talita Alves Faria Martins Magalhães, Melina Oliveira de Souza, Sttefany Viana Gomes, Raiana Mendes e Silva, Flaviano dos Santos Martins, Renata Nascimento de Freitas & Joana Ferreira do Amaral. (2021) Açaí (Euterpe oleracea Martius) Promotes Jejunal Tissue Regeneration by Enhancing Antioxidant Response in 5-Fluorouracil-Induced Mucositis. Nutrition and Cancer 73:3, pages 523-533.
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Hanru Wang, Yoga D. Jatmiko, Susan E. P. Bastian, Suzanne Mashtoub & Gordon S. Howarth. (2017) Effects of Supernatants from Escherichia coli Nissle 1917 and Faecalibacterium prausnitzii on Intestinal Epithelial Cells and a Rat Model of 5-Fluorouracil-Induced Mucositis. Nutrition and Cancer 69:2, pages 307-318.
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Hanru Wang, Mark S. Geier & Gordon S. Howarth. (2016) Prebiotics: A Potential Treatment Strategy for the Chemotherapy-damaged Gut?. Critical Reviews in Food Science and Nutrition 56:6, pages 946-956.
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Suzanne Mashtoub, Benjamin Feo, Alexandra L. Whittaker, Kerry A. Lymn, Daniel Martinez-Puig & Gordon S. Howarth. (2015) Oral Nucleotides Only Minimally Improve 5-Fluorouracil-Induced Mucositis in Rats. Nutrition and Cancer 67:6, pages 994-1000.
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Oluwadamilola O. Olaku, Mary O. Ojukwu, Farah Z. Zia & Jeffrey D. White. (2015) The Role of Grape Seed Extract in the Treatment of Chemo/Radiotherapy Induced Toxicity: A Systematic Review of Preclinical Studies. Nutrition and Cancer 67:5, pages 730-740.
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Hanru Wang, Caitlin L. Brook, Alexandra L. Whittaker, Andrew Lawrence, Roger Yazbeck & Gordon S. Howarth. (2013) Effects of Streptococcus thermophilus TH-4 in a rat model of doxorubicin-induced mucositis. Scandinavian Journal of Gastroenterology 48:8, pages 959-968.
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Sezin Yuce Sari, Caglayan Selenge Beduk Esen, Gozde Yazici, Deniz Yuce, Mustafa Cengiz & Gokhan Ozyigit. (2021) Do grape and black mulberry molasses have an effect on oral mucositis and quality of life in patients with head and neck cancer?. Supportive Care in Cancer 30:1, pages 327-336.
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Waid A. Saka, Titilayo E. Ayoade, Tunmise M. Akhigbe & Roland E. Akhigbe. (2021) Moringa oleifera seed oil partially abrogates 2,3-dichlorovinyl dimethyl phosphate (Dichlorvos)-induced cardiac injury in rats: evidence for the role of oxidative stress . Journal of Basic and Clinical Physiology and Pharmacology 32:3, pages 237-246.
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Roger Yazbeck, Gordon S. Howarth, Margaret Kosek, Geoffrey P. Davidson & Ross N. Butler. (2021) Breath 13 CO 2 —evidence for a noninvasive biomarker to measure added refined sugar uptake . Journal of Applied Physiology 130:4, pages 1025-1032.
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Lauren C Chartier, Gordon S Howarth, Debbie Trinder & Suzanne Mashtoub. (2021) Emu oil and grape seed extract reduce tumour burden and disease parameters in murine colitis-associated colorectal cancer. Carcinogenesis 42:2, pages 202-209.
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Jinjoo Lee, Myung In Jeong, Hyo-Rim Kim, Hyejin Park, Won-Kyoung Moon & Bonglee Kim. (2020) Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia. Antioxidants 9:9, pages 836.
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João Antônio Leal de Miranda, Conceição da Silva Martins, Lázaro de Sousa Fideles, Maria Lucianny Lima Barbosa, João Erivan Façanha Barreto, Helder Bindá Pimenta, Francisco Orlando Rafael Freitas, Paulo Vitor de Souza Pimentel, Claudio Silva Teixeira, Ariel Gustavo Scafuri, Maria Claudia dos Santos Luciano, Joabe Lima Araújo, Jefferson Almeida Rocha, Icaro Gusmão Pinto Vieira, Nágila Maria Pontes Silva Ricardo, Matheus da Silva Campelo, Maria Elenir Nobre Pinho Ribeiro, Gerly Anne de Castro Brito & Gilberto Santos Cerqueira. (2020) Troxerutin Prevents 5-Fluorouracil Induced Morphological Changes in the Intestinal Mucosa: Role of Cyclooxygenase-2 Pathway. Pharmaceuticals 13:1, pages 10.
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Hannah R. Wardill, Wim J.E. Tissing, Hannelouise Kissow & Andrea M. Stringer. (2019) Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets. Current Opinion in Supportive & Palliative Care 13:2, pages 119-133.
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Huiyuan Chen, Jifu Zhen, Zhaoliang Wu, Xiaomin Li, Shimin Liu, Zhiru Tang & Zhihong Sun. (2019) Grape seed extract and chromium nicotinate reduce impacts of heat stress in Simmental × Qinchuan steers. Animal Production Science 59:10, pages 1868.
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Avinash Kumar, Melinee D’silva, Kshiti Dholakia & Anait Levenson. (2018) In Vitro Anticancer Properties of Table Grape Powder Extract (GPE) in Prostate Cancer. Nutrients 10:11, pages 1804.
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Souheila Amor, Pauline Châlons, Virginie Aires & Dominique Delmas. (2018) Polyphenol Extracts from Red Wine and Grapevine: Potential Effects on Cancers. Diseases 6:4, pages 106.
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Per T. Sangild, René Liang Shen, Peter Pontoppidan & Mathias Rathe. (2018) Animal models of chemotherapy-induced mucositis: translational relevance and challenges. American Journal of Physiology-Gastrointestinal and Liver Physiology 314:2, pages G231-G246.
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David A. J. Stone, Emma J. Bellgrove, Rebecca E. A. Forder, Gordon S. Howarth & Matthew S. Bansemer. (2018) Inducing Subacute Enteritis in Yellowtail Kingfish Seriola lalandi : the Effect of Dietary Inclusion of Soybean Meal and Grape Seed Extract on Hindgut Morphology and Inflammation . North American Journal of Aquaculture 80:1, pages 59-68.
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Xiao-Xin Chen, Kar Ho Lam, Qing-Xi Chen, George Pak-Heng Leung, Sydney Chi Wai Tang, Stephen Cho-Wing Sze, Jian-Bo Xiao, Feng Feng, Ying Wang, Kalin Yan-Bo Zhang & Zhang-Jin Zhang. (2017) Ficus virens proanthocyanidins induced apoptosis in breast cancer cells concomitantly ameliorated 5-fluorouracil induced intestinal mucositis in rats. Food and Chemical Toxicology 110, pages 49-61.
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Alexandra L Whittaker, Ying Zhu, Gordon S Howarth, Chi S Loung, Susan E P Bastian & Michelle G Wirthensohn. (2017) Effects of commercially produced almond by-products on chemotherapy-induced mucositis in rats. World Journal of Gastrointestinal Pathophysiology 8:4, pages 176-187.
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Natália L. Sousa, Glaucia B. Cabral, Pabline M. Vieira, Aisy B. Baldoni & Francisco J. L. Aragão. (2017) Bio-detoxification of ricin in castor bean (Ricinus communis L.) seeds. Scientific Reports 7:1.
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Jamila Bettaib, Hélène Talarmin, Feten Zar Kalai, Marie-Agnès Giroux-Metges & Riadh Ksouri. (2017) Limoniastrum guyonianum prevents H2O2-induced oxidative damage in IEC-6 cells by enhancing enzyamtic defense, reducing glutathione depletion and JNK phosphorylation. Biomedicine & Pharmacotherapy 95, pages 1404-1411.
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Zhiliang Wei, Bin Tan, Shougen Cao, Shanglong Liu, Xiaojie Tan, Zengwu Yao, Na Yin, Jiante Li, Dongfeng Zhang & Yanbing Zhou. (2017) The influence of neoadjuvant chemotherapy on gastric cancer patients’ postoperative infectious complications: What is the negative role played by the intestinal barrier dysfunction?. Oncotarget 8:26, pages 43376-43388.
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Jamila Bettaib, Hélène Talarmin, Mickaël Droguet, Christian Magné, Mondher Boulaaba, Marie-Agnès Giroux-metges & Riadh Ksouri. (2017) Tamarix gallica phenolics protect IEC-6 cells against H2O2 induced stress by restricting oxidative injuries and MAPKs signaling pathways. Biomedicine & Pharmacotherapy 89, pages 490-498.
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Raja A.H Kuchay. (2016) A review of complementary therapies for chemotherapy induced gastrointestinal mucositis. Drug Discoveries & Therapeutics 10:6, pages 292-299.
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Juliana E Bajic, Georgina L Eden, Lorrinne S Lampton, Ker Y Cheah, Kerry A Lymn, Jinxin V Pei, Andrea J Yool & Gordon S Howarth. (2016) Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis. World Journal of Gastroenterology 22:37, pages 8322.
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AK Al-Asmari, AM Al-Zahrani, AQ Khan, HM Al-Shahrani & M Ali Al Amri. (2015) Taurine ameliorates 5-flourouracil-induced intestinal mucositis, hepatorenal and reproductive organ damage in Wistar rats. Human & Experimental Toxicology 35:1, pages 10-20.
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E. Mitchell Seymour & Steven F. Bolling. 2016. Grapes and Health. Grapes and Health 77 97 .
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Taku Yamashita, Koji Araki, Masayuki Tomifuji, Daisuke Kamide, Yuya Tanaka & Akihiro Shiotani. (2014) A traditional Japanese medicine—Hangeshashinto (TJ-14)—alleviates chemoradiation-induced mucositis and improves rates of treatment completion. Supportive Care in Cancer 23:1, pages 29-35.
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Yasser Elkerm & Rashad Tawashi. (2014) Date Palm Pollen as a Preventative Intervention in Radiation- and Chemotherapy-Induced Oral Mucositis. Integrative Cancer Therapies 13:6, pages 468-472.
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Tan Yang, Xiaomin Li, Wang Zhu, Cheng Chen, Zhihong Sun, Zhiliang Tan & Jinghe Kang. (2014) Alteration of Antioxidant Enzymes and Associated Genes Induced by Grape Seed Extracts in the Primary Muscle Cells of Goats In Vitro. PLoS ONE 9:9, pages e107670.
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Ker Y. Cheah, Gordon S. Howarth, Keren A. Bindon, James A. Kennedy & Susan E. P. Bastian. (2014) Low Molecular Weight Procyanidins from Grape Seeds Enhance the Impact of 5-Fluorouracil Chemotherapy on Caco-2 Human Colon Cancer Cells. PLoS ONE 9:6, pages e98921.
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Ker Yeaw Cheah, Gordon Stanley Howarth & Susan Elaine Putnam Bastian. (2014) Grape Seed Extract Dose-Responsively Decreases Disease Severity in a Rat Model of Mucositis; Concomitantly Enhancing Chemotherapeutic Effectiveness in Colon Cancer Cells. PLoS ONE 9:1, pages e85184.
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Guan Yang, Hui Wang, Yifei Kang & Mei-Jun Zhu. (2014) Grape seed extract improves epithelial structure and suppresses inflammation in ileum of IL-10-deficient mice. Food Funct. 5:10, pages 2558-2563.
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Juan Carlos Bertoglio, Isabel Folatre, Ezio Bombardelli, Antonella Riva, Paolo Morazzoni, Massimo Ronchi & Giovanna Petrangolini. (2012) Management of gastrointestinal mucositis due to cancer therapies in pediatric patients: results of a case series with SAMITAL ® . Future Oncology 8:11, pages 1481-1486.
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Nefise Ozlen Sahin, Mehmet Berköz, Ebru Derici Eker, Bartosz Pomierny & Katarzyna Przejczowska. (2012) Cytotoxic and antioxidant effects of grape seed oil on the treatment of leukemia with methotrexate. European Journal of Chemistry 3:2, pages 147-151.
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Peixia Song, Ruoji Zhang, Xiaoxiao Wang, Pingli He, Lulin Tan & Xi Ma. (2011) Dietary Grape-Seed Procyanidins Decreased Postweaning Diarrhea by Modulating Intestinal Permeability and Suppressing Oxidative Stress in Rats. Journal of Agricultural and Food Chemistry 59:11, pages 6227-6232.
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Tania Marchbank, Ehighale Ojobo, Christopher J. Playford & Raymond J. Playford. (2011) Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and rat gastric damage models of injury . British Journal of Nutrition 105:9, pages 1303-1310.
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Si Yong Park, Yoo-Hyun Lee, Kyung-Chul Choi, Ah-Reum Seong, Hyo-Kyoung Choi, Ok-Hee Lee, Han-Joon Hwang & Ho-Geun Yoon. (2011) Grape Seed Extract Regulates Androgen Receptor-Mediated Transcription in Prostate Cancer Cells Through Potent Anti–Histone Acetyltransferase Activity. Journal of Medicinal Food 14:1-2, pages 9-16.
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Stephen T. Sonis, Gregory Lyng & Kimberly Pouliot. 2011. Tumor Models in Cancer Research. Tumor Models in Cancer Research 499 519 .
Ornella Letari, Catherine Booth, Albino Bonazzi, Paolo Garofalo, Francesco Makovec, Lucio C. Rovati & Gianfranco Caselli. (2009) Efficacy of CR3294, a new benzamidine derivative, in the prevention of 5-fluorouracil-induced gastrointestinal mucositis and diarrhea in mice. Cancer Chemotherapy and Pharmacology 66:5, pages 819-827.
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