mAbs, Volume 4, Issue 6 (2012)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

mAbs, Volume 4, Issue 6 (2012)

See all volumes and issues
Vol 16, 2024 Vol 15, 2023 Vol 14, 2022 Vol 13, 2021 Vol 12, 2020 Vol 11, 2019 Vol 10, 2018 Vol 9, 2017 Vol 8, 2016 Vol 7, 2015 Vol 6, 2014 Vol 5, 2013 Volume 4, 2012 Vol 3, 2011 Vol 2, 2010 Vol 1, 2009
Download citations Download PDFs Download issue

Letter to the Editor

Letter
Fab-arm exchange is a misnomer
Janardan P. Pandey
Page: 635
Published online: 01 Nov 2012
CitationforFab-arm exchange is a misnomer | PDF (279.5 KB)
  • 189 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access
Letter
Fab-arm exchange
What’s in a name?
Janine Schuurman, Aran F. Labrijn & Paul W.H.I. Parren
Page: 636
Published online: 06 Sep 2012
CitationforFab-arm exchange | Full Text | References | PDF (301.8 KB)
  • 1306 Views
  • 3 CrossRef citations
  • 0Altmetric
Open Access

Meeting Report

Meeting Report
Fourth World Antibody-Drug Conjugate Summit
February 29–March 1, 2012, Frankfurt, Germany
Alain Beck, John Lambert, Michael Sun & Kedan Lin
Pages: 637-647
Published online: 01 Nov 2012
AbstractforFourth World Antibody-Drug Conjugate Summit | Full Text | References | PDF (574.1 KB)
  • 1996 Views
  • 29 CrossRef citations
  • 0Altmetric
Open Access

Meeting Preview

Calendar
IBC’s 23rd Antibody Engineering and 10th Antibody Therapeutics Conferences and the Annual Meeting of The Antibody Society
December 2–6, 2012, San Diego, CA
John Marquardt, Richard H.J. Begent, Kerry Chester, James S. Huston, Andrew Bradbury, Jamie K. Scott, Philip E. Thorpe, Trudi Veldman, Janice M. Reichert & Louis M. Weiner
Pages: 648-652
Published online: 24 Sep 2012
AbstractforIBC’s 23rd Antibody Engineering and 10th Antibody Therapeutics Conferences and the Annual Meeting of The Antibody Society | Full Text | PDF (464.8 KB)
  • 896 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Review

Review Article
Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies
Christian Klein, Claudio Sustmann, Markus Thomas, Kay Stubenrauch, Rebecca Croasdale, Jürgen Schanzer, Ulrich Brinkmann, Hubert Kettenberger, Jörg T. Regula & Wolfgang Schaefer
Pages: 653-663
Published online: 27 Aug 2012
AbstractforProgress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies | Full Text | References | PDF (1.5 MB)
  • 8216 Views
  • 154 CrossRef citations
  • 0Altmetric
Free Access

Report

Article
Tailored amino acid diversity for the evolution of antibody affinity
Andrea González-Muñoz, Evert Bokma, Desmond O’Shea, Kevin Minton, Martin Strain, Katherine Vousden, Christine Rossant, Lutz Jermutus & Ralph Minter
Pages: 664-672
Published online: 27 Aug 2012
AbstractforTailored amino acid diversity for the evolution of antibody affinity | Full Text | References | PDF (1.7 MB) | Supplemental
  • 1417 Views
  • 11 CrossRef citations
  • 0Altmetric
Open Access
Article
Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain
Mischa R. Müller, Kenneth Saunders, Christopher Grace, Macy Jin, Nicole Piche-Nicholas, John Steven, Ronan O’Dwyer, Leeying Wu, Lam Khetemenee, Yulia Vugmeyster, Timothy P. Hickling, Lioudmila Tchistiakova, Stephane Olland, Davinder Gill, Allan Jensen & Caroline J. Barelle
Pages: 673-685
Published online: 01 Nov 2012
AbstractforImproving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain | Full Text | References | PDF (1.3 MB) | Supplemental
  • 2828 Views
  • 66 CrossRef citations
  • 0Altmetric
Free Access
Article
Fusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies
Shubhada N. Joshi, David C. Butler & Anne Messer
Pages: 686-693
Published online: 28 Aug 2012
AbstractforFusion to a highly charged proteasomal retargeting sequence increases soluble cytoplasmic expression and efficacy of diverse anti-synuclein intrabodies | Full Text | References | PDF (820.4 KB)
  • 2096 Views
  • 53 CrossRef citations
  • 0Altmetric
Free Access
Article
Identification of a single base-pair mutation of TAA (Stop codon) → GAA (Glu) that causes light chain extension in a CHO cell derived IgG1
Taylor Zhang, Yungfu Huang, Scott Chamberlain, Tony Romeo, Judith Zhu-Shimoni, Daniel Hewitt, Mary Zhu, Viswanatham Katta, Brad Mauger & Yung-Hsiang Kao
Pages: 694-700
Published online: 27 Sep 2012
AbstractforIdentification of a single base-pair mutation of TAA (Stop codon) → GAA (Glu) that causes light chain extension in a CHO cell derived IgG1 | Full Text | References | PDF (1.2 MB)
  • 1212 Views
  • 26 CrossRef citations
  • 0Altmetric
Open Access
Article
Characterization of antibody variants during process development: The tale of incomplete processing of N-terminal secretion peptide
alexandre Ambrogelly, Yan-Hui Liu, Hong Li, selina Mengisen, bingyi Yao, Wei Xu & Susan Cannon-Carlson
Pages: 701-709
Published online: 29 Aug 2012
AbstractforCharacterization of antibody variants during process development: The tale of incomplete processing of N-terminal secretion peptide | PDF (1.9 MB) | Supplemental
  • 1497 Views
  • 26 CrossRef citations
  • 0Altmetric
Free Access
Article
Biochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621
Neil R. Michaud, Jitesh P. Jani, Stephen Hillerman, Konstantinos E. Tsaparikos, Elsa G. Barbacci-Tobin, Elisabeth Knauth, Henry Putz Jr.Mary Campbell, George A. Karam, Boris Chrunyk, David F. Gebhard, Larry L. Green, Jinghai J. Xu, Margaret C. Dunn, Tim M. Coskran, Jean-Martin Lapointe, Bruce D. Cohen, Kevin G. Coleman, Vahe Bedian, Patrick Vincent, Shama Kajiji, Stefan J. Steyn, Gary V. Borzillo & Gerrit Los
Pages: 710-723
Published online: 24 Sep 2012
AbstractforBiochemical and pharmacological characterization of human c-Met neutralizing monoclonal antibody CE-355621 | Full Text | References | PDF (1.7 MB) | Supplemental
  • 933 Views
  • 7 CrossRef citations
  • 0Altmetric
Free Access
Article
Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies
Deborah L. Mortensen, Saileta Prabhu, Eric G. Stefanich, Saloumeh Kadkhodayan-Fischer, Thomas R. Gelzleichter, Dana Baker, Jenny Jiang, Kristin Wallace, Suhasini Iyer, Paul J. Fielder & Wendy S. Putnam
Pages: 724-731
Published online: 27 Sep 2012
AbstractforEffect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies | Full Text | References | PDF (1.5 MB)
  • 1478 Views
  • 26 CrossRef citations
  • 0Altmetric
Free Access
Article
Characterization of a variety of neutralizing anti-heparin-binding epidermal growth factor-like growth factor monoclonal antibodies by different immunization methods
Isamu Tsuji, Shuji Sato, Kentaro Otake, Takahiro Watanabe, Hiroko Kamada & Tomofumi Kurokawa
Pages: 732-739
Published online: 24 Sep 2012
AbstractforCharacterization of a variety of neutralizing anti-heparin-binding epidermal growth factor-like growth factor monoclonal antibodies by different immunization methods | Full Text | References | PDF (1 MB)
  • 780 Views
  • 5 CrossRef citations
  • 0Altmetric
Free Access
Article
Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice
Vasco Filipe, Wim Jiskoot, Abdul Hafid Basmeleh, Andhyk Halim, Huub Schellekens & Vera Brinks
Pages: 740-752
Published online: 05 Sep 2012
AbstractforImmunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice | Full Text | References | PDF (2.5 MB) | Supplemental
  • 2889 Views
  • 129 CrossRef citations
  • 0Altmetric
Free Access
Article
A strategy for risk mitigation of antibodies with fast clearance
Isidro Hötzel, Frank-Peter Theil, Lisa J. Bernstein, Saileta Prabhu, Rong Deng, Leah Quintana, Jeff Lutman, Renuka Sibia, Pamela Chan, Daniela Bumbaca, Paul Fielder, Paul J. Carter & Robert F. Kelley
Pages: 753-760
Published online: 01 Nov 2012
AbstractforA strategy for risk mitigation of antibodies with fast clearance | Full Text | References | PDF (1.1 MB) | Supplemental
  • 9049 Views
  • 182 CrossRef citations
  • 0Altmetric
Open Access
Article
Characterization and comparison of commercially available TNF receptor 2-Fc fusion protein products
Qingqiao Tan, Qingcheng Guo, Chen Fang, Chong Wang, Bohua Li, Hao Wang, Jing Li & Yajun Guo
Pages: 761-774
Published online: 02 Oct 2012
AbstractforCharacterization and comparison of commercially available TNF receptor 2-Fc fusion protein products | Full Text | References | PDF (4.3 MB)
  • 3424 Views
  • 44 CrossRef citations
  • 0Altmetric
Free Access

Short Communication

Brief Report
Biodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site
Thomas List & Dario Neri
Pages: 775-783
Published online: 02 Oct 2012
AbstractforBiodistribution studies with tumor-targeting bispecific antibodies reveal selective accumulation at the tumor site | Full Text | References | PDF (3.2 MB) | Supplemental
  • 1632 Views
  • 28 CrossRef citations
  • 0Altmetric
Free Access
Brief Report
FCGR2C genotyping by pyrosequencing reveals linkage disequilibrium with FCGR3A V158F and FCGR2A H131R polymorphisms in a Caucasian population
Julien Lejeune, Benoît Piègu, Valérie Gouilleux-Gruart, Marc Ohresser, Hervé Watier & Gilles Thibault
Pages: 784-787
Published online: 02 Oct 2012
AbstractforFCGR2C genotyping by pyrosequencing reveals linkage disequilibrium with FCGR3A V158F and FCGR2A H131R polymorphisms in a Caucasian population | Full Text | References | PDF (434.2 KB) | Supplemental
  • 816 Views
  • 12 CrossRef citations
  • 0Altmetric
Free Access

Editor's Corner

Editorial
2012–13 Upcoming meetings
Janice M. Reichert
Pages: 788-790
Published online: 17 Sep 2012
Abstractfor2012–13 Upcoming meetings | Full Text | PDF (364.8 KB)
  • 398 Views
  • 0 CrossRef citations
  • 0Altmetric
Open Access

Explore articles