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Antagonist properties of monoclonal antibodies targeting human CD28

Role of valency and the heavy-chain constant domain

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Pages 47-55 | Published online: 05 Dec 2012

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Nicolas Poirier, Caroline Mary, Stephanie Le Bas-Bernardet, Veronique Daguin, Lyssia Belarif, Melanie Chevalier, Jeremy Hervouet, David Minault, Simon Ville, Vianney Charpy, Gilles Blancho & Bernard Vanhove. (2014) Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28. mAbs 6:3, pages 697-706.
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D. Kervella & G. Blancho. (2022) Nouvelles stratégies immunosuppressives en transplantation. Bulletin de l'Académie Nationale de Médecine 206:4, pages 540-550.
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Sabrina Pengam, Justine Durand, Claire Usal, Vanessa Gauttier, Nahzli Dilek, Bernard Martinet, Véronique Daguin, Caroline Mary, Virginie Thepenier, Géraldine Teppaz, Karine Renaudin, Gilles Blancho, Bernard Vanhove & Nicolas Poirier. (2019) SIRPα/CD47 axis controls the maintenance of transplant tolerance sustained by myeloid-derived suppressor cells. American Journal of Transplantation 19:12, pages 3263-3275.
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Bernard Vanhove, Nicolas Poirier, Jean-Paul Soulillou & Gilles Blancho. (2019) Selective Costimulation Blockade With Antagonist Anti-CD28 Therapeutics in Transplantation. Transplantation 103:9, pages 1783-1789.
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Xiaoqiong Wu, Siqi Chen, Limin Lin, Jiayu Liu, Yanlan Wang, Yumei Li, Qing Li & Zhong Wang. (2018) A Single Domain–Based Anti-Her2 Antibody Has Potent Antitumor Activities. Translational Oncology 11:2, pages 366-373.
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George Adigbli & Fadi Issa. (2018) Preserving Treg Function. Transplantation 102:2, pages 179-182.
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Bernard Vanhove, Nicolas Poirier, Fadi Fakhouri, Laetitia Laurent, Bert ’t Hart, Pedro Papotto, Luiz Rizzo, Masaaki Zaitsu, Fadi Issa, Kathryn Wood, Jean-Paul Soulillou & Gilles Blancho. (2017) Antagonist Anti-CD28 Therapeutics for the Treatment of Autoimmune Disorders. Antibodies 6:4, pages 19.
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Leslie S. Kean, Laurence A. Turka & Bruce R. Blazar. (2017) Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy. Immunological Reviews 276:1, pages 192-212.
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Alain C. Tissot & Ulrich Brinkmann. 2017. Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases. Next-Generation Therapies and Technologies for Immune-Mediated Inflammatory Diseases 75 97 .
Nicolas Poirier, Gilles Blancho, Maryvonne Hiance, Caroline Mary, Tim Van Assche, Jos Lempoels, Steven Ramael, Weirong Wang, Virginie Thepenier, Cecile Braudeau, Nina Salabert, Regis Josien, Ian Anderson, Ian Gourley, Jean-Paul Soulillou, Didier Coquoz & Bernard Vanhove. (2016) First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28. The Journal of Immunology 197:12, pages 4593-4602.
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Akiko Furukawa, Steven A. Wisel & Qizhi Tang. (2016) Impact of Immune-Modulatory Drugs on Regulatory T Cell. Transplantation 100:11, pages 2288-2300.
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Florence Herr, Melanie Brunel, Nathalie Roders & Antoine Durrbach. (2016) Co-stimulation Blockade Plus T-Cell Depletion in Transplant Patients: Towards a Steroid- and Calcineurin Inhibitor-Free Future?. Drugs 76:17, pages 1589-1600.
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Nicolas Poirier, Melanie Chevalier, Caroline Mary, Jeremy Hervouet, David Minault, Paul Baker, Simon Ville, Stephanie Le Bas-Bernardet, Nahzli Dilek, Lyssia Belarif, Elisabeth Cassagnau, Linda Scobie, Gilles Blancho & Bernard Vanhove. (2016) Selective CD28 Antagonist Blunts Memory Immune Responses and Promotes Long-Term Control of Skin Inflammation in Nonhuman Primates. The Journal of Immunology 196:1, pages 274-283.
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Michelle Yap, Sophie Brouard, Claire Pecqueur & Nicolas Degauque. (2015) Targeting CD8 T-Cell Metabolism in Transplantation. Frontiers in Immunology 6.
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Thulasi Ramani, Carol S. Auletta, Daniel Weinstock, Barbara Mounho-Zamora, Patricia C. Ryan, Theodora W. Salcedo & Gregory Bannish. (2015) Cytokines. International Journal of Toxicology 34:4, pages 355-365.
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Cameron McDonald-HymanLaurence A. TurkaBruce R. Blazar. (2015) Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation. Science Translational Medicine 7:280.
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Steven L. Rosinski, Rainer Storb, Roland K. Strong, George E. Sale, Diane M. Stone, Mesfin M. Gewe, Della J. Friend, V. Kraig Abrams, Julie Randolph-Habecker & Scott S. Graves. (2015) Anti-CD28 Antibody-Initiated Cytokine Storm in Canines. Transplantation Direct 1:2, pages 1-11.
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N. Poirier, N. Dilek, C. Mary, S. Ville, F. Coulon, J. Branchereau, X. Tillou, V. Charpy, S. Pengam, V. Nerriere-Daguin, J. Hervouet, D. Minault, S. Le Bas-Bernardet, K. Renaudin, B. Vanhove & G. Blancho. (2015) FR104, an Antagonist Anti-CD28 Monovalent Fab’ Antibody, Prevents Alloimmunization and Allows Calcineurin Inhibitor Minimization in Nonhuman Primate Renal Allograft. American Journal of Transplantation 15:1, pages 88-100.
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Nahzli Dilek, Nicolas Poirier, Philippe Hulin, Flora Coulon, Caroline Mary, Simon Ville, Henri Vie, Béatrice Clémenceau, Gilles Blancho & Bernard Vanhove. (2013) Targeting CD28, CTLA-4 and PD-L1 Costimulation Differentially Controls Immune Synapses and Function of Human Regulatory and Conventional T-Cells. PLoS ONE 8:12, pages e83139.
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