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A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma

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Pages 755-763 | Received 31 Jan 2014, Accepted 28 Feb 2014, Published online: 28 Feb 2014

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Jon D. Wright, Hsing-Mao Chu, Chun-Hsiang Huang, Che Ma, Tse Wen Chang & Carmay Lim. (2015) Structural and Physical Basis for Anti-IgE Therapy. Scientific Reports 5:1.
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M. Carlsson, L. Thorell, A. Sj?lander & S. Larsson-Faria. (2015) Variability of Total and Free IgE Levels and IgE Receptor Expression in Allergic Subjects in and Out of Pollen Season. Scandinavian Journal of Immunology 81:4, pages 240-248.
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Stephanie L. Logsdon & Hans C. Oettgen. 2015. IgE Antibodies: Generation and Function. IgE Antibodies: Generation and Function 39 61 .

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