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mAbs Volume 3, 2011 - Issue 5
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The improvement of an anti-CD22 immunotoxin

Conversion to single-chain and disulfide stabilized form and affinity maturation by alanine scan

Seiji Kawa Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD USA
,
Masanori Onda Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD USA
,
Mitchell Ho Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD USA
,
Robert J. Kreitman Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD USA
,
Tapan K. Bera Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD USA
&
Ira Pastan Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health; Bethesda, MD USACorrespondence[email protected]
Pages 479-486 | Received 23 Jun 2011, Accepted 28 Jul 2011, Published online: 01 Sep 2011

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Katja Simon-Keller, Stefan Barth, Angela Vincent & Alexander Marx. (2013) Targeting the fetal acetylcholine receptor in rhabdomyosarcoma. Expert Opinion on Therapeutic Targets 17:2, pages 127-138.
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Simon K. Krebs, Marlitt Stech, Felix Jorde, Nathanaël Rakotoarinoro, Franziska Ramm, Sophie Marinoff, Sven Bahrke, Antje Danielczyk, Doreen A. Wüstenhagen & Stefan Kubick. (2022) Synthesis of an Anti-CD7 Recombinant Immunotoxin Based on PE24 in CHO and E. coli Cell-Free Systems. International Journal of Molecular Sciences 23:22, pages 13697.
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Maryam Keshtvarz, Jafar Salimian, Jafar Amani, Masoumeh Douraghi & Ehsan Rezaie. (2021) In silico analysis of STX2a-PE15-P4A8 chimeric protein as a novel immunotoxin for cancer therapy. In Silico Pharmacology 9:1.
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Wei Sun, Zhaona Yang, Heng Lin, Ming Liu, Chenxi Zhao, Xueying Hou, Zhuowei Hu & Bing Cui. (2019) Improvement in affinity and thermostability of a fully human antibody against interleukin-17A by yeast-display technology and CDR grafting. Acta Pharmaceutica Sinica B 9:5, pages 960-972.
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Tayebeh Farhadi, Atefeh Fakharian & Seyed MohammadReza Hashemian. (2017) Affinity Improvement of a Humanized Antiviral Antibody by Structure-Based Computational Design. International Journal of Peptide Research and Therapeutics 25:1, pages 181-186.
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Thomas Pirzer, Kira-Sophie Becher, Marcel Rieker, Tobias Meckel, Henning D. Mootz & Harald Kolmar. (2018) Generation of Potent Anti-HER1/2 Immunotoxins by Protein Ligation Using Split Inteins. ACS Chemical Biology 13:8, pages 2058-2066.
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Jijie Gu, Andrew McCluskey & Tariq Ghayur. 2017. Protein Therapeutics. Protein Therapeutics 229 270 .
Kathryn E. Tiller, Ratul Chowdhury, Tong Li, Seth D. Ludwig, Sabyasachi Sen, Costas D. Maranas & Peter M. Tessier. (2017) Facile Affinity Maturation of Antibody Variable Domains Using Natural Diversity Mutagenesis. Frontiers in Immunology 8.
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Jayaprakasam Madhumathi, Sithambaram Devilakshmi, Surapally Sridevi & Rama S. Verma. (2016) Immunotoxin therapy for hematologic malignancies: where are we heading?. Drug Discovery Today 21:2, pages 325-332.
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Bong-Kook Ko, Soyoung Choi, Lei Guang Cui, Young-Ha Lee, In-Sik Hwang, Kyu-Tae Kim, Hyunbo Shim & Jong-Seo Lee. (2015) Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer. PLOS ONE 10:7, pages e0134600.
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Alan S. Wayne, David J. FitzGerald, Robert J. Kreitman & Ira Pastan. (2014) Immunotoxins for leukemia. Blood 123:16, pages 2470-2477.
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Masato Kiyoshi, Jose M. M. Caaveiro, Eri Miura, Satoru Nagatoishi, Makoto Nakakido, Shinji Soga, Hiroki Shirai, Shigeki Kawabata & Kouhei Tsumoto. (2014) Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex. PLoS ONE 9:1, pages e87099.
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Miller Tran, Ryan E. Henry, David Siefker, Christina Van, Greg Newkirk, Julie Kim, Jack Bui & Stephen P. Mayfield. (2013) Production of anti-cancer immunotoxins in algae: Ribosome inactivating proteins as fusion partners. Biotechnology and Bioengineering 110:11, pages 2826-2835.
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