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Epigenetics Volume 7, 2012 - Issue 7
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Research Paper

Normal early pregnancy

A transient state of epigenetic change favoring hypomethylation

Wendy M. White Department of OB/GYN; Division of Maternal Fetal Medicine; Mayo Clinic College of Medicine; Rochester, MN USACorrespondence[email protected]
,
Brian C. Brost Department of OB/GYN; Division of Maternal Fetal Medicine; Mayo Clinic College of Medicine; Rochester, MN USA
,
Zhifu Sun Department of Biomedical Statistics and Informatics; Mayo Clinic College of Medicine; Rochester, MN USA
,
Carl Rose Department of OB/GYN; Division of Maternal Fetal Medicine; Mayo Clinic College of Medicine; Rochester, MN USA
,
Iasmina Craici Department of Internal Medicine; Division of Nephrology and Hypertension; Mayo Clinic College of Medicine; Rochester, MN USA
,
Steven J. Wagner Department of Internal Medicine; Division of Nephrology and Hypertension; Mayo Clinic College of Medicine; Rochester, MN USA
,
Stephen Turner Department of Internal Medicine; Division of Nephrology and Hypertension; Mayo Clinic College of Medicine; Rochester, MN USA
&
Vesna D. Garovic Department of Internal Medicine; Division of Nephrology and Hypertension; Mayo Clinic College of Medicine; Rochester, MN USA
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Pages 729-734 | Published online: 01 Jul 2012

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Tejaswi V. Badam, Sandra Hellberg, Ratnesh B. Mehta, Jeannette Lechner-Scott, Rodney A. Lea, Jorg Tost, Xavier Mariette, Judit Svensson-Arvelund, Colm E. Nestor, Mikael Benson, Göran Berg, Maria C. Jenmalm, Mika Gustafsson & Jan Ernerudh. (2022) CD4+ T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases. Epigenetics 17:9, pages 1040-1055.
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Wendy M. White, Zhifu Sun, Kristi S. Borowski, Brian C. Brost, Norman P. Davies, Carl H. Rose & Vesna D. Garovic. (2016) Preeclampsia/Eclampsia candidate genes show altered methylation in maternal leukocytes of preeclamptic women at the time of delivery. Hypertension in Pregnancy 35:3, pages 394-404.
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Wendy M. White, Brian Brost, Zhifu Sun, Carl Rose, Iasmina Craici, Steven J. Wagner, Stephen T. Turner & Vesna D. Garovic. (2013) Genome-wide methylation profiling demonstrates hypermethylation in maternal leukocyte DNA in preeclamptic compared to normotensive pregnancies. Hypertension in Pregnancy 32:3, pages 257-269.
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Maria Pia Campagna, Jeannette Lechner-Scott, Vicki E. Maltby, Rodney A. Lea, Helmut Butzkueven & Vilija G. Jokubaitis. (2023) Conceiving complexity: Biological mechanisms underpinning the lasting effect of pregnancy on multiple sclerosis outcomes. Autoimmunity Reviews 22:9, pages 103388.
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Jesse R. Poganik, Bohan Zhang, Gurpreet S. Baht, Alexander Tyshkovskiy, Amy Deik, Csaba Kerepesi, Sun Hee Yim, Ake T. Lu, Amin Haghani, Tong Gong, Anna M. Hedman, Ellika Andolf, Göran Pershagen, Catarina Almqvist, Clary B. Clish, Steve Horvath, James P. White & Vadim N. Gladyshev. (2023) Biological age is increased by stress and restored upon recovery. Cell Metabolism 35:5, pages 807-820.e5.
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Mariana Andrawus, Lital Sharvit & Gil Atzmon. (2022) Epigenetics and Pregnancy: Conditional Snapshot or Rolling Event. International Journal of Molecular Sciences 23:20, pages 12698.
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Ming-Wei Lin, Mong-Hsun Tsai, Ching-Yu Shih, Yi-Yun Tai, Chien-Nan Lee & Shin-Yu Lin. (2022) Comparison of DNA Methylation Changes Between the Gestation Period and the After-Delivery State: A Pilot Study of 10 Women. Frontiers in Nutrition 9.
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Ranine Ghamrawi, Igor Velickovic, Ognjen Milicevic, Wendy M. White, Lillian Rosa Thistlethwaite, Julie M. Cunningham, Aleksandar Milosavljevic, Natasa M. Milic & Vesna D. Garovic. (2022) Buffy Coat DNA Methylation Profile Is Representative of Methylation Patterns in White Blood Cell Types in Normal Pregnancy. Frontiers in Bioengineering and Biotechnology 9.
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Calen P Ryan, Meaghan J Jones, Rachel D Edgar, Nanette R Lee, Michael S Kobor, Thomas W McDade & Christopher W Kuzawa. (2022) Immune cell type and DNA methylation vary with reproductive status in women: possible pathways for costs of reproduction. Evolution, Medicine, and Public Health 10:1, pages 47-58.
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Emily W. Harville, Pashupati P. Mishra, Mika Kähönen, Emma Raitoharju, Saara Marttila, Olli Raitakari & Terho Lehtimäki. (2021) Reproductive history and blood cell DNA methylation later in life: the Young Finns Study. Clinical Epigenetics 13:1.
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Jagyashila Das & Arindam Maitra. (2021) Maternal DNA Methylation During Pregnancy: a Review. Reproductive Sciences 28:10, pages 2758-2769.
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Sonja Suvakov, Ranine Ghamrawi, Hajrunisa Cubro, Haitao Tu, Wendy M. White, Yvonne S. Butler Tobah, Natasa M. Milic, Joseph P. Grande, Julie M. Cunningham, Fouad T. Chebib, Larissa G.P. Langhi Prata, Yi Zhu, Tamara Tchkonia, James L. Kirkland, Karl A. Nath, Aleksandar Milosavljevic & Vesna D. Garovic. (2021) Epigenetic and senescence markers indicate an accelerated ageing-like state in women with preeclamptic pregnancies. EBioMedicine 70, pages 103536.
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Grazyna Jasienska. (2020) Costs of reproduction and ageing in the human female. Philosophical Transactions of the Royal Society B: Biological Sciences 375:1811, pages 20190615.
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Jacob K Kresovich, Quaker E Harmon, Zongli Xu, Hazel B Nichols, Dale P Sandler & Jack A Taylor. (2019) Reproduction, DNA methylation and biological age. Human Reproduction 34:10, pages 1965-1973.
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Stefano Michelassi. (2019) PREECLAMPSIA: Parte 2°: fisiopatologia e trattamento. Giornale di Tecniche Nefrologiche e Dialitiche 31:2, pages 79-88.
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Christiana A. Demetriou, Karin van Veldhoven, Caroline Relton, Silvia Stringhini, Kyriacos Kyriacou & Paolo Vineis. 2019. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1177 1192 .
Christiana A. Demetriou, Karin van Veldhoven, Caroline Relton, Silvia Stringhini, Kyriacos Kyriacou & Paolo Vineis. 2017. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1 16 .
Michel Neidhart. 2016. DNA Methylation and Complex Human Disease. DNA Methylation and Complex Human Disease 465 484 .
Christiana A. Demetriou, Karin van Veldhoven, Caroline Relton, Silvia Stringhini, Kyriacos Kyriacou & Paolo Vineis. (2015) Biological embedding of early-life exposures and disease risk in humans: a role for DNA methylation. European Journal of Clinical Investigation 45:3, pages 303-332.
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Iasmina M. Craici, Steven J. Wagner, Tracey L. Weissgerber, Joseph P. Grande & Vesna D. Garovic. (2014) Advances in the pathophysiology of pre-eclampsia and related podocyte injury. Kidney International 86:2, pages 275-285.
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