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Xing Liu, Jianxin Sui, Cui Li, Xudong Peng, Qian Wang, Nan Jiang, Qiang Xu, Luokai Wang, Jing Lin & Guiqiu Zhao. (2022) Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis. International Journal of Nanomedicine 17, pages 537-551.
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Greg Hussack & Jamshid Tanha. (2016) An update on antibody-based immunotherapies for Clostridium difficile infection. Clinical and Experimental Gastroenterology 9, pages 209-224.
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Simon Krah, Christian Schröter, Stefan Zielonka, Martin Empting, Bernhard Valldorf & Harald Kolmar. (2016) Single-domain antibodies for biomedical applications. Immunopharmacology and Immunotoxicology 38:1, pages 21-28.
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Stefan Zielonka, Martin Empting, Julius Grzeschik, Doreen Könning, Caroline J Barelle & Harald Kolmar. (2015) Structural insights and biomedical potential of IgNAR scaffolds from sharks. mAbs 7:1, pages 15-25.
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Marina Kovaleva, Laura Ferguson, John Steven, Andrew Porter & Caroline Barelle. (2014) Shark variable new antigen receptor biologics – a novel technology platform for therapeutic drug development. Expert Opinion on Biological Therapy 14:10, pages 1527-1539.
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Articles from other publishers (61)
P. Smyth, L. Ferguson, J. F. Burrows, R. E. Burden, S. R. Tracey, Ú. M. Herron, M. Kovaleva, R. Williams, A. J. Porter, D. B. Longley, C. J. Barelle & C. J. Scott. (2023) Evaluation of variable new antigen receptors (vNARs) as a novel cathepsin S (CTSS) targeting strategy. Frontiers in Pharmacology 14.
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Shannon R. Tracey, Peter Smyth, Una M. Herron, James F. Burrows, Andrew J. Porter, Caroline J. Barelle & Christopher J. Scott. (2023)
Development of a cationic polyethyleneimine-poly(lactic-
co
-glycolic acid) nanoparticle system for enhanced intracellular delivery of biologics
. RSC Advances 13:48, pages 33721-33735.
Crossref
Crossref
Maryam Ehsasatvatan & Bahram Baghban Kohnehrouz. (2023) Designing and computational analyzing of chimeric long-lasting GLP-1 receptor agonists for type 2 diabetes. Scientific Reports 13:1.
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Aziz Ullah, Goeun Shin & Sung In Lim. (2023) Human serum albumin binders: A piggyback ride for long-acting therapeutics. Drug Discovery Today 28:10, pages 103738.
Crossref
Crossref
Mirna Burciaga-Flores, Ana Laura Márquez-Aguirre, Salvador Dueñas, Jahaziel Gasperin-Bulbarela, Alexei F. Licea-Navarro & Tanya A. Camacho-Villegas. (2023) First pan-specific vNAR against human TGF-β as a potential therapeutic application: in silico modeling assessment. Scientific Reports 13:1.
Crossref
Crossref
Lei Jia, Yu Wang, Yajun Shen, Bo Zhong, Zhan Luo, Junjie Yang, Guodong Chen, Xiaofeng Jiang, Jianqing Chen & Zhengbing Lyu. (2023) IgNAR characterization and gene loci identification in whitespotted bamboo shark (Chiloscyllium plagiosum) genome. Fish & Shellfish Immunology 133, pages 108535.
Crossref
Crossref
Yuto Nakatani, Zhengmao Ye, Yuki Ishizue, Taishi Higashi, Teruko Imai, Ikuo Fujii & Masataka Michigami. (2022) “Human and Mouse Cross-Reactive” Albumin-Binding Helix–Loop–Helix Peptide Tag for Prolonged Bioactivity of Therapeutic Proteins. Molecular Pharmaceutics 19:7, pages 2279-2286.
Crossref
Crossref
Martin A. Rossotti, Kasandra Bélanger, Kevin A. Henry & Jamshid Tanha. (2021) Immunogenicity and humanization of single‐domain antibodies. The FEBS Journal 289:14, pages 4304-4327.
Crossref
Crossref
Linfei Zhao, Mingliang Chen, Xiaona Wang, Shoukai Kang, Weiwei Xue & Zengpeng Li. (2022) Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (Chiloscyllium plagiosum). Marine Drugs 20:5, pages 307.
Crossref
Crossref
Qianyu Duan, Shuai Xia, Fanke Jiao, Qian Wang, Rui Wang, Lu Lu, Shibo Jiang & Wei Xu. (2022) A Modified Fibronectin Type III Domain-Conjugated, Long-Acting Pan-Coronavirus Fusion Inhibitor with Extended Half-Life. Viruses 14:4, pages 655.
Crossref
Crossref
Samata S. Pandey, Marina Kovaleva, Caroline J. Barelle & Obinna C. Ubah. 2022. Single-Domain Antibodies. Single-Domain Antibodies
19
33
.
Arghavan Soleimanizadeh, Heiko Dinter & Katharina Schindowski. (2021) Central Nervous System Delivery of Antibodies and Their Single-Domain Antibodies and Variable Fragment Derivatives with Focus on Intranasal Nose to Brain Administration. Antibodies 10:4, pages 47.
Crossref
Crossref
Aurélie Rondon, Sohaib Mahri, Francisco Morales‐Yanez, Mireille Dumoulin & Rita Vanbever. (2021) Protein Engineering Strategies for Improved Pharmacokinetics. Advanced Functional Materials 31:44.
Crossref
Crossref
Hajime Enatsu, Nako Okamoto, Yoshiki Nomura, Masayoshi Onitsuka, Noriko Yamano-Adachi, Yuichi Koga & Takeshi Omasa. (2021) Production of monoclonal shark-derived immunoglobulin new antigen receptor antibodies using Chinese hamster ovary cell expression system. Journal of Bioscience and Bioengineering 132:3, pages 302-309.
Crossref
Crossref
Zhuolun Shen, Yufei Xiang, Sandra Vergara, Apeng Chen, Zhengyun Xiao, Ulises Santiago, Changzhong Jin, Zhe Sang, Jiadi Luo, Kong Chen, Dina Schneidman-Duhovny, Carlos Camacho, Guillermo Calero, Baoli Hu & Yi Shi. (2021) A resource of high-quality and versatile nanobodies for drug delivery. iScience 24:9, pages 103014.
Crossref
Crossref
Salma Nassor Juma, Xiaoxia Gong, Sujie Hu, Zhengbing Lv, Jianzhong Shao, Lili Liu & Guiqian Chen. (2021) Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical Applications. Cells 10:5, pages 1140.
Crossref
Crossref
Richard J. Austin, Bryan D. Lemon, Wade H. Aaron, Manasi Barath, Patricia A. Culp, Robert B. DuBridge, Luke B. Evnin, Adrie Jones, Anand Panchal, Purbasa Patnaik, Vanitha Ramakrishnan, Sony S. Rocha, Pui Seto, Kenneth Sexton, Kathryn L. Strobel, Russell Wall, Stephen Yu, Timothy Z. Yu, Che-Leung Law, Patrick A. Baeuerle & Holger Wesche. (2021) TriTACs, a Novel Class of T-Cell–Engaging Protein Constructs Designed for the Treatment of Solid Tumors. Molecular Cancer Therapeutics 20:1, pages 109-120.
Crossref
Crossref
Adam Leach, Peter Smyth, Laura Ferguson, John Steven, Michelle K. Greene, Cristina M. Branco, Aidan P. McCann, Andrew Porter, Caroline J. Barelle & Christopher J. Scott. (2020) Anti-DLL4 VNAR targeted nanoparticles for targeting of both tumour and tumour associated vasculature. Nanoscale 12:27, pages 14751-14763.
Crossref
Crossref
Henk van Faassen, Shannon Ryan, Kevin A. Henry, Shalini Raphael, Qingling Yang, Martin A. Rossotti, Eric Brunette, Susan Jiang, Arsalan S. Haqqani, Traian Sulea, C. Roger MacKenzie, Jamshid Tanha & Greg Hussack. (2020)
Serum albumin‐binding V
H
Hs with variable pH sensitivities enable tailored half‐life extension of biologics
. The FASEB Journal 34:6, pages 8155-8171.
Crossref
Crossref
Wei Shien Cheong, Chiuan Yee Leow, Abu Bakar Abdul Majeed & Chiuan Herng Leow. (2020) Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody. International Journal of Biological Macromolecules 147, pages 369-375.
Crossref
Crossref
Obinna C. Ubah, Andrew J. Porter & Caroline J. Barelle. (2020)
In Vitro
ELISA and Cell-Based Assays Confirm the Low Immunogenicity of VNAR Therapeutic Constructs in a Mouse Model of Human RA: An Encouraging Milestone to Further Clinical Drug Development
. Journal of Immunology Research 2020, pages 1-14.
Crossref
Crossref
Magdalena J Buschhaus, Stefan Becker, Andrew J Porter & Caroline J Barelle. (2019) Isolation of highly selective IgNAR variable single-domains against a human therapeutic Fc scaffold and their application as tailor-made bioprocessing reagents. Protein Engineering, Design and Selection 32:9, pages 385-399.
Crossref
Crossref
Haofei Hong, Zhifang Zhou, Kun Zhou, Shaozhong Liu, Zhongwu Guo & Zhimeng Wu. (2019) Site-specific C-terminal dinitrophenylation to reconstitute the antibody Fc functions for nanobodies. Chemical Science 10:40, pages 9331-9338.
Crossref
Crossref
Hongyu Zhang, Mi Deng, Fen Pei, Shouye Wang & Mitchell Ho. (2019) Next-Generation Antibody Therapeutics: Discovery, Development and Beyond: highlights of the third annual conference of the Chinese Antibody Society. Antibody Therapeutics 2:4, pages 99-107.
Crossref
Crossref
Kathryn L. Pepple, Leslie Wilson, Russell N. Van Gelder, Marina Kovaleva, Obinna C. Ubah, John Steven, Caroline J. Barelle & Andrew Porter. (2019) Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand. Translational Vision Science & Technology 8:5, pages 11.
Crossref
Crossref
Alexander V. Grishin, Nikita V. Shestak, Natalia V. Lavrova, Alexander M. Lyashchuk, Liubov I. Popova, Natalia V. Strukova, Maria S. Generalova, Anna V. Ryazanova, Nikita B. Polyakov, Zoya M. Galushkina, Lyubov A. Soboleva, Irina S. Boksha, Anna S. Karyagina & Vladimir G. Lunin. (2019) Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation. Molecules 24:16, pages 2892.
Crossref
Crossref
Armin Sepp, Guy Meno-Tetang, Andrew Weber, Andrew Sanderson, Oliver Schon & Alienor Berges. (2019) Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats. Journal of Pharmacokinetics and Pharmacodynamics 46:4, pages 339-359.
Crossref
Crossref
Alessandro Zorzi, Sara Linciano & Alessandro Angelini. (2019) Non-covalent albumin-binding ligands for extending the circulating half-life of small biotherapeutics. MedChemComm 10:7, pages 1068-1081.
Crossref
Crossref
S. Sh. Gapizov, L. E. Petrovskaya, L. N. Shingarova, E. A. Kryukova, E. F. Boldyreva, E. P. Lukashev, S. A. Yakimov, E. V. Svirshchevskaya, D. A. Dolgikh & M. P. Kirpichnikov. (2019) Fusion with an albumin‐binding domain improves pharmacokinetics of an αvβ3‐integrin binding fibronectin scaffold protein. Biotechnology and Applied Biochemistry 66:4, pages 617-625.
Crossref
Crossref
Kasandra Bélanger, Umar Iqbal, Jamshid Tanha, Roger MacKenzie, Maria Moreno & Danica Stanimirovic. (2019) Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases. Antibodies 8:2, pages 27.
Crossref
Crossref
Obinna C. Ubah, John Steven, Andrew J. Porter & Caroline J. Barelle. (2019) An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model. Frontiers in Immunology 10.
Crossref
Crossref
Obinna C. UbahMagdalena J. BuschhausLaura FergusonMarina KovalevaJohn StevenAndrew J. PorterCaroline J. Barelle. (2018) Next-generation flexible formats of VNAR domains expand the drug platform's utility and developability. Biochemical Society Transactions 46:6, pages 1559-1565.
Crossref
Crossref
Ronan O’Dwyer, Marina Kovaleva, Jiquan Zhang, John Steven, Emma Cummins, Deborah Luxenberg, Alfredo Darmanin-Sheehan, Miguel F. Carvalho, Matthew Whitters, Kenneth Saunders & Caroline J. Barelle. (2018) Anti-ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen-Induced Mouse Model of Rheumatoid Arthritis. Journal of Immunology Research 2018, pages 1-13.
Crossref
Crossref
Bushra Husain & Diego Ellerman. (2018) Expanding the Boundaries of Biotherapeutics with Bispecific Antibodies. BioDrugs 32:5, pages 441-464.
Crossref
Crossref
Dalia Millán-Gómez, Salvador Dueñas, Patricia L.A. Muñoz, Tanya Camacho-Villegas, Carolina Elosua, Olivia Cabanillas-Bernal, Teresa Escalante, Almudena Perona, David Abia, Florian Drescher, Pierrick G.J. Fournier, Marco A. Ramos, Rosa E. Mares, Jorge Paniagua-Solis, Teresa Mata-Gonzalez, Jorge Gonzalez-Canudas, Robert M. Hoffman, Alexei Licea-Navarro & Noemí Sánchez-Campos. (2018)
In silico-designed
mutations increase variable new-antigen receptor single-domain antibodies for VEGF165 neutralization
. Oncotarget 9:46, pages 28016-28029.
Crossref
Crossref
Tanya Camacho-Villegas, María Mata-González, Walter García-Ubbelohd, Linda Núñez-García, Carolina Elosua, Jorge Paniagua-Solis & Alexei Licea-Navarro. (2018) Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF165 Neutralization. Marine Drugs 16:4, pages 113.
Crossref
Crossref
Julius Grzeschik, Doreen Könning, Steffen C. Hinz, Simon Krah, Christian Schröter, Martin Empting, Harald Kolmar & Stefan Zielonka. 2018. Phage Display. Phage Display
147
167
.
Obinna C. Ubah, John Steven, Marina Kovaleva, Laura Ferguson, Charlotte Barelle, Andrew J. R. Porter & Caroline J. Barelle. (2017) Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development. Frontiers in Immunology 8.
Crossref
Crossref
John Steven, Mischa R. Müller, Miguel F. Carvalho, Obinna C. Ubah, Marina Kovaleva, Gerard Donohoe, Thomas Baddeley, Dawn Cornock, Kenneth Saunders, Andrew J. Porter & Caroline Jane Barelle. (2017) In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development. Frontiers in Immunology 8.
Crossref
Crossref
Marina Kovaleva, Katherine Johnson, John Steven, Caroline J. Barelle & Andrew Porter. (2017) Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis. Frontiers in Immunology 8.
Crossref
Crossref
Daniel Steiner, Frieder W Merz, Ivo Sonderegger, Maya Gulotti-Georgieva, Denis Villemagne, Douglas J Phillips, Patrik Forrer, Michael T Stumpp, Christof Zitt & H Kaspar Binz. (2017) Half-life extension using serum albumin-binding DARPin® domains. Protein Engineering, Design and Selection 30:9, pages 583-591.
Crossref
Crossref
Doreen Könning, Stefan Zielonka, Julius Grzeschik, Martin Empting, Bernhard Valldorf, Simon Krah, Christian Schröter, Carolin Sellmann, Björn Hock & Harald Kolmar. (2017) Camelid and shark single domain antibodies: structural features and therapeutic potential. Current Opinion in Structural Biology 45, pages 10-16.
Crossref
Crossref
Ellen R. Goldman, Jinny L. Liu, Dan Zabetakis & George P. Anderson. (2017) Enhancing Stability of Camelid and Shark Single Domain Antibodies: An Overview. Frontiers in Immunology 8.
Crossref
Crossref
Mohammed M. Al Qaraghuli & Valerie A. Ferro. (2017) Analysis of the binding loops configuration and surface adaptation of different crystallized single-domain antibodies in response to various antigens. Journal of Molecular Recognition 30:4, pages e2592.
Crossref
Crossref
Sara Mashoof & Michael Criscitiello. (2016) Fish Immunoglobulins. Biology 5:4, pages 45.
Crossref
Crossref
George P. Anderson, Daniel D. Teichler, Dan Zabetakis, Lisa C. Shriver-Lake, Jinny L. Liu, Stephen G. Lonsdale, Sarah A. Goodchild & Ellen R. Goldman. (2016) Importance of Hypervariable Region 2 for Stability and Affinity of a Shark Single-Domain Antibody Specific for Ebola Virus Nucleoprotein. PLOS ONE 11:8, pages e0160534.
Crossref
Crossref
Selena G. Burgess, Arkadiusz Oleksy, Tommaso Cavazza, Mark W. Richards, Isabelle Vernos, David Matthews & Richard Bayliss. (2016) Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain. Open Biology 6:7, pages 160089.
Crossref
Crossref
Jeannette Nilsen, Kine Marita Knudsen Sand, Malin Bern, Peng Lei, Inger Sandlie & Jan Terje Andersen. 2016. Albumin in Medicine. Albumin in Medicine
179
208
.
Caroline Barelle & Andy Porter. (2015) VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins. Antibodies 4:3, pages 240-258.
Crossref
Crossref
Malin Bern, Kine Marita Knudsen Sand, Jeannette Nilsen, Inger Sandlie & Jan Terje Andersen. (2015) The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery. Journal of Controlled Release 211, pages 144-162.
Crossref
Crossref
Sven Hoefman, Ingrid Ottevaere, Judith Baumeister & Maria Sargentini-Maier. (2015) Pre-Clinical Intravenous Serum Pharmacokinetics of Albumin Binding and Non-Half-Life Extended Nanobodies®. Antibodies 4:3, pages 141-156.
Crossref
Crossref
晟 刘. (2015) Research Advance in Single-Domain Antibody. QianRen Biology 02:03, pages 26-38.
Crossref
Crossref
Uli Binder & Arne Skerra. 2015. Biobetters. Biobetters
269
311
.
Stefan Zielonka, Niklas Weber, Stefan Becker, Achim Doerner, Andreas Christmann, Christine Christmann, Christina Uth, Janine Fritz, Elena Schäfer, Björn Steinmann, Martin Empting, Pia Ockelmann, Michael Lierz & Harald Kolmar. (2014) Shark Attack: High affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation. Journal of Biotechnology 191, pages 236-245.
Crossref
Crossref
Frank R. Brennan. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies
927
968
.
Jinny L. Liu, Dan Zabetakis, Jazmine C. Brown, George P. Anderson & Ellen R. Goldman. (2014) Thermal stability and refolding capability of shark derived single domain antibodies. Molecular Immunology 59:2, pages 194-199.
Crossref
Crossref
Frank R. Brennan, Annick Cauvin, Jay Tibbitts & Alison Wolfreys. (2014) Optimized Nonclinical Safety Assessment Strategies Supporting Clinical Development of Therapeutic Monoclonal Antibodies Targeting Inflammatory Diseases. Drug Development Research, pages n/a-n/a.
Crossref
Crossref
Gabriele Proetzel, Michael V. Wiles & Derry C. Roopenian. (2013) Genetically Engineered Humanized Mouse Models for Preclinical Antibody Studies. BioDrugs 28:2, pages 171-180.
Crossref
Crossref
Achim Doerner, Laura Rhiel, Stefan Zielonka & Harald Kolmar. (2014) Therapeutic antibody engineering by high efficiency cell screening. FEBS Letters 588:2, pages 278-287.
Crossref
Crossref
Oleg V. Kovalenko, Andrea Olland, Nicole Piché-Nicholas, Adarsh Godbole, Daniel King, Kristine Svenson, Valerie Calabro, Mischa R. Müller, Caroline J. Barelle, William Somers, Davinder S. Gill, Lidia Mosyak & Lioudmila Tchistiakova. (2013) Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis. Journal of Biological Chemistry 288:24, pages 17408-17419.
Crossref
Crossref
Katherine Griffiths, Olan Dolezal, Kathy Parisi, Julie Angerosa, Con Dogovski, Miles Barraclough, Abdulmonem Sanalla, Joanne Casey, Iveth González, Matthew Perugini, Stewart Nuttall & Michael Foley. (2013) Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic Applications. Antibodies 2:4, pages 66-81.
Crossref
Crossref