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Hanine Rafidi, Sharmila Rajan, Konnie Urban, Whitney Shatz-Binder, Keliana Hui, Gregory Z. Ferl, Amrita V. Kamath & C. Andrew Boswell. (2022) Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies. mAbs 14:1.
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Shan Chung, Van Nguyen, Yuwen Linda Lin, Julien Lafrance-Vanasse, Suzie J. Scales, Kevin Lin, Rong Deng, Kathi Williams, Gizette Sperinde, Juan Jenny Li, Kai Zheng, Siddharth Sukumaran, Devin Tesar, James A. Ernst, Saloumeh Fischer, Greg A. Lazar, Saileta Prabhu & An Song. (2019) An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans. mAbs 11:5, pages 942-955.
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Charlotte Bon, Thomas Hofer, Alain Bousquet-Mélou, Mark R. Davies & Ben-Fillippo Krippendorff. (2017) Capacity limits of asialoglycoprotein receptor-mediated liver targeting. mAbs 9:8, pages 1360-1369.
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Miro J. Eigenmann, Ludivine Fronton, Hans Peter Grimm, Michael B. Otteneder & Ben-Fillippo Krippendorff. (2017) Quantification of IgG monoclonal antibody clearance in tissues. mAbs 9:6, pages 1007-1015.
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Lindsay B. Avery, Mengmeng Wang, Mania S. Kavosi, Alison Joyce, Jeffrey C. Kurz, Yao-Yun Fan, Martin E. Dowty, Minlei Zhang, Yiqun Zhang, Aili Cheng, Fei Hua, Hannah M. Jones, Hendrik Neubert, Robert J. Polzer & Denise M. O'Hara. (2016) Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies. mAbs 8:6, pages 1064-1078.
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Yao-Yun Fan, Lindsay B. Avery, Mengmeng Wang, Denise M. O'Hara, Sheldon Leung & Hendrik Neubert. (2016) Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice. mAbs 8:5, pages 848-853.
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Jay Tibbitts, David Canter, Ryan Graff, Alison Smith & Leslie A. Khawli. (2016) Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development. mAbs 8:2, pages 229-245.
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Articles from other publishers (56)
Miho Nagayasu, Yoko Takano & Kazuhisa Ozeki. (2023) Development of a New Method to Evaluate the Biodistribution of Antibodies Using Non-Radioactive Metal Labeling and Inductively Coupled Plasma Mass Spectrometry. Pharmaceutical Research 40:7, pages 1807-1819.
Crossref
Crossref
Million A. Tegenge, Iftekhar Mahmood, Evi B. Struble & Zuben Sauna. (2023) Pharmacokinetics of antibodies during pregnancy: General pharmacokinetics and pregnancy related physiological changes (Part 1). International Immunopharmacology 117, pages 109914.
Crossref
Crossref
Bruce van Dijk, J. Fred F. Hooning van Duyvenbode, Lisanne de Vor, F. Ruben H. A. Nurmohamed, Marnix G. E. H. Lam, Alex J. Poot, Ruud M. Ramakers, Sofia Koustoulidou, Freek J. Beekman, Jos van Strijp, Suzan H. M. Rooijakkers, Ekaterina Dadachova, H. Charles Vogely, Harrie Weinans & Bart C. H. van der Wal. (2023) Evaluating the Targeting of a Staphylococcus-aureus-Infected Implant with a Radiolabeled Antibody In Vivo. International Journal of Molecular Sciences 24:5, pages 4374.
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Hossein Salimi-Moosavi & Marcus Soto. (2022) A Non-radiometric Approach to Determine Tissue Vascular Blood Volume in Biodistribution Studies. The AAPS Journal 24:6.
Crossref
Crossref
Alizée Bouleau, Hervé Nozach, Steven Dubois, Dimitri Kereselidze, Céline Chevaleyre, Cheng-I Wang, Michael J. Evans, Vincent Lebon, Bernard Maillère & Charles Truillet. (2022)
Optimizing Immuno-PET Imaging of Tumor PD-L1 Expression: Pharmacokinetic, Biodistribution, and Dosimetric Comparisons of
89
Zr-Labeled Anti-PD-L1 Antibody Formats
. Journal of Nuclear Medicine 63:8, pages 1259-1265.
Crossref
Crossref
Ahmed M. Abu-Dief, Mosa Alsehli & Aziz Awaad. (2022) A higher dose of PEGylated gold nanoparticles reduces the accelerated blood clearance phenomenon effect and induces spleen B lymphocytes in albino mice. Histochemistry and Cell Biology 157:6, pages 641-656.
Crossref
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Yara Al Ojaimi, Timothée Blin, Juliette Lamamy, Matthieu Gracia, Aubin Pitiot, Caroline Denevault-Sabourin, Nicolas Joubert, Jean-Pierre Pouget, Valérie Gouilleux-Gruart, Nathalie Heuzé-Vourc’h, Débora Lanznaster, Sophie Poty & Thomas Sécher. (2022) Therapeutic antibodies – natural and pathological barriers and strategies to overcome them. Pharmacology & Therapeutics 233, pages 108022.
Crossref
Crossref
Kenta Haraya, Haruka Tsutsui, Yasunori Komori & Tatsuhiko Tachibana. (2022) Recent Advances in Translational Pharmacokinetics and Pharmacodynamics Prediction of Therapeutic Antibodies Using Modeling and Simulation. Pharmaceuticals 15:5, pages 508.
Crossref
Crossref
Jakob C. Stüber, Karin F. Rechberger, Saša M. Miladinović, Thomas Pöschinger, Tamara Zimmermann, Remi Villenave, Miro J. Eigenmann, Thomas E. Kraft, Dhaval K. Shah, Hubert Kettenberger & Wolfgang F. Richter. (2022) Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies. AAPS Open 8:1.
Crossref
Crossref
Lisanne de Vor, Bruce van Dijk, Kok van Kessel, Jeffrey S Kavanaugh, Carla de Haas, Piet C Aerts, Marco C Viveen, Edwin C Boel, Ad C Fluit, Jakub M Kwiecinski, Gerard C Krijger, Ruud M Ramakers, Freek J Beekman, Ekaterina Dadachova, Marnix GEH Lam, H Charles Vogely, Bart CH van der Wal, Jos AG van Strijp, Alexander R Horswill, Harrie Weinans & Suzan HM Rooijakkers. (2022) Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm. eLife 11.
Crossref
Crossref
Aaron S. DevanathanAngela D.M. Kashuba. (2021) Human Immunodeficiency Virus Persistence in the Spleen: Opportunities for Pharmacologic Intervention. AIDS Research and Human Retroviruses 37:10, pages 725-735.
Crossref
Crossref
Alyssa Marie M. Castillo, Trang T. Vu, Sophia G. Liva, Min Chen, Zhiliang Xie, Justin Thomas, Bryan Remaily, Yizhen Guo, Uma L. Subrayan, Travis Costa, Timothy H. Helms, Donald J. Irby, Kyeongmin Kim, Dwight H. Owen, Samuel K. Kulp, Thomas A. Mace, Mitch A. Phelps & Christopher C. Coss. (2021) Murine cancer cachexia models replicate elevated catabolic pembrolizumab clearance in humans. JCSM Rapid Communications 4:2, pages 232-244.
Crossref
Crossref
Rebecca Faresjö, Gillian Bonvicini, Xiaotian T. Fang, Ximena Aguilar, Dag Sehlin & Stina Syvänen. (2021) Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size. Fluids and Barriers of the CNS 18:1.
Crossref
Crossref
Shu-Chen Lu, Michelle Chen, Larissa Atangan, Elizabeth A. Killion, Renee Komorowski, Yuan Cheng, Chawita Netirojjanakul, James R. Falsey, Marina Stolina, Denise Dwyer, Clarence Hale, Shanaka Stanislaus, Todd Hager, Veena A. Thomas, John M. Harrold, David J. Lloyd & Murielle M. Véniant. (2021) GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys. Cell Reports Medicine 2:5, pages 100263.
Crossref
Crossref
Hsuan-Ping Chang, Se Jin Kim & Dhaval K. Shah. (2021) Whole-Body Pharmacokinetics of Antibody in Mice Determined using Enzyme-Linked Immunosorbent Assay and Derivation of Tissue Interstitial Concentrations. Journal of Pharmaceutical Sciences 110:1, pages 446-457.
Crossref
Crossref
Esther Kuilamu, Christopher Subasic, Gary J Cowin, Fiona Simpson, Rodney F Minchin & Lisa M Kaminskas. (2020) Cetuximab Exhibits Sex Differences in Lymphatic Exposure after Intravenous Administration in Rats in the Absence of Differences in Plasma Exposure. Pharmaceutical Research 37:11.
Crossref
Crossref
Kip P. Conner, Siva Charan Devanaboyina, Veena A. Thomas & Dan A. Rock. (2020) The biodistribution of therapeutic proteins: Mechanism, implications for pharmacokinetics, and methods of evaluation. Pharmacology & Therapeutics 212, pages 107574.
Crossref
Crossref
Lidia Nazarova, Hanine Rafidi, Danielle Mandikian, Gregory Z. Ferl, James T. Koerber, Christopher W. Davies, Sheila Ulufatu, Jason Ho, Jeffrey Lau, Shang-Fan Yu, James Ernst, Jack D. Sadowsky & C. Andrew Boswell. (2020) Effect of Modulating FcRn Binding on Direct and Pretargeted Tumor Uptake of Full-length Antibodies. Molecular Cancer Therapeutics 19:4, pages 1052-1058.
Crossref
Crossref
John S. Ruano-Salguero & Kelvin H. Lee. (2020) Antibody transcytosis across brain endothelial-like cells occurs nonspecifically and independent of FcRn. Scientific Reports 10:1.
Crossref
Crossref
Ian Nessler, Cornelius Cilliers & Greg M. Thurber. (2020) Practical Guide for Quantification of In Vivo Degradation Rates for Therapeutic Proteins with Single-Cell Resolution Using Fluorescence Ratio Imaging. Pharmaceutics 12:2, pages 132.
Crossref
Crossref
Taiki Kurino, Reiko Matsuda, Ayu Terui, Hiroyuki Suzuki, Tomomi Kokubo, Tomoya Uehara, Yasushi Arano, Akihiro Hisaka & Hiroto Hatakeyama. (2020) Poor outcome with anti-programmed death-ligand 1 (PD-L1) antibody due to poor pharmacokinetic properties in PD-1/PD-L1 blockade-sensitive mouse models. Journal for ImmunoTherapy of Cancer 8:1, pages e000400.
Crossref
Crossref
Janie Duvenhage, Thomas Ebenhan, Seike Garny, Ignacio Hernández González, René Leyva Montaña, Roger Price, Lyn-Marie Birkholtz & Jan Rijn Zeevaart. (2019) Molecular Imaging of a Zirconium-89 Labeled Antibody Targeting Plasmodium falciparum–Infected Human Erythrocytes. Molecular Imaging and Biology 22:1, pages 115-123.
Crossref
Crossref
Donmienne Leung, Jacqueline Wurst, Tao Liu, Ruben Martinez, Amita Datta-Mannan & Yiqing Feng. (2020) Antibody Conjugates-Recent Advances and Future Innovations. Antibodies 9:1, pages 2.
Crossref
Crossref
Puregmaa Khongorzul, Cai Jia Ling, Farhan Ullah Khan, Awais Ullah Ihsan & Juan Zhang. (2020) Antibody–Drug Conjugates: A Comprehensive Review. Molecular Cancer Research 18:1, pages 3-19.
Crossref
Crossref
Margaret P. Manspeaker & Susan N. Thomas. (2020) Lymphatic immunomodulation using engineered drug delivery systems for cancer immunotherapy. Advanced Drug Delivery Reviews 160, pages 19-35.
Crossref
Crossref
Veena A. Thomas & Joseph P. Balthasar. (2019) Understanding Inter-Individual Variability in Monoclonal Antibody Disposition. Antibodies 8:4, pages 56.
Crossref
Crossref
Amita Datta-Mannan. (2019) Mechanisms Influencing the Pharmacokinetics and Disposition of Monoclonal Antibodies and Peptides. Drug Metabolism and Disposition 47:10, pages 1100-1110.
Crossref
Crossref
Martin R. Edelmann, Hubert Kettenberger, Alexander Knaupp, Tilman Schlothauer & Michael B. Otteneder. (2019) Radiolabeled IgG antibodies: Impact of various labels on neonatal Fc receptor binding. Journal of Labelled Compounds and Radiopharmaceuticals 62:11, pages 751-757.
Crossref
Crossref
Michal Pyzik, Kine M. K. Sand, Jonathan J. Hubbard, Jan Terje Andersen, Inger Sandlie & Richard S. Blumberg. (2019) The Neonatal Fc Receptor (FcRn): A Misnomer?. Frontiers in Immunology 10.
Crossref
Crossref
Mohammad Tabrizi, Divas Neupane, Sophia E. Elie, Harish Shankaran, Veronica Juan, Shuli Zhang, SuChun Hseih, Laurence Fayadat-Dilman, Daping Zhang, Yaoli Song, Vaishnavi Ganti, Michael Judo, Daniel Spellman, Wolfgang Seghezzi & Enrique Escandon. (2019) Pharmacokinetic Properties of Humanized IgG1 and IgG4 Antibodies in Preclinical Species: Translational Evaluation. The AAPS Journal 21:3.
Crossref
Crossref
Patrick M. Glassman & Joseph P. Balthasar. (2019) Physiologically-based modeling of monoclonal antibody pharmacokinetics in drug discovery and development. Drug Metabolism and Pharmacokinetics 34:1, pages 3-13.
Crossref
Crossref
Rong Deng, C. Andrew Boswell, Wendy S. Putnam, Meina T. Tang, Amit Garg, Chunze Li, Shan Chung & Sandhya Girish. 2019. Pharmaceutical Biotechnology. Pharmaceutical Biotechnology
151
190
.
Jennifer L. Mantle & Kelvin H. Lee. (2018) A differentiating neural stem cell-derived astrocytic population mitigates the inflammatory effects of TNF-α and IL-6 in an iPSC-based blood-brain barrier model. Neurobiology of Disease 119, pages 113-120.
Crossref
Crossref
Frank-Jan Warnders, Marjolijn N. Lub-de Hooge, Elisabeth G. E. de Vries & Jos G. W. Kosterink. (2018) Influence of protein properties and protein modification on biodistribution and tumor uptake of anticancer antibodies, antibody derivatives, and non-Ig scaffolds. Medicinal Research Reviews 38:6, pages 1837-1873.
Crossref
Crossref
Christoph Niederalt, Lars Kuepfer, Juri Solodenko, Thomas Eissing, Hans-Ulrich Siegmund, Michael Block, Stefan Willmann & Jörg Lippert. (2017) A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim. Journal of Pharmacokinetics and Pharmacodynamics 45:2, pages 235-257.
Crossref
Crossref
Lena D’Hooghe, Andrew D. Chalmers, Sam Heywood & Paul Whitley. (2017) Cell surface dynamics and cellular distribution of endogenous FcRn. PLOS ONE 12:8, pages e0182695.
Crossref
Crossref
Kirk W Johnson, Ann Neale, Allan Gordon, Julie Roessig, Padma Bezwada, Sabine Vukelich, Ira Goldfine & Paul Rubin. (2017) Attenuation of Insulin Action by an Allosteric Insulin Receptor Antibody in Healthy Volunteers. The Journal of Clinical Endocrinology & Metabolism 102:8, pages 3021-3028.
Crossref
Crossref
Saskia Fuhrmann, Charlotte Kloft & Wilhelm Huisinga. (2017) Impact of altered endogenous IgG on unspecific mAb clearance. Journal of Pharmacokinetics and Pharmacodynamics 44:4, pages 351-374.
Crossref
Crossref
Mauro Cataldi, Chiara Vigliotti, Teresa Mosca, MariaRosaria Cammarota & Domenico Capone. (2017) Emerging Role of the Spleen in the Pharmacokinetics of Monoclonal Antibodies, Nanoparticles and Exosomes. International Journal of Molecular Sciences 18:6, pages 1249.
Crossref
Crossref
David M. Francis & Susan N. Thomas. (2017) Progress and opportunities for enhancing the delivery and efficacy of checkpoint inhibitors for cancer immunotherapy. Advanced Drug Delivery Reviews 114, pages 33-42.
Crossref
Crossref
Anand Giddabasappa, Vijay R. Gupta, Rand Norberg, Parul Gupta, Mary E. Spilker, Joann Wentland, Brian Rago, Jeetendra Eswaraka, Mauricio Leal & Puja Sapra. (2016) Biodistribution and Targeting of Anti-5T4 Antibody–Drug Conjugate Using Fluorescence Molecular Tomography. Molecular Cancer Therapeutics 15:10, pages 2530-2540.
Crossref
Crossref
João Pedro Martins, Patrick J. Kennedy, Hélder A. Santos, Cristina Barrias & Bruno Sarmento. (2016) A comprehensive review of the neonatal Fc receptor and its application in drug delivery. Pharmacology & Therapeutics 161, pages 22-39.
Crossref
Crossref
Gurkishan S. Chadha & Marilyn E. Morris. (2016) Monoclonal Antibody Pharmacokinetics in Type 2 Diabetes Mellitus and Diabetic Nephropathy. Current Pharmacology Reports 2:2, pages 45-56.
Crossref
Crossref
Sean B. Joseph, Saileta Prabhu & C. Andrew Boswell. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
14
.
Baiteng Zhao & Tae H. Han. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
11
.
Chetan Rathi & Bernd Meibohm. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
16
.
Weirong Wang & Thomayant Prueksaritanont. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia
1
11
.
Mauricio Leal, JoAnn Wentland, Xiaogang Han, Yanhua Zhang, Brian Rago, Nicole Duriga, Franklin Spriggs, Eugene Kadar, Wei Song, James McNally, Quazi Shakey, Leslie Lorello, Judy Lucas & Puja Sapra. (2015) Preclinical Development of an anti-5T4 Antibody–Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice. Bioconjugate Chemistry 26:11, pages 2223-2232.
Crossref
Crossref
Klaus Mayer, Anna-Lena Baumann, Michael Grote, Stefan Seeber, Hubert Kettenberger, Sebastian Breuer, Tobias Killian, Wolfgang Schäfer & Ulrich Brinkmann. (2015) TriFabs—Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery. International Journal of Molecular Sciences 16:11, pages 27497-27507.
Crossref
Crossref
Mary Jane Masson Hinrichs & Rakesh Dixit. (2015) Antibody Drug Conjugates: Nonclinical Safety Considerations. The AAPS Journal 17:5, pages 1055-1064.
Crossref
Crossref
Daniel H. Bedinger, Dorothy A. Kieffer, Ira D. Goldfine, Marina K. Roell & Sean H. Adams. (2015) Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice. Journal of Cellular Biochemistry 116:9, pages 2109-2119.
Crossref
Crossref
Akiko Ishii-Watabe, Minoru Tada, Takuo Suzuki & Nana Kawasaki. (2015) Nonclinical Evaluation of Next-generation Therapeutic Monoclonal Antibodies次世代抗体医薬品の非臨床評価. YAKUGAKU ZASSHI 135:7, pages 857-866.
Crossref
Crossref
Gurkishan S. Chadha & Marilyn E. Morris. (2015) Effect of Type 2 Diabetes Mellitus and Diabetic Nephropathy on IgG Pharmacokinetics and Subcutaneous Bioavailability in the Rat. The AAPS Journal 17:4, pages 965-975.
Crossref
Crossref
Chetan Rathi & Bernd Meibohm. (2015) Clinical pharmacology of bispecific antibody constructs. The Journal of Clinical Pharmacology 55:S3, pages S21-S28.
Crossref
Crossref
Kip P. Conner, Brooke M. Rock, Gayle K. Kwon, Joseph P. Balthasar, Lubna Abuqayyas, Larry C. Wienkers & Dan A. Rock. (2014)
Evaluation of Near Infrared Fluorescent Labeling of Monoclonal Antibodies as a Tool for Tissue Distribution
. Drug Metabolism and Disposition 42:11, pages 1906-1913.
Crossref
Crossref
Tae H. Han & Baiteng Zhao. (2014) Absorption, Distribution, Metabolism, and Excretion Considerations for the Development of Antibody-Drug Conjugates. Drug Metabolism and Disposition 42:11, pages 1914-1920.
Crossref
Crossref