666
Views
72
CrossRef citations to date
0
Altmetric
Review

A Potential Role for Epigenetic Modulatory Drugs in the Enhancement of Cancer/Germ-Line Antigen Vaccine Efficacy

Pages 116-120 | Received 31 Mar 2006, Accepted 06 Jun 2006, Published online: 11 Jul 2006

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Ashok Sharma, Mustafa Albahrani, Wa Zhang, Christina N. Kufel, Smitha R. James, Kunle Odunsi, David Klinkebiel & Adam R. Karpf. (2019) Epigenetic activation of POTE genes in ovarian cancer. Epigenetics 14:2, pages 185-197.
Read now
Arash Salmaninejad, Mohammad Reza Zamani, Mehrnaz Pourvahedi, Zahra Golchehre, Ali Hosseini Bereshneh & Nima Rezaei. (2016) Cancer/Testis Antigens: Expression, Regulation, Tumor Invasion, and Use in Immunotherapy of Cancers. Immunological Investigations 45:7, pages 619-640.
Read now
Wa Zhang, Carter J Barger, Petra A Link, Paulette Mhawech-Fauceglia, Austin Miller, Stacey N Akers, Kunle Odunsi & Adam R Karpf. (2015) DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45 (CT45) genes is associated with disease progression and reduced survival in epithelial ovarian cancer. Epigenetics 10:8, pages 736-748.
Read now
Pragya Srivastava, Benjamin E Paluch, Junko Matsuzaki, Smitha R James, Golda Collamat-Lai, Pietro Taverna, Adam R Karpf & Elizabeth A Griffiths. (2015) Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts . Epigenetics 10:3, pages 237-246.
Read now
Smitha R James, Carlos D Cedeno, Ashok Sharma, Wa Zhang, James L Mohler, Kunle Odunsi, Elizabeth M Wilson & Adam R Karpf. (2013) DNA methylation and nucleosome occupancy regulate the cancer germline antigen gene . Epigenetics 8:8, pages 849-863.
Read now

Articles from other publishers (67)

Dawn Sijin Nin & Lih-Wen Deng. (2023) Biology of Cancer-Testis Antigens and Their Therapeutic Implications in Cancer. Cells 12:6, pages 926.
Crossref
Antonios Revythis, Anu Limbu, Christos Mikropoulos, Aruni Ghose, Elisabet Sanchez, Matin Sheriff & Stergios Boussios. (2022) Recent Insights into PARP and Immuno-Checkpoint Inhibitors in Epithelial Ovarian Cancer. International Journal of Environmental Research and Public Health 19:14, pages 8577.
Crossref
Hina Qayoom, Umar Mehraj, Shariqa Aisha, Shazia Sofi & Manzoor Ahmad Mir. 2022. Drug Repurposing - Molecular Aspects and Therapeutic Applications. Drug Repurposing - Molecular Aspects and Therapeutic Applications.
Ning Jin, Tiffany L. George, Gregory A. Otterson, Claire Verschraegen, Haitao Wen, David Carbone, James Herman, Erin M. Bertino & Kai He. (2021) Advances in epigenetic therapeutics with focus on solid tumors. Clinical Epigenetics 13:1.
Crossref
Bingcan Zhang. (2021) Cancer Testis Antigens and Immunotherapy: A new Dawn. E3S Web of Conferences 251, pages 02033.
Crossref
Sunil Kumar Saini, Andreas Due Ørskov, Anne-Mette Bjerregaard, Ashwin Unnikrishnan, Staffan Holmberg-Thydén, Annie Borch, Kathrine Valentini Jensen, Govardhan Anande, Amalie Kai Bentzen, Andrea Marion Marquard, Tripti Tamhane, Marianne Bach Treppendahl, Anne Ortved Gang, Inge Høgh Dufva, Zoltan Szallasi, Nicola Ternette, Anders Gorm Pedersen, Aron Charles Eklund, John Pimanda, Kirsten Grønbæk & Sine Reker Hadrup. (2020) Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers. Nature Communications 11:1.
Crossref
Wa Zhang, David Klinkebiel, Carter J. Barger, Sanjit Pandey, Chittibabu Guda, Austin Miller, Stacey N. Akers, Kunle Odunsi & Adam R. Karpf. (2020) Global DNA Hypomethylation in Epithelial Ovarian Cancer: Passive Demethylation and Association with Genomic Instability. Cancers 12:3, pages 764.
Crossref
Sajad Ahmad Bhat, Shalini Kashipathi Sureshbabu, Chinna Susan Philip & Shubhada Chiplunkar. 2020. Epigenetics of the Immune System. Epigenetics of the Immune System 315 352 .
Kaipeng Xie, Chenyang Fu, Suli Wang, Hanzi Xu, Siyu Liu, Yang Shao, Zhen Gong, Xiaoli Wu, Bo Xu, Jing Han, Juan Xu, Pengfei Xu, Xuemei Jia & Jiangping Wu. (2019) Cancer-testis antigens in ovarian cancer: implication for biomarkers and therapeutic targets. Journal of Ovarian Research 12:1.
Crossref
Li-man Li, Zhen-xian Liu & Qing-yuan Cheng. (2019) Exosome plays an important role in the development of hepatocellular carcinoma. Pathology - Research and Practice 215:8, pages 152468.
Crossref
Hathaichanok Phuengkham, Long Ren, Il Woo Shin & Yong Taik Lim. (2019) Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy. Advanced Materials 31:34, pages 1803322.
Crossref
Myrna R. Nahas, Dina Stroopinsky, Jacalyn Rosenblatt, Leandra Cole, Athalia R. Pyzer, Eleni Anastasiadou, Anna Sergeeva, Adam Ephraim, Abigail Washington, Shira Orr, Malgorzata McMasters, Matthew Weinstock, Salvia Jain, Rebecca K. Leaf, Haider Ghiasuddin, Maryam Rahimian, Jessica Liegel, Jeffrey J. Molldrem, Frank Slack, Donald Kufe & David Avigan. (2019) Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine. British Journal of Haematology 185:4, pages 679-690.
Crossref
Kevin Dzobo. (2019) Epigenomics-Guided Drug Development: Recent Advances in Solving the Cancer Treatment “jigsaw puzzle”. OMICS: A Journal of Integrative Biology 23:2, pages 70-85.
Crossref
Simone Jueliger, Pietro Taverna, Oriana Lo Re & Manlio Vinciguerra. 2019. Handbook of Immunosenescence. Handbook of Immunosenescence 2709 2737 .
Karla M. O’Neill, Rachelle E. Irwin, Sarah-Jayne Mackin, Sara-Jayne Thursby, Avinash Thakur, Ciske Bertens, Laura Masala, Jayne E. P. Loughery, Darragh G. McArt & Colum P. Walsh. (2018) Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression. Epigenetics & Chromatin 11:1.
Crossref
Elizabeth K. Duperret, Shujing Liu, Megan Paik, Aspen Trautz, Regina Stoltz, Xiaoming Liu, Kan Ze, Alfredo Perales-Puchalt, Charles Reed, Jian Yan, Xiaowei Xu & David B. Weiner. (2018) A Designer Cross-reactive DNA Immunotherapeutic Vaccine that Targets Multiple MAGE-A Family Members Simultaneously for Cancer Therapy. Clinical Cancer Research 24:23, pages 6015-6027.
Crossref
D. Hammerl, M. Smid, A.M. Timmermans, S. Sleijfer, J.W.M. Martens & R. Debets. (2018) Breast cancer genomics and immuno-oncological markers to guide immune therapies. Seminars in Cancer Biology 52, pages 178-188.
Crossref
Peter A. Prieto, Miles C. Andrews, Alexandria P. Cogdill & Jennifer A. Wargo. 2018. Immunotherapy in Translational Cancer Research. Immunotherapy in Translational Cancer Research 268 285 .
Roberta Zappasodi, Taha Merghoub & Jedd D. Wolchok. (2018) Emerging Concepts for Immune Checkpoint Blockade-Based Combination Therapies. Cancer Cell 33:4, pages 581-598.
Crossref
Simone Jueliger, Pietro Taverna, Oriana Lo Re & Manlio Vinciguerra. 2018. Handbook of Immunosenescence. Handbook of Immunosenescence 1 30 .
Masafumi Horie, Bogumil Kaczkowski, Mitsuhiro Ohshima, Hirotaka Matsuzaki, Satoshi Noguchi, Yu Mikami, Marina Lizio, Masayoshi Itoh, Hideya Kawaji, Timo Lassmann, Piero Carninci, Yoshihide Hayashizaki, Alistair R.R. Forrest, Daiya Takai, Yoko Yamaguchi, Patrick Micke, Akira Saito & Takahide Nagase. (2017) Integrative CAGE and DNA Methylation Profiling Identify Epigenetically Regulated Genes in NSCLC. Molecular Cancer Research 15:10, pages 1354-1365.
Crossref
Janson W.T. Tse, Laura J. Jenkins, Fiona Chionh & John M. Mariadason. (2017) Aberrant DNA Methylation in Colorectal Cancer: What Should We Target?. Trends in Cancer 3:10, pages 698-712.
Crossref
Manh-Cuong Vo, Thanh-Nhan Nguyen-Pham, Hyun-Ju Lee, Sung-Hoon Jung, Nu-Ri Choi, My-Dung Hoang, Hyeoung-Joon Kim & Je-Jung Lee. (2017) Chaetocin enhances dendritic cell function via the induction of heat shock protein and cancer testis antigens in myeloma cells. Oncotarget 8:28, pages 46047-46056.
Crossref
Cornelia Siebenkäs, Katherine B. Chiappinelli, Angela A. Guzzetta, Anup Sharma, Jana Jeschke, Rajita Vatapalli, Stephen B. Baylin & Nita Ahuja. (2017) Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells. PLOS ONE 12:6, pages e0179501.
Crossref
Sophia Xiao Pfister & Alan Ashworth. (2017) Marked for death: targeting epigenetic changes in cancer. Nature Reviews Drug Discovery 16:4, pages 241-263.
Crossref
Paul Zajac, Elke Schultz-Thater, Luigi Tornillo, Charlotte Sadowski, Emanuele Trella, Chantal Mengus, Giandomenica Iezzi & Giulio C. Spagnoli. (2017) MAGE-A Antigens and Cancer Immunotherapy. Frontiers in Medicine 4.
Crossref
Peter A. Jones, Jean-Pierre J. Issa & Stephen Baylin. (2016) Targeting the cancer epigenome for therapy. Nature Reviews Genetics 17:10, pages 630-641.
Crossref
Krista P. Terracina, Laura J. Graham, Kyle K. Payne, Masoud H. Manjili, Annabel Baek, Sheela R. Damle & Harry D. Bear. (2016) DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer. Cancer Immunology, Immunotherapy 65:9, pages 1061-1073.
Crossref
Benjamin E. Paluch, Abdul R. Naqash, Zachary Brumberger, Michael J. Nemeth & Elizabeth A. Griffiths. (2016) Epigenetics: A primer for clinicians. Blood Reviews 30:4, pages 285-295.
Crossref
Katherine B. Chiappinelli, Cynthia A. Zahnow, Nita Ahuja & Stephen B. Baylin. (2016) Combining Epigenetic and Immunotherapy to Combat Cancer. Cancer Research 76:7, pages 1683-1689.
Crossref
Christopher A. Hamm & Fabricio F. Costa. (2015) Epigenomes as therapeutic targets. Pharmacology & Therapeutics 151, pages 72-86.
Crossref
Andreas D. Ørskov, Marianne B. Treppendahl, Anni Skovbo, Mette S. Holm, Lone S. Friis, Marianne Hokland & Kirsten Grønbæk. (2015) Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients: A rationale for combined targeting of PD-1 and DNA methylation . Oncotarget 6:11, pages 9612-9626.
Crossref
Lei Wang, Nan Jin, Anita Schmitt, Jochen Greiner, Georg Malcherek, Michael Hundemer, Jiju Mani, Dirk Hose, Marc S Raab, Anthony D. Ho, Bao-an Chen, Hartmut Goldschmidt & Michael Schmitt. (2015) T cell-based targeted immunotherapies for patients with multiple myeloma. International Journal of Cancer 136:8, pages 1751-1768.
Crossref
Ahmed Almatrafi, Julia Feichtinger, Ellen G. Vernon, Natalia Gomez Escobar, Jane A. Wakeman, Lee D. Larcombe & Ramsay J. McFarlane. (2014) Identification of a class of human cancer germline genes with transcriptional silencing refractory to the hypomethylating drug 5-aza-2ˈ-deoxycytidine. Oncoscience 1:11, pages 745-750.
Crossref
Natalie Vandeven & Paul Nghiem. (2014) Pathogen-Driven Cancers and Emerging Immune Therapeutic Strategies. Cancer Immunology Research 2:1, pages 9-14.
Crossref
Kunle Odunsi, Junko Matsuzaki, Smitha R. James, Paulette Mhawech-Fauceglia, Takemasa Tsuji, Austin Miller, Wa Zhang, Stacey N. Akers, Elizabeth A. Griffiths, Anthony Miliotto, Amy Beck, Carl A. Batt, Gerd Ritter, Shashikant Lele, Sacha Gnjatic & Adam R. Karpf. (2014) Epigenetic Potentiation of NY-ESO-1 Vaccine Therapy in Human Ovarian Cancer. Cancer Immunology Research 2:1, pages 37-49.
Crossref
Elizabeth Griffiths, Richard L. Momparler & Adam R. Karpf. 2014. Epigenetic Therapy of Cancer. Epigenetic Therapy of Cancer 171 188 .
David L Bartlett, Zuqiang Liu, Magesh Sathaiah, Roshni Ravindranathan, Zongbi Guo, Yukai He & Zong Sheng Guo. (2013) Oncolytic viruses as therapeutic cancer vaccines. Molecular Cancer 12:1.
Crossref
Robert Kim, Prakash Kulkarni & Sridhar Hannenhalli. (2013) Derepression of Cancer/Testis Antigens in cancer is associated with distinct patterns of DNA Hypomethylation. BMC Cancer 13:1.
Crossref
Han Han, Xiaojing Yang, Kurinji Pandiyan & Gangning Liang. (2013) Synergistic Re-Activation of Epigenetically Silenced Genes by Combinatorial Inhibition of DNMTs and LSD1 in Cancer Cells. PLoS ONE 8:9, pages e75136.
Crossref
Pierre-François Cartron, Christophe Blanquart, Eric Hervouet, Marc Gregoire & François M. Vallette. (2012) HDAC1‐mSin3a‐NCOR1, Dnmt3b‐HDAC1‐Egr1 and Dnmt1‐PCNA‐UHRF1‐G9a regulate the NY‐ESO1 gene expression . Molecular Oncology 7:3, pages 452-463.
Crossref
Xingchun Zhou, Fan Yang, Tao Zhang, Ran Zhuang, Yuanjie Sun, Liang Fang, Chunmei Zhang, Ying Ma, GaoSheng Huang, FuCheng Ma, Chaojun Song & Boquan Jin. (2013) Heterogeneous Expression of CT10, CT45 and GAGE7 Antigens and their Prognostic Significance in Human Breast Carcinoma. Japanese Journal of Clinical Oncology 43:3, pages 243-250.
Crossref
V Boncheva, S A Bonney, S E Brooks, M Tangney, G O'Sullivan, A Mirnezami & B-A Guinn. (2013) New targets for the immunotherapy of colon cancer—does reactive disease hold the answer?. Cancer Gene Therapy 20:3, pages 157-168.
Crossref
Curt Balch & Kenneth P. Nephew. 2013. Epigenetic Alterations in Oncogenesis. Epigenetic Alterations in Oncogenesis 285 311 .
Lei Li, Fadi Saade & Nikolai Petrovsky. (2012) The future of human DNA vaccines. Journal of Biotechnology 162:2-3, pages 171-182.
Crossref
Prakash Kulkarni, Takumi Shiraishi, Krithika Rajagopalan, Robert Kim, Steven M. Mooney & Robert H. Getzenberg. (2012) Cancer/testis antigens and urological malignancies. Nature Reviews Urology 9:7, pages 386-396.
Crossref
Jooeun Bae, Weihua Song, Robert Smith, John Daley, Yu-Tzu Tai, Kenneth C. Anderson & Nikhil C. Munshi. (2012) A novel immunogenic CS1-specific peptide inducing antigen-specific cytotoxic T lymphocytes targeting multiple myeloma. British Journal of Haematology 157:6, pages 687-701.
Crossref
Paul V. Licciardi & Tom C. Karagiannis. (2012) Regulation of Immune Responses by Histone Deacetylase Inhibitors. ISRN Hematology 2012, pages 1-10.
Crossref
Ádám Jóna, Noor Khaskhely, Daniela Buglio, Jessica A. Shafer, Enrico Derenzini, Catherine M. Bollard, L. Jeffrey Medeiros, Árpád Illés, Yuan Ji & Anas Younes. (2011) The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors. Experimental Hematology 39:10, pages 1007-1017.e1.
Crossref
Yanqiu Hu, Jun Xing, Lei Wang, Min Huang, Xuejiang Guo, Ling Chen, Min Lin, Yadong Zhou, Zhihua Liu, Zuomin Zhou & Jiahao Sha. (2011) RGS22, a novel cancer/testis antigen, inhibits epithelial cell invasion and metastasis. Clinical & Experimental Metastasis 28:6, pages 541-549.
Crossref
Elisabetta Fratta, Sandra Coral, Alessia Covre, Giulia Parisi, Francesca Colizzi, Riccardo Danielli, Hugues Jean Marie Nicolay, Luca Sigalotti & Michele Maio. (2011) The biology of cancer testis antigens: Putative function, regulation and therapeutic potential. Molecular Oncology 5:2, pages 164-182.
Crossref
Jin Wang, Anouk Emadali, Aurore Le Bescont, Mary Callanan, Sophie Rousseaux & Saadi Khochbin. (2011) Induced malignant genome reprogramming in somatic cells by testis-specific factors. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1809:4-6, pages 221-225.
Crossref
Hsing-Chen Tsai & Stephen B Baylin. (2011) Cancer epigenetics: linking basic biology to clinical medicine. Cell Research 21:3, pages 502-517.
Crossref
Alfonso Quintás-Cardama, Fabio P. S. Santos & Guillermo Garcia-Manero. (2010) Therapy with azanucleosides for myelodysplastic syndromes. Nature Reviews Clinical Oncology 7:8, pages 433-444.
Crossref
Marc Pellegrini, Tak W. Mak & Pamela S. Ohashi. (2010) Fighting cancers from within: augmenting tumor immunity with cytokine therapy. Trends in Pharmacological Sciences 31:8, pages 356-363.
Crossref
Marc Pellegrini & Tak W. Mak. (2010) Tumor immune therapy: Lessons from infection and implications for cancer – Can IL‐7 help overcome immune inhibitory networks?. European Journal of Immunology 40:7, pages 1852-1861.
Crossref
Curtis Balch, Daniela E Matei, Tim H-M Huang & Kenneth P Nephew. (2010) Role of epigenomics in ovarian and endometrial cancers. Epigenomics 2:3, pages 419-447.
Crossref
Elizabeth M. Wilson. (2010) Androgen receptor molecular biology and potential targets in prostate cancer. Therapeutic Advances in Urology 2:3, pages 105-117.
Crossref
Stacey N Akers, Kunle Odunsi & Adam R Karpf. (2010) Regulation of cancer germline antigen gene expression: implications for cancer immunotherapy. Future Oncology 6:5, pages 717-732.
Crossref
A Villagra, E M Sotomayor & E Seto. (2009) Histone deacetylases and the immunological network: implications in cancer and inflammation. Oncogene 29:2, pages 157-173.
Crossref
Morten Gjerstorff, Jorge S. Burns, Ole Nielsen, Moustapha Kassem & Henrik Ditzel. (2009) Epigenetic Modulation of Cancer-Germline Antigen Gene Expression in Tumorigenic Human Mesenchymal Stem Cells. The American Journal of Pathology 175:1, pages 314-323.
Crossref
Petra A. Link, Omkaram Gangisetty, Smitha R. James, Anna Woloszynska-Read, Makoto Tachibana, Yoichi Shinkai & Adam R. Karpf. (2009) Distinct Roles for Histone Methyltransferases G9a and GLP in Cancer Germ-Line Antigen Gene Regulation in Human Cancer Cells and Murine Embryonic Stem Cells. Molecular Cancer Research 7:6, pages 851-862.
Crossref
Petra A. Link, Maria R. Baer, Smitha R. James, David A. Jones & Adam R. Karpf. (2008) p53-Inducible Ribonucleotide Reductase ( p53R2/RRM2B ) Is a DNA Hypomethylation–Independent Decitabine Gene Target That Correlates with Clinical Response in Myelodysplastic Syndrome/Acute Myelogenous Leukemia . Cancer Research 68:22, pages 9358-9366.
Crossref
Egor Prokhortchouk & Pierre-Antoine Defossez. (2008) The cell biology of DNA methylation in mammals. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783:11, pages 2167-2173.
Crossref
Amirtha Ganesh Dakshinamurthy, Rajkumar Ramesar, Paul Goldberg & Jonathan M. Blackburn. (2008) Infrequent and low expression of cancer-testis antigens located on the X chromosome in colorectal cancer: Implications for immunotherapy in South African populations. Biotechnology Journal 3:11, pages 1417-1423.
Crossref
Anna Woloszynska-Read, Paulette Mhawech-Fauceglia, Jihnhee Yu, Kunle Odunsi & Adam R. Karpf. (2008) Intertumor and Intratumor NY-ESO-1 Expression Heterogeneity Is Associated with Promoter-Specific and Global DNA Methylation Status in Ovarian Cancer. Clinical Cancer Research 14:11, pages 3283-3290.
Crossref
Bostjan HumarParry Guilford. (2008) Hereditary diffuse gastric cancer and lost cell polarity: a short path to cancer. Future Oncology 4:2, pages 229-239.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.