mAbs, Volume 6, Issue 3 (2014)

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mAbs, Volume 6, Issue 3 (2014)

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Meeting Report

Meeting Report
Antibody Engineering and Therapeutics
December 8-12, 2013, Huntington Beach, CA
Juan Carlos Almagro, Gary L Gilliland, Felix Breden, Jamie K Scott, Devin Sok, Matthias Pauthner, Janice M Reichert, Gustavo Helguera, Raiees Andrabi, Robert Mabry, Mathieu Bléry, James E Voss, Juha Laurén, Lubna Abuqayyas, Stefan Barghorn, Eshel Ben-Jacob, James E Crowe, James S Huston, Stephen Albert Johnston, Eric Krauland, Fridtjof Lund-Johansen, Wayne A Marasco, Paul WHI Parren & Kai Y Xu
Pages: 577-618
Published online: 03 Mar 2014
AbstractforAntibody Engineering and Therapeutics | Full Text | References | PDF (608 KB)
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Book Review

Antibody Fc: Linking Adaptive and Innate Immunity
Editors Margaret E. Ackerman, Falk Nimmerjahn
Janice M. Reichert
Pages: 619-621
Published online: 21 Mar 2014
AbstractforAntibody Fc: Linking Adaptive and Innate Immunity | Full Text | PDF (165.1 KB)
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Short Communication

Brief Report
A Two-in-One antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions
Chingwei V Lee, Patrick Koenig & Germaine Fuh
Pages: 622-627
Published online: 11 Mar 2014
AbstractforA Two-in-One antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions | Full Text | References | PDF (679.5 KB)
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Report

Article
The functional repertoire of rabbit antibodies and antibody discovery via next-generation sequencing
Sreekumar Kodangattil, Christine Huard, Cindy Ross, Jian Li, Huilan Gao, Alessandro Mascioni, Santosh Hodawadekar, Snehal Naik, Jessica Min-debartolo, Alberto Visintin & Juan C Almagro
Pages: 628-636
Published online: 30 Jan 2014
AbstractforThe functional repertoire of rabbit antibodies and antibody discovery via next-generation sequencing | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
A combinatorial mutagenesis approach for functional epitope mapping on phage-displayed target antigen
Application to antibodies against epidermal growth factor
Yanelys Cabrera Infante, Amaury Pupo & Gertrudis Rojas
Pages: 637-648
Published online: 03 Mar 2014
AbstractforA combinatorial mutagenesis approach for functional epitope mapping on phage-displayed target antigen | Full Text | References | PDF (805.6 KB)
  • 1627 Views
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Article
Influence of glycosylation pattern on the molecular properties of monoclonal antibodies
Kai Zheng, Mark Yarmarkovich, Christopher Bantog, Robert Bayer & Thomas W Patapoff
Pages: 649-658
Published online: 24 Mar 2014
AbstractforInfluence of glycosylation pattern on the molecular properties of monoclonal antibodies | Full Text | References | PDF (1.5 MB)
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Article
Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry
Qingchun Zhang, Andrew M Goetze, Huanchun Cui, Jenna Wylie, Steve Trimble, Art Hewig & Gregory C Flynn
Pages: 659-670
Published online: 11 Feb 2014
AbstractforComprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry | Full Text | References | PDF (842.1 KB) | Supplemental
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Article
Engineering toward a bacterial “endoplasmic reticulum” for the rapid expression of immunoglobulin proteins
Dan Groff, Stephanie Armstrong, Patrick J Rivers, Juan Zhang, Junhao Yang, Evan Green, James Rozzelle, Shengwen Liang, Joseph D Kittle, Alexander R Steiner, Ramesh Baliga, Christopher D Thanos, Trevor J Hallam, Aaron K Sato & Alice Y Yam
Pages: 671-678
Published online: 11 Feb 2014
AbstractforEngineering toward a bacterial “endoplasmic reticulum” for the rapid expression of immunoglobulin proteins | Full Text | References | PDF (981 KB) | Supplemental
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Article
Red colored IgG4 caused by vitamin B12 from cell culture media combined with disulfide reduction at harvest
Gayle E Derfus, Jemelle Dizon-Maspat, Jared T Broddrick, Arleene C Velayo, Josh D Toschi, Rodell T Santuray, Stephen K Hsu, Charles M Winter, Rajesh Krishnan & Ashraf Amanullah
Pages: 679-688
Published online: 19 Feb 2014
AbstractforRed colored IgG4 caused by vitamin B12 from cell culture media combined with disulfide reduction at harvest | Full Text | References | PDF (1.3 MB)
  • 3120 Views
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Article
Quantitative cumulative biodistribution of antibodies in mice
Effect of modulating binding affinity to the neonatal Fc receptor
Victor Yip, Enzo Palma, Devin B Tesar, Eduardo E Mundo, Daniela Bumbaca, Elizabeth K Torres, Noe A Reyes, Ben Q Shen, Paul J Fielder, Saileta Prabhu, Leslie A Khawli & C Andrew Boswell
Pages: 689-696
Published online: 26 Feb 2014
AbstractforQuantitative cumulative biodistribution of antibodies in mice | Full Text | References | PDF (814 KB)
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Article
Advantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28
Nicolas Poirier, Caroline Mary, Stephanie Le Bas-Bernardet, Veronique Daguin, Lyssia Belarif, Melanie Chevalier, Jeremy Hervouet, David Minault, Simon Ville, Vianney Charpy, Gilles Blancho & Bernard Vanhove
Pages: 697-706
Published online: 05 Mar 2014
AbstractforAdvantages of Papio anubis for preclinical testing of immunotoxicity of candidate therapeutic antagonist antibodies targeting CD28 | Full Text | References | PDF (1.6 MB)
  • 1116 Views
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Article
A novel anti-aldolase C antibody specifically interacts with residues 85–102 of the protein
Simona Langellotti, Maurizio Romano, Corrado Guarnaccia, Vincenzo Granata, Stefania Orrù, Adriana Zagari, Francisco E Baralle & Francesco Salvatore
Pages: 707-716
Published online: 13 Feb 2014
AbstractforA novel anti-aldolase C antibody specifically interacts with residues 85–102 of the protein | Full Text | References | PDF (943.2 KB) | Supplemental
  • 1106 Views
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Article
Human-like antibodies neutralizing Western equine encephalitis virus
Birgit Hülseweh, Torsten Rülker, Thibaut Pelat, Claudia Langermann, Andrè Frenzel, Thomas Schirrmann, Stefan Dübel, Philippe Thullier & Michael Hust
Pages: 717-726
Published online: 11 Feb 2014
AbstractforHuman-like antibodies neutralizing Western equine encephalitis virus | Full Text | References | PDF (1.7 MB)
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Article
A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells
Uwe Reusch, Carmen Burkhardt, Ivica Fucek, Fabrice Le Gall, Mikaelle Le Gall, Karin Hoffmann, Stefan HJ Knackmuss, Sergej Kiprijanov, Melvyn Little & Eugene A Zhukovsky
Pages: 727-738
Published online: 26 Mar 2014
AbstractforA novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+ tumor cells | Full Text | References | PDF (1.2 MB) | Supplemental
  • 6363 Views
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Article
Combating non-Hodgkin lymphoma by targeting both CD20 and HLA-DR through CD20–243 CrossMab
Lei Zhao, Feiyue Xie, Xin Tong, Huafei Li, Yaling Chen, Weizhu Qian, Shuyan Duan, Juan Zheng, Ziye Zhao, Bohua Li, Dapeng Zhang, Jian Zhao, Jianxin Dai, Xin Tong, Sheng Hou & Yajun Guo
Pages: 739-747
Published online: 26 Mar 2014
AbstractforCombating non-Hodgkin lymphoma by targeting both CD20 and HLA-DR through CD20–243 CrossMab | Full Text | References | PDF (2.1 MB) | Supplemental
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Article
Ocaratuzumab, an Fc-engineered antibody demonstrates enhanced antibody-dependent cell-mediated cytotoxicity in chronic lymphocytic leukemia
Carolyn M Cheney, Deborah M Stephens, Xiaokui Mo, Sarwish Rafiq, Jonathan Butchar, Joseph M Flynn, Jeffrey A Jones, Kami Maddocks, Adrienne O’Reilly, Abhijit Ramachandran, Susheela Tridandapani, Natarajan Muthusamy & John C Byrd
Pages: 748-754
Published online: 04 Mar 2014
AbstractforOcaratuzumab, an Fc-engineered antibody demonstrates enhanced antibody-dependent cell-mediated cytotoxicity in chronic lymphocytic leukemia | Full Text | References | PDF (488 KB) | Supplemental
  • 1860 Views
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Article
A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma
E Suzanne Cohen, Claire L Dobson, Helena Käck, Bing Wang, Dorothy A Sims, Christopher O Lloyd, Elizabeth England, D Gareth Rees, Hongwei Guo, Sophia N Karagiannis, Siobhan O’Brien, Sofia Persdotter, Helena Ekdahl, Robin Butler, Feenagh Keyes, Sarah Oakley, Mats Carlsson, Emmanuel Briend, Trevor Wilkinson, Ian K Anderson, Phillip D Monk, Karin von Wachenfeldt, Per-Olof F Eriksson, Hannah J Gould, Tristan J Vaughan & Richard D May
Pages: 755-763
Published online: 28 Feb 2014
AbstractforA novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma | Full Text | References | PDF (2 MB) | Supplemental
  • 3699 Views
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Article
A novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy
Angeline XH Goh, Sebastien Bertin-Maghit, Siok Ping Yeo, Adrian Ho, Heidi Derks, Alessandra Mortellaro & Cheng-I Wang
Pages: 764-772
Published online: 26 Mar 2014
AbstractforA novel human anti-interleukin-1β neutralizing monoclonal antibody showing in vivo efficacy | Full Text | References | PDF (948.3 KB) | Supplemental
  • 3308 Views
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Article
Discovery and characterization of olokizumab
A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
Stevan Shaw, Tim Bourne, Chris Meier, Bruce Carrington, Rich Gelinas, Alistair Henry, Andrew Popplewell, Ralph Adams, Terry Baker, Steve Rapecki, Diane Marshall, Adrian Moore, Helen Neale & Alastair Lawson
Pages: 773-781
Published online: 02 Apr 2014
AbstractforDiscovery and characterization of olokizumab | Full Text | References | PDF (2.5 MB)
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Article
Immunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab
Lazaro E Aira, Alejandro López-Requena, Dasha Fuentes, Liset Sánchez, Teresita Pérez, Aleida Urquiza, Heber Bautista, Leopoldina Falcón, Patricia Hernández & Zaima Mazorra
Pages: 782-792
Published online: 04 Mar 2014
AbstractforImmunological and histological evaluation of clinical samples from psoriasis patients treated with anti-CD6 itolizumab | Full Text | References | PDF (704.7 KB) | Supplemental
  • 1174 Views
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Article
ELLIPSE Study
A Phase 1 study evaluating the tolerance of bevacizumab nasal spray in the treatment of epistaxis in hereditary hemorrhagic telangiectasia
Sophie Dupuis-Girod, Alexis Ambrun, Evelyne Decullier, Géraldine Samson, Adeline Roux, Anne-Emmanuelle Fargeton, Catherine Rioufol, Verane Schwiertz, François Disant, François Chapuis, Yves Donazzolo, Gilles Paintaud, Patrick Edery & Frederic Faure
Pages: 793-798
Published online: 30 Jan 2014
AbstractforELLIPSE Study | Full Text | References | PDF (516.8 KB)
  • 1183 Views
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