mAbs, Volume 5, Issue 1 (2013)

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mAbs, Volume 5, Issue 1 (2013)

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Editorial

Editorial
Which are the antibodies to watch in 2013?
Janice M. Reichert
Pages: 1-4
Published online: 19 Dec 2012
AbstractforWhich are the antibodies to watch in 2013? | Full Text | References | PDF (313.3 KB)
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Meeting Report

Meeting Report
American Association of Pharmaceutical Scientists National Biotechnology Conference Short Course: Translational Challenges in Developing Antibody-Drug Conjugates
May 24, 2012, San Diego, CA
Karen Thudium, Sanela Bilic, Douglas Leipold, William Mallet, Surinder Kaur, Bernd Meibohm, Hans Erickson, Jay Tibbitts, Hong Zhao & Manish Gupta
Pages: 5-12
Published online: 19 Dec 2012
AbstractforAmerican Association of Pharmaceutical Scientists National Biotechnology Conference Short Course: Translational Challenges in Developing Antibody-Drug Conjugates | Full Text | References | PDF (1.2 MB)
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Review

Review Article
Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates
Michael Ritchie, Lioudmila Tchistiakova & Nathan Scott
Pages: 13-21
Published online: 06 Dec 2012
AbstractforImplications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates | Full Text | References | PDF (918 KB)
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Review Article
Epitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties
Christian Klein, Alfred Lammens, Wolfgang Schäfer, Guy Georges, Manfred Schwaiger, Ekkehard Mössner, Karl-Peter Hopfner, Pablo Umaña & Gerhard Niederfellner
Pages: 22-33
Published online: 04 Dec 2012
AbstractforEpitope interactions of monoclonal antibodies targeting CD20 and their relationship to functional properties | Full Text | References | PDF (2.9 MB)
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Review Article
Approaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells
Fabrizio Marcucci, Matteo Bellone, Cristiano Rumio & Angelo Corti
Pages: 34-46
Published online: 04 Dec 2012
AbstractforApproaches to improve tumor accumulation and interactions between monoclonal antibodies and immune cells | Full Text | References | PDF (769.2 KB)
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Report

Article
Antagonist properties of monoclonal antibodies targeting human CD28
Role of valency and the heavy-chain constant domain
Caroline Mary, Flora Coulon, Nicolas Poirier, Nahzli Dilek, Bernard Martinet, Gilles Blancho & Bernard Vanhove
Pages: 47-55
Published online: 05 Dec 2012
AbstractforAntagonist properties of monoclonal antibodies targeting human CD28 | Full Text | References | PDF (1,010.7 KB)
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Article
Generation and characterization of rendomab-B1, a monoclonal antibody displaying potent and specific antagonism of the human endothelin B receptor
Bertrand Allard, Anne WIJKHUISEN, Aurélie Borrull, Frederique Deshayes, Fabienne Priam, Patricia Lamourette, Frédéric Ducancel, Didier Boquet & Jean-Yves Couraud
Pages: 56-69
Published online: 05 Dec 2012
AbstractforGeneration and characterization of rendomab-B1, a monoclonal antibody displaying potent and specific antagonism of the human endothelin B receptor | PDF (2.4 MB)
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Article
Generation and characterization of monospecific and bispecific hexavalent trimerbodies
Ana Blanco-Toribio, Noelia Sainz-Pastor, Ana Álvarez-Cienfuegos, Nekane Merino, Ángel M. Cuesta, David Sánchez-Martín, Jaume Bonet, Patricia Santos-Valle, Laura Sanz, Baldo Oliva, Francisco J. Blanco & Luis Álvarez-Vallina
Pages: 70-79
Published online: 05 Dec 2012
AbstractforGeneration and characterization of monospecific and bispecific hexavalent trimerbodies | PDF (1.5 MB)
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Article
Human TNF cytokine neutralization with a vNAR from Heterodontus francisci shark: A potential therapeutic use
Tanya Camacho-Villegas, Teresa Mata-Gonzalez, Jorge Paniagua-Solis, Edna Sanchez & Alexei Licea
Pages: 80-85
Published online: 05 Dec 2012
AbstractforHuman TNF cytokine neutralization with a vNAR from Heterodontus francisci shark: A potential therapeutic use | PDF (814.3 KB)
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Article
Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting
Galahad Deperalta, Melissa Alvarez, Charity Bechtel, Ken Dong, Ross McDonald & Victor Ling
Pages: 86-101
Published online: 17 Dec 2012
AbstractforStructural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Characterization of monoclonal antibody size variants containing extra light chains
Connie Lu, Dandan Liu, Hongbin Liu & Paul Motchnik
Pages: 102-113
Published online: 19 Dec 2012
AbstractforCharacterization of monoclonal antibody size variants containing extra light chains | Full Text | References | PDF (2.1 MB)
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Article
Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry
Liangjie Tang, Shanmuuga Sundaram, Jingming Zhang, Ping Carlson, Alice Matathia, Babita Parekh, Qinwei Zhou & Ming-Ching Hsieh
Pages: 114-125
Published online: 06 Dec 2012
AbstractforConformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry | PDF (1.9 MB)
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Article
Adsorption behavior of a human monoclonal antibody at hydrophilic and hydrophobic surfaces
Ruairidh G. Couston, Maximilian W. Skoda, Shahid Uddin & Christopher F. van der Walle
Pages: 126-139
Published online: 29 Nov 2012
AbstractforAdsorption behavior of a human monoclonal antibody at hydrophilic and hydrophobic surfaces | Full Text | References | PDF (2.1 MB)
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Article
Recombinant antibody fragments allow repeated measurements of C-reactive protein with a quartz crystal microbalance immunosensor
Laila Al-Halabi, Anne Balck, Monika Michalzik, David Fröde, Stephanus Büttgenbach, Michael Hust, Thomas Schirrmann & Stefan Dübel
Pages: 140-149
Published online: 06 Dec 2012
AbstractforRecombinant antibody fragments allow repeated measurements of C-reactive protein with a quartz crystal microbalance immunosensor | Full Text | References | PDF (1.6 MB)
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Article
A novel approach for the simultaneous quantification of a therapeutic monoclonal antibody in serum produced from two distinct host cell lines
Brian J. Geist, Darryl Davis, Thomas McIntosh, Tong-Yuan Yang, Kenneth Goldberg, Chao Han, Charles Pendley & Hugh M. Davis
Pages: 150-161
Published online: 26 Nov 2012
AbstractforA novel approach for the simultaneous quantification of a therapeutic monoclonal antibody in serum produced from two distinct host cell lines | PDF (2.7 MB) | Supplemental
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Article
Validation of an automated method for compounding monoclonal antibody patient doses
Case studies of Avastin® (bevacizumab), Remicade® (infliximab) and Herceptin® (trastuzumab)
Bas J.M. Peters, Martinus A.H. Capelle, Tudor Arvinte & Ewoudt M.W. van de Garde
Pages: 162-170
Published online: 19 Dec 2012
AbstractforValidation of an automated method for compounding monoclonal antibody patient doses | Full Text | References | PDF (5.5 MB)
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Editor's Corner

Editorial
Note of appreciation to reviewers
Janice M. Reichert
Pages: 171-173
Published online: 19 Dec 2012
AbstractforNote of appreciation to reviewers | Full Text | PDF (319.3 KB)
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