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Research Paper

Clinical evaluation for batch consistency of an inactivated enterovirus 71 vaccine in a large-scale phase 3 clinical trial

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Pages 1366-1372 | Received 03 Jan 2014, Accepted 01 Mar 2014, Published online: 14 Mar 2014

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Li Zhang, Pengfei Jin, Mingwei Wei, Hudachuan Jiang, Jingxin Li & Fengcai Zhu. (2022) A comparison of the test-negative and the matched case-control study designs for estimation of EV71 vaccine immunological surrogate endpoints from a randomized controlled trial. Human Vaccines & Immunotherapeutics 18:5.
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Zhijian Yang, Fan Gao, Xiaoliang Wang, Likang Shi, Zheng Zhou, Yuanxiang Jiang, Xinxing Ma, Chao Zhang, Chenliang Zhou, Xianfang Zeng, Ge Liu, Jiang Fan, Qunying Mao & Li Shi. (2020) Development and characterization of an enterovirus 71 (EV71) virus-like particles (VLPs) vaccine produced in Pichia pastoris. Human Vaccines & Immunotherapeutics 16:7, pages 1602-1610.
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Qun-ying Mao, Yiping Wang, Lianlian Bian, Miao Xu & Zhenglun Liang. (2016) EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD). Expert Review of Vaccines 15:5, pages 599-606.
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Pengfei Jin, Jingxin Li, Xuefeng Zhang, Fangyue Meng, Yang Zhou, Xuejun Yao, Zhengkai Gan & Fengcai Zhu. (2016) Validation and evaluation of serological correlates of protection for inactivated enterovirus 71 vaccine in children aged 6-35 months . Human Vaccines & Immunotherapeutics 12:4, pages 916-921.
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Wei Zhang, Yujia Kong, Zhiwei Jiang, Chanjuan Li, Ling Wang & Jielai Xia. (2016) Comprehensive safety assessment of a human inactivated diploid enterovirus 71 vaccine based on a phase III clinical trial. Human Vaccines & Immunotherapeutics 12:4, pages 922-930.
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Qunying Mao, Yiping Wang, Lianlian Bian, Miao Xu & Zhenglun Liang. (2016) EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases. Emerging Microbes & Infections 5:1, pages 1-7.
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Michel Klein & Pele Chong. (2015) Is a multivalent hand, foot, and mouth disease vaccine feasible?. Human Vaccines & Immunotherapeutics 11:11, pages 2688-2704.
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Lianlian Bian, Yiping Wang, Xin Yao, Qunying Mao, Miao Xu & Zhenglun Liang. (2015) Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide. Expert Review of Anti-infective Therapy 13:9, pages 1061-1071.
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Kevin Messacar, Matthew R. Vogt, Edwin J. Asturias & Mark J. Abzug. 2023. Plotkin's Vaccines. Plotkin's Vaccines 330 340.e5 .
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Subrat Kumar Swain, Ayushman Gadnayak, Jatindra Nath Mohanty, Rachita Sarangi & Jayashankar Das. (2022) Does enterovirus 71 urge for effective vaccine control strategies? Challenges and current opinion. Reviews in Medical Virology 32:4.
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Zheng Zhao, Canjun Zheng, Hongchao Qi, Yue Chen, Michael P. Ward, Fengfeng Liu, Jie Hong, Qing Su, Jiaqi Huang, Xi Chen, Jiaxu Le, Xiuliang Liu, Minrui Ren, Jianbo Ba, Zhijie Zhang, Zhaorui Chang & Zhongjie Li. (2022) Impact of the coronavirus disease 2019 interventions on the incidence of hand, foot, and mouth disease in mainland China. The Lancet Regional Health - Western Pacific 20, pages 100362.
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Jin Luo, Chunling Huo, Huan Qin, Junhong Hu, Lei Lei & Zishu Pan. (2021) Chimeric enterovirus 71 virus-like particle displaying conserved coxsackievirus A16 epitopes elicits potent immune responses and protects mice against lethal EV71 and CA16 infection. Vaccine 39:30, pages 4135-4143.
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Jiangning Liu, Binbin Zhao, Ling Xue, Jing Wu, Yanfeng Xu, Yongdong Liu & Chuan Qin. (2020) Immunization with a fusion protein vaccine candidate generated from truncated peptides of human enterovirus 71 protects mice from lethal enterovirus 71 infections. Virology Journal 17:1.
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Shuying Luo, Fei Wu, Xiaojun Ye, Tao Fu, Jingbo Tao, Weibiao Luo, Ying Wang, Jianwei Jia & Lingqiao Lou. (2019) Safety Comparison of Two Enterovirus 71 (EV71) Inactivated Vaccines in Yiwu, China. Journal of Tropical Pediatrics 65:6, pages 547-551.
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Xiao-Feng Liu, Xiu-Mei Sun, Xiao-Wei Sun, Yu-Qing Yang, Cong-Hui Huang & Han Wen. (2019) Epidemiological study on hand, foot and mouth disease in Tongzhou District, Beijing, 2013–2017. Journal of International Medical Research 47:6, pages 2615-2625.
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Hye-Jin Kim, Ho Sun Son, Sang Won Lee, Youngsil Yoon, Ji-Yeon Hyeon, Gyung Tae Chung, June-Woo Lee & Jung Sik Yoo. (2019) Efficient expression of enterovirus 71 based on virus-like particles vaccine. PLOS ONE 14:3, pages e0210477.
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Jie Li, Rong Zhu, Da Huo, Yiwei Du, Yuxiang Yan, Zhichao Liang, Yanxia Luo, Yang Yang, Lei Jia, Lijuan Chen, Quanyi Wang & Yan He. (2018) An outbreak of Coxsackievirus A6–associated hand, foot, and mouth disease in a kindergarten in Beijing in 2015. BMC Pediatrics 18:1.
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Pele Choi-Sing Chong & Michel Klein. 2018. Plotkin's Vaccines. Plotkin's Vaccines 288 294.e3 .
Ping-Chin Chang, Shou-Chien Chen & Kow-Tong Chen. (2016) The Current Status of the Disease Caused by Enterovirus 71 Infections: Epidemiology, Pathogenesis, Molecular Epidemiology, and Vaccine Development. International Journal of Environmental Research and Public Health 13:9, pages 890.
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Cheng-Yi Chang, Jian-Ri Li, Yen-Chuan Ou, Wen-Ying Chen, Su-Lan Liao, Shue-Ling Raung, An-Lu Hsiao & Chun-Jung Chen. (2015) Enterovirus 71 infection caused neuronal cell death and cytokine expression in cultured rat neural cells. IUBMB Life 67:10, pages 789-800.
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P. Chong, C.-C. Liu, Y.-H. Chow, A.-H. Chou & M. Klein. (2014) Review of Enterovirus 71 Vaccines. Clinical Infectious Diseases 60:5, pages 797-803.
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Li Li, Hongzhang Yin, Zhijie An & Zijian Feng. (2015) Considerations for developing an immunization strategy with enterovirus 71 vaccine. Vaccine 33:9, pages 1107-1112.
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Hui Zhao, Hao-Yang Li, Jian-Feng Han, Yong-Qiang Deng, Shun-Ya Zhu, Xiao-Feng Li, Hui-Qin Yang, Yue-Xiang Li, Yu Zhang, E-De Qin, Rong Chen & Cheng-Feng Qin. (2015) Novel recombinant chimeric virus-like particle is immunogenic and protective against both enterovirus 71 and coxsackievirus A16 in mice. Scientific Reports 5:1.
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Chia-Chyi Liu, Yen-Hung Chow, Pele Chong & Michel Klein. (2014) Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases. Vaccine 32:47, pages 6177-6182.
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