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Research Paper

A Role for DNA Methylation in Regulating the Growth Suppressor PMEPA1 Gene in Prostate Cancer

Pages 100-105 | Published online: 26 Jun 2007

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Andrew J. Tompkins, Devasis Chatterjee, Michael Maddox, Justin Wang, Emily Arciero, Giovanni Camussi, Peter J. Quesenberry & Joseph F. Renzulli. (2015) The emergence of extracellular vesicles in urology: fertility, cancer, biomarkers and targeted pharmacotherapy. Journal of Extracellular Vesicles 4:1.
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Shashwat Sharad, Lakshmi Ravindranath, Michael C Haffner, Hua Li, Wusheng Yan, Isabell A Sesterhenn, Yongmei Chen, Amina Ali, Alagarsamy Srinivasan, David G McLeod, Srinivasan Yegnasubramanian, Shiv Srivastava, Albert Dobi & Gyorgy Petrovics. (2014) Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer. Epigenetics 9:6, pages 918-927.
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Articles from other publishers (18)

Yenifer Yamile Segura‐Moreno, María Carolina Sanabria‐Salas, Jorge Andrés Mesa‐López De Mesa, Rodolfo Varela‐Ramirez, Natalia Lizeth Acosta‐Vega & Martha Lucía Serrano. (2022) Determination of ERG (+), EZH2 , NKX3.1 , and SPINK‐1 subtypes to evaluate their association with clonal origin and disease progression in multifocal prostate cancer . Cancer Reports 6:2.
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Saikat Singha Roy & Soma Barman. (2018) A non-invasive cancer gene detection technique using FLANN based adaptive filter. Microsystem Technologies 27:2, pages 463-478.
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Shashwat Sharad, Allissa Amanda Dillman, Zsófia M. Sztupinszki, Zoltan Szallasi, Inger Rosner, Jennifer Cullen, Shiv Srivastava, Alagarsamy Srinivasan & Hua Li. (2020) Characterization of unique PMEPA1 gene splice variants (isoforms d and e ) from RNA Seq profiling provides novel insights into prognostic evaluation of prostate cancer . Oncotarget 11:4, pages 362-377.
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Shashwat Sharad, Zsófia M. Sztupinszki, Yongmei Chen, Claire Kuo, Lakshmi Ravindranath, Zoltan Szallasi, Gyorgy Petrovics, Taduru L. Sreenath, Albert Dobi, Inger L. Rosner, Alagarsamy Srinivasan, Shiv Srivastava, Jennifer Cullen & Hua Li. (2019) Analysis of PMEPA1 Isoforms (a and b) as Selective Inhibitors of Androgen and TGF-β Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer. Cancers 11:12, pages 1995.
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Susumu Itoh & Fumiko Itoh. (2018) TMEPAI family: involvement in regulation of multiple signalling pathways. The Journal of Biochemistry 164:3, pages 195-204.
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Noboru Funakubo, Xianghe Xu, Toshio Kukita, Seiji Nakamura, Hiroshi Miyamoto & Akiko Kukita. (2018) Pmepa1 induced by RANKL-p38 MAPK pathway has a novel role in osteoclastogenesis. Journal of Cellular Physiology 233:4, pages 3105-3118.
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Shashwat Sharad, Taduru Sreenath, Shiv Srivastava & Albert Dobi. 2017. Biomarkers in Cancer Screening and Early Detection. Biomarkers in Cancer Screening and Early Detection 16 26 .
Hua Li, Ahmed A. Mohamed, Shashwat Sharad, Elizabeth Umeda, Yingjie Song, Denise Young, Gyorgy Petrovics, David G. McLeod, Isabell A. Sesterhenn, Taduru Sreenath, Albert Dobi & Shiv Srivastava. (2015) Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN . Oncotarget 6:17, pages 15137-15149.
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TATIANA MARTINS TILLI, LUCIANA BUENO FERREIRA & ETEL RODRIGUES PEREIRA GIMBA. (2015) Osteopontin-c mediates the upregulation of androgen responsive genes in LNCaP cells through PI3K/Akt and androgen receptor signaling. Oncology Letters 9:4, pages 1845-1850.
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Miguel Torres-Martín, Luis Lassaletta, Jose M de Campos, Alberto Isla, Giovanny R. Pinto, Rommel R. Burbano, Bárbara Melendez, Javier S. Castresana & Juan A. Rey. (2015) Genome-wide methylation analysis in vestibular schwannomas shows putative mechanisms of gene expression modulation and global hypomethylation at the HOX gene cluster. Genes, Chromosomes and Cancer 54:4, pages 197-209.
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Rajesh Thangapazham, Francisco Saenz, Shilpa Katta, Ahmed A Mohamed, Shyh-Han Tan, Gyorgy Petrovics, Shiv Srivastava & Albert Dobi. (2014) Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer. BMC Cancer 14:1.
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Colm J. O'Rourke, Vinicius Knabben, Eva Bolton, Diarmaid Moran, Thomas Lynch, Donal Hollywood & Antoinette S. Perry. (2013) Manipulating the epigenome for the treatment of urological malignancies. Pharmacology & Therapeutics 138:2, pages 185-196.
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Luciana Bueno Ferreira, Antonio Palumbo, Kivvi Duarte de Mello, Cinthya Sternberg, Mauricio S Caetano, Felipe Leite de Oliveira, Adriana Freitas Neves, Luiz Eurico Nasciutti, Luiz Ricardo Goulart & Etel Rodrigues Pereira Gimba. (2012) PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling. BMC Cancer 12:1.
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Mukesh Verma, Payal Patel & Mudit Verma. (2011) Biomarkers in Prostate Cancer Epidemiology. Cancers 3:4, pages 3773-3798.
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Karen Chiam, Margaret M. Centenera, Lisa M. Butler, Wayne D. Tilley & Tina Bianco-Miotto. (2011) GSTP1 DNA Methylation and Expression Status Is Indicative of 5-aza-2′-Deoxycytidine Efficacy in Human Prostate Cancer Cells. PLoS ONE 6:9, pages e25634.
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Jill C Rubinstein, Nam Tran, Shuangge Ma, Ruth Halaban & Michael Krauthammer. (2010) Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma. BMC Medical Genomics 3:1.
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Ting Liu, Carlynn Willmore-Payne, Lester J. Layfield & Joseph A. Holden. (2009) Lack of BRAF Activating Mutations in Prostate Adenocarcinoma. Applied Immunohistochemistry & Molecular Morphology 17:2, pages 121-125.
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Hongyun Li, Linda L. Xu, Katsuaki Masuda, Eliza Raymundo, David G. McLeod, Albert Dobi & Shiv Srivastava. (2008) A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells. Journal of Biological Chemistry 283:43, pages 28988-28995.
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