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mAbs Volume 5, 2013 - Issue 1
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Human TNF cytokine neutralization with a vNAR from Heterodontus francisci shark: A potential therapeutic use

Tanya Camacho-Villegas Marine Science Faculty; Universidad Autonoma de Baja California (UABC); Ensenada Baja California, Mexico; Marine Biotechnology Department; Centro de Investigacion Cientifica y de Educacion Superior de Ensenada (CICESE); Ensenada Baja California, Mexico
,
Teresa Mata-Gonzalez Laboratorios Silanes S.A. de C.V.; Distrito Federal, Mexico
,
Jorge Paniagua-Solis Laboratorios Silanes S.A. de C.V.; Distrito Federal, Mexico; Teraclon IDF; Parque Cientifico de Madrid; Tres Cantos, Madrid, España
,
Edna Sanchez Marine Biotechnology Department; Centro de Investigacion Cientifica y de Educacion Superior de Ensenada (CICESE); Ensenada Baja California, Mexico
&
Alexei Licea Marine Biotechnology Department; Centro de Investigacion Cientifica y de Educacion Superior de Ensenada (CICESE); Ensenada Baja California, MexicoCorrespondence[email protected]
Pages 80-85 | Received 26 Jul 2012, Accepted 18 Oct 2012, Published online: 05 Dec 2012

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Yanchun Gao, Ruihong Wang, Lin Liu, Shitao Feng, Xiaozhi Xi, Wengong Yu, Yuchao Gu & Ye Wang. (2023) Identification and characterization of shark VNARs targeting the Helicobacter pylori adhesin HpaA. Artificial Cells, Nanomedicine, and Biotechnology 51:1, pages 509-519.
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Yongzhong Wang, Zhen Fan, Lei Shao, Xiaowei Kong, Xianjuan Hou, Dongrui Tian, Ying Sun, Yazhong Xiao & Li Yu. (2016) Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications. International Journal of Nanomedicine 11, pages 3287-3303.
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Stefan Zielonka, Martin Empting, Julius Grzeschik, Doreen Könning, Caroline J Barelle & Harald Kolmar. (2015) Structural insights and biomedical potential of IgNAR scaffolds from sharks. mAbs 7:1, pages 15-25.
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Marina Kovaleva, Laura Ferguson, John Steven, Andrew Porter & Caroline Barelle. (2014) Shark variable new antigen receptor biologics – a novel technology platform for therapeutic drug development. Expert Opinion on Biological Therapy 14:10, pages 1527-1539.
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Articles from other publishers (29)

Karen Manoutcharian & Goar Gevorkian. (2023) Shark VNAR phage display libraries: An alternative source for therapeutic and diagnostic recombinant antibody fragments. Fish & Shellfish Immunology 138, pages 108808.
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Jianqing Wen, Jinyu Gong, Pengwei Li, Penghui Deng, Mengsi Sun, Yujie Wu, Chenxi Tian, Hao Wang & Yunchen Bi. (2023) Identification and characterization of IgNAR and VNAR repertoire from the ocellate spot skate (Okamejei kenojei). Frontiers in Marine Science 10.
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Mirna Burciaga-Flores, Ana Laura Márquez-Aguirre, Salvador Dueñas, Jahaziel Gasperin-Bulbarela, Alexei F. Licea-Navarro & Tanya A. Camacho-Villegas. (2023) First pan-specific vNAR against human TGF-β as a potential therapeutic application: in silico modeling assessment. Scientific Reports 13:1.
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Guillermo Valenzuela-Nieto, Zaray Miranda-Chacon, Constanza Salinas-Rebolledo, Ronald Jara, Alexei Cuevas, Anne Berking & Alejandro Rojas-Fernandez. (2022) Nanobodies: COVID-19 and Future Perspectives. Frontiers in Drug Discovery 2.
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Dan Li, Hejiao English, Jessica Hong, Tianyuzhou Liang, Glenn Merlino, Chi-Ping Day & Mitchell Ho. (2022) A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer. Molecular Therapy - Oncolytics 24, pages 849-863.
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Ana Carolina Alcala Aristiguieta. 2022. Biomedical Innovations to Combat COVID-19. Biomedical Innovations to Combat COVID-19 231 240 .
Jahaziel Gasperin-Bulbarela, Olivia Cabanillas-Bernal, Salvador Dueñas & Alexei F. Licea-Navarro. 2022. Single-Domain Antibodies. Single-Domain Antibodies 71 93 .
Samata S. Pandey, Marina Kovaleva, Caroline J. Barelle & Obinna C. Ubah. 2022. Single-Domain Antibodies. Single-Domain Antibodies 19 33 .
Likun Wei, Meiniang Wang, Haitao Xiang, Yuan Jiang, Jinhua Gong, Dan Su, M. A. R. Al Azad, Hongming Dong, Limin Feng, Jiajun Wu, Leo Lai Chan, Naibo Yang & Jiahai Shi. (2021) Bamboo Shark as a Small Animal Model for Single Domain Antibody Production. Frontiers in Bioengineering and Biotechnology 9.
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Yasaman Asaadi, Fatemeh Fazlollahi Jouneghani, Sara Janani & Fatemeh Rahbarizadeh. (2021) A comprehensive comparison between camelid nanobodies and single chain variable fragments. Biomarker Research 9:1.
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Salma Nassor Juma, Xiaoxia Gong, Sujie Hu, Zhengbing Lv, Jianzhong Shao, Lili Liu & Guiqian Chen. (2021) Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical Applications. Cells 10:5, pages 1140.
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Wei Shien Cheong, Chiuan Yee Leow, Abu Bakar Abdul Majeed & Chiuan Herng Leow. (2020) Diagnostic and therapeutic potential of shark variable new antigen receptor (VNAR) single domain antibody. International Journal of Biological Macromolecules 147, pages 369-375.
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Hejiao English, Jessica Hong & Mitchell Ho. (2020) Ancient species offers contemporary therapeutics: an update on shark VNAR single domain antibody sequences, phage libraries and potential clinical applications. Antibody Therapeutics 3:1, pages 1-9.
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Vladimir Bobkov, Marta Arimont, Aurélien Zarca, Timo W.M. De Groof, Bas van der Woning, Hans de Haard & Martine J. Smit. (2019) Antibodies Targeting Chemokine Receptors CXCR4 and ACKR3. Molecular Pharmacology 96:6, pages 753-764.
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Olivia Cabanillas-Bernal, Salvador Dueñas, Marta Ayala-Avila, Alexandra Rucavado, Teresa Escalante & Alexei F. Licea-Navarro. (2019) Synthetic libraries of shark vNAR domains with different cysteine numbers within the CDR3. PLOS ONE 14:6, pages e0213394.
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D.P.N. De Silva, E. Tan, N. Mizuno, S. Hosoya, Md S. Reza, S. Watabe, S. Kinoshita & S. Asakawa. (2019) Transcriptomic analysis of immunoglobulin novel antigen receptor (IgNAR) heavy chain constant domains of brownbanded bamboo shark (Chiloscyllium punctatum). Fish & Shellfish Immunology 84, pages 370-376.
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Sara Žigon-Branc, Ariana Barlič, Miomir Knežević, Matjaž Jeras & Gordana Vunjak-Novakovic. (2018) Testing the potency of anti-TNF-α and anti-IL-1β drugs using spheroid cultures of human osteoarthritic chondrocytes and donor-matched chondrogenically differentiated mesenchymal stem cells. Biotechnology Progress 34:4, pages 1045-1058.
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Tanya Camacho-Villegas, María Mata-González, Walter García-Ubbelohd, Linda Núñez-García, Carolina Elosua, Jorge Paniagua-Solis & Alexei Licea-Navarro. (2018) Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF165 Neutralization. Marine Drugs 16:4, pages 113.
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Chiuan Herng Leow, Qin Cheng, Katja Fischer & James McCarthy. 2018. Antibody Engineering. Antibody Engineering.
Obinna C. Ubah, John Steven, Marina Kovaleva, Laura Ferguson, Charlotte Barelle, Andrew J. R. Porter & Caroline J. Barelle. (2017) Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development. Frontiers in Immunology 8.
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Chiuan Leow, Katja Fischer, Chiuan Leow, Qin Cheng, Candy Chuah & James McCarthy. (2017) Single Domain Antibodies as New Biomarker Detectors. Diagnostics 7:4, pages 52.
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Doreen Könning, Laura Rhiel, Martin Empting, Julius Grzeschik, Carolin Sellmann, Christian Schröter, Stefan Zielonka, Stephan Dickgießer, Thomas Pirzer, Desislava Yanakieva, Stefan Becker & Harald Kolmar. (2017) Semi-synthetic vNAR libraries screened against therapeutic antibodies primarily deliver anti-idiotypic binders. Scientific Reports 7:1.
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Sara Mashoof & Michael Criscitiello. (2016) Fish Immunoglobulins. Biology 5:4, pages 45.
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Doreen Könning, Stefan Zielonka, Carolin Sellmann, Christian Schröter, Julius Grzeschik, Stefan Becker & Harald Kolmar. (2016) Isolation of a pH-Sensitive IgNAR Variable Domain from a Yeast-Displayed, Histidine-Doped Master Library. Marine Biotechnology 18:2, pages 161-167.
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Martin F. Flajnik. 2016. Encyclopedia of Immunobiology. Encyclopedia of Immunobiology 160 165 .
Caroline Barelle & Andy Porter. (2015) VNARs: An Ancient and Unique Repertoire of Molecules That Deliver Small, Soluble, Stable and High Affinity Binders of Proteins. Antibodies 4:3, pages 240-258.
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Ariana Barlič, Sara Žigon, Andrej Blejec & Nevenka Kregar Velikonja. (2015) Gene expression of cultured human chondrocytes as a model for assessing neutralization efficacy of soluble TNFα by TNFα antagonists. Biologicals 43:3, pages 171-180.
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Weizao Chen, Ponraj Prabakaran & Dimiter S. Dimitrov. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies 487 518 .
Jinny L. Liu, Dan Zabetakis, Jazmine C. Brown, George P. Anderson & Ellen R. Goldman. (2014) Thermal stability and refolding capability of shark derived single domain antibodies. Molecular Immunology 59:2, pages 194-199.
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