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ATM kinase is a master switch for the ΔNp63α phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage

Pages 2846-2855 | Published online: 15 Sep 2008

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Fanyan Meng & Guojun Wu. (2014) Novel mechanism links p63 and cisplatin resistance. Cell Cycle 13:6, pages 881-881.
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Yiping Huang, Dafna Kesselman, Darya Kizub, Rafael Guerrero-Preston & Edward A. Ratovitski. (2013) Phospho-ΔNp63α/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure. Cell Cycle 12:4, pages 684-697.
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Ivano Amelio, Francesca Grespi, Margherita Annicchiarico-Petruzzelli & Gerry Melino. (2012) p63 the guardian of human reproduction. Cell Cycle 11:24, pages 4545-4551.
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Yiping Huang, Lauren N. Bell, Jun Okamura, Myoung Soo Kim, Robert P. Mohney, Rafael Guerrero-Preston & Edward A. Ratovitski. (2012) Phospho-ΔNp63α/SREBF1 protein interactions: Bridging cell metabolism and cisplatin chemoresistance. Cell Cycle 11:20, pages 3810-3827.
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Yiping Huang, Jun Seop Jeong, Jun Okamura, Myoung Sook-Kim, Heng Zhu, Rafael Guerrero-Preston & Edward A. Ratovitski. (2012) Global tumor protein p53/p63 interactome. Cell Cycle 11:12, pages 2367-2379.
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Yiping Huang, Rafael Guerrero-Preston & Edward A. Ratovitski. (2012) Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell Cycle 11:6, pages 1247-1259.
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Yiping Huang, Alice Y. Chuang & Edward A. Ratovitski. (2011) Phospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure. Cell Cycle 10:22, pages 3938-3947.
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Articles from other publishers (35)

Yasser Abuetabh, H. Helena Wu, Chengsen Chai, Habib Al Yousef, Sujata Persad, Consolato M. Sergi & Roger Leng. (2022) DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities. Experimental & Molecular Medicine 54:10, pages 1658-1669.
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Huimin Chen, Ke Hu, Ying Xie, Yucheng Qi, Wenjuan Li, Yaohui He, Shijie Fan, Wen Liu & Chenghua Li. (2022) CDK1 Promotes Epithelial–Mesenchymal Transition and Migration of Head and Neck Squamous Carcinoma Cells by Repressing ∆Np63α-Mediated Transcriptional Regulation. International Journal of Molecular Sciences 23:13, pages 7385.
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Rosalba Pecorari, Francesca Bernassola, Gerry Melino & Eleonora Candi. (2022) Distinct interactors define the p63 transcriptional signature in epithelial development or cancer. Biochemical Journal 479:12, pages 1375-1392.
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Peng Zhou, Caiyun Zhang, Xianmin Song, Dadong Zhang, Minhui Zhu & Hongliang Zheng. (2022) ΔNp63α promotes Bortezomib resistance via the CYGB–ROS axis in head and neck squamous cell carcinoma. Cell Death & Disease 13:4.
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Sumiran Kumar Gurung, Lokesh Nigam, Kunwar Somesh Vikramdeo & Neelima Mondal. 2022. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1427 1442 .
Casimir Bamberger, Sandra Pankow & John R. YatesIIIIII. (2021) SMG1 and CDK12 Link ΔNp63α Phosphorylation to RNA Surveillance in Keratinocytes. Journal of Proteome Research 20:12, pages 5347-5358.
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Zuzana Pokorná, Jan Vysloužil, Václav Hrabal, Borˇivoj Vojtěšek & Philip J Coates. (2021) The foggy world(s) of p63 isoform regulation in normal cells and cancer. The Journal of Pathology 254:4, pages 454-473.
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Sumiran Kumar Gurung, Lokesh Nigam, Kunwar Somesh Vikramdeo & Neelima Mondal. 2020. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1 16 .
Julian M. Rozenberg, Olga S. Rogovaya, Gerry Melino, Nickolai A. Barlev & Alexander Kagansky. (2020) Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia. Cells 10:1, pages 25.
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Matthew L. Fisher, Seamus Balinth & Alea A. Mills. (2020) p63-related signaling at a glance. Journal of Cell Science 133:17.
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Yanhong Zhang, Xiuli Feng, Jin Zhang & Xinbin Chen. (2020) Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression. Molecular Cancer Research 18:7, pages 1039-1049.
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Mónica Mendoza-Rodríguez, Jorge Ayala-Sumuano, Lázaro García-Morales, Horacio Zamudio-Meza, Eloy Pérez-Yepez & Isaura Meza. (2019) IL-1β Inflammatory Cytokine-Induced TP63 Isoform ∆NP63α Signaling Cascade Contributes to Cisplatin Resistance in Human Breast Cancer Cells. International Journal of Molecular Sciences 20:2, pages 270.
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Sahar Eldakhakhny, Qing Zhou, Emma J. Crosbie & Berna S. Sayan. (2018) Human papillomavirus E7 induces p63 expression to modulate DNA damage response. Cell Death & Disease 9:2.
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Jinyu Li, Jörg Vervoorts, Paolo Carloni, Giulia Rossetti & Bernhard Lüscher. (2017) Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/CDK2 identifies a novel catalytically relevant determinant. BMC Bioinformatics 18:1.
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Stephen Armstrong, Hong Wu, Benfan Wang, Yasser Abuetabh, Consolato Sergi & Roger Leng. (2016) The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System. International Journal of Molecular Sciences 17:12, pages 2041.
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Jinghui Jia, Zehua Wang, Jing Cai & Yuan Zhang. (2015) PMS2 expression in epithelial ovarian cancer is posttranslationally regulated by Akt and essential for platinum-induced apoptosis. Tumor Biology 37:3, pages 3059-3069.
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Linda Helander, Animesh Sharma, Hans E. Krokan, Kristjan Plaetzer, Barbara Krammer, Nicole Tortik, Odrun A. Gederaas, Geir Slupphaug & Lars Hagen. (2016) Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Molecular BioSystems 12:3, pages 796-805.
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Sara Nicolai, Antonello Rossi, Nicola Di Daniele, Gerry Melino, Margherita Annicchiarico-Petruzzelli & Giuseppe Raschellà. (2015) DNA repair and aging: the impact of the p53 family. Aging 7:12, pages 1050-1065.
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Ji Chen, Hua Shi, Jin Qi, Dingyi Liu, Zemin Yang & Chenghua Li. (2015) JNK1 inhibits transcriptional and pro‐apoptotic activity of TAp63γ. FEBS Letters 589:23, pages 3686-3690.
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Decai Li, Chenghua Li, Min Wu, Qiongqiong Chen, Qiao Wang, Jian Ren & Yujun Zhang. (2015) PKCδ stabilizes TAp63 to promote cell apoptosis. FEBS Letters 589:16, pages 2094-2099.
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Edward A. Ratovitski. (2015) Phospho‐ΔNp63α‐responsive microRNAs contribute to the regulation of necroptosis in squamous cell carcinoma upon cisplatin exposure. FEBS Letters 589:12, pages 1352-1358.
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Xiaona Ji, Qiang Huang, Long Yu, Ruth Nussinov & Buyong Ma. (2014) Bioinformatics Study of Cancer-Related Mutations within p53 Phosphorylation Site Motifs. International Journal of Molecular Sciences 15:8, pages 13275-13298.
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S. S. McDade, D. Patel, M. Moran, J. Campbell, K. Fenwick, I. Kozarewa, N. J. Orr, C. J. Lord, A. A. Ashworth & D. J. McCance. (2014) Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress. Nucleic Acids Research 42:10, pages 6270-6285.
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S Mohanty, S Saha, D Md S Hossain, A Adhikary, S Mukherjee, A Manna, S Chakraborty, M Mazumdar, P Ray, K Das, J Chakraborty, G Sa & T Das. (2014) ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors. Cell Death & Disease 5:1, pages e1021-e1021.
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Chenghua Li & Zhi-Xiong Xiao. (2014) Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway. BioMed Research International 2014, pages 1-8.
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Edward A. Ratovitski. (2013) Phospho‐ΔNp63α‐dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: At the crossroads of cell life and death. FEBS Letters 587:16, pages 2536-2541.
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Tanusree Sen, Nilkantha Sen, Yiping Huang, Debasish Sinha, Zhen-Ge Luo, Edward A. Ratovitski & David Sidransky. (2011) Tumor Protein p63/Nuclear Factor κB Feedback Loop in Regulation of Cell Death. Journal of Biological Chemistry 286:50, pages 43204-43213.
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C Lazzari, A Prodosmo, F Siepi, C Rinaldo, F Galli, M Gentileschi, A Bartolazzi, A Costanzo, A Sacchi, L Guerrini & S Soddu. (2011) HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage. Oncogene 30:48, pages 4802-4813.
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Y Huang, A Chuang, H Hao, C Talbot, T Sen, B Trink, D Sidransky & E Ratovitski. (2011) Phospho-ΔNp63α is a key regulator of the cisplatin-induced microRNAome in cancer cells. Cell Death & Differentiation 18:7, pages 1220-1230.
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Tanusree Sen, Nilkantha Sen, Mariana Brait, Shahnaz Begum, Aditi Chatterjee, Mohammad Obaidul Hoque, Edward Ratovitski & David Sidransky. (2011) ΔNp63α Confers Tumor Cell Resistance to Cisplatin through the AKT1 Transcriptional Regulation. Cancer Research 71:3, pages 1167-1176.
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Yiping Huang & Edward A. Ratovitski. (2010) Phospho-ΔNp63α/Rpn13-dependent regulation of LKB1 degradation modulates autophagy in cancer cells. Aging 2:12, pages 959-968.
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Ashley L Craig, Jitka Holcakova, Lee E Finlan, Marta Nekulova, Roman Hrstka, Nuri Gueven, James DiRenzo, Graeme Smith, Ted R Hupp & Borivoj Vojtesek. (2010) ΔNp63 transcriptionally regulates ATM to control p53 Serine-15 phosphorylation. Molecular Cancer 9:1.
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Yiping Huang & Edward A. Ratovitski. (2010) Phosphorylated TP63 Induces Transcription of RPN13, Leading to NOS2 Protein Degradation. Journal of Biological Chemistry 285:53, pages 41422-41431.
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Chotika Suyarnsestakorn, Thatchawan Thanasupawat, Kantima Leelahavanichkul, J. Silvio Gutkind & Apiwat Mutirangura. (2010) Ataxia telangiectasia mutated nuclear localization in head and neck cancer cells is PPP2R2B-dependent. Asian Biomedicine 4:3, pages 373-383.
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L Collavin, A Lunardi & G Del Sal. (2010) p53-family proteins and their regulators: hubs and spokes in tumor suppression. Cell Death & Differentiation 17:6, pages 901-911.
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